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公开(公告)号：KR100993024B1
公开(公告)日：2010-11-08
申请号：KR1020100046525
申请日：2010-05-18
Applicant: 서울대학교산학협력단
CPC classification number: A61K31/167 , A61K9/1075 , A61K9/127 , A61K47/38 , B82Y5/00
Abstract: PURPOSE: A composition containing a compound for enhancing cell growth is provided to enhance growth of brain cells, nerve cells, cardiac cells, and stem cells and to treat diseases which are needed to cell proliferation. CONSTITUTION: A composition for enhancing cell growth contains a compound of chemical formula 1. A formulation for enhancing cell growth contains the compound of chemical formula 1. The formulation is used in the form of lipid nanoparticle, polymer nanoparticle or polymer gel. The lipid nanoparticle contains positive charge lipid, neutral lipid or negative charge lipid. The lipid nanoparticle additionally contains surfactant. The polymer nanoparticle or polymer gel contains natural polymer or synthetic polymer. The formulation further contains cell target ligand.
Abstract translation: 目的：提供含有增强细胞生长的化合物的组合物，以增强脑细胞，神经细胞，心脏细胞和干细胞的生长，并治疗细胞增殖所需的疾病。 构成：用于增强细胞生长的组合物含有化学式1的化合物。用于增强细胞生长的制剂含有化学式1的化合物。该制剂以脂质纳米颗粒，聚合物纳米颗粒或聚合物凝胶的形式使用。 脂质纳米颗粒含有正电荷脂质，中性脂质或负电荷脂质。 脂质纳米颗粒另外含有表面活性剂。 聚合物纳米颗粒或聚合物凝胶含有天然聚合物或合成聚合物。 制剂还含有细胞靶配体。
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公开(公告)号：KR101596369B1
公开(公告)日：2016-02-22
申请号：KR1020140051527
申请日：2014-04-29
Applicant: 서울대학교산학협력단
Abstract: 본발명은갑각류에서유래된양전하를갖는다당류인키토산과카테콜합성물질을이용한췌장소도막의표면개질방법에관한것으로, 구체적으로, 본발명의표면개질방법에의해변형된췌장소도는기존의클러스터형태에서단일세포로쉽게부서지는성질이완화되고혈액과의초기접촉시나타나는염증매개물질활성화를억제하여혈액응고를방지하여이식초기의췌장소도손실을최소화할수 있고, 또한키토산이결합된췌장소도막 표면에폴리에틸렌글리콜과같은중합체를가교제로이용하여다층성표면개질을추가적으로도입하여숙주면역반응을최소화하고이식된췌장소도의생존기간을연장시킬수 있다.
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公开(公告)号：KR1020150130778A
公开(公告)日：2015-11-24
申请号：KR1020140057801
申请日：2014-05-14
Applicant: 서울대학교산학협력단
CPC classification number: C12N5/0676
Abstract: 본발명의헤테로스페로이드(hetero-spheroid) 제조방법은세포크기조절을통하여췌장소도단일세포의생존율을향상및 영양분공급을원활히하고, 이식전 및후에혈관내피성장인자(vascular endothelial growth factor(VEGF)) 및 CD31을많이발현시켜신생혈관생성을촉진하고, 항괴사유전자인 Bcl-2 유전자발현을증가시키고세포괴사관련단백질의양을감소시켜세포괴사억제를확인함으로써당뇨병치료를위한취도세포이식방법으로유용하게사용될수 있다.
Abstract translation: 本发明的异型球体的制备方法：提高胰岛细胞的存活率，通过控制细胞大小顺利地提供营养; 通过在移植前后充分表达血管内皮生长因子（VEGF）和CD31促进血管生成; 并通过增加作为抗细胞坏死基因的Bcl-2基因的表达，并减少与细胞坏死相关的蛋白质的量来证实细胞坏死的抑制。 因此，异种球的制备方法可以有效地用作移植用于治疗糖尿病的胰岛细胞的方法。
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公开(公告)号：KR1020150090599A
公开(公告)日：2015-08-06
申请号：KR1020140011447
申请日：2014-01-29
Applicant: 서울대학교산학협력단
Abstract: 본발명은생리활성펩타이드및 피브린젤 부착능을가지는펩타이드로구성된카이머릭펩타이드를유효성분으로포함하는줄기세포생착율증강용조성물및 이의제조방법에관한것으로, 구체적으로생리활성펩타이드에피브린젤 부착능을가진펩타이드를연결한카이머릭펩타이드를합성하여줄기세포와피브린젤을혼합하여이식한결과, 생체내생리활성펩타이드의소실이감소하는것을확인함으로써, 상기생리활성펩타이드및 피브린젤 부착능을가지는펩타이드로구성된카이머릭펩타이드를줄기세포생착율증강용조성물및 이의제조방법으로유용하게사용될수 있다.
