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公开(公告)号：KR102070911B1
公开(公告)日：2020-01-30
申请号：KR1020170048413
申请日：2017-04-14
Applicant: 서울대학교산학협력단
IPC: G16B20/00 , C12Q1/6827
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公开(公告)号：KR1020170119295A
公开(公告)日：2017-10-26
申请号：KR1020170048413
申请日：2017-04-14
Applicant: 서울대학교산학협력단
Abstract: (a) 초병렬시퀀싱에의해생성된리드중 검증하고자하는적어도하나의제1 리드를선정하는단계; (b) 상기제1 리드에대응되는핵산단편을시퀀싱플레이트로부터회수하는단계; (c) 상기각 단편또는그의증폭산물에대하여염기서열분석을수행하여제2 리드를생성하는단계; 및 (d) 상기제2 리드와그에대응되는제1 리드를비교하여상기제1 리드의오류를검증하는단계를포함하는, 초병렬시퀀싱의오류확인방법이제공된다. 또한, 상기방법을수행하기위한, 초병렬시퀀싱의오류확인장치를제공된다.
Abstract translation: （a）在由超级并行排序产生的线索期间选择至少一个要被验证的第一线索; （b）从测序板回收对应于第一引物的核酸片段; （c）对每个片段或其扩增产物进行碱基序列分析以产生第二引物; （d）通过比较第二导联与相应的第一导联来验证第一导联的误差。 而且，提供了一种用于检查超级并行排序中的错误的装置，用于执行上述方法。
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公开(公告)号：KR102138864B1
公开(公告)日：2020-07-28
申请号：KR1020180042269
申请日：2018-04-11
Applicant: 서울대학교산학협력단 , 경희대학교 산학협력단
IPC: G16B30/00
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Patent Agency Ranking
公开(公告)号：KR101888868B1
公开(公告)日：2018-08-16
申请号：KR1020160147000
申请日：2016-11-04
Applicant: 주식회사 셀레믹스 , 서울대학교산학협력단
Abstract: 분자클론들이형성된기판을제공하는단계; 상기분자클론들중 원하는분자클론에비접촉식으로에너지를인가하여상기원하는분자클론을상기기판으로부터추출하는단계; 상기추출한분자클론의염기서열과 DNA 바코드를화학적으로연결하는단계; 및상기 DNA 바코드가연결된염기서열을병렬적염기서열분석방법으로분석하는단계를포함하는분자클론추출및 확인방법이제공된다.
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公开(公告)号：KR101509293B1
公开(公告)日：2015-04-07
申请号：KR1020120114103
申请日：2012-10-15
Applicant: 서울대학교산학협력단
CPC classification number: C12P19/34 , B01J2219/00315 , B01J2219/00441 , B01J2219/00468 , B01J2219/005 , B01J2219/00596 , B01J2219/00648 , B01J2219/00691 , B01J2219/00693 , B01J2219/00722 , C40B20/02 , C40B50/14 , C40B60/04
Abstract: 고체지지체상에존재하는올리고뉴클레오타이드들의복제라이브러리를갖는염기서열분석기판을제공하는단계; 상기복제라이브러리를시퀀싱하는단계; 상기염기서열분석기판상의상기고체지지체의실측위치정보를얻는단계; 상기시퀀싱의결과로주어지는상기고체지지체로부터발생한신호의픽셀정보와상기실측위치정보를맵핑하는단계; 상기맵핑한결과를이용하여원하는염기서열을갖는상기고체지지체를상기염기서열분석기판으로부터추출하는단계; 및상기추출된상기고체지지체상의올리고뉴클레오타이드를증폭하여대량으로복제하는단계를포함하는고순도뉴클레오타이드의대량생산방법이제공된다.
