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公开(公告)号：KR1020150117331A
公开(公告)日：2015-10-20
申请号：KR1020140042354
申请日：2014-04-09
Applicant: 아주대학교산학협력단
Abstract: 입자정렬을이용한코팅방법및 이에의해제조된입자코팅기판이개시된다. 본발명의입자정렬을이용한코팅방법은, (a) 밀착성고분자기판위에복수의제1 입자를코팅하여 1차코팅막을형성하는단계; (b) 마스크패턴이형성된마스크를대고상기밀착성고분자기판을향해빛 또는활성기체를조사하여상기밀착성고분자기판표면의빛 또는활성기체가조사된노광부의부착력을변화시키는단계; 및 (c) 상기밀착성고분자기판상상기노광부와빛 또는활성기체가조사되지않은비노광부의부착력차이에따른상기복수의제1 입자간의함침정도차이와, 상기제1 입자를상기밀착성고분자기판으로부터제거하기위한입자제거부재를이용하여상기복수의제1 입자중 일부를상기밀착성고분자기판으로부터선택적으로제거하는단계를포함하는것을특징으로한다. 본발명에의할경우, 용매또는부착보조제를사용하지않고건조상태의입자들을밀착성고분자기판위에서압력을가하는간단한과정을통해코팅막을형성할수 있게된다.
Abstract translation: 公开了使用粒子排列的涂布方法和由其制造的颗粒涂布基材。 使用本发明的粒子排列的涂布方法包括以下步骤：（a）在粘合性聚合物基材上涂布多个第一粒子，形成第一涂膜; （b）用形成有掩模图案的掩模向粘合剂聚合物基材发射光或活性气体，并且改变其上发射粘合聚合物基材的光或活性气体的曝光单元的粘合力; 和（c）根据曝光单元和非曝光单元之间的粘合力，使用第一颗粒之间的浸渍差异，将光或活性气体在其上的选择性地从粘合剂聚合物基底中选择性地除去一部分第一颗粒 不发射在粘合剂聚合物基材上，并且使用用于从粘合剂聚合物基材除去第一颗粒的颗粒去除构件。 根据本发明，涂布方法能够通过使用简单的步骤在不使用溶剂或粘附补充剂的情况下对粘合剂聚合物基材上的干燥颗粒进行加压而形成涂膜。
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公开(公告)号：KR1020140125662A
公开(公告)日：2014-10-29
申请号：KR1020130043771
申请日：2013-04-19
Applicant: 아주대학교산학협력단
Abstract: A cell culture substrate of the present invention has a micro-structure satisfying several perspectives that should be significantly considered to provide an effective three-dimensional cell culture environment. The micro-structure enables a cell to be cultured and aggregated in a flow-like three-dimensional micro pellet form, promotes redifferentiation of the cell while suppressing dedifferentiation of the cell during cell culture, suppresses development of cytoskeleton, and increases fluidity and mobility of the cell.
Abstract translation: 本发明的细胞培养基质具有满足几个观点的微观结构，应该被认为是提供有效的三维细胞培养环境。 微结构使细胞以流动状的三维微粒形式培养和聚集，促进细胞的再分化，同时抑制细胞培养过程中细胞的去分化，抑制细胞骨架的发育，并增加细胞骨架的流动性和流动性 细胞。
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13.发明公开
公开(公告)号：KR1020140024025A
公开(公告)日：2014-02-27
申请号：KR1020140009076
申请日：2014-01-24
Applicant: 아주대학교산학협력단
Abstract: The present invention relates to a method for manufacturing patterned substrates which patterns a substrate with a carbon nanotube Langmuir-Blodgett (LB) thin film using a micro contact printing method or a lift-off method, and to growth and differentiation control of stem cells using the same. By using the present invention: manufacturing can be simply completed by attaching and detaching a mold; patterns can be formed on curved surfaces so that patterns can be formed on various shaped substrates; and various shaped patterns can be formed so that the method for manufacturing patterned substrates can be applied in various industries. In addition, the present invention controls growth and differentiation of the stem cells through patterning of the carbon nanotube LB thin film so that the stem cells can be grew in short time and differentiation can be enhanced. [Reference numerals] (AA) Barrier; (BB) Carbon nanotube; (CC) Water; (DD) Transfer carbon nanotube LB thin film to PDMS mold; (EE) PDMS mold; (FF) Carbon nanotube; (GG) Heat at 80°C for 5 minutes after attaching on a substrate; (HH) Substrate; (II) Remove mold; (JJ) Carbon nanotube LB thinfilm pattern; (KK) Transfer the carbon nanotube LB thin film to the substrate; (LL) Carbon nanotube LB thin film; (MM) Heat at 80°C for 5 minutes after attaching the PDMS mold to the thin film; (NN) Remove mold
Abstract translation: 本发明涉及使用微接触印刷法或剥离法利用碳纳米管Langmuir-Blodgett（LB）薄膜对基板进行图案化的图案化基板的制造方法，以及使用 一样。 通过使用本发明：可以通过附接和分离模具简单地完成制造; 可以在弯曲表面上形成图案，使得可以在各种成形基板上形成图案; 并且可以形成各种形状的图案，使得用于制造图案化基板的方法可以应用于各种行业。 此外，本发明通过图案化碳纳米管LB薄膜来控制干细胞的生长和分化，使得干细胞可以在短时间内生长并且可以增强分化。 （附图标记）（AA）屏障; （BB）碳纳米管; （CC）水; （DD）将碳纳米管LB薄膜转移至PDMS模具; （EE）PDMS模具; （FF）碳纳米管; （GG）附着在基板上80℃加热5分钟; （HH）基板; （二）去除模具; （JJ）碳纳米管LB薄膜图案; （KK）将碳纳米管LB薄膜转移到基板上; （LL）碳纳米管LB薄膜; （MM）将PDMS模具附着在薄膜上之后，在80℃下加热5分钟; （NN）去除模具
