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公开(公告)号：KR1020090128048A
公开(公告)日：2009-12-15
申请号：KR1020080054033
申请日：2008-06-10
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: A61B1/24 , A61C5/90 , A61C19/063
Abstract: PURPOSE: An oral cavity retractor is provided to easily install into a mouth and perform the treatment and the consultation without the stimulation or damage on the gum or teeth of a patient. CONSTITUTION: The oral cavity retractor includes: a pair of holders(5,5') for supporting lips; a support stand(10) for interlinking one side of a pair of holders; and a support stand(10') for interlinking the other side. The holder has 'U' shape section to cover the inside and outside of the lips and mutually arranged with opposability. The material of the oral cavity retractor is selected from the low density polyethylene, the ethylene vinyl acetate copolymer, the polyurethanes, and the silicon.
Abstract translation: 目的：提供口腔牵开器以容易地安装到口中并执行治疗和咨询，而不会刺激或损伤患者的牙龈或牙齿。 构成：口腔牵开器包括：一对用于支撑嘴唇的保持器（5,5'）; 支撑架（10），用于连接一对支架的一侧; 和用于使另一侧相互连接的支撑架（10'）。 支架具有“U”形部分，以覆盖唇部的内部和外部，并且相互排列相反的位置。 口腔牵开器的材料选自低密度聚乙烯，乙烯 - 乙酸乙烯酯共聚物，聚氨酯和硅。
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公开(公告)号：KR1020090034240A
公开(公告)日：2009-04-07
申请号：KR1020070099511
申请日：2007-10-02
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: A61K49/1866 , A61K49/0041 , A61K49/0043 , A61K49/0093 , A61K49/085 , A61K49/14 , B82Y5/00
Abstract: A composite of cell-penetrating peptides and magnetic nano particles is provided to secure high stability in comparison with existing viral peptide transporters and maximize effects of video diagnosis by aiming optimal targets. A method for preparing a composite of cell-penetrating peptides and magnetic nano particles comprises the following steps of: preparing a magnetic nano particle containing amino groups by reforming a surface of the magnetic nano particle with amino groups; mixing fluorescent materials to the magnetic nano particle containing amino groups to prepare fluorescent marker magnetic nano particle; and coupling a cell-penetrating peptide with the prepared fluorescent marker magnetic nano particle to produce a composite of cell-penetrating peptides and magnetic nano particles.
Abstract translation: 提供细胞穿透肽和磁性纳米颗粒的复合物，以确保与现有的病毒肽转运蛋白相比具有高度的稳定性，并通过瞄准最佳靶标来最大化视频诊断的效果。 一种制备细胞穿透肽和磁性纳米颗粒复合物的方法包括以下步骤：通过用氨基重整磁性纳米颗粒的表面来制备含有氨基的磁性纳米颗粒; 将荧光材料与含有氨基的磁性纳米颗粒混合，制备荧光标记磁性纳米颗粒; 并将细胞穿透肽与制备的荧光标记物磁纳米颗粒偶联，以产生细胞穿透肽和磁性纳米颗粒的复合物。
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公开(公告)号：KR1020080107198A
公开(公告)日：2008-12-10
申请号：KR1020070055211
申请日：2007-06-05
Applicant: 재단법인서울대학교산학협력재단 , 주식회사 나이벡
CPC classification number: A61L27/52 , A61L27/227 , A61L27/50 , A61L27/54 , A61L2300/25 , A61L2400/06 , A61L2430/02
Abstract: An implantation type bone regeneration material, and a method for preparing the bone regeneration material are provided to maximize the tissue regeneration and to allow it to be coated on the surface of various medical device such as implant, etc. An implantation type bone regeneration material comprises a gel forming base selected from the group consisting of chitosan, alginic acid, silk fibroin, propylene glycol, propylene glycol alginate, poloxamer, chondroitin sulphate and their combination; and a bone formation promoting peptide containing at least one amino acid sequence selected from the sequence numbers 1 to 7 which is combined or mixed with the gel forming base.
