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公开(公告)号：KR1020140018454A
公开(公告)日：2014-02-13
申请号：KR1020120079604
申请日：2012-07-20
Applicant: 성균관대학교산학협력단
IPC: A61K9/127 , A61K47/30 , A61K31/375
CPC classification number: A61K9/1273 , A61K31/375 , A61K47/59 , A61K48/00
Abstract: The present invention relates to a gene carrier in a nano micelle form containing anti-oxidants inside and a preparing method of the same. The present invention also relates to a gene transfer complex encountered with a nucleic acid material by mixing the gene carrier and the nucleic acid material. The gene transfer complex has a structure which contains the antioxidants in the interior of the micelle, reduces an oxidative stress induced when the nano sized gene complex flows into the inside of a cell, reduces damage to mitochondrial membrane, and improves gene transfer efficiency of the gene carrier.
Abstract translation: 本发明涉及内含抗氧化剂的纳米胶束形式的基因载体及其制备方法。 本发明还涉及通过混合基因载体和核酸材料与核酸材料相遇的基因转移复合物。 基因转移复合物具有在胶束内部含有抗氧化剂的结构，当纳米尺寸基因复合物流入细胞内部时，降低诱导的氧化应激，减少对线粒体膜的损伤，提高基因转移效率 基因载体。
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公开(公告)号：KR1020130088081A
公开(公告)日：2013-08-07
申请号：KR1020130010577
申请日：2013-01-30
Applicant: 성균관대학교산학협력단
CPC classification number: A61K38/38 , A61K9/1635 , A61K9/1641 , A61K9/1658 , A61K9/16 , A61K47/30 , A61K47/50
Abstract: PURPOSE: A method for preparing nanoparticles of an associated body of polyethylene glycol and albumin is provided to prevent toxic responses or hypersensitive reaction caused by the formulation of a water-insoluble drug because a surfactant and a solubilizing agent do not exist and to enhance drug compliance. CONSTITUTION: A method for preparing nanoparticles of an associated body of non-peptide polymers and albumin, containing a water-insoluble drug or inorganic nanoparticles for a bio image, comprises the steps of: mixing the non-peptide polymers and albumin to prepare an associated body of non-peptide polymers and albumin; dissolving the water-insoluble drug or the inorganic nanoparticles and the associated body in an organic solvent to prepare a mixture; and removing the organic solvent from the mixture and adding a hydrophilic solvent.
Abstract translation: 目的：提供一种制备聚乙二醇和白蛋白相关体内纳米颗粒的方法，以防止由于不存在表面活性剂和增溶剂而引起的水不溶性药物的引起的毒性反应或过敏反应，并提高药物依从性 。 构成：用于制备含有生物图像的水不溶性药物或无机纳米颗粒的非肽聚合物和白蛋白缔合体的纳米颗粒的方法包括以下步骤：将非肽聚合物和白蛋白混合以制备相关的 非肽聚合物和白蛋白体; 将水不溶性药物或无机纳米颗粒和相关体溶解在有机溶剂中以制备混合物; 并从混合物中除去有机溶剂并加入亲水溶剂。
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14.发明公开플라스미드 ＤＮＡ의 능동적 핵전이 및 고효율 유전자 발현을 위한 환원성 고분자와 핵전이 단백질 결합서열을 지닌 플라스미드 ＤＮＡ로 구성된 유전자 전달 시스템 无效高效的基因交付系统建立在具有核蛋白结合力的可重复聚合物和PLASMID DNA上，用于主动核定位
公开(公告)号：KR1020120007208A
公开(公告)日：2012-01-20
申请号：KR1020100067836
申请日：2010-07-14
Applicant: 성균관대학교산학협력단
Inventor： 정지훈
Abstract: PURPOSE: A gene delivery system containing a vector and reducible polymers is provided to stabilize DNA in an extracellular region and to promote absorption. CONSTITUTION: A gene delivery system containing a vector with intracellular nuclear protein binding motif and reducible polymers. The reducible polymer is protamine, amido amine, oligo imine, poly(oligo-arginine), poly-L-lysine, chitosan, PAMAM(poly amido amine) dendrimer, stearyl-PLL complex, poly ornithine, poly alginine, poly ethylene imine, amido ethylene imine, or poly(amido ethylene imine). The intracellular nuclear protein binding motif is NF-kappa B binding motif.
