公开(公告)号：KR100359145B1

公开(公告)日：2002-10-31

申请号：KR1019990057227

申请日：1999-12-13

Applicant: 로레알

Inventor： 시모네쟝-띠에리 ,  쏜느빌오딜 ,  르그레실비

IPC: A61K8/49 ,  A61Q19/02 ,  A61K8/04 ,  B82Y5/00

CPC classification number: B82Y5/00 ,  A61K8/062 ,  A61K8/90 ,  A61K9/0048 ,  A61K9/1075 ,  A61K31/77 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  B01F17/0028 ,  Y10S514/873 ,  Y10S514/937 ,  Y10S514/938

Abstract: 본발명은에틸렌옥시드및 프로필렌옥시드블록공중합체로부터선택된계면활성제, 및분자량이 400 초과인하나이상의오일을함유하며, 계면활성제의양에대한오일상의양의중량비가 2 내지 10인것을특징으로하는, 오일구(球)의수평균크기가 100 nm 미만인나노에멀젼에관한것이다. 사용된계면활성제는예를들어하기식 (I) 의블록공중합체이다: HO(CHO)(CHO)(CHO)H (I) (식중, x, y 및 z 는정수이고, x + z 는 2 내지 100 이고, y 는 14 내지 60 이다). 블록공중합체는바람직하게는 2 내지 16 의 HLB 가지며, 특히상품명 Pluronic L81, Pluronic L92 및 Pluronic L44 (ICI 사) 으로시판되는제품이다. 수득되는에멀젼은투명하며, 저장에대해안정하다. 이는우수한투명도를유지하고우수한화장특성을가지면서다량의오일을함유할수 있다. 이는국부용조성물, 제약학적조성물또는안과학적조성물의구성성분이된다. 본발명은또한, 본발명에따른나노에멀젼의, 화장품및 피부과학분야에서의용도, 특히피부및/또는점막의보습, 및모발의트리트먼트를위한용도, 및눈의트리트먼트를위한안약으로서안과학분야에서의용도에관한것이다.

公开(公告)号：KR100345098B1

公开(公告)日：2002-07-24

申请号：KR1019990059292

申请日：1999-12-20

Applicant: 로레알

Inventor： 시모네쟝-띠에리 ,  쏜느빌오딜 ,  르그레실비

IPC: A61K8/20 ,  A61Q11/00

CPC classification number: A61Q19/00 ,  A61K8/06 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  B01F17/0064 ,  B82Y5/00 ,  Y10S514/844 ,  Y10S514/845 ,  Y10S514/846 ,  Y10S514/88 ,  Y10S514/912

Abstract: 본발명은인산지방에스테르및 그의옥시에틸렌화유도체에서선택된음이온성계면활성제, 및분자량이 400 이상인하나이상의오일을함유하며, 계면활성제의양에대한오일상의양의중량비율이 2 내지 10인것을특징으로하는, 오일구(球)의수평균크기가 100 nm 미만인나노에멀젼에관한것이다. 사용되는음이온성계면활성제는예를들면, C~C알킬포스페이트의칼륨염, 스테아릴/이소스테아릴알콜과인산의에스테르, 세틸알콜과인산의에스테르 ,트리데실알콜과인산의에스테르, 이들에스테르의옥시에틸렌화유도체, 그리고이들의혼합물로부터선택된다. 수득되는에멀젼은투명하며, 저장에대해안정하다. 이들은우수한투명도를유지하고우수한화장특성을가지면서다량의오일을함유할수 있다. 이들은국소용조성물, 약학용조성물또는안과용조성물을구성할수 있다. 본발명은또한, 본발명에따른나노에멀젼의, 화장및 피부분야에서의용도, 특히피부및/또는점막의보습, 및모발의트리트먼트를위한용도, 및눈의트리트먼트를위한아이로션으로서안 분야에서의용도에관한것이다.

