公开(公告)号：KR100358548B1

公开(公告)日：2002-10-25

申请号：KR1019990057231

申请日：1999-12-13

Applicant: 로레알

Inventor： 시모네쟝-띠에리 ,  쏜느빌오딜 ,  르그레실비

IPC: A61K8/19 ,  A61Q19/00 ,  B82Y5/00

CPC classification number: A61Q19/00 ,  A61K8/062 ,  A61K9/0048 ,  A61K9/1075 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  A61Q19/007 ,  B01F17/0021 ,  B82Y5/00 ,  Y10S514/844 ,  Y10S514/847 ,  Y10S514/88 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/939 ,  Y10S514/941 ,  Y10S514/942 ,  Y10S514/943 ,  Y10S514/975

Abstract: 본발명은 45 ℃이하의온도에서고체이며글리세롤에스테르에서선택된계면활성제, 및분자량이 400 초과인하나이상의오일을함유하며, 계면활성제의양에대한오일상의양의중량비율이 2 내지 10 인것을특징으로하는, 오일구 (球) 의평균크기가 100 ㎚미만인나노에멀젼에관한것이다. 사용되는계면활성제는예를들면, 데카글리세롤모노스테아레이트, 디스테아레이트, 트리스테아레이트및 펜타스테아레이트, 디글리세롤모노스테아레이트및 이들의혼합물에서선택된다. 수득되는에멀젼은투명하며, 저장에대해안정하다. 이는우수한투명도를유지하고우수한화장특성을가지면서다량의오일을함유할수 있다. 본발명은또한본 발명에따른나노에멀젼의, 화장품및 피부과학분야에서의용도, 특히피부및/또는점막의보습및 모발의트리트먼트를위한용도, 및눈의트리트먼트를위한아이로션으로서안과학분야에서의용도에관한것이다.

公开(公告)号：KR100345097B1

公开(公告)日：2002-07-24

申请号：KR1019990057463

申请日：1999-12-14

Applicant: 로레알

Inventor： 시모네쟝-띠에리 ,  쏜느빌오딜 ,  르그레실비

IPC: A61K6/083 ,  B82Y5/00

CPC classification number: A61Q19/00 ,  A61K8/06 ,  A61K9/0048 ,  A61K9/1075 ,  A61K2800/21 ,  A61K2800/262 ,  A61K2800/413 ,  A61Q1/14 ,  A61Q5/00 ,  A61Q19/007 ,  B01F17/0021 ,  B82Y5/00 ,  Y10S514/844 ,  Y10S514/845 ,  Y10S514/937 ,  Y10S514/938

Abstract: 본발명은에톡실화지방에테르및 에톡실화지방에스테르에서선택된 45 ℃이하의온도에서고형인계면활성제, 및분자량이 400 이상인하나이상의오일을함유하며, 계면활성제의양에대한오일상의양의중량비율이 2 내지 10인것을특징으로하는, 오일구(球)의평균크기가 100 nm 미만인나노에멀젼에관한것이다. 사용되는계면활성제는예를들면, 5 - 30 산화에틸렌단위를포함하는베헤닐알콜에톡실화에테르, 2 산화에틸렌단위를포함하는스테아릴알콜에톡실화에테르, 40 산화에틸렌단위를포함하는스테아르산에스테르, 8 산화에틸렌단위를포함하는베헨산에스테르, 및이들의혼합물에서선택된다. 수득되는에멀젼은투명하며, 저장에대해안정하다. 이는우수한투명도를유지하고우수한화장특성을가지면서다량의오일을함유할수 있다. 이는국소용조성물, 약학용조성물또는안과용조성물을구성할수 있다. 본발명은또한, 본발명에따른나노에멀젼의, 화장품및 피부과학분야에서의용도, 특히피부및/또는점막의보습, 및모발의트리트먼트를위한용도, 및눈의트리트먼트를위한아이로션으로서안과학분야에서의용도에관한것이다.