Abstract translation: 目的：提供含有载体和可还原聚合物的基因递送系统，以稳定细胞外区域的DNA并促进吸收。 构成：含有具有细胞内核蛋白结合基序和可还原聚合物的载体的基因递送系统。 可还原的聚合物是鱼精蛋白，酰氨基胺，寡聚亚胺，聚（寡聚精氨酸），聚-L-赖氨酸，壳聚糖，PAMAM（聚酰氨基胺）树枝状聚合物，硬脂基PLL复合物，聚鸟氨酸，聚精氨酸，聚乙烯亚胺， 酰氨基亚乙基亚胺或聚（酰胺亚乙基亚胺）。 细胞内核蛋白结合基序是NF-κB结合基序。
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公开(公告)号：KR1020110061881A
公开(公告)日：2011-06-10
申请号：KR1020090118416
申请日：2009-12-02
Applicant: 성균관대학교산학협력단
IPC: A61K47/34 , A61K47/12 , A61K31/711 , A61K31/7105
CPC classification number: A61K47/34 , A61K31/7105 , A61K31/711 , A61K47/28
Abstract: PURPOSE: A conjugate containing polyethyleneimine and bile acid is provided to ensure high transport efficiency and to transport nucleic acid drugs. CONSTITUTION: A conjugate containing polyethyleneimine and bile acid is conjugated by reaction of carboxy group of bile acid and amine group of polyethyleneidmine. The bile acid is cholic acid, 5 beta-cholanic acid, chenodeoxycholic acid, glycoholic acid, taurocholic acid, deoxycholic acid, lithocholic acid, or 7-oxo-lithochoilc acid. The conjugated contain macromolecule or hydrophobic drugs. The macromolecule is plasmid DNA, siRNA, or antisense oligonucleotide. The hydrophobic drug is doxorubicin, adriamycin, cisplatin, paclitaxel, taxol, docetaxel, or daunomycin.
Abstract translation: 目的：提供含有聚乙烯亚胺和胆汁酸的缀合物，以确保高运输效率和运输核酸药物。 构成：含有聚乙烯亚胺和胆汁酸的共轭物通过胆汁酸羧基和聚乙烯胺胺基的反应而结合。 胆汁酸是胆酸，5β-胆酸，鹅脱氧胆酸，甘醇酸，牛磺胆酸，脱氧胆酸，石胆酸或7-氧代 - 苯基胆酸。 共轭含有大分子或疏水性药物。 大分子是质粒DNA，siRNA或反义寡核苷酸。 疏水性药物是多柔比星，阿霉素，顺铂，紫杉醇，紫杉醇，多西他赛或道诺霉素。
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Patent Agency Ranking16.发明公开카테콜기를 포함하는 유기화합물로 개질된 친수성 고분자를 이용한 칼슘 포스페이트 나노 복합체 및 그 제조방법 审中-实审使用含有CATECHOL组的水解聚合物改性有机化合物的磷酸钙纳米聚集体及其制备方法
公开(公告)号：KR1020140116045A
公开(公告)日：2014-10-01
申请号：KR1020140108520
申请日：2014-08-20
Applicant: 성균관대학교산학협력단
IPC: C12N15/87
Abstract: The present invention relates to a nanocomposite for gene transfer including a hydrophilic polymer modified with a single molecule or a polymer including calcium phosphate, a transferring gene, and a catechol group. According to the present invention, the nanocomposite for gene transfer including a hydrophilic polymer modified with a single molecule or a polymer including calcium phosphate, a transferring gene, and a catechol group acts as an excellent gene deliverer by controlling particle growth and stabilizing the particles at the same time. The nanocomposite for gene transfer of the present invention has excellent biostability, does not have cytotoxicity, and has excellent gene transfection efficiency.
Abstract translation: 本发明涉及用于基因转移的纳米复合物，其包括用单一分子改性的亲水性聚合物或包含磷酸钙，转移基因和儿茶酚基团的聚合物。 根据本发明，包括用单分子改性的亲水性聚合物或包含磷酸钙，转移基因和儿茶酚基团的聚合物的基因转移用纳米复合物通过控制颗粒生长并使颗粒稳定化而作为优异的基因递送器 同一时间。 本发明的用于基因转移的纳米复合物具有优异的生物稳定性，不具有细胞毒性，并且具有优异的基因转染效率。
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公开(公告)号：KR102220167B1
公开(公告)日：2021-02-25
申请号：KR1020180105543
申请日：2018-09-04
Applicant: 성균관대학교산학협력단
IPC: C07K1/113 , C07K14/56 , C07K14/765 , C07K16/00 , C12N9/88
Abstract: 본발명은단백질을용해시키고, 온도에따른단백질의안정성을향상시킬수 있는단백질안정화용조성물및 이를이용한단백질을안정화하는방법에관한것으로천연물질인당이나콜린클로라이드를특정비율로혼합했을때 수소결합에의해고체로부터융점이낮은액체가생성이되어, 단백질약물을용해시키고온도변화에민감한단백질을안정화시킬수 있으므로장기간보관이가능할뿐만아니라, 단백질약물생산으로부터운송에이르기까지고비용이요구되는저온저장의문제점을해결할수 있어경제적이며, 전력체계의문제점으로인하여단백질약물보급이어려운지역으로약품보급도가능하게할 것으로기대된다.
