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公开(公告)号：KR1020080071463A
公开(公告)日：2008-08-04
申请号：KR1020070009707
申请日：2007-01-30
Applicant: 재단법인서울대학교산학협력재단
Abstract: An MRI(magnetic resonance imaging) T1 contrasting agent comprising manganese oxide nanoparticles is provided to enhance image resolution as compared to the conventional T1-weighted image, show cell distribution by improving cell-penetrating ability and minimize side effects. An MRI T1 contrasting agent comprises manganese oxide nanoparticles which are coated by a biocompatible material selected from polyvinylalcohol, polylactide, polyglycolide, poly(lactide-co-glycolide), polyanhydride, polyester, polyetherester, polycaprolactone, polyesteramide, polyacrylate, polyurethane, polyvinyl fluoride, poly(vinyl imidazole), chlorosulphonate polyolefin, polyethylene oxide, poly(ethylene glycol) and dextran, and have particle size of 50 nm or less, preferably 40 nm or less, or more preferably 35 nm or less. Further, a thickness of the poly(ethylene glycol) is 5 to 10 nm.
Abstract translation: 提供包含氧化锰纳米颗粒的MRI（磁共振成像）T1对比剂，以增强与常规T1加权图像相比的图像分辨率，通过提高细胞穿透能力和最小化副作用来显示细胞分布。 MRI T1对比剂包括由选自聚乙烯醇，聚丙交酯，聚乙交酯，聚（丙交酯 - 共 - 乙交酯），聚酐，聚酯，聚醚酯，聚己内酯，聚酯酰胺，聚丙烯酸酯，聚氨酯，聚氟乙烯， 聚（乙烯基咪唑），氯磺酸酯聚烯烃，聚环氧乙烷，聚（乙二醇）和葡聚糖，其粒径为50nm以下，优选为40nm以下，更优选为35nm以下。 此外，聚（乙二醇）的厚度为5〜10nm。
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公开(公告)号：KR1020080051285A
公开(公告)日：2008-06-11
申请号：KR1020060122077
申请日：2006-12-05
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: C01G49/04 , A61K9/5115 , A61K9/5192 , B82Y30/00 , C01B13/18 , C01F5/06 , C01F7/441 , C01G49/06 , C01P2002/72 , C01P2004/03 , C01P2004/04 , C01P2004/34 , C01P2004/62 , C01P2004/64 , C01P2004/90 , C01P2006/12 , C01P2006/17
Abstract: A method for preparing metal oxide hollow nanocapsules is provided to produce the metal oxide hollow nanocapsules having excellent dispersibility in a water system and a uniform size distribution. A method for preparing metal oxide hollow nanocapsules includes the steps of: (a) dispersing metal oxyhydroxide particles in a mixture of water and alcohol to obtain a metal oxyhydroxide dispersion; (b) adding a silica precursor to the metal oxyhydroxide dispersion to form a silica coating layer on a metal oxyhydroxide particle by a sol-gel reaction; (c) heat-treating the metal oxyhydroxide having a silica coating layer to prepare the metal oxide hollow nanocapsules having a silica coating layer; and (d) removing the silica coating layer. Further, the metal oxyhydroxide is selected from akaganeite, boehmite, heterogenite, chromia aerogel, indium oxyhydroxide, manganite, nickel oxyhydroxide or tungsten oxyhydroxide.
Abstract translation: 提供了制备金属氧化物空心纳米胶囊的方法，以制备在水系中具有优异分散性和均匀尺寸分布的金属氧化物中空纳米胶囊。 制备金属氧化物空心纳米胶囊的方法包括以下步骤：（a）将金属羟基氧化物颗粒分散在水和醇的混合物中，得到氢氧化金属氢氧化物分散体; （b）将二氧化硅前体加入到羟基氧化金属分散体中，通过溶胶 - 凝胶反应在金属羟基氧化物颗粒上形成二氧化硅涂层; （c）对具有二氧化硅涂层的金属氢氧化物进行热处理以制备具有二氧化硅涂层的金属氧化物空心纳米胶囊; 和（d）除去二氧化硅涂层。 此外，金属氢氧化物选自菱铁矿，勃姆石，异质岩，氧化铬气凝胶，羟基氧化铟，亚锰酸盐，羟基氧化镍或羟基氧化钨。
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公开(公告)号：KR1020080008668A
公开(公告)日：2008-01-24
申请号：KR1020060068178
申请日：2006-07-20
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: C07K1/22 , B82Y5/00 , B82Y25/00 , H01F1/0054
Abstract: A method for selective binding, separation or purification of specific proteins using magnetic nanoparticles is provided to bind the nanoparticles selectively to a specific amino acid-tagged protein and separate the protein effectively. A method for selective binding, separation or purification of specific proteins includes the steps of: binding magnetic nanoparticles of 1-1000nm in size, which consists of Group I transition metals (iron, manganese, nickel, cobalt, zinc, etc) or transition metal ions, to specific amino acid-tagged proteins in In-Vivo blends; separating the proteins bound with the nanoparticles from the In-Vivo blends by an externally applied magnetic field; and separating the specific proteins from the separated nanoparticles.
Abstract translation: 提供了使用磁性纳米颗粒选择性结合，分离或纯化特定蛋白质的方法，以将纳米粒子选择性地结合到特定的氨基酸标记的蛋白质上并有效分离蛋白质。 选择性结合，分离或纯化特定蛋白质的方法包括以下步骤：结合尺寸为1-1000nm的磁性纳米颗粒，其由I族过渡金属（铁，锰，镍，钴，锌等）或过渡金属 离子，在体内共混物中的特定氨基酸标记的蛋白质; 通过外部施加的磁场将与纳米颗粒结合的蛋白与体内共混物分离; 并从分离的纳米颗粒中分离特定的蛋白质。
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公开(公告)号：KR1020040050142A
公开(公告)日：2004-06-16
申请号：KR1020020077770
申请日：2002-12-09
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: B01J37/0018 , B01J23/44 , B82Y30/00
Abstract: PURPOSE: Provided is a method for preparing a hollow palladium catalyst consisting of palladium nano particles. CONSTITUTION: The method comprises the steps of (a) reacting palladium compound precursor on the surface of silica derivatized by functional group to prepare a composite of palladium and silica; and (b) removing the silica from the composite of palladium and silica by using etchant, wherein the palladium compound precursor is selected from the group consisting of palladium acetylacetonate, palladium acetate, palladium chloride, palladium bromide, palladium iodide, chloropalladium acid, palladium sulfate, palladium nitrate and combinