公开(公告)号：KR1020140094964A

公开(公告)日：2014-07-31

申请号：KR1020130007675

申请日：2013-01-23

Applicant: 성균관대학교산학협력단

Inventor： 정지훈 ,  이규리 ,  이민상

IPC: A61K48/00 ,  A61K47/48

CPC classification number: A61K48/0008 ,  A61K47/50 ,  A61K47/6929 ,  A61K48/00

Abstract: The present invention relates to a nanocomposite for gene delivery comprising monomers including calcium phosphate, delivery genes and catechol groups or hydrophilic polymers modified with polymers, and to a manufacturing method thereof. The nanocomposite for gene delivery comprising monomers including calcium phosphate, delivery genes and catechol groups or hydrophilic polymers modified with polymers according to the present invention acts as an excellent gene delivery by stabilizing particles while suppressing the growth of the particles. The nanocomposite for gene delivery of the present invention exhibits excellent biostability and has excellent gene transfection efficiency without cytotoxicity.

Abstract translation: 本发明涉及用于基因递送的纳米复合物，其包括磷酸钙，递送基因和儿茶酚基团或由聚合物改性的亲水性聚合物的单体，及其制造方法。 用于包括磷酸钙，递送基因和儿茶酚基团的单体的基因递送的纳米复合物或根据本发明的用聚合物改性的亲水性聚合物通过在抑制颗粒的生长的同时稳定颗粒而作为优异的基因递送。 用于本发明的基因递送的纳米复合物表现出优异的生物稳定性，并且具有优异的基因转染效率而没有细胞毒性。

公开(公告)号：KR101465725B1

公开(公告)日：2014-12-01

申请号：KR1020130007675

申请日：2013-01-23

Applicant: 성균관대학교산학협력단

Inventor： 정지훈 ,  이규리 ,  이민상

IPC: A61K48/00 ,  A61K47/48

Abstract: 본발명은칼슘포스페이트, 전달유전자, 및카테콜기를포함하는단분자로개질된친수성고분자를포함하는유전자전달용나노복합체및 이의제조방법에대한것이다. 본발명에따른칼슘포스페이트, 전달유전자, 및카테콜기를포함하는단분자로개질된친수성고분자를포함하는유전자전달용나노복합체는입자의성장을억제함과동시에입자를안정화시켜훌륭한유전자전달체로기능한다. 본발명의유전자전달용나노복합체는생체안정성이우수하며, 세포독성이없고유전자형질감염효율이우수하다.

公开(公告)号：KR1020140116045A

公开(公告)日：2014-10-01

申请号：KR1020140108520

申请日：2014-08-20

Applicant: 성균관대학교산학협력단

Inventor： 정지훈 ,  이규리 ,  이민상

IPC: C12N15/87

Abstract: The present invention relates to a nanocomposite for gene transfer including a hydrophilic polymer modified with a single molecule or a polymer including calcium phosphate, a transferring gene, and a catechol group. According to the present invention, the nanocomposite for gene transfer including a hydrophilic polymer modified with a single molecule or a polymer including calcium phosphate, a transferring gene, and a catechol group acts as an excellent gene deliverer by controlling particle growth and stabilizing the particles at the same time. The nanocomposite for gene transfer of the present invention has excellent biostability, does not have cytotoxicity, and has excellent gene transfection efficiency.

Abstract translation: 本发明涉及用于基因转移的纳米复合物，其包括用单一分子改性的亲水性聚合物或包含磷酸钙，转移基因和儿茶酚基团的聚合物。 根据本发明，包括用单分子改性的亲水性聚合物或包含磷酸钙，转移基因和儿茶酚基团的聚合物的基因转移用纳米复合物通过控制颗粒生长并使颗粒稳定化而作为优异的基因递送器 同一时间。 本发明的用于基因转移的纳米复合物具有优异的生物稳定性，不具有细胞毒性，并且具有优异的基因转染效率。

公开(公告)号：KR101813313B1

公开(公告)日：2018-01-02

申请号：KR1020140108520

申请日：2014-08-20

Applicant: 성균관대학교산학협력단

Inventor： 정지훈 ,  이규리 ,  이민상

IPC: C12N15/87

Abstract: 본발명은칼슘포스페이트, 전달유전자, 및카테콜기를포함하는단분자로개질된친수성고분자를포함하는유전자전달용나노복합체및 이의제조방법에대한것이다. 본발명에따른칼슘포스페이트, 전달유전자, 및카테콜기를포함하는단분자로개질된친수성고분자를포함하는유전자전달용나노복합체는입자의성장을억제함과동시에입자를안정화시켜훌륭한유전자전달체로기능한다. 본발명의유전자전달용나노복합체는생체안정성이우수하며, 세포독성이없고유전자형질감염효율이우수하다.

Abstract translation: 本发明涉及包含用含有磷酸钙的单分子，转移基因和儿茶酚基团改性的亲水性聚合物的基因转移纳米复合材料及其制备方法。 根据本发明的包含含有磷酸钙，转移基因和儿茶酚基团的单磷酸酯修饰的亲水聚合物的基因转移纳米复合物通过抑制颗粒生长和稳定颗粒起到良好的基因载体的作用 。 本发明的基因转移纳米复合材料是生物稳定的，没有细胞毒性，并且基因转染效率优异。