Abstract translation: 提供植入型骨再生材料和骨再生材料的制备方法以使组织再生最大化并使其能够涂覆在诸如植入物等各种医疗装置的表面上。植入型骨再生材料包括 选自壳聚糖，藻酸，丝素蛋白，丙二醇，丙二醇藻酸盐，泊洛沙姆，硫酸软骨素及其组合的凝胶形成碱; 以及含有选自序列号1〜7中的至少一个氨基酸序列的骨形成促进肽，其与凝胶形成基质结合或混合。
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公开(公告)号：KR1020080052151A
公开(公告)日：2008-06-11
申请号：KR1020070034300
申请日：2007-04-06
Applicant: 재단법인서울대학교산학협력재단 , 주식회사 나이벡
CPC classification number: A61K8/22 , A61K8/0241 , A61K8/24 , A61K8/25 , A61K8/64 , A61K8/8147 , A61K8/86 , A61K8/88 , A61K2800/413 , A61Q11/00
Abstract: A delivery system of teeth-whitening functional materials is provided to whiten rapidly the teeth by increasing permeation rate, maintain teeth-whitening effects for a long time by inhibiting corrosion of the materials for a sufficient time, and preserve use feeling of conventional teeth-whitening agents. A teeth-whitening composition comprises sticky polymer for coating teeth such as polyvinylpyrrolidone having K value of 12-120, teeth-whitening materials, materials for promoting permeation of the teeth-whitening materials, hydrophobic surfactant, stabilizer, pyrophosphate and silicate dioxide(SiO2), wherein the teeth-whitening materials include peroxide, chlorous acid metal, perborate, percarbonate or peroxy acid; and the materials for promoting permeation of the teeth-whitening materials are peptide having positive charge including LMWP(low molecular weight protamine), TAT(transactivator of transcription), penetratin, polyarginine, polylysine or protamine.
Abstract translation: 提供牙齿美白功能材料的递送系统，通过提高渗透速度快速增白牙齿，通过抑制材料的腐蚀足够长时间，长时间保持牙齿美白效果，并且保持常规牙齿美白的使用感 代理商。 牙齿美白组合物包含用于涂覆牙齿的粘性聚合物，例如K值为12-120的聚乙烯吡咯烷酮，牙齿增白材料，用于促进牙齿美白材料渗透的材料，疏水表面活性剂，稳定剂，焦磷酸盐和二氧化硅（SiO 2） 其中所述牙齿美白材料包括过氧化物，亚硫酸金属，过硼酸盐，过碳酸盐或过氧酸; 并且用于促进牙齿美白材料渗透的材料是具有正电荷的肽，包括LMWP（低分子量鱼精蛋白），TAT（转录反式激活因子），穿透素，聚精氨酸，聚赖氨酸或鱼精蛋白。
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公开(公告)号：KR1020080024006A
公开(公告)日：2008-03-17
申请号：KR1020060088257
申请日：2006-09-12
Applicant: 재단법인서울대학교산학협력재단 , 주식회사 나이벡
IPC: A61F2/28
CPC classification number: A61L27/365 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/4649 , A61L27/3608 , A61L27/3683 , A61L27/54 , A61L2300/102 , A61L2300/112 , A61L2300/402 , A61L2300/406 , A61L2300/414 , A61L2300/416 , A61L2430/02 , A61L2300/10 , A61L2300/40
Abstract: A manufacturing method of a bone grafting substitute using a horse bone is provided to remove effectively fat and organic matters from horse bone that has a structure similar to that of a human. A manufacturing method of a bone grafting substitute using a horse bone includes the steps of: boiling horse bone to remove fat and protein and drying the horse bone; pulverizing the dried bone and precipitating the bone powder in organic solvent; removing the organic solvent and drying; making the bone powder treated with sodium hypochlorite solution having a density of 2-20%; removing the sodium hypochlorite solution and impurities and drying the bone powder; adding purified water to the bone powder, performing compression and hydrothermal treatment at 120-124deg.C for 30 minutes to 5 hours and drying the bone powder; and performing thermal treatment of bone powder at 500-1,000deg.C for 1-24hours.