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公开(公告)号：KR1020180000318A
公开(公告)日：2018-01-02
申请号：KR1020170079007
申请日：2017-06-22
Applicant: 성균관대학교산학협력단
Abstract: 본발명은체세포직접교차분화유도나노입자의제조방법, 상기나노입자를포함하는체세포로부터조직특이세포로의직접교차분화유도용조성물, 및상기조성물을이용한직접교차분화방법에관한것이다. 본발명에따른상기나노입자를포함하는조성물은성체줄기세포추출물을기본으로조직특이세포분화인자에따른맞춤형세포치료에유용하게이용될수 있으며, 조직내로직접주사가능한나노입자제형이므로생체조직내 체세포의직접교차분화를통한손상조직재생에유리한장점이있다.
Abstract translation: 本发明涉及纳米颗粒的体细胞转分化诱导的制造方法，用于诱导从含有纳米微粒体细胞，和方法直接跨组织特异性细胞分化的组合物区分直接与该组合物相交。 含有本发明的纳米粒子的成体干细胞的组合物可有利地用于根据基于组织特异性细胞分化因子，以提取所述定制细胞处理，因为它是体细胞生物体组织内配制成直接组织注射的纳米颗粒 通过直接交叉分化有利于再生受损组织。
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19.发明授权카테콜기를 포함하는 유기화합물로 개질된 친수성 고분자를 이용한 칼슘 포스페이트 나노 복합체 및 그 제조방법 有权使用包含邻苯二酚基团的有机化合物改性的亲水性聚合物的磷酸钙纳米复合材料及其制造方法
公开(公告)号：KR101813313B1
公开(公告)日：2018-01-02
申请号：KR1020140108520
申请日：2014-08-20
Applicant: 성균관대학교산학협력단
IPC: C12N15/87
Abstract: 본발명은칼슘포스페이트, 전달유전자, 및카테콜기를포함하는단분자로개질된친수성고분자를포함하는유전자전달용나노복합체및 이의제조방법에대한것이다. 본발명에따른칼슘포스페이트, 전달유전자, 및카테콜기를포함하는단분자로개질된친수성고분자를포함하는유전자전달용나노복합체는입자의성장을억제함과동시에입자를안정화시켜훌륭한유전자전달체로기능한다. 본발명의유전자전달용나노복합체는생체안정성이우수하며, 세포독성이없고유전자형질감염효율이우수하다.
Abstract translation: 本发明涉及包含用含有磷酸钙的单分子，转移基因和儿茶酚基团改性的亲水性聚合物的基因转移纳米复合材料及其制备方法。 根据本发明的包含含有磷酸钙，转移基因和儿茶酚基团的单磷酸酯修饰的亲水聚合物的基因转移纳米复合物通过抑制颗粒生长和稳定颗粒起到良好的基因载体的作用 。 本发明的基因转移纳米复合材料是生物稳定的，没有细胞毒性，并且基因转染效率优异。
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公开(公告)号：KR101455921B1
公开(公告)日：2014-11-12
申请号：KR1020130010577
申请日：2013-01-30
Applicant: 성균관대학교산학협력단
CPC classification number: A61K38/38 , A61K9/1635 , A61K9/1641 , A61K9/1658
Abstract: 본 발명은 수용액상에서의 가용화 및 안정화를 통해 생체 내 전달을 매개할 수 있는 수난용성 약물을 내부에 포함하는 비펩타이드성 중합체와 알부민 회합체 나노입자 제조방법에 관한 것으로, 특히 유기용매만을 사용하더라도 비펩타이드성 중합체와 알부민 회합체 및 수난용성 약물의 동시 용해가 가능하므로 별도의 화학적 또는 물리적인 작용을 가하지 않더라도 두 성분의 혼합이 잘 이루어지게 되는 특징이 있다.
또한, 본 발명에 따른 폴리에틸렌글리콜과 알부민 회합체 나노입자 제조방법은, 계면활성제, 가용화제를 포함하지 않으므로, 수난용성 약물의 제제화에 의한 과민반응 또는 독성반응을 일으키지 않는 동시에 환자의 순응도를 높일 수 있는 장점이 있다. 또한 다양한 수난용성 약물 뿐만 아니라, 영상/진단용 무기나노입자의 안정화 등에도 유용하게 사용될 수 있다.
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