公开(公告)号：KR1020000052462A

公开(公告)日：2000-08-25

申请号：KR1019990057227

申请日：1999-12-13

Applicant: 로레알

Inventor： 시모네쟝-띠에리 ,  쏜느빌오딜 ,  르그레실비

IPC: A61K8/49 ,  A61Q19/02 ,  A61K8/04 ,  B82Y5/00

CPC classification number: B82Y5/00 ,  A61K8/062 ,  A61K8/90 ,  A61K9/0048 ,  A61K9/1075 ,  A61K31/77 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  B01F17/0028 ,  Y10S514/873 ,  Y10S514/937 ,  Y10S514/938

Abstract: PURPOSE: Nanoemulsion based on block copolymers of ethylene oxide and propylene oxide is provided to give the stability of storage, the maintenance of good transparency and the incorporation of bulky oil. In addition to the nanoemulsion above, their use in cosmetics, skin science and/or ophthalmology are provided. CONSTITUTION: A nanoemulsion is comprised of oil phase dispersed in water phase, has less than 100 nm of a number average size of oil small sphere, contains surfactants selected from block copolymers of ethylene oxide and propylene oxide, has also at least one oil having more than 400 of molecular weight, and has 2 to 10 at their ratios of oil phase for amounts of the surfactant. The surfactant is also characterized by selecting from block copolymers represented by formulae HO(C2H4O)x(C3H6O)y(C2H4O)zH (1), wherein x, y and z are integers, x + y is 2 to 100, and y is 14 to 60, and their mixtures, with 2 to 16 of HLB.

Abstract translation: 目的：提供基于环氧乙烷和环氧丙烷的嵌段共聚物的纳米乳液，以提供储存的稳定性，维持良好的透明度和引入大体积的油。 除了上述纳米乳液之外，还提供了它们在化妆品，皮肤科学和/或眼科学中的用途。 构成：纳米乳液由分散在水相中的油相组成，具有小于100nm的数均粒径的油小球，含有选自环氧乙烷和环氧丙烷的嵌段共聚物的表面活性剂，还具有至少一种具有更多的油的油 分子量大于400，对于表面活性剂的用量，油相的比例为2〜10。 表面活性剂的特征还在于选自式HO（C2H4O）x（C3H6O）y（C2H4O）zH（1）表示的嵌段共聚物，其中x，y和z为整数，x + y为2至100，y为 14至60，以及它们的混合物，具有2至16个HLB。

公开(公告)号：KR100369258B1

公开(公告)日：2003-01-24

申请号：KR1019990057228

申请日：1999-12-13

Applicant: 로레알

Inventor： 시모네쟝-띠에리 ,  쏜느빌오딜 ,  르그레실비

IPC: A61K9/107 ,  A61K9/10 ,  B82Y5/00

CPC classification number: A61Q19/007 ,  A61K8/06 ,  A61K8/4993 ,  A61K9/0048 ,  A61K9/1075 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  A61Q5/00 ,  B82Y5/00 ,  Y10S514/844 ,  Y10S514/938 ,  Y10S514/941 ,  Y10S514/942

Abstract: A nanoemulsion comprising a dispersed lipid phase in an aqueous phase with the lipid globules having an average size of less than 100 nm contains: (1) a surfactant (solid at up to 45 degrees C); (2) at least one oil with a molecular weight of more than 400; and (3) at least one ionic amphiphilic lipid . A nanoemulsion comprising a dispersed lipid phase in an aqueous phase with the lipid globules having an average size of less than 100 nm contains: (1) a surfactant (solid at up to 45 degrees C) such as sorbitan fatty esters optionally oxyethylenated; (2) at least one oil with a molecular weight of more than 400; and (3) at least one ionic amphiphilic lipid such as alkaline salts of dicetyl- and dimyristylphosphate, alkaline salts of cholesterol sulfate or phosphate, lipoaminoacids, sodium salts of phosphatidic acid, cationic amphiphilic lipid or alkylsulfonic derivatives at a lipid phase/surfactant weight ratio of 2-10. Independent claims are also included for: (1) a topical composition comprising the above described composition; (2) an ophthalmic support comprising the above described composition; (3) a pharmaceutical composition comprising the above described composition; (4) a cosmetic method for the care and/or hydration of the skin, mucosa and/or scalp by applying the above described composition; and (5) the preparation of the composition by mixing an aqueous phase and a lipid phase at 10-80 degrees C and homogenizing the mixture at 6 x 10 -18 x 10 Pa.