Abstract translation: 提供使用马骨的骨移植替代物的制造方法，以有效地除去具有与人相似结构的马骨脂肪和有机物质。 使用马骨的骨移植替代物的制造方法包括以下步骤：煮马骨去除脂肪和蛋白质并干燥马骨; 粉碎干骨，并将骨粉沉淀在有机溶剂中; 除去有机溶剂并干燥; 使用密度为2-20％的次氯酸钠溶液处理骨粉末; 除去次氯酸钠溶液和杂质，干燥骨粉; 向骨粉中加入净化水，在120-124℃下进行压缩和水热处理30分钟至5小时，并干燥骨粉; 并在500-1,000℃下进行骨粉热处理1-24小时。
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Patent Agency Ranking
公开(公告)号：KR100757241B1
公开(公告)日：2007-09-10
申请号：KR1020060088455
申请日：2006-09-13
Applicant: 재단법인서울대학교산학협력재단 , 주식회사 나이벡
IPC: A61F2/28
CPC classification number: A61L27/227 , A61F2002/2817 , A61F2002/2835 , A61F2310/00293 , A61L2430/02 , A61F2/28
Abstract: A bone graft containing osteogenesis enhancing peptides is provided to maximize regenerative power of tissue finally by facilitating transport, proliferation and differentiation of cells. A bone graft contains peptides in which amino acid sequence No. 35 is added to N-end of amino acid sequence selected from a group consisting of the following: one or more amino acid sequences among amino acid sequence nos. 1-35; and amino acid in which any two amino acid sequences selected from amino acid sequence nos. 1-35 are connected to each other. The bone graft is obtained by depositing the bone graft in a peptide solution. It is desirable that 10-100mg of peptides are contained based on the unit weight (1g) of the bone graft.
Abstract translation: 提供含有成骨增强肽的骨移植物，以最终通过促进细胞的运输，增殖和分化来最大化组织的再生能力。 骨移植物含有将氨基酸序列编号35添加到氨基酸序列的N末端的肽，所述氨基酸序列选自下列各项之一：氨基酸序列中的一个或多个氨基酸序列。 1-35; 和氨基酸，其中任何两个氨基酸序列选自氨基酸序列。 1-35彼此连接。 通过将骨移植物沉积在肽溶液中获得骨移植物。 基于骨移植物的单位重量（1g），希望含有10-100mg的肽。
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公开(公告)号：KR1020070082785A
公开(公告)日：2007-08-22
申请号：KR1020060015864
申请日：2006-02-17
Applicant: 재단법인서울대학교산학협력재단
Abstract: A self-assembly nano structure comprising hydrophilic bioactive peptides and hydrophobic materials is provided to promote adhesion, proliferation and differentiation of cells in the damaged tissue by adhering the self-assembly nano structure on the surface of a biological material and permeating the bioactive peptides into the living body while the peptides maintains structural stability, and maximize the tissue regeneration restoring efficiency. The self-assembly nano structure comprises a hydrophilic bioactive peptide selected from a cell adhesion-inducing peptide, a tissue growth factor-derived peptide or a cell permeation peptide and a hydrophobic material selected from a hydrophobic hydrocarbon, a hydrophobic polymer, a hydrophobic peptide and silane, and is prepared by applying the more than CMC(critical micelle concentration) of hydrophilic bioactive peptide and hydrophobic material to the water system, wherein the hydrophilic bioactive peptide and hydrophobic material are linked by an amide bonding; and the hydrophobic material is modified by a carboxyl group or an amine group for amide bonding.
Abstract translation: 提供了包含亲水生物活性肽和疏水材料的自组装纳米结构，以通过将生物材料表面上的自组装纳米结构粘附到生物活性肽的表面上以促进受损组织中细胞的粘附，增殖和分化， 活体，而肽保持结构稳定性，并最大限度地提高组织再生恢复效率。 自组装纳米结构包括选自细胞粘附诱导肽，组织生长因子衍生肽或细胞渗透肽的亲水性生物活性肽和选自疏水性烃，疏水性聚合物，疏水性肽的疏水性物质， 硅烷，并且通过将多于CMC（临界胶束浓度）的亲水生物活性肽和疏水性材料应用于水系统制备，其中亲水生物活性肽和疏水性材料通过酰胺键连接; 并且疏水性材料被羧基或用于酰胺键合的胺基改性。
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公开(公告)号：KR1020060101019A
公开(公告)日：2006-09-22
申请号：KR1020050022838
申请日：2005-03-18
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: A61L27/54 , A61F2310/00976 , A61L27/12 , A61L2430/02
Abstract: 본 발명은 표면에 골조직 형성 증진 펩타이드가 고정된 골이식재 및 조직공학용 지지체에 관한 것으로, 보다 구체적으로 세포부착 유도 펩타이드 및/또는 조직성장인자 유래 펩타이드가 표면에 고정된 골이식재 및 조직공학용 지지체에 관한 것이다.