公开(公告)号：KR1020000048105A

公开(公告)日：2000-07-25

申请号：KR1019990057228

申请日：1999-12-13

Applicant: 로레알

Inventor： 시모네쟝-띠에리 ,  쏜느빌오딜 ,  르그레실비

IPC: A61K9/107 ,  A61K9/10 ,  B82Y5/00

CPC classification number: A61Q19/007 ,  A61K8/06 ,  A61K8/4993 ,  A61K9/0048 ,  A61K9/1075 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  A61Q5/00 ,  B82Y5/00 ,  Y10S514/844 ,  Y10S514/938 ,  Y10S514/941 ,  Y10S514/942

Abstract: PURPOSE: A nanoemulsion based on fatty esters of oxyethylated or non-oxylated sorbitan is provided, which is stable in preservation; maintains excellent transparency; has good cosmetic property; and contains a lot of oil. An use of the nanoemulsion in the fields of cosmetics, dermatology and/or ophthalmology is also provided. CONSTITUTION: A nanoemulsion based on fatty esters of oxyethylated or non-oxylated sorbitan comprises of: a surfactant being solid under 45°C, selected from sorbitan fatty ester and oxyethylated sorbitan fatty ester; one or more oil having over 400 of molecular weight; more than one of ionic pro-bipolar lipid selected from a group comprising alkalic salt of dicetyl and dimyristyl phosphate, alkalic salt of cholesterol sulfate, alkalic salt of cholesterol phosphate, lipoamino acid, sodium salt of phsphatidic acid, cationic pro-bipolar lipid, and alkyl sulfon derivatives; and weight ratio of oil phase to the surfactant is 2-10, and average size of oil globule of the nanoemulsion is smaller than 100nm.

Abstract translation: 目的：提供基于氧乙基化或非氧化脱水山梨醇的脂肪酯的纳米乳液，其在保存中是稳定的; 保持良好的透明度; 具有良好的化妆品性能; 并含有大量的油。 还提供了在化妆品，皮肤病学和/或眼科学领域中使用纳米乳剂。 构成：基于氧乙基化或非氧化脱水山梨糖醇的脂肪酸酯的纳米乳液包括：在45℃下为固体的表面活性剂，选自脱水山梨醇脂肪酸酯和氧乙基化脱水山梨醇脂肪酸酯; 一种或多种具有超过400分子量的油; 选自包括二鲸蜡基和二肉豆蔻基磷酸的碱性盐，胆固醇硫酸的碱性盐，胆固醇磷酸的碱性盐，脂氨基酸，硫磺酸的钠盐，阳离子亲双酚脂质和 烷基磺酸衍生物; 油相与表面活性剂的重量比为2-10，纳米乳液的油球平均粒径小于100nm。

公开(公告)号：KR100369260B1

公开(公告)日：2003-01-24

申请号：KR1019990058632

申请日：1999-12-17

Applicant: 로레알

Inventor： 시모네쟝-띠에리 ,  쏜느빌오딜 ,  르그레실비

IPC: A61K9/107 ,  A61K9/51 ,  B82Y5/00

CPC classification number: B82Y5/00 ,  A61K8/06 ,  A61K8/37 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  Y10S514/844 ,  Y10S514/845 ,  Y10S514/846 ,  Y10S514/912 ,  Y10S514/937 ,  Y10S514/938

Abstract: An oil-in-water nanoemulsion with a droplet size of less than 100 nm contains an oil (I) with a molecular weight above 400 and an alkyl ether citrate surfactant (II), the weight ratio of oil phase to (II) being 2-10:1. An Independent claim is also included for production of the composition by mixing the aqueous phase with the oil phase under vigorous agitation at 10-80 degrees C and homogenizing the mixture at 60-180 MPa.

Abstract translation: 液滴尺寸小于100nm的水包油纳米乳液含有分子量大于400的油（I）和烷基醚柠檬酸盐表面活性剂（II），油相与（II）的重量比为2 -10：1。 还包括独立权利要求用于通过在10-80℃剧烈搅拌下将水相与油相混合并在60-180MPa下均化混合物来制备组合物。

公开(公告)号：KR1020000062214A

公开(公告)日：2000-10-25

申请号：KR1019990059292

申请日：1999-12-20

Applicant: 로레알

Inventor： 시모네쟝-띠에리 ,  쏜느빌오딜 ,  르그레실비

IPC: A61K8/20 ,  A61Q11/00

CPC classification number: A61Q19/00 ,  A61K8/06 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  B01F17/0064 ,  B82Y5/00 ,  Y10S514/844 ,  Y10S514/845 ,  Y10S514/846 ,  Y10S514/88 ,  Y10S514/912