Abstract translation: 包含在含水相中的分散脂质相的纳米乳剂与平均尺寸小于100nm的脂质球包含：（1）表面活性剂（在高达45摄氏度下的固体）; （2）至少一种分子量大于400的油; 和（3）至少一种离子两亲脂质。 包含在水相中的分散的脂质相和平均尺寸小于100nm的脂质球的纳米乳剂包含：（1）表面活性剂（在高达45摄氏度下的固体），例如任选氧乙烯化的脱水山梨糖醇脂肪酸酯; （2）至少一种分子量大于400的油; 和（3）脂质相/表面活性剂重量比的至少一种离子两亲脂质，例如二鲸蜡基和二肉豆蔻基磷酸的碱性盐，胆固醇硫酸盐或磷酸盐的碱性盐，脂氨基酸，磷脂酸的钠盐，阳离子两亲脂质或烷基磺酸衍生物 为2-10。 独立权利要求还包括：（1）包含上述组合物的局部组合物; （2）包含上述组合物的眼科支持物; （3）包含上述组合物的药物组合物; （4）通过应用上述组合物护理和/或水合皮肤，粘膜和/或头皮的美容方法; 和（5）通过在10-80℃混合水相和脂质相并在6×10 7 -18×10 7 M 2下均化混合物来制备组合物。 霸。

公开(公告)号：KR100354357B1

公开(公告)日：2002-09-28

申请号：KR1019990055800

申请日：1999-12-08

Applicant: 로레알

Inventor： 쏜느빌오딜 ,  시모네쟝-띠에리 ,  르그레실비

IPC: A61K9/107 ,  B82Y5/00

CPC classification number: B82Y5/00 ,  A61K8/06 ,  A61K8/37 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  Y10S514/844 ,  Y10S514/937 ,  Y10S514/938

Abstract: 본발명은지방산또는지방알콜, 카르복실산및 글리세롤의혼합에스테르에서선택된계면활성제, 및분자량이 400 이상인하나이상의오일을함유하며, 계면활성제의양에대한오일상의양의중량비율이 2 내지 10인것을특징으로하는, 오일구(球)의수평균크기가 100 nm 미만인나노에멀젼에관한것이다. 사용되는계면활성제는예를들면, C-C지방산또는지방알콜및 α-히드록시산및/또는숙신산과글리세롤의혼합에스테르, 및이들의혼합물에서선택된다. 수득되는에멀젼은투명하며, 저장에대해안정하다. 이는우수한투명도를유지하고우수한화장특성을가지면서다량의오일을함유할수 있다. 본발명은또한, 본발명에따른나노에멀젼의, 화장품및 피부과학분야에서의용도, 특히피부및/또는점막의보습, 및모발의트리트먼트를위한용도, 및눈의트리트먼트를위한아이로션으로서안과학분야에서의용도에관한것이다.

公开(公告)号：KR1020000047999A

公开(公告)日：2000-07-25

申请号：KR1019990055800

申请日：1999-12-08

Applicant: 로레알

Inventor： 쏜느빌오딜 ,  시모네쟝-띠에리 ,  르그레실비

IPC: A61K9/107 ,  B82Y5/00

CPC classification number: B82Y5/00 ,  A61K8/06 ,  A61K8/37 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  Y10S514/844 ,  Y10S514/937 ,  Y10S514/938

Abstract: PURPOSE: Conventional nanoemulsions have defects of stickiness and instability, etc. Nanoemulsions comprising ester mixture of fatty acid or alcohol, carboxylic acid and glycerol and their use for cosmetics, dermatological and/or ophthalmological are provided. CONSTITUTION: A nanoemulsions comprise a detergent selected from ester mixtures of fatty acid or alcohol, carboxylic acid and glycerol, and at least an oil having molecualr weight of over 400, wherein the volume of oil based on the volume of detergent is 2 through 10 in the weight ratio and mean size of the oil spheres is below 100nm. The detergent used in the emulsion is, for example, mixture of C8-C22 fatty acid or fatty alcohol, -hydroxy acid and/or succinic acid and glycerol. The emulsions are transparent and highly stable enough to be stored. The emulsions further provide excellent properties as cosmetics while containing much oil. The emulsions are used for cosmetics; and in the fields of dermatology such as moisturization of skin and/or mucosa and treatment of hair; and ophthalmology such as eye lotion for treatment of eye.

