公开(公告)号：KR100882899B1

公开(公告)日：2009-02-10

申请号：KR1020060095841

申请日：2006-09-29

Applicant: 고려대학교 산학협력단

Inventor： 이재원 ,  이정복 ,  손인석 ,  김철민

IPC: G06F19/10 ,  G06F19/12 ,  G06F19/18

Abstract: 복제 실험 및 염료 교환 실험의 신뢰도 검증 방법이 개시된다.
본 발명은 복수의 서로 다른 실험조건에 각각 할당된 복수의 DNA 칩들 중에서 복제 실험용 DNA 칩 및 염료 교환 실험용 DNA 칩을 선택하는 단계, 상기 선택된 복제 실험용 DNA 칩과 염료 교환 실험용 DNA 칩 사이의 강도 차이 값을 입력하는 단계 및 상기 선택된 복제 실험용 DNA 칩과 염료 교환 실험용 DNA 칩 상에서 상기 입력된 강도 차이 이상에 해당하는 반점 영역을 디스플레이하는 단계를 포함한다.
본 발명에 의하면, 실험 조건, 기능별 카테고리 등에 따라 DNA 칩 상의 유전자 정보를 분류하여 데이터베이스를 구축하고, 간단하고 직관적인 인터페이스를 이용하여 검색을 하도록 함으로써, 실험의 신뢰도를 검증하거나 유효 유전자, 기능별 유전자, 프라이머 정보를 검색함에 있어 조작정도를 최소화하여 편리성을 제공하고, 검색결과를 사용자가 용이하게 파악하기 쉽게 테이블 및 이미지로 검색결과를 디스플레이할 수 있고, 실험을 검증하기 위해 필요한 프라이머 등의 정보를 체계적으로 제공할 수 있다.

公开(公告)号：KR1020080088541A

公开(公告)日：2008-10-02

申请号：KR1020080073693

申请日：2008-07-28

Applicant: 고려대학교 산학협력단

Inventor： 이재원 ,  이정복 ,  손인석 ,  김철민

IPC: G06F19/18 ,  G06F19/12

CPC classification number: G06F19/28 ,  G06F19/18

Abstract: A method for constructing a database providing laboratory primer information is provided to enable a user to search an EST(Expressed Sequence Tag) probe set conveniently by minimizing user manipulation, enable the user to understand a search result easily by displaying the search result in a table and an image, and systematically offer information of primer needed for verifying an experiment. An analysis result is generated from a chromatogram file by an analysis tool(220). Annotation information is generated from the analysis tool by an annotation generation tool and primer information is generated from the analysis result through an EST clustering tool(230). A primer database is generated by combining the annotation information, the primer information, and clone information extracted from the analysis result(240). The primer information includes information of various kinds of parameters for designing a laboratory primer.

Abstract translation: 提供了一种构建提供实验室引导信息的数据库的方法，以使用户能够通过最小化用户操纵来方便地搜索EST（表达序列标签）探针组，使用户能够通过在表中显示搜索结果来轻松地了解搜索结果 和图像，并系统地提供验证实验所需的引物信息。 通过分析工具（220）从色谱图文件生成分析结果。 通过注释生成工具从分析工具生成注释信息，并且通过EST聚类工具（230）从分析结果生成引物信息。 通过组合从分析结果（240）提取的注释信息，引物信息和克隆信息来生成引物数据库。 引物信息包括用于设计实验室底漆的各种参数的信息。

公开(公告)号：KR1020080088539A

公开(公告)日：2008-10-02

申请号：KR1020080073687

申请日：2008-07-28

Applicant: 고려대학교 산학협력단

Inventor： 이재원 ,  이정복 ,  손인석 ,  김철민

IPC: G06F19/18 ,  G06F19/12

CPC classification number: G06F19/28 ,  G06F19/12 ,  G06F19/26

Abstract: A method for searching effective genes is provided to enable a user to search the effective genes conveniently by minimizing user manipulation, and enable the user to understand a search result easily by displaying the search result in a table and an image. Effective gene information for a plurality of different experiment conditions is stored to a database(210), and a list of the different experiment conditions is displayed through an output device(220). A signal selecting one of the displayed experiment conditions is received from a data input device(230). Block information of a spot effective to the selected experiment condition, and the information including column/row indexes in a block are extracted from gene information stored in the database. The extracted information is displayed through an output device by using a table or a DNA(DeoxyriboNucleic Acid) chip image(240).

