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公开(公告)号：KR1020080076885A
公开(公告)日：2008-08-20
申请号：KR1020080073913
申请日：2008-07-29
Applicant: 로레알
CPC classification number: C12N15/1137 , A61K8/606 , A61K2800/782 , A61Q19/02 , C12N2310/14 , C12Y114/18001
Abstract: A composition comprising a novel double-stranded RNA oligonucleotide is provided to decrease expression of tyrosinase, thereby being used to prevent formation and eliminating pigmentation marks and preventing skin browning. A cosmetic composition comprises at least one double-stranded RNA oligonucleotide of a sequence selected from the group consisting of SEQ ID : NOs. 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, and 47 together with a population of cationic particulates less than or equal to 1 micrometer in size, and having a zeta potential ranging from 10 to 80 mV, wherein the composition prevents the formation of and/or eliminating pigmentation marks, and/or senescence marks, and/or for lightening and/or bleaching browned skin and/or rendering the color of browned skin uniformly.
Abstract translation: 提供包含新型双链RNA寡核苷酸的组合物以减少酪氨酸酶的表达，从而用于防止形成和消除色素沉着痕迹并防止皮肤褐变。 化妆品组合物包含至少一种选自SEQ ID NO：1的序列的双链RNA寡核苷酸。 1，2，3，4，5，6，7，8，9，10，11，12，13，14，15，16，17，18，19，20，21，22，23，24，25， 26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46和47以及阳离子群体 微粒尺寸小于或等于1微米，ζ电位范围为10至80mV，其中组合物防止形成和/或消除色素沉着痕迹和/或衰老标记，和/或用于减轻和/ 或漂白褐色皮肤和/或使褐色皮肤的颜色均匀。
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公开(公告)号：KR100455005B1
公开(公告)日：2004-11-06
申请号：KR1020027003218
申请日：2001-06-19
Applicant: 로레알
CPC classification number: A61Q19/00 , A61K8/06 , A61K8/31 , A61K8/8111 , A61K8/922 , A61Q19/005 , A61Q19/007 , Y10S514/845 , Y10S514/88 , Y10S514/937
Abstract: Composition comprising an aqueous phase dispersed in an oil phase includes an emulsifier comprising a polar portion and a nonpolar polyolefin portion of at least 40 carbon atoms.
Abstract translation: 包含分散在油相中的水相的组合物包括乳化剂，其包含极性部分和至少40个碳原子的非极性聚烯烃部分。
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3.发明授权화장,피부학적,안과학적및/또는약제학적분야에서알콕시화알케닐숙시네이트또는글루코스의알콕시화알케닐숙시네이트기재나노에멀션및그의용도 失效化妆品，皮肤，而不是科学和/或药物领域烷氧基hwaal烯基琥珀酸盐或葡萄糖的烷氧基hwaal的链烯基琥珀描述的纳米乳剂和在其使用
公开(公告)号：KR100372378B1
公开(公告)日：2003-02-17
申请号：KR1020000004979
申请日：2000-02-01
Applicant: 로레알
CPC classification number: B82Y5/00 , A61K8/06 , A61K9/0048 , A61K2800/21 , A61K2800/413 , A61Q1/14 , B01F17/0021 , B01F17/0028
Abstract: Oil-in-water nanoemulsions, in which the average size of the oil particles is below 100 nm, contains an alkoxylated alkenyl succinate, alkoxylated glucose alkenyl succinate, or alkoxylated methyl glucose succinate as surfactant, and at least one oil with a molecular weight above 400, the weight ratio of oil to surfactant being 2-10.
Abstract translation: 在这项研究中，我们调查了链烷醇胺对链烷醇胺降解的影响，如链烷醇胺，链烷醇胺，链烷醇胺， 400，油与表面活性剂的重量比为2-10。
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4.发明公开에톡실화 지방 에테르 또는 에톡실화 지방 에스테르를기재로 한 나노에멀젼, 및 화장품, 피부과학 및/또는안과학 분야에서의 그의 용도 失效基于乙氧基脂肪酸或乙氧基脂肪酸酯的纳米乳剂，其在化妆品，皮肤科学和/或眼科学中的使用
公开(公告)号：KR1020000052471A
公开(公告)日：2000-08-25
申请号：KR1019990057463
申请日：1999-12-14
Applicant: 로레알
CPC classification number: A61Q19/00 , A61K8/06 , A61K9/0048 , A61K9/1075 , A61K2800/21 , A61K2800/262 , A61K2800/413 , A61Q1/14 , A61Q5/00 , A61Q19/007 , B01F17/0021 , B82Y5/00 , Y10S514/844 , Y10S514/845 , Y10S514/937 , Y10S514/938
Abstract: PURPOSE: Nanoemulsion based on ethoxylated fatty ether or ethoxylated fatty ester is provided to give the stability of storage, the maintenance of good transparency and the incorporation of bulky oil with good cosmetic property. In addition to the nanoemulsion above, their use in cosmetics, skin science and/or ophthalmology are provided. CONSTITUTION: A nanoemulsion is comprised of oil phase dispersed in water phase, has less than 100 nm of number average size of oil sphere, contains surfactants be solid state at less than 45°C and selected from ethoxylated fatty ether or ethoxylated fatty ester, has also at least one oil having more than 400 of molecular weight, and has 2 to 10 at their ratios of oil phase for amount of the surfactant. The nanoemulsion is characterized in that its turbidity is 60 to 600 NTUs. The amount of the surfactant is characterized by being 0.2 to 15wt%, and preferably 3 to 6 wt.% based on total weight of nanoemulsion.
Abstract translation: 目的：提供基于乙氧基化脂肪醚或乙氧基化脂肪酸酯的纳米乳液，以提供保存的稳定性，维持良好的透明度和引入具有良好化妆品性质的大体积油。 除了上述纳米乳液之外，还提供了它们在化妆品，皮肤科学和/或眼科学中的用途。 构成：纳米乳液由分散在水相中的油相组成，具有小于100nm的数量平均尺寸的油球，在低于45℃下含有表面活性剂为固态，并且选自乙氧基化脂肪醚或乙氧基化脂肪酸酯，具有 还含有至少一种具有多于400个分子量的油，并且对于表面活性剂的量，其油相比例为2至10。 纳米乳液的特征在于其浊度为60至600NTU。 表面活性剂的量的特征在于基于纳米乳液的总重量为0.2〜15重量％，优选为3〜6重量％。
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5.发明公开
公开(公告)号：KR1020000048108A
公开(公告)日：2000-07-25
申请号：KR1019990057231
申请日：1999-12-13
Applicant: 로레알
CPC classification number: A61Q19/00 , A61K8/062 , A61K9/0048 , A61K9/1075 , A61K2800/21 , A61K2800/413 , A61Q1/14 , A61Q19/007 , B01F17/0021 , B82Y5/00 , Y10S514/844 , Y10S514/847 , Y10S514/88 , Y10S514/937 , Y10S514/938 , Y10S514/939 , Y10S514/941 , Y10S514/942 , Y10S514/943 , Y10S514/975
Abstract: PURPOSE: A nanoemulsion based on fatty esters of glycerol which is stable in storage and keeps good transparency and has good make-up property and is able to contain a lot of oil and uses thereof are provided. CONSTITUTION: In a nanoemulsion consisting of an oily phase dispersed in an aqueous phase and having an average size of the oil sphere of less than 100 nanometer, it comprises a surfactant which is a solid at a temperature of under 45°C and is selected from fatty esters of glycerol and at least one oil having molecular weight of not less than 400 and the weight ratio of the amount of the surfactant to the amount of the oily phase is 2-10. The nanoemulsion is used in the fields of cosmetics and dermatology, particularly in moisturizing the skin and/or mucous membrane and in the treatment of hair, and ophthalmology as an eye-lotion for the treatment of eye.
Abstract translation: 目的：提供一种基于甘油脂肪酸酯的纳米乳液，其在储存中稳定并保持良好的透明性并具有良好的补充性能并且能够含有大量的油及其用途。 构成：在由油相分散在水相中并具有小于100纳米的油球的平均尺寸的纳米乳液中，它包含在45℃以下为固体的表面活性剂，选自 甘油的脂肪酸酯和至少一种分子量不小于400的油，表面活性剂的量与油相量的重量比为2-10。 纳米乳剂用于化妆品和皮肤病领域，特别是在保湿皮肤和/或粘膜以及治疗头发和眼科学中作为治疗眼睛的洗眼剂。
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Patent Agency Ranking
公开(公告)号：KR101307734B1
公开(公告)日：2013-09-11
申请号：KR1020080073913
申请日：2008-07-29
Applicant: 로레알
CPC classification number: C12N15/1137 , A61K8/606 , A61K2800/782 , A61Q19/02 , C12N2310/14 , C12Y114/18001
Abstract: 본 발명은 티로시나제 발현을 감소시키는 신규한 이중 가닥 RNA 올리고뉴클레오티드, 미용 및/또는 약학적 목적을 위한 이의 용도 및 제타 전위가 10 내지 80 mV 이고 크기가 1 ㎛ 이하인 양이온성 입자와 이의 결합에 관한 것이다.
티로시나제, RNA 올리고뉴클레오티드, 제타 전위, 양이온성 입자Abstract translation: 组合物包含至少一种与阳离子颗粒大小和10-80mVζ电位相关联的双链RNA寡核苷酸（I）。 组合物包含至少一种尺寸为1μm的阳离子颗粒相关的双链RNA寡核苷酸（I）（SEQ ID No.1-48，包括在说明书中给出的48个完全限定的19-25个氨基酸序列之一） 10-80mV的ζ电位。 包括用于美容工艺漂白，清除颜色和/或使包含局部施用（I）的褐色皮肤的颜色均匀的独立权利要求。 活动：皮肤病学。 机制：酪氨酸酶表达抑制剂。 （I）对酪氨酸酶信使RNA降解的能力进行了测试。 结果表明，包含本说明书中给出的完全限定的25个氨基酸序列的SEQ ID No.43的双链RNA寡核苷酸表现出99.1％的酪氨酸酶抑制。
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7.发明授权수-분산성 음이온 폴리머로 이루어진 나노캡슐, 이들의제조 방법, 및 이들을 함유하는 화장품 또는 피부과용조성물 失效수분산온온온로로캡슐캡슐캡슐캡슐캡슐캡슐및및및및및및및및및및및화화화화화화화화화물물물물물물물물물물물물물물물물물물물물물
公开(公告)号：KR100374421B1
公开(公告)日：2003-03-04
申请号：KR1019990063481
申请日：1999-12-28
Applicant: 로레알
CPC classification number: A61K9/5146 , A61K8/11 , A61K9/5153 , A61K2800/413 , A61Q19/00 , B01J13/04
Abstract: Nanocapsules comprising the following components are new: (a) a lipid core comprising a lipophilic active ingredient (I); and (b) a water-insoluble shell comprising a water-dispersible anionic polymer (II) selected from polyesters, poly(ester amides), polyurethanes, vinyl copolymers, shellac, sandarac gum and dammars. Independent claims are also included for the following: (1) a cosmetic or dermatological composition containing the nanocapsules in a carrier; (2) a process for producing the nanocapsules, comprising: (i) dissolving a lipid phase comprising (I) and optionally a coating agent in a nontoxic organic solvent having a lower boiling point than water; (ii) preparing an aqueous dispersion of (II); (iii) adding a hydrophilic surfactant to the dispersion; (iv) combining the organic phase of (i) with the organic phase of (iii); and (v) evaporating the organic solvent and optionally part of the aqueous phase; (3) a process for producing the nanocapsules, comprising: (i) dissolving (II), a lipid phase comprising (I) and optionally a coating agent in a water-miscible organic solvent; (ii) pouring the solution into an aqueous surfactant solution; and (iii) evaporating the organic solvent and optionally part of the aqueous phase.