Abstract translation: 目的：常规纳米乳液具有粘性和不稳定性等缺陷。提供了包含脂肪酸或醇，羧酸和甘油的酯混合物的纳米乳剂及其用于化妆品，皮肤病学和/或眼科学的用途。 构成：纳米乳剂包含选自脂肪酸或醇的酯混合物，羧酸和甘油的至少一种分子量超过400的油的洗涤剂，其中基于洗涤剂体积的油的体积为2至10 油球的重量比和平均尺寸低于100nm。 在乳液中使用的洗涤剂是例如C 8 -C 22脂肪酸或脂肪醇，羟基酸和/或琥珀酸和甘油的混合物。 乳液是透明的并且足够稳定以便储存。 乳液进一步提供作为化妆品的优异性能，同时含有很多油。 乳剂用于化妆品; 以及皮肤病学领域如皮肤和/或粘膜的保湿和头发的治疗; 眼科等眼科治疗眼睛。

公开(公告)号：KR100372378B1

公开(公告)日：2003-02-17

申请号：KR1020000004979

申请日：2000-02-01

Applicant: 로레알

Inventor： 시모네쟝-띠에리 ,  쏜느빌오딜 ,  르그레실비

IPC: A61K9/107 ,  B82Y5/00

CPC classification number: B82Y5/00 ,  A61K8/06 ,  A61K9/0048 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  B01F17/0021 ,  B01F17/0028

Abstract: Oil-in-water nanoemulsions, in which the average size of the oil particles is below 100 nm, contains an alkoxylated alkenyl succinate, alkoxylated glucose alkenyl succinate, or alkoxylated methyl glucose succinate as surfactant, and at least one oil with a molecular weight above 400, the weight ratio of oil to surfactant being 2-10.

Abstract translation: 在这项研究中，我们调查了链烷醇胺对链烷醇胺降解的影响，如链烷醇胺，链烷醇胺，链烷醇胺， 400，油与表面活性剂的重量比为2-10。

公开(公告)号：KR1020000052471A

公开(公告)日：2000-08-25

申请号：KR1019990057463

申请日：1999-12-14

Applicant: 로레알

Inventor： 시모네쟝-띠에리 ,  쏜느빌오딜 ,  르그레실비

IPC: A61K6/083 ,  B82Y5/00

CPC classification number: A61Q19/00 ,  A61K8/06 ,  A61K9/0048 ,  A61K9/1075 ,  A61K2800/21 ,  A61K2800/262 ,  A61K2800/413 ,  A61Q1/14 ,  A61Q5/00 ,  A61Q19/007 ,  B01F17/0021 ,  B82Y5/00 ,  Y10S514/844 ,  Y10S514/845 ,  Y10S514/937 ,  Y10S514/938

Abstract: PURPOSE: Nanoemulsion based on ethoxylated fatty ether or ethoxylated fatty ester is provided to give the stability of storage, the maintenance of good transparency and the incorporation of bulky oil with good cosmetic property. In addition to the nanoemulsion above, their use in cosmetics, skin science and/or ophthalmology are provided. CONSTITUTION: A nanoemulsion is comprised of oil phase dispersed in water phase, has less than 100 nm of number average size of oil sphere, contains surfactants be solid state at less than 45°C and selected from ethoxylated fatty ether or ethoxylated fatty ester, has also at least one oil having more than 400 of molecular weight, and has 2 to 10 at their ratios of oil phase for amount of the surfactant. The nanoemulsion is characterized in that its turbidity is 60 to 600 NTUs. The amount of the surfactant is characterized by being 0.2 to 15wt%, and preferably 3 to 6 wt.% based on total weight of nanoemulsion.