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公开(公告)号：KR1020140013389A
公开(公告)日：2014-02-05
申请号：KR1020120080203
申请日：2012-07-23
Applicant: 아주대학교산학협력단
CPC classification number: C12Q1/6883 , C12Q1/6837 , C12Q2600/142 , C12Q2600/158 , G01N33/5014
Abstract: The present invention relates to a biomarker composition for diagnosing toxicity of nanoparticles, wherein the biomarker composition comprises at least one gene selected from aldehyde dehydrogenase, glutamic-pyruvate transaminase, glutamate dehydrogenase, glutamic oxaloacetic transaminase, glutamic acid decarboxylase, and glutamate-ammonia ligase, and causes a change in expression due to the exposure to nanoparticles. A biomarker according to the present invention is a genetic marker having a high correlation with the toxicity of nanoparticles. The biomarker of the present invention is used to confirm the toxicity of nanoparticles at a degree of more accurate and excellent detection. Therefore, the biomarker of the present invention is useful for monitoring or evaluating the toxicity of nanoparticles and useful as a tool for establishing effects on various diseases or the health, which is caused by the exposure to the nanoparticles.
Abstract translation: 本发明涉及一种用于诊断纳米颗粒的毒性的生物标志物组合物，其中该生物标志物组合物包含至少一种选自醛脱氢酶，谷氨酸 - 丙酮酸转氨酶，谷氨酸脱氢酶，谷氨酰氧乙酸转氨酶，谷氨酸脱羧酶和谷氨酸 - 氨连接酶的基因， 并且由于暴露于纳米颗粒而导致表达的改变。 根据本发明的生物标志物是与纳米颗粒的毒性高度相关的遗传标记。 本发明的生物标志物用于在更精确和优异的检测程度上确认纳米颗粒的毒性。 因此，本发明的生物标志物可用于监测或评估纳米颗粒的毒性，并且可用作建立对暴露于纳米颗粒引起的各种疾病或健康的作用的工具。
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公开(公告)号：KR1020110129178A
公开(公告)日：2011-12-01
申请号：KR1020100048660
申请日：2010-05-25
Applicant: 아주대학교산학협력단
CPC classification number: C01B32/158 , B82Y30/00 , B82Y40/00 , C01B32/16 , H01L27/115
Abstract: PURPOSE: An n-acetylated chitosan-carbon nano-tube complex and a method for manufacturing the same are provided to individualize the complex and to improve the bio compatibility of the complex by applying carbon nano-tube to n-acetylated chitosan. CONSTITUTION: In an n-acetylated chitosan-carbon nano-tube complex, an n-acetylated chitosan is non-covalently bonded with carbon nano-tube. The diameter of the n-acetylated chitosan-carbon nano-tube complex is less than or equal to 10nm. A method for manufacturing the n-acetylated chitosan-carbon nano-tube complex includes the following: Carbon nano-tube is introduced into an N-acetylated chitosan aqueous solution, and an ultrasonic wave is applied to the solution. A centrifugation process is further implemented after the ultrasonic wave applying process. The centrifugation process is implemented at 1000-5000RPM for 3-10 hours. The complex is individualized by the centrifugation process.
Abstract translation: 目的：提供正乙酰化的壳聚糖 - 碳纳米管复合物及其制备方法，以使复合物个体化，并通过将碳纳米管应用于正乙酰化壳聚糖来提高复合物的生物相容性。 构成：在正乙酰化壳聚糖 - 碳纳米管络合物中，正乙酰化壳聚糖与碳纳米管非共价键合。 正乙酰化壳聚糖 - 碳纳米管络合物的直径小于或等于10nm。 制造正乙酰化壳聚糖 - 碳纳米管络合物的方法包括：将碳纳米管引入N-乙酰化壳聚糖水溶液中，并向该溶液施加超声波。 在超声波施加处理之后进一步实现离心处理。 离心过程在1000-5000RPM下进行3-10小时。 复合物通过离心过程个性化。
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Patent Agency Ranking
公开(公告)号：KR102264385B1
公开(公告)日：2021-06-08
申请号：KR1020140064339
申请日：2014-05-28
Applicant: 주식회사 에이엔케이 , 아주대학교산학협력단
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17.发明授权바이오 센서용 광학 표지자, 이를 포함하는 광학 바이오센서 및 상기 바이오 센서용 광학 표지자의 제조방법 有权用于生物传感器的光学标记物，包含其的光学生物传感器以及用于生产用于生物传感器的光学标记物的方法
公开(公告)号：KR101799163B1
公开(公告)日：2017-11-17
申请号：KR1020150184599
申请日：2015-12-23
Applicant: 아주대학교산학협력단
CPC classification number: C12Q1/68 , C23C16/06 , G01N21/41 , G01N33/532 , G01N33/533 , G01N33/58
Abstract: 목적생체물질과선택적으로결합하고, 입사광을재귀반사시키는바이오센서용광학표지자가개시된다. 광학표지자는투명한코어입자, 코어입자표면의일부를피복하고코어입자보다굴절률이작은물질로형성된전반사유도층, 전반사유도층상에형성된수식층및 수식층에결합되고목적생체물질과선택적으로결합하는생체인지물질을구비한다. 이러한광학표지자는비분광광원및 분광광원모두에대해서우수한광학표지자로서기능할수 있다.