Abstract translation: 包含以下组分的纳米胶囊是新的：（a）包含亲脂性活性成分（I）的脂质核; 和（b）水不溶性壳，其包含选自聚酯，聚（酯酰胺），聚氨酯，乙烯基共聚物，虫胶，砂糖树胶和阻尼剂的水分散性阴离子聚合物（II）。 独立权利要求还包括以下内容：（1）在载体中含有纳米胶囊的化妆品或皮肤病学组合物; （2）制备纳米胶囊的方法，其包括：（i）将包含（I）和任选的涂布剂的脂质相溶解在沸点低于水的无毒有机溶剂中; （ii）制备（II）的水分散体; （iii）向分散体中加入亲水性表面活性剂; （iv）将（i）的有机相与（iii）的有机相合并; 和（v）蒸发有机溶剂和任选的部分水相; （3）制备纳米胶囊的方法，其包括：（i）将（II），包含（I）和任选的涂布剂的脂质相溶解在可与水混溶的有机溶剂中; （ii）将该溶液倒入表面活性剂水溶液中; 和（iii）蒸发有机溶剂和任选的部分水相。
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8.发明授权알킬에테르시트레이트 기재 나노에멀젼, 및 화장, 피부학,약학 및/또는 안과학 분야에서의 그의 용도 失效알킬에테르시트레이트기재나노에멀젼，및화장，피부학，약학교/또는안과학분야에서의그의용도
公开(公告)号：KR100369260B1
公开(公告)日：2003-01-24
申请号：KR1019990058632
申请日：1999-12-17
Applicant: 로레알
CPC classification number: B82Y5/00 , A61K8/06 , A61K8/37 , A61K2800/21 , A61K2800/413 , A61Q1/14 , Y10S514/844 , Y10S514/845 , Y10S514/846 , Y10S514/912 , Y10S514/937 , Y10S514/938
Abstract: An oil-in-water nanoemulsion with a droplet size of less than 100 nm contains an oil (I) with a molecular weight above 400 and an alkyl ether citrate surfactant (II), the weight ratio of oil phase to (II) being 2-10:1. An Independent claim is also included for production of the composition by mixing the aqueous phase with the oil phase under vigorous agitation at 10-80 degrees C and homogenizing the mixture at 60-180 MPa.
Abstract translation: 液滴尺寸小于100nm的水包油纳米乳液含有分子量大于400的油（I）和烷基醚柠檬酸盐表面活性剂（II），油相与（II）的重量比为2 -10：1。 还包括独立权利要求用于通过在10-80℃剧烈搅拌下将水相与油相混合并在60-180MPa下均化混合物来制备组合物。
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9.发明公开
公开(公告)号：KR1020000062214A
公开(公告)日：2000-10-25
申请号：KR1019990059292
申请日：1999-12-20
Applicant: 로레알
CPC classification number: A61Q19/00 , A61K8/06 , A61K2800/21 , A61K2800/413 , A61Q1/14 , B01F17/0064 , B82Y5/00 , Y10S514/844 , Y10S514/845 , Y10S514/846 , Y10S514/88 , Y10S514/912
Abstract: 본발명은인산지방에스테르및 그의옥시에틸렌화유도체에서선택된음이온성계면활성제, 및분자량이 400 이상인하나이상의오일을함유하며, 계면활성제의양에대한오일상의양의중량비율이 2 내지 10인것을특징으로하는, 오일구(球)의수평균크기가 100 nm 미만인나노에멀젼에관한것이다. 사용되는음이온성계면활성제는예를들면, C~C알킬포스페이트의칼륨염, 스테아릴/이소스테아릴알콜과인산의에스테르, 세틸알콜과인산의에스테르 ,트리데실알콜과인산의에스테르, 이들에스테르의옥시에틸렌화유도체, 그리고이들의혼합물로부터선택된다. 수득되는에멀젼은투명하며, 저장에대해안정하다. 이들은우수한투명도를유지하고우수한화장특성을가지면서다량의오일을함유할수 있다. 이들은국소용조성물, 약학용조성물또는안과용조성물을구성할수 있다. 본발명은또한, 본발명에따른나노에멀젼의, 화장및 피부분야에서의용도, 특히피부및/또는점막의보습, 및모발의트리트먼트를위한용도, 및눈의트리트먼트를위한아이로션으로서안 분야에서의용도에관한것이다.