Abstract translation: 目的：提供基于乙氧基化脂肪醚或乙氧基化脂肪酸酯的纳米乳液，以提供保存的稳定性，维持良好的透明度和引入具有良好化妆品性质的大体积油。 除了上述纳米乳液之外，还提供了它们在化妆品，皮肤科学和/或眼科学中的用途。 构成：纳米乳液由分散在水相中的油相组成，具有小于100nm的数量平均尺寸的油球，在低于45℃下含有表面活性剂为固态，并且选自乙氧基化脂肪醚或乙氧基化脂肪酸酯，具有 还含有至少一种具有多于400个分子量的油，并且对于表面活性剂的量，其油相比例为2至10。 纳米乳液的特征在于其浊度为60至600NTU。 表面活性剂的量的特征在于基于纳米乳液的总重量为0.2〜15重量％，优选为3〜6重量％。

公开(公告)号：KR1020000048108A

公开(公告)日：2000-07-25

申请号：KR1019990057231

申请日：1999-12-13

Applicant: 로레알

Inventor： 시모네쟝-띠에리 ,  쏜느빌오딜 ,  르그레실비

IPC: A61K8/19 ,  A61Q19/00 ,  B82Y5/00

CPC classification number: A61Q19/00 ,  A61K8/062 ,  A61K9/0048 ,  A61K9/1075 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  A61Q19/007 ,  B01F17/0021 ,  B82Y5/00 ,  Y10S514/844 ,  Y10S514/847 ,  Y10S514/88 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/939 ,  Y10S514/941 ,  Y10S514/942 ,  Y10S514/943 ,  Y10S514/975

Abstract: PURPOSE: A nanoemulsion based on fatty esters of glycerol which is stable in storage and keeps good transparency and has good make-up property and is able to contain a lot of oil and uses thereof are provided. CONSTITUTION: In a nanoemulsion consisting of an oily phase dispersed in an aqueous phase and having an average size of the oil sphere of less than 100 nanometer, it comprises a surfactant which is a solid at a temperature of under 45°C and is selected from fatty esters of glycerol and at least one oil having molecular weight of not less than 400 and the weight ratio of the amount of the surfactant to the amount of the oily phase is 2-10. The nanoemulsion is used in the fields of cosmetics and dermatology, particularly in moisturizing the skin and/or mucous membrane and in the treatment of hair, and ophthalmology as an eye-lotion for the treatment of eye.

Abstract translation: 目的：提供一种基于甘油脂肪酸酯的纳米乳液，其在储存中稳定并保持良好的透明性并具有良好的补充性能并且能够含有大量的油及其用途。 构成：在由油相分散在水相中并具有小于100纳米的油球的平均尺寸的纳米乳液中，它包含在45℃以下为固体的表面活性剂，选自 甘油的脂肪酸酯和至少一种分子量不小于400的油，表面活性剂的量与油相量的重量比为2-10。 纳米乳剂用于化妆品和皮肤病领域，特别是在保湿皮肤和/或粘膜以及治疗头发和眼科学中作为治疗眼睛的洗眼剂。

公开(公告)号：KR100369260B1

公开(公告)日：2003-01-24

申请号：KR1019990058632

申请日：1999-12-17

Applicant: 로레알

Inventor： 시모네쟝-띠에리 ,  쏜느빌오딜 ,  르그레실비

IPC: A61K9/107 ,  A61K9/51 ,  B82Y5/00

CPC classification number: B82Y5/00 ,  A61K8/06 ,  A61K8/37 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  Y10S514/844 ,  Y10S514/845 ,  Y10S514/846 ,  Y10S514/912 ,  Y10S514/937 ,  Y10S514/938

Abstract: An oil-in-water nanoemulsion with a droplet size of less than 100 nm contains an oil (I) with a molecular weight above 400 and an alkyl ether citrate surfactant (II), the weight ratio of oil phase to (II) being 2-10:1. An Independent claim is also included for production of the composition by mixing the aqueous phase with the oil phase under vigorous agitation at 10-80 degrees C and homogenizing the mixture at 60-180 MPa.

Abstract translation: 液滴尺寸小于100nm的水包油纳米乳液含有分子量大于400的油（I）和烷基醚柠檬酸盐表面活性剂（II），油相与（II）的重量比为2 -10：1。 还包括独立权利要求用于通过在10-80℃剧烈搅拌下将水相与油相混合并在60-180MPa下均化混合物来制备组合物。