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公开(公告)号：KR1020130139671A
公开(公告)日：2013-12-23
申请号：KR1020120063335
申请日：2012-06-13
Applicant: 재단법인대구경북과학기술원 , 주식회사 삼양사
Abstract: The present invention relates to a device for forming homogeneous monomer droplets and, more specifically, to a device for forming homogeneous monomer droplets, which forms droplets with uniform shapes for making polymer particles in a bead type such as polystyrene beads, thereby improving uniformity in shapes and sizes of polymer beads. According to the present invention, the device collects a monomer solution with low viscosity at one point using a distribution plate and separately transfers the collected monomer solution to each droplet hole formed at a multi-hole distribution plate when the monomer solution is transferred, thereby forming monomer droplets with improved uniformity.
Abstract translation: 本发明涉及一种用于形成均匀单体液滴的装置，更具体地说，涉及一种用于形成均匀单体液滴的装置，其形成具有均匀形状的液滴，以使聚合物颗粒形成诸如聚苯乙烯珠的珠粒，从而改善形状的均匀性 和聚合物珠粒的尺寸。 根据本发明，该装置使用分配板在一点收集低粘度的单体溶液，并且当单体溶液转移时，将收集的单体溶液分别转移到形成在多孔分布板上的每个液滴孔，由此形成 具有改善均匀性的单体液滴。
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公开(公告)号：KR1020130054676A
公开(公告)日：2013-05-27
申请号：KR1020110120209
申请日：2011-11-17
Applicant: 재단법인대구경북과학기술원
IPC: C08F290/06 , C08G83/00 , A61K9/127 , A61K47/48
CPC classification number: C08F226/10 , A61K47/69 , C08F220/56 , C08G63/08 , C08G65/32
Abstract: PURPOSE: A core cross-linked polymer micelle composition is provided to improve biostability, to minimize side effect due to toxicity of chemicals, and to be used as a drug carrier. CONSTITUTION: A core cross-linked polymer micelle composition is represented by chemical formula 1. In the chemical formula 1, P is an aqueous polymer, X is a fat-soluble polymer, Y is a connection ring, and Z is polycysteine with 3-20 cysteine. The aqueous polymer P is one or more linear, block, graft, or dendrimer polymer selected form polyethylene glycol, polyvinylpyrrolidone, and poly[N-2-(hydroxypropyl)methacrylamide]. The molecular weight of the aqueous polymer P is 500-20,000 Dalton.
Abstract translation: 目的：提供核心交联聚合物胶束组合物以改善生物稳定性，以最小化由于化学药物毒性引起的副作用，并用作药物载体。 构成：核心交联聚合物胶束组合物由化学式1表示。在化学式1中，P为水性聚合物，X为脂溶性聚合物，Y为连接环，Z为多元半胱氨酸， 20半胱氨酸。 水性聚合物P是选自聚乙二醇，聚乙烯吡咯烷酮和聚[N-2-（羟丙基）甲基丙烯酰胺]的一种或多种线性，嵌段，接枝或树枝状聚合物聚合物。 水性聚合物P的分子量为500〜20,000道尔顿。
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公开(公告)号：KR1020120050190A
公开(公告)日：2012-05-18
申请号：KR1020100111577
申请日：2010-11-10
Applicant: 재단법인대구경북과학기술원
CPC classification number: G01N33/6803 , B82Y5/00 , B82Y15/00 , B82Y40/00
Abstract: PURPOSE: A magnetic nanoparticles which are surface modified with phosphocholine, a formation method thereof, and a protein isolation method using thereof are provided to simplify isolating process in order to easily isolate using magnetic nano particles which is surface modified with the choline phosphate and a magnet. CONSTITUTION: A magnetic nanoparticles which are surface modified with phosphocholine comprises magnetic nano particles and materials having choline phosphate group. The choline phosphate is combined with magnetic nano particle surface and is exposed. A formation method of material having choline phosphate comprises a step of radical polymerizing monomers having choline phosphate groups which is represented by the following structural formula at surfaces of the magnetic nano particles. The structural formula 1 is Choline phosphate -X-R. A isolation method of C-reactive protein comprises next steps: adding magnetic nanoparticles which are surface modified with choline phosphate to sample solution containing the C-reactive protein; forming a complex of the C-reactive proteins and magnetic nano particles; isolating the composite from the sample solution by using the magnet; and isolating the C-reactive protein from the isolated composite by using a dissociating agent.