Abstract: 본발명은인산지방에스테르및 그의옥시에틸렌화유도체에서선택된음이온성계면활성제, 및분자량이 400 이상인하나이상의오일을함유하며, 계면활성제의양에대한오일상의양의중량비율이 2 내지 10인것을특징으로하는, 오일구(球)의수평균크기가 100 nm 미만인나노에멀젼에관한것이다. 사용되는음이온성계면활성제는예를들면, C~C알킬포스페이트의칼륨염, 스테아릴/이소스테아릴알콜과인산의에스테르, 세틸알콜과인산의에스테르 ,트리데실알콜과인산의에스테르, 이들에스테르의옥시에틸렌화유도체, 그리고이들의혼합물로부터선택된다. 수득되는에멀젼은투명하며, 저장에대해안정하다. 이들은우수한투명도를유지하고우수한화장특성을가지면서다량의오일을함유할수 있다. 이들은국소용조성물, 약학용조성물또는안과용조성물을구성할수 있다. 본발명은또한, 본발명에따른나노에멀젼의, 화장및 피부분야에서의용도, 특히피부및/또는점막의보습, 및모발의트리트먼트를위한용도, 및눈의트리트먼트를위한아이로션으로서안 분야에서의용도에관한것이다.

公开(公告)号：KR1020000057867A

公开(公告)日：2000-09-25

申请号：KR1020000004979

申请日：2000-02-01

Applicant: 로레알

Inventor： 시모네쟝-띠에리 ,  쏜느빌오딜 ,  르그레실비

IPC: A61K9/107 ,  B82Y5/00

CPC classification number: B82Y5/00 ,  A61K8/06 ,  A61K9/0048 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  B01F17/0021 ,  B01F17/0028

Abstract: PURPOSE: Nanoemulsion from alkoxylated alkenyl succinate or alkoxylate alkenyl succinate of glucose, and its preparation method are provided, for moisturizing the skin and/or mucous membrane or treating the eyes in cosmetics, dermatology, ophthalmology and/or pharmaceutics. CONSTITUTION: A nanoemulsion comprises 0.2-15 wt% of at least one surfactant selected from alkoxylated alkenyl succinate, alkoxylated alkenyl succinate of glucose and alkoxylated alkenyl succinate of methylglucose; at least one oil whose molecular weight is more than 400; optionally 0.01-5 wt% of at least one ionic amphiphilic lipid selected from the group consisting of anionic amphiphilic lipids and alkylsulfonic acid derivatives; 0.01-30 wt% of optionally additives for improving transparency, selected from alcohols of low molecular weight, glycol, sugar and their mixture; and optionally cosmetic, dermatological, ophthalmological or pharmaceutical active ingredients, wherein the ratio of the oil to the surfactant is 2-10, preferably 3-6 by weight, and the nanoemulsion contains the oil phase diffused in oil drop and aqueous phase whose number mean size is less than 100 nm. The nanoemulsion is prepared by stirring the aqueous phase and the oily phase strongly at the temperature of 10-80°C to mix them; and homogenizing the mixture at the pressure of 6X10¬6 - 18X10¬7 Pa.

Abstract translation: 目的：提供葡萄糖的烷氧基化烯基琥珀酸酯或烷氧基化烯基琥珀酸酯的纳米乳液及其制备方法，用于在化妆品，皮肤病学，眼科学和/或药物学中保湿皮肤和/或粘膜或治疗眼睛。 构成：纳米乳液包含0.2-15重量％的至少一种表面活性剂，选自烷氧基化烯基琥珀酸酯，烷氧基化链烯基琥珀酸酯葡萄糖和烷氧基化烯基琥珀酸甲基葡萄糖; 至少一种分子量大于400的油; 任选0.01-5重量％的至少一种选自阴离子两亲性脂质和烷基磺酸衍生物的离子两亲性脂质; 0.01-30重量％的任选的提高透明度的添加剂，选自低分子量的醇，二醇，糖及其混合物; 和任选的化妆品，皮肤病学，眼科学或药物活性成分，其中油与表面活性剂的比例为2-10重量％，优选3-6重量％，并且纳米乳液含有在油滴和水相中扩散的油相，其数量平均 尺寸小于100nm。 通过在10-80℃的温度下强烈搅拌水相和油相来混合纳米乳液， 并在6×10 -6〜18×10 -7 Pa的压力下均化混合物。