Abstract translation: 提供了一种搜索有效基因的方法，使得用户能够通过最小化用户操纵来方便地搜索有效基因，并且使用户能够通过将搜索结果显示在表格和图像中来​​容易地理解搜索结果。 用于多个不同实验条件的有效基因信息被存储到数据库（210），并且通过输出设备（220）显示不同实验条件的列表。 从数据输入装置（230）接收选择显示的实验条件之一的信号。 阻止对所选实验条件有效的点的信息，并且从存储在数据库中的基因信息中提取包括块中的列/行索引的信息。 提取的信息通过使用表或DNA（脱氧核糖核酸）芯片图像（240）通过输出装置显示。

公开(公告)号：KR100742780B1

公开(公告)日：2007-07-26

申请号：KR1020060098214

申请日：2006-10-10

Applicant: 고려대학교 산학협력단

Inventor： 이재원 ,  조환규 ,  김철민 ,  이정복 ,  손인석

IPC: G01N35/00

Abstract: Provided are a method for automatically analyzing a microarray image which can increase automation level of analyzation with user convenience and consistent product quality by using visual effect such as color mapping and a computer-readable recording medium on which a program for causing a computer to execute the automatic microarray image analyzation method is recorded. The method includes the steps of loading a microarray scanning image(110), performing block indexing using modified K-nearest neighbor on the image(120), producing an epsilon graph using a spot extracted from each block of the image as a fixed point, in which the half point is higher than a predetermined critical intensity(130), performing spot indexing using the epsilon graph(140), and displaying each spot visually on the image according to the spot indexing. The method further includes a step of producing profile information of each spot by analyzing pixels included in each spots. The profile information includes name of gene, index of column and row of the block in which the spot belongs, index of column and row of each spot, average intensity of luminescent material, number of pixel according to the luminescent material and sum of the intensity.

Abstract translation: 本发明提供一种自动分析微阵列图像的方法，该微阵列图像通过使用视觉效果（诸如颜色映射）和计算机可读记录介质来提高用户便利性和一致的产品质量的分析自动化水平，计算机可读记录介质上具有用于使计算机执行 记录自动微阵列图像分析方法。 该方法包括加载微阵列扫描图像（110），使用图像（120）上的修改的K最近邻居执行块索引，使用从图像的每个块提取的点作为固定点产生ε图， 其中半点高于预定临界强度（130），使用epsilon图（140）执行光点索引，并且根据光点索引在图像上视觉地显示每个光点。 该方法还包括通过分析包含在每个地点中的像素来产生每个地点的简档信息的步骤。 概况信息包括基因名称，该点所属块的列和行的索引，每个点的列和行的索引，发光材料的平均强度，根据发光材料的像素的数目以及强度的总和 。

公开(公告)号：KR102095890B1

公开(公告)日：2020-04-01

申请号：KR1020180159811

申请日：2018-12-12

Applicant: 고려대학교 산학협력단

Inventor： 김규태 ,  박소정 ,  박일후 ,  이국진 ,  김철민

IPC: G01N7/00 ,  G01N33/00

公开(公告)号：KR1020090087529A

公开(公告)日：2009-08-18

申请号：KR1020080012822

申请日：2008-02-13

Applicant: 고려대학교 산학협력단

Inventor： 김태근 ,  신영철 ,  김철민

IPC: H01L33/20 ,  H01L33/22 ,  H01L33/42

Abstract: A gallium nitride light emitting diode and method for manufacturing the same are provided to obtain 2D photonic crystal effect from the transparent electrode layer by controlling the size and pattern of the opal structure. The nitride layer(300), buffer layer(320), N-GaN layer(330), active layer(340), P-GaN layer(350) are successively formed on the SiC and GaN the substrate(200). The light generated in the active layer is incident to the transparent electrode layer(530) through the P-GaN layer. The light is flowed in into the transparent electrode layer inside while being scattered in the interface of the transparent electrode layer and the patterned P-GaN layer. The recessed part is formed in the surface of the P-GaN layer of the nitride layer(300) through the dry etch.