Abstract translation: 目的：提供用磷酸胆碱表面改性的磁性纳米颗粒，其形成方法和使用其的蛋白质分离方法，以简化隔离过程，以便使用磷酸胆碱和磁体表面改性的磁性纳米颗粒容易地分离 。 构成：用磷酸胆碱表面改性的磁性纳米颗粒包括磁性纳米颗粒和具有磷酸胆碱基团的材料。 磷酸胆碱与磁性纳米颗粒表面结合并暴露。 具有磷酸胆碱的材料的形成方法包括在磁性纳米颗粒的表面上自由基聚合由下列结构式表示的具有磷酸胆碱基团的单体的步骤。 结构式1是胆碱磷酸酯-X-R。 C-反应蛋白的分离方法包括以下步骤：将含有磷酸胆碱的表面改性的磁性纳米颗粒加入到含有C-反应蛋白的样品溶液中; 形成C-反应蛋白和磁性纳米颗粒的复合物; 通过使用磁体从样品溶液中分离出复合物; 并通过使用离解剂从分离的复合物中分离C反应蛋白。
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公开(公告)号：KR1020120048348A
公开(公告)日：2012-05-15
申请号：KR1020100109942
申请日：2010-11-05
Applicant: 재단법인대구경북과학기술원
IPC: G01N33/68 , G01N33/553
Abstract: PURPOSE: A chip for detecting C-reactive proteins is provided to improve binding constant to the C-reactive proteins and detection effect. CONSTITUTION: A chip for detecting C-reactive proteins comprises: a metal substrate; and a molecularly imprinted layer which is formed on a metal substrate and contains phospho choline groups. The metal substrate contains gold, silver, copper, palladium, or combination thereof. The molecularly imprinted layer contains a monomolecular layer of HS-CnH2n+1-phospho choline or HC≡C-CH2-CmH2m+1-phospho choline. The chip also has a blocking layer on the metal substrate.
Abstract translation: 目的：提供用于检测C反应蛋白的芯片，以提高C-反应蛋白的结合常数和检测效果。 构成：用于检测C反应蛋白的芯片包括：金属底物; 以及形成在金属基板上并含有磷酸胆碱基团的分子印迹层。 金属基底含有金，银，铜，钯或其组合。 分子印迹层含有HS-CnH2n + 1-磷酸胆碱或HC≡C-CH2-CmH2m + 1-磷酸胆碱的单分子层。 芯片还在金属基板上具有阻挡层。
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公开(公告)号：KR101072389B1
公开(公告)日：2011-10-11
申请号：KR1020090117327
申请日：2009-11-30
Applicant: 재단법인대구경북과학기술원
Abstract: 본발명에따르면, 상기양친매성고분자를이용하여티올민감형약물전달체를제조할수 있다. 상기약물전달체는티올에대한민감도가높아, 티올농도가높은부위의질환에대해약물전달체가쉽게붕괴되면서질화부위에선택적으로많은양의약물을단시간내에효과적으로방출시킬수 있다. 따라서암 또는염증성질환의치료제로서본 발명의약물전달체의사용이기대된다.
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Patent Agency Ranking
公开(公告)号：KR1020110073731A
公开(公告)日：2011-06-30
申请号：KR1020090130454
申请日：2009-12-24
Applicant: 재단법인대구경북과학기술원
IPC: C07D487/22 , A61K31/409 , A61P35/00
Abstract: PURPOSE: A soluble nanostructure containing soluble porphyrin derivatives is provided to ensure high photodynamic therapeutic agent and to prevent side effects. CONSTITUTION: A soluble nanostructure for photodynamic therapy contains soluble porphyrin derivative of chemical formula 1. The porphyrin derivative is prepared by amidation of protoporphyrin IX(chemical formula 2) with polyethylene glycol derivatives(chemical formulas 3 and 4) of amino terminal. A coupling agent for amidation is 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride(EDC), N,N'-dicyclohexylcarbodiimide(DCC), or N,N'-diisopropylcarbodiimide(DIC).
Abstract translation: 目的：提供含有可溶性卟啉衍生物的可溶性纳米结构，以确保高光动力治疗剂并防止副作用。 构成：用于光动力学治疗的可溶性纳米结构含有化学式1的可溶性卟啉衍生物。卟啉衍生物通过原卟啉IX（化学式2）与氨基末端的聚乙二醇衍生物（化学式3和4）的酰胺化而制备。 用于酰胺化的偶联剂是1-乙基-3-（3-二甲基氨基丙基）碳二亚胺盐酸盐（EDC），N，N'-二环己基碳二亚胺（DCC）或N，N'-二异丙基碳二亚胺（DIC）。
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公开(公告)号：KR1020110060583A
公开(公告)日：2011-06-08
申请号：KR1020090117204
申请日：2009-11-30
Applicant: 재단법인대구경북과학기술원
IPC: G01N33/483 , G01N21/27
Abstract: PURPOSE: A sensor chip for detecting estradiol is provided to simultaneously detect various substances and a smell amount of substance such as estrogen. CONSTITUTION: A sensor chip for detecting estradiol comprises: a substrate having a gold layer; a self-assembled monolayer(SAM) of thiol-acrylate polymers formed on the gold layer; and a molecular polymer layer which is formed by polymerization of the acrylate monomers and cross-linking agent. The sensor chip is applied to surface Plasmon resonance or quartz crystal microbalance. The thiol-acrylate polymer is prepared by mixing a compound with acrylate at both ends with a compound containing multiple thiol groups, and performing photopolymerization.
Abstract translation: 目的：提供用于检测雌二醇的传感器芯片，以同时检测各种物质和异味等物质如雌激素。 构成：用于检测雌二醇的传感器芯片包括：具有金层的基底; 在金层上形成的硫醇 - 丙烯酸酯聚合物的自组装单层（SAM）; 以及通过丙烯酸酯单体和交联剂的聚合形成的分子聚合物层。 传感器芯片应用于表面等离子体共振或石英晶体微量天平。 通过将化合物与丙烯酸酯的两端与含有多个硫醇基的化合物混合并进行光聚合来制备硫醇 - 丙烯酸酯聚合物。
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公开(公告)号：KR1020100027568A
公开(公告)日：2010-03-11
申请号：KR1020080086537
申请日：2008-09-03
Applicant: 재단법인대구경북과학기술원
IPC: C08F263/04 , C08J3/12
CPC classification number: C08F263/04 , C08F8/12 , C08F261/04 , C08J3/075 , C08J3/12
Abstract: PURPOSE: A fabrication method of monodisperse microball-shaped hydrogel particles is provided to prepare polymer particles using relatively inexpensive water-soluble dispersing stabilizers and a large amount of water as a polymerization solvent through a single process. CONSTITUTION: A fabrication method of monodisperse microball-shaped hydrogel particles comprises the steps of: forming monodispersed polyvinyl acetate microspheres using dispersion polymerization of vinyl acetate monomers; and saponifying the polyvinyl acetate microspheres from a dispersing medium in the same arrangement state so that the polyvinyl acetate microspheres have a dual structure of a polyvinyl acetate/polyvinyl alcohol shell.
Abstract translation: 目的：提供单分散微球形水凝胶颗粒的制造方法，通过单一工艺使用相对便宜的水溶性分散稳定剂和大量的水作为聚合溶剂制备聚合物颗粒。 构成：单分散微球状水凝胶颗粒的制造方法包括以下步骤：使用乙酸乙烯酯单体的分散聚合形成单分散的聚乙酸乙烯酯微球; 并以相同的布置状态从分散介质中皂化聚乙酸乙烯酯微球，使得聚乙酸乙烯酯微球具有聚乙酸乙烯酯/聚乙烯醇壳的双重结构。
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公开(公告)号：KR102051593B1
公开(公告)日：2020-01-08
申请号：KR1020180140943
申请日：2018-11-15
Applicant: 재단법인대구경북과학기술원
IPC: C07C381/00 , C08G65/333 , C08G69/08 , A61K9/107 , A61K45/06
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公开(公告)号：KR1020170116880A
公开(公告)日：2017-10-20
申请号：KR1020160045110
申请日：2016-04-12
Applicant: 재단법인대구경북과학기술원
IPC: C08J3/12 , G01N33/543 , G01N33/532 , C08J3/20 , C08L1/12
CPC classification number: C08J3/128 , C08J3/12 , C08J3/20 , C08L1/12 , G01N33/532 , G01N33/54313
Abstract: 본발명은진단시약용셀룰로오스아세테이트착색미립자비드의염색성향상을위한표면개질방법에관한것으로서, 유화용매증발법(에멀젼법)을통해얻어진셀룰로오스아세테이트나노비드의염색성을더욱향상시키기위하여표면을개질하는기술에관한것이다. 본발명의진단시약용셀룰로오스아세테이트착색미립자의염색성향상을위한표면개질방법에따르면, 기존방법인에멀젼법에의해제조되는셀룰로오스아세테이트착색미립자비드의경우잔류하는히드록시기에의해우수한수분산성을가지고소수성표면특성으로인한단백질흡착성을유지시켜면역크로마토그래피키트의고분자프로브(probe)로의사용가능성은높지만, 히드록시기의수가상대적으로적어염료등의착색제와의결합성이높게나타나지않음으로인해진단시약으로서의활용성이크게높지않았는데, 본출원에서는염색성을향상시킴으로써진단시약으로서의활용성을높일수 있고, 또한단백질과의흡착성문제는표면개질로인해표면을주름진형태로제조함으로써표면적을향상시켜해결할수 있는효과가있다.
Abstract translation: 药用醋酸纤维素着色的本发明诊断涉及一种表面改性方法的染色增强的微粒珠，乳液溶剂蒸发方法（乳液法），将所得醋酸纤维素纳米珠修改表面，以进一步提高染色技术与 Lt。 在本发明的诊断时，根据用于药用醋酸纤维素有色微粒，在由乳液方法具有优良的水分散性由剩余的羟基基团与疏水性表面性能的传统方法制造的醋酸纤维素的着色颗粒珠的情况下的染色性改进的表面改性方法 以保持蛋白质吸附由于免疫层析可用性聚合物探针（探针）的试剂盒是高，羟基高相对着色剂的数量和决定合成，如染料不下降到利用因为性显著增加作为诊断试剂 也没了，反过来，益处通过改进在本申请中的染色性能的诊断试剂的利用率，并且存在可以解决的问题通过将蛋白质的吸附是由表面产生，以提高表面积，由于表面改性以波纹形状的效果。
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