公开(公告)号：KR1020000052504A

公开(公告)日：2000-08-25

申请号：KR1019990058632

申请日：1999-12-17

Applicant: 로레알

Inventor： 시모네쟝-띠에리 ,  쏜느빌오딜 ,  르그레실비

IPC: A61K9/107 ,  A61K9/51 ,  B82Y5/00

CPC classification number: B82Y5/00 ,  A61K8/06 ,  A61K8/37 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  Y10S514/844 ,  Y10S514/845 ,  Y10S514/846 ,  Y10S514/912 ,  Y10S514/937 ,  Y10S514/938

Abstract: PURPOSE: Nanoemulsion based on alkylethercitrate is provided to give the stability of storage, the maintenance of good transparency and the incorporation of bulky oil with good cosmetic property. In addition to the nanoemulsion above, their use in cosmetics, skin science, pharmacy and/or ophthalmology are provided. CONSTITUTION: A nanoemulsion is comprised of oil phase dispersed in water phase, has less than 100nm of number average size of oil small sphere, contains anionic surfactants selected from alkylethercitrate, also at least one oil having more than 400 of molecular weight, and has 2 to 10 at their ratios of oil phase for amounts of the surfactant. The nanoemulsion is characterized in that its turbidity is 60 to 600 NTUs. The amount of the surfactant is characterized by being 0.2 to 15wt%, preferably 3 to 6wt% based on total weight of nanoemulsion.

Abstract translation: 目的：提供基于烷基醚酸酯的纳米乳液，以提供储存的稳定性，维持良好的透明度和掺入具有良好化妆品性质的大体积油。 除了上述纳米乳液之外，还提供了它们在化妆品，皮肤科学，药学和/或眼科学中的应用。 构成：纳米乳液由分散在水相中的油相组成，具有小于100nm的小球体数均粒径，含有选自烷基醚的阴离子表面活性剂，还含有至少一种具有400以上分子量的油，并且具有2 以相对于表面活性剂的量的油相比为10。 纳米乳液的特征在于其浊度为60至600NTU。 表面活性剂的用量相对于纳米乳液的总重量为0.2〜15重量％，优选为3〜6重量％。

公开(公告)号：KR1020000048107A

公开(公告)日：2000-07-25

申请号：KR1019990057230

申请日：1999-12-13

Applicant: 로레알

Inventor： 시모네쟝-띠에리 ,  쏜느빌오딜 ,  르그레실비

IPC: A61K9/107 ,  A61K9/50 ,  B82Y5/00

CPC classification number: A61Q19/007 ,  A61K8/06 ,  A61K8/062 ,  A61K8/60 ,  A61K8/602 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  A61Q5/00 ,  A61Q19/00 ,  B82Y5/00 ,  Y10S514/938

Abstract: PURPOSE: A nanoemulsion based on fatty esters of sugar or fatty ethers of sugar is provided, which has stability in preservation; maintains excellent transparency; has good cosmetic property; and contains a lot of oil. An use of the nanoemulsion in the fields of cosmetics, dermatology and/or ophtalmology is also provided. CONSTITUTION: A nanoemulsion based on fatty esters of sugar or fatty ethers of sugar comprises of: a surfactant(C8-C22 fatty esters of sucrose, maltose, glucose and fructose, esters of C14-C22 fatty acid and methylglucose, alkyl polyglucoside and mixture thereof) being solid under 45°C, selected from an esters of fatty acid and sugar, and an ether of fatty alcohol and sugar; one or more oil having over 400 of molecular weight. In the o/w nanoemulsion, weight ratio of oil phase to the surfactant is 2-10, and average size of an oil globule of the nanoemulsion is smaller than 100nm by passing through high-pressure homogenizer more than one times.

Abstract translation: 目的：提供基于糖或糖的脂肪醚的脂肪酯的纳米乳液，其具有保存的稳定性; 保持良好的透明度; 具有良好的化妆品性能; 并含有大量的油。 还提供了在化妆品，皮肤病学和/或眼科学领域中使用纳米乳剂。 构成：基于糖或糖的脂肪醚的脂肪酸的纳米乳液包括：表面活性剂（蔗糖，麦芽糖，葡萄糖和果糖的C8-C22脂肪酯，C14-C22脂肪酸和甲基葡萄糖的酯，烷基聚葡萄糖苷及其混合物 ）在45℃下为固体，选自脂肪酸和糖的酯，以及脂肪醇和糖的醚; 一种或多种具有超过400分子量的油。 在o / w纳米乳液中，油相与表面活性剂的重量比为2-10，通过高压均化器超过一次，纳米乳液的油球的平均尺寸小于100nm。