Abstract translation: 公开了一种用于选择性结合目标生物材料并回射入射光的生物传感器的光学标记。 光学标记物是透明的核颗粒中，涂层结合到形成在全反射诱导层式层和式层的核粒子表面的一部分，并且，比芯粒子和粘接为目的的生物材料和任选形成的更小的折射率的材料的全反射衍生层 提供生物化学物质。 这种光学标记可以用作非光谱和光谱光源的优异光学标记。
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公开(公告)号：KR101599540B1
公开(公告)日：2016-03-04
申请号：KR1020140064505
申请日：2014-05-28
Applicant: 아주대학교산학협력단
IPC: C08J7/04
Abstract: 밀착성고분자기판에경화제(1차경화제)를포함시켜혼합한밀착성고분자기판을투액성기판에도포하는단계; 상기투액성기판상에위치한밀착성고분자기판상에입자를위치시키는단계; 상기입자를밀착성고분자기판의표면에입자를코팅하는단계; 코팅된입자와밀착성고분자층의결합력을향상시키기위해입자가코팅된기판을공기분위기하에서 UV를조사시키는단계; 경화제(2차경화제)를용기상에도포하는단계; 상기입자가코팅된밀착성고분자기판뒷면의투액성기판을상기용기상에위치시켜경화제(2차경화제)를흡수시키는단계로이루어진마이크로미터수준입자의함침율향상방법이개시된다.
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公开(公告)号：KR1020150137178A
公开(公告)日：2015-12-09
申请号：KR1020140064337
申请日：2014-05-28
Applicant: 아주대학교산학협력단
Abstract: 본발명은입자정렬을이용하여높은밀도로복수의미세입자를단층수준으로코팅할수 있는입자정렬을이용한코팅방법에관한것이다. 본발명에의한입자정렬을이용한코팅방법은, (a) 밀착성고분자기판을준비하는준비단계와, (b) 밀착성고분자기판위에복수의입자를압력을가하여밀착성고분자기판표면에복수의입자에각기대응하는복수의오목부가형성되도록하면서코팅하여코팅막을형성하는단계와, (c) 코팅막이형성된밀착성고분자기판을늘려밀착성고분자기판위에코팅된복수의입자사이의간격을벌림으로써, 코팅막을확장시키는단계와, (d) 밀착성고분자기판의부착력보다는큰 부착력을갖는전사기판에확장된코팅막을전사하는단계를포함한다.
Abstract translation: 本发明涉及使用粒子排列的涂布方法。 该方法可以使用颗粒排列以高密度涂覆多个细颗粒作为单层。 根据本发明，涂布方法包括：（a）制备粘合型聚合物基材的制备步骤; （b）将颗粒压在粘合型聚合物基材上以在与各颗粒相对应的粘合型聚合物基材表面上形成多个凹形单元以将该基材涂布在该颗粒上并在其上形成涂膜的步骤; （c）通过在其上延伸具有涂膜的粘合型聚合物基材来延伸涂膜，来扩大涂布在粘合型聚合物基材上的颗粒之间的间隙的步骤; 和（d）将延伸涂膜转印到具有比粘合型聚合物基材的粘合力更高的粘合力的转印基材上的步骤。
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公开(公告)号：KR101407080B1
公开(公告)日：2014-06-12
申请号：KR1020120137171
申请日：2012-11-29
Applicant: 아주대학교산학협력단
CPC classification number: B05D3/12 , B05D7/02 , B81C1/00031 , B81C1/0038 , C09D1/00 , C09D125/06 , Y10T428/24612
Abstract: 본 실시예에 따른 입자 정렬을 이용한 코팅 방법은, 매끈한면을 가지는 밀착성 고분자 기판을 준비하는 준비 단계; 및 상기 밀착성 고분자 기판의 상기 매끈한면 위에 복수의 입자를 압력을 가하여 상기 밀착성 고분자 기판의 상기 매끈한면에 상기 복수의 입자에 각기 대응하는 복수의 오목부를 형성하면서 상기 복수의 입자와 상기 밀착성 고분자 기판 사이의 결합특성을 강화하며 상기 복수의 입자를 코팅하는 코팅 단계를 포함한다.
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