Abstract translation: 提供了一种氮化镓发光二极管及其制造方法，用于通过控制蛋白石结构的尺寸和图案从透明电极层获得2D光子晶体效应。 在SiC和GaN衬底（200）上依次形成氮化物层（300），缓冲层（320），N-GaN层（330），有源层（340），P-GaN层（350）。 在有源层中产生的光通过P-GaN层入射到透明电极层（530）。 在透明电极层和图案化的P-GaN层的界面中散射时，光在内部流入透明电极层。 凹陷部分通过干蚀刻形成在氮化物层（300）的P-​​GaN层的表面中。

公开(公告)号：KR1020080088540A

公开(公告)日：2008-10-02

申请号：KR1020080073692

申请日：2008-07-28

Applicant: 고려대학교 산학협력단

Inventor： 이재원 ,  이정복 ,  손인석 ,  김철민

IPC: G06F19/18 ,  G06F19/12

CPC classification number: G06F19/28 ,  G06F19/20

Abstract: A method for searching an EST(Expressed Sequence Tag) function is provided to enable a user to search the EST function conveniently by minimizing user manipulation, and enable the user to understand a search result easily by displaying the search result in a table and an image. Function group information is generated by classifying ESTs included in a plurality of DNA(DeoxyriboNucleic Acid) chips and is stored to a database(210). A list of function categories is displayed through an output device(220). The EST corresponding to the selected category is extracted from the function group information stored in the database when a signal selecting one of the function categories is received from a data input device(230). Block information of the extracted EST and the information including column/row indexes in a block are displayed through an output device by using a table or a DNA chip image(240).

Abstract translation: 提供了一种用于搜索EST（表达序列标签）功能的方法，以使用户能够通过最小化用户操纵来方便地搜索EST功能，并且使用户能够通过将搜索结果显示在表格和图像中来​​容易地理解搜索结果 。 通过对包含在多个DNA（脱氧核糖核酸）芯片中的EST进行分类而生成功能组信息，并存储到数据库210。 通过输出设备（220）显示功能类别的列表。 当从数据输入装置（230）接收到选择功能类别之一的信号时，从存储在数据库中的功能组信息中提取与所选类别相对应的EST。 通过使用表或DNA芯片图像（240），通过输出装置显示提取的EST的块信息和包括块/行索引的信息。

公开(公告)号：KR1020080030147A

公开(公告)日：2008-04-04

申请号：KR1020060095841

申请日：2006-09-29

Applicant: 고려대학교 산학협력단

Inventor： 이재원 ,  이정복 ,  손인석 ,  김철민

IPC: G06F19/10 ,  G06F19/12 ,  G06F19/18

CPC classification number: G06F19/28 ,  G06F19/12 ,  G06F19/18 ,  G06F19/20 ,  G06F19/26

Abstract: A method for verifying reliability of duplication experiment and dye-swap experiment, finding effective genes, searching EST according to function and building database with laboratory primer information, and a recording medium thereof are provided to minimize user manipulation by classifying gene information of a DNA chip and constructing a database. DNA chips for duplication experiment and dye-swap experiment are selected from a plurality of DNA chips allocated to the plural experiment conditions different from each other respectively(210). An intensity difference value between the selected duplication experiment DNA chip and the dye-swap experiment DNA chip is inputted(220). A spot region larger than the inputted intensity difference value on the selected duplication experiment DNA chip and the dye-swap experiment DNA chip is displayed(230).

Abstract translation: 提供了重复实验和染色互换实验的可靠性方法，找到有效基因，根据功能搜索EST和建立实验室引物信息的数据库及其记录介质，以通过对DNA芯片的基因信息进行分类来最小化用户操作 并构建数据库。 从分别分配到彼此不同的多个实验条件的多个DNA芯片（210）中选择用于重复实验和染色交换实验的DNA芯片（210）。 输入所选复制实验DNA芯片和染色交换实验DNA芯片之间的强度差值（220）。 显示大于所选复制实验DNA芯片和染料交换实验DNA芯片上输入的强度差值的斑点区域（230）。