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公开(公告)号：KR1020140075611A
公开(公告)日：2014-06-19
申请号：KR1020130151869
申请日：2013-12-06
Applicant: 서울대학교산학협력단
CPC classification number: C12Q1/6806 , B01J19/00 , B01J19/0046 , B01J2219/00441 , B01J2219/00452 , B01J2219/00531 , B01J2219/0054 , B01J2219/00608 , B01J2219/00659 , B01J2219/00689 , B01J2219/00711 , B01J2219/00716 , B01J2219/00722 , B01J2219/00725 , C12Q1/24 , G01N33/50 , C12Q1/68
Abstract: The present invention provides a method for separating biochemical molecules on a micro-array substrate comprising: a step for supplying a micro-array substrate to which assemblies of different kinds of biochemical molecules are attached by being separated into each individual spot unit, and in which individual spots are regularly arranged; a step for acquiring position information of the individual spots in which the desired assembly among the assemblies of the biochemical molecules is located; a step for locating an extracting tool for applying energy to separate the desired assembly according to the position information; and a step for separating the desired assembly from the micro-array substrate by applying energy in a contact or non-contact method by using the extracting tool.
Abstract translation: 本发明提供了一种分离微阵列基板上的生化分子的方法，其特征在于包括：通过将不同种类的生物化学分子的组件分离成每个单独的点单元来供给微阵列基板的步骤，其中， 定期安排个别景点; 获取生物化学分子的组合体中期望的组合所位于的各个位置的位置信息的步骤; 用于定位用于施加能量以根据位置信息分离所需组件的提取工具的步骤; 以及通过使用提取工具以接触或非接触方式施加能量从微阵列基板分离所需组件的步骤。
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公开(公告)号：KR1020130046342A
公开(公告)日：2013-05-07
申请号：KR1020120080601
申请日：2012-07-24
Applicant: 서울대학교산학협력단
CPC classification number: C12P19/34 , B01J2219/00315 , B01J2219/00441 , B01J2219/00468 , B01J2219/005 , B01J2219/00596 , B01J2219/00648 , B01J2219/00691 , B01J2219/00693 , B01J2219/00722 , C40B20/02 , C40B50/14 , C40B60/04 , C12N15/1006 , C12Q1/6806
Abstract: PURPOSE: A method for producing a large amount of high purity nucleotides is provided to quickly and accurately isolated microbeads with a predetermined base sequence and to amplify in a usable amount. CONSTITUTION: A method for producing a large amount of high purity nucleotides comprises: a step of providing a sequencing substrate with a replication library of oligonucleotides on a solid support(S110); a step of sequencing the replication library(S120); a step of obtaining measured location information of the solid support on the sequencing substrate(S130); a step of mapping pixel information and measured location information generated from the solid support(S140); a step of isolating a solid support with desired base sequence from the sequencing substrate using the mapping result(S150); and a step of amplifying the oligonucleotide of the isolated solid support(S160). [Reference numerals] (AA) Start; (BB) End; (S110) Provide a sequencing analysis substrate with a replication library of oligos on a solid support; (S120) Sequence the replication library; (S130) Obtain the actual location information of the solid support; (S140) Map pixel information and the actual location information; (S150) Extract the solid support using a mapping result; (S160) Massively replicate by amplifying the oligos of the extracted solid support
Abstract translation: 目的：提供用于产生大量高纯度核苷酸的方法，以预定的碱基序列快速且准确地分离出微珠并以可用量进行放大。 构成：用于生产大量高纯度核苷酸的方法包括：在固体支持物上提供具有寡核苷酸复制文库的测序底物的步骤（S110）; 对复制库进行排序的步骤（S120）; 获得测序基板上的固体支持物的测量位置信息的步骤（S130）; 映射从固体支持物生成的像素信息和测量位置信息的步骤（S140）; 使用映射结果从测序底物中分离具有所需碱基序列的固体支持物的步骤（S150）; 和扩增分离的固体支持物的寡核苷酸的步骤（S160）。 （附图标记）（AA）开始; （BB）结束; （S110）在固体支持物上提供具有寡核苷酸复制文库的测序分析底物; （S120）顺序复制库; （S130）获取实体支持的实际位置信息; （S140）映射像素信息和实际位置信息; （S150）使用映射结果提取固体支持; （S160）通过扩增提取的固体支持物的寡核苷酸大量复制
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