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10.发明公开화장,피부학적,안과학적및/또는약제학적분야에서알콕시화알케닐숙시네이트또는글루코스의알콕시화알케닐숙시네이트기재나노에멀션및그의용도 失效来自烷基化的烷基取代的烷基取代的烷基磺酸酯或烷基酸的烷基酸的烷基化，以及其在化妆品，皮肤学，眼科学和/或药物中的应用
公开(公告)号：KR1020000057867A
公开(公告)日：2000-09-25
申请号：KR1020000004979
申请日：2000-02-01
Applicant: 로레알
CPC classification number: B82Y5/00 , A61K8/06 , A61K9/0048 , A61K2800/21 , A61K2800/413 , A61Q1/14 , B01F17/0021 , B01F17/0028
Abstract: PURPOSE: Nanoemulsion from alkoxylated alkenyl succinate or alkoxylate alkenyl succinate of glucose, and its preparation method are provided, for moisturizing the skin and/or mucous membrane or treating the eyes in cosmetics, dermatology, ophthalmology and/or pharmaceutics. CONSTITUTION: A nanoemulsion comprises 0.2-15 wt% of at least one surfactant selected from alkoxylated alkenyl succinate, alkoxylated alkenyl succinate of glucose and alkoxylated alkenyl succinate of methylglucose; at least one oil whose molecular weight is more than 400; optionally 0.01-5 wt% of at least one ionic amphiphilic lipid selected from the group consisting of anionic amphiphilic lipids and alkylsulfonic acid derivatives; 0.01-30 wt% of optionally additives for improving transparency, selected from alcohols of low molecular weight, glycol, sugar and their mixture; and optionally cosmetic, dermatological, ophthalmological or pharmaceutical active ingredients, wherein the ratio of the oil to the surfactant is 2-10, preferably 3-6 by weight, and the nanoemulsion contains the oil phase diffused in oil drop and aqueous phase whose number mean size is less than 100 nm. The nanoemulsion is prepared by stirring the aqueous phase and the oily phase strongly at the temperature of 10-80°C to mix them; and homogenizing the mixture at the pressure of 6X10¬6 - 18X10¬7 Pa.
Abstract translation: 目的：提供葡萄糖的烷氧基化烯基琥珀酸酯或烷氧基化烯基琥珀酸酯的纳米乳液及其制备方法，用于在化妆品，皮肤病学，眼科学和/或药物学中保湿皮肤和/或粘膜或治疗眼睛。 构成：纳米乳液包含0.2-15重量％的至少一种表面活性剂，选自烷氧基化烯基琥珀酸酯，烷氧基化链烯基琥珀酸酯葡萄糖和烷氧基化烯基琥珀酸甲基葡萄糖; 至少一种分子量大于400的油; 任选0.01-5重量％的至少一种选自阴离子两亲性脂质和烷基磺酸衍生物的离子两亲性脂质; 0.01-30重量％的任选的提高透明度的添加剂，选自低分子量的醇，二醇，糖及其混合物; 和任选的化妆品，皮肤病学，眼科学或药物活性成分，其中油与表面活性剂的比例为2-10重量％，优选3-6重量％，并且纳米乳液含有在油滴和水相中扩散的油相，其数量平均 尺寸小于100nm。 通过在10-80℃的温度下强烈搅拌水相和油相来混合纳米乳液， 并在6×10 -6〜18×10 -7 Pa的压力下均化混合物。
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