Abstract translation: 本发明涉及一种组合物，其包含作为活性成分的由生物活性肽组成的嵌合肽和具有提高干细胞移植率的纤维蛋白凝胶粘合能力的肽及其制造方法。 具体地说，由生物活性肽构成的嵌合肽和具有纤维蛋白凝胶粘合能力的肽可以有效地用作提高干细胞的移植率的组合物及其制造方法，通过确认生物活性肽在 通过合成其中生物活性肽连接到具有纤维蛋白凝胶粘合能力的肽并混合干细胞和纤维蛋白凝胶的嵌合肽作为移植的结果。
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公开(公告)号：KR1020120032209A
公开(公告)日：2012-04-05
申请号：KR1020100093726
申请日：2010-09-28
Applicant: 서울대학교산학협력단
CPC classification number: A61F2/0077 , A61F2002/0081 , A61L27/20 , A61L27/50 , B01J13/20
Abstract: PURPOSE: A capsule for encapsulating pancreas islet having modified surface and a preparation method thereof are provided to effectively block the attack of an immune cell. CONSTITUTION: A capsule for encapsulating pancreas islet having modified surface is as follows. Pancreas islet is encapsulated in a capsule comprised of alginate. The capsule surface is reformed by biocompatible polymer. In the biocompatible polymer, a functional radical is attached to the side chain or end thereof. The functional radical is selected from a group consisting of an amine radical, hydroxyl radical, a carboxyl radical, and a sulfone radical.
Abstract translation: 目的：提供一种用于包封具有改良表面的胰岛的胶囊及其制备方法，以有效阻断免疫细胞的侵袭。 构成：用于封装具有改性表面的胰岛的胶囊如下。 胰岛被包裹在由藻酸盐组成的胶囊中。 胶囊表面由生物相容性聚合物重整。 在生物相容性聚合物中，功能性基团连接到侧链或其末端。 官能团选自胺基，羟基，羧基和砜基。
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Patent Agency Ranking16.发明公开
公开(公告)号：KR1020150124676A
公开(公告)日：2015-11-06
申请号：KR1020140051475
申请日：2014-04-29
Applicant: 서울대학교산학협력단
Abstract: 본발명은덴드리틱 PEG(dendritic PEG)를이용한췌장소도표면개질방법및 이를이용한표면개질된췌장소도에관한것으로, 본발명에따른췌장소도의표면개질방법은, 덴드리틱 PEG를췌장소도의표면에코팅하여세포생존율은영향이없고, 당농도에반응하는민감성영향을받지않으며, 효과적으로면역세포의활성화를감소시켜이식후 췌장소도의생존기간을늘림으로써상기덴드리틱 PEG가코팅된췌장소도를췌장소도이식의전처리과정에유용하게사용될수 있다.
Abstract translation: 本发明涉及使用树突状PEG和使用其的表面改性胰岛来改性胰岛表面的方法。 根据本发明的胰岛表面改性方法通过在胰岛的表面上涂覆树突状PEG并且对葡萄糖浓度没有敏感性而对细胞活力没有影响。 通过树突状PEG包被的胰岛可以通过在移植后通过延长胰岛的存活期有效降低免疫细胞的活化来用于胰岛的预处理。
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公开(公告)号：KR101259074B1
公开(公告)日：2013-04-29
申请号：KR1020100116824
申请日：2010-11-23
Applicant: 서울대학교산학협력단
Abstract: 본 발명은 엑센딘-4(Exendin-4)가 도입된 췌장소도세포 및 이를 이용한 당뇨병 치료방법에 관한 것으로, 보다 상세하게는 렌티바이러스를 이용하여 엑센딘-4를 췌장소도세포에 도입하여 지속적으로 효과 단백질인 엑센딘-4 단백질의 분비를 유도하고, 인슐린의 분비능력을 향상시키며, 세포괴사를 줄이고, 주사시 발생할 수 있는 전신적인 부작용을 최소화하는 효과를 나타내므로, 상기 엑센딘-4가 도입된 췌장소도세포는 당뇨병 치료방법으로 유용하게 이용될 수 있다.