본 발명의 골이식재 및 조직공학용 지지체는 표면에 부착된 골조직 형성 증진 펩타이드에 의해 재생에 관련된 세포의 이행, 증식 및 분화를 촉진하여 최종적으로 조직재생력을 극대화시킬 수 있다. 또한 표면에 고정된 펩타이드는 분자량이 적어 체내에 적용시 면역반응의 위험이 적고, 체내에서 안정한 형태로 존재할 수 있어 약효의 지속화가 가능하여, 치주조직, 치조골재생 및 기타 골조직 재생 수술시 용이하여 수술 편의성이 우수하며 또한 높은 치료효과를 기대할 수 있다.
조직성장인자, 생리활성 펩타이드, 고정화, 골이식재, 지지체, 골재생력-
公开(公告)号：KR1020090034239A
公开(公告)日：2009-04-07
申请号：KR1020070099510
申请日：2007-10-02
Applicant: 재단법인서울대학교산학협력재단
IPC: C07K19/00
CPC classification number: C07K14/51 , C07K2319/10
Abstract: Cell permeable fusion protein for ossification is provided to prevent and treat diseases like periodontal disease osteoporosis or osteogenesis imperfecta, and osteonosus by transporting protein within cell restricting adipocyte. Cell permeable fusion protein for ossification is formed by performing a covalent bond of amino terminal of a bone tissue and cell-penetrating peptide. The cell-penetrating peptide is oligopeptide containing over 70% of a mixture, low molecular weight protamine, trans activator of transcription, penetratin, polyarginine, polylysine, protamine, protamine, histidine, and arginine.
Abstract translation: 提供用于骨化的细胞可渗透融合蛋白以预防和治疗诸如牙周病骨质疏松症或成骨不全的疾病，以及通过在限制脂肪细胞的细胞内转运蛋白质来治疗骨质疏松症。 用于骨化的细胞可渗透融合蛋白是通过进行骨组织和细胞穿透肽的氨基末端的共价键而形成的。 细胞穿透肽是含有超过70％的混合物，低分子量鱼精蛋白，转录反式激活因子，穿透素，聚精氨酸，聚赖氨酸，鱼精蛋白，鱼精蛋白，组氨酸和精氨酸的寡肽。
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公开(公告)号：KR100676945B1
公开(公告)日：2007-02-01
申请号：KR1020050022838
申请日：2005-03-18
Applicant: 재단법인서울대학교산학협력재단
Abstract: 본 발명은 표면에 골조직 형성 증진 펩타이드가 고정된 골이식재 및 조직공학용 지지체에 관한 것으로, 보다 구체적으로 세포부착 유도 펩타이드 및/또는 조직성장인자 유래 펩타이드가 표면에 고정된 골이식재 및 조직공학용 지지체에 관한 것이다.
본 발명의 골이식재 및 조직공학용 지지체는 표면에 부착된 골조직 형성 증진 펩타이드에 의해 재생에 관련된 세포의 이행, 증식 및 분화를 촉진하여 최종적으로 조직재생력을 극대화시킬 수 있다. 또한 표면에 고정된 펩타이드는 분자량이 적어 체내에 적용시 면역반응의 위험이 적고, 체내에서 안정한 형태로 존재할 수 있어 약효의 지속화가 가능하여, 치주조직, 치조골재생 및 기타 골조직 재생 수술시 용이하여 수술 편의성이 우수하며 또한 높은 치료효과를 기대할 수 있다.
조직성장인자, 생리활성 펩타이드, 고정화, 골이식재, 지지체, 골재생력
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