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18.发明公开이중기능성 고차구조의 ＰＥＧ 및 생체활성 복합체를 이용한 췌장소도 표면개질 방법 및 이를 이용한 표면개질된 췌장소도 有权使用具有生物活性复合物的高功能高结构PEG和具有改性表面的胰岛素修饰胰蛋白酶表面的方法
公开(公告)号：KR1020120110856A
公开(公告)日：2012-10-10
申请号：KR1020110029010
申请日：2011-03-30
Applicant: 서울대학교산학협력단
Abstract: PURPOSE: A method for modifying the surface of pancreatic islets is provided to effectively reduce immune response and to induce antithrombogenicity effect. CONSTITUTION: A method for modifying the surface of pancreatic islet comprises: a step of activating PEG or derivatives thereof for conjugation of PEG or derivatives thereof on the surface of the pancreatic islet; a step of conjugating the activated PEG or derivatives thereof with an amine group on the surface; and a step of conjugating the terminal function groups of the PEG or derivatives with the bioactive complex. The bioactive complex is conjugated with heparin or derivatives thereof, and bioactivation materials. [Reference numerals] (AA) Pancreatic islet cells; (BB) Heparin catechol; (CC) 8-armed star shaped PEG
Abstract translation: 目的：提供一种改善胰岛表面的方法，有效降低免疫反应，诱发抗血栓形成的作用。 构成：用于改变胰岛表面的方法包括：活化PEG或其衍生物以在胰岛表面上缀合PEG或其衍生物的步骤; 将活化的PEG或其衍生物与表面上的胺基缀合的步骤; 以及将PEG或衍生物的末端官能团与生物活性复合物缀合的步骤。 生物活性复合物与肝素或其衍生物和生物活化材料缀合。 （AA）胰岛细胞; （BB）肝素儿茶酚; （CC）8型星形PEG
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公开(公告)号：KR101085203B1
公开(公告)日：2011-11-21
申请号：KR1020110030122
申请日：2011-04-01
Applicant: 서울대학교산학협력단
IPC: A61K9/127 , A61K31/685 , A61K31/397 , A61K47/48
CPC classification number: A61K47/544 , A61K9/127 , A61K47/554 , A61K47/6909 , A61K47/6911 , A61K48/0033
Abstract: PURPOSE: A cationic phospholipids liposome containing 1,2-dioleoyl-sn-glycero-3-ethyl phosphocholine(DOPC) and sterol compounds is provided to enhance drug delivery efficiency and to remarkably reduce cytotoxicity. CONSTITUTION: A composition for lung-specific drug delivery comprises a cationic phospholipids nanoparticles containing 1,2-dioleoyl-sn-glycero-3-ethyl phosphocholine(DOPC) and sterol compounds. The sterol compounds are 3b-[N-(N',N'-dimethylaminoethane)-cabamyl]cholesterol(DC-Chol), stigmasterol, campesterol, sitosterol, ergosterol, lanosterol, dinosterol, gorgosterol, avenasterol, saringosterol, or fucosterol. The drug is anticancer drug.
Abstract translation: 目的：提供含有1,2-二油酰-sn-甘油-3-乙基磷酸胆碱（DOPC）和甾醇化合物的阳离子磷脂脂质体，以提高药物输送效率，显着降低细胞毒性。 构成：用于肺特异性药物递送的组合物包含含有1,2-二油酰-sn-甘油-3-乙基磷酸胆碱（DOPC）和甾醇化合物的阳离子磷脂纳米颗粒。 甾醇化合物是3b- [N-（N'，N'-二甲基氨基乙烷） - 卡巴糖基]胆固醇（DC-Chol），豆甾醇，菜油甾醇，谷甾醇，麦角甾醇，羊毛甾醇，二羟甲基甾醇，戈尔柯斯醇，麦考酚酯，柚脂醇或岩藻甾醇。 药物是抗癌药。
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公开(公告)号：KR102207221B1
公开(公告)日：2021-03-24
申请号：KR1020170028590
申请日：2017-03-06
Applicant: 서울대학교산학협력단 , 파로스젠 주식회사 , 한국과학기술연구원 , 울산대학교 산학협력단 , 재단법인 아산사회복지재단
Inventor： 변영로 , 김인산 , 타슬림아흐메드알-힐랄 , 김상윤 , 장예지
Abstract: 본명세서에기재된발명은병리학적신생혈관생성을억제하고, 종양, 암, 죽상동맥경화증(atherosclerosis),결핵(tuberculosis), 천식(asthma), 폐동맥고혈압(pulmonary arterial hypertension,PAH), 신생물(neoplasms) 및신생물-관련질환(neoplasm-related conditions)과같은병리학적신생혈관생성과관련성이있는질환을치료하는데유용하거나, 환자내에서의도펠발현을탐지하는데유용한도펠-타겟팅분자에대한것이다. 관련된조성물및 방법은모두본 명세서에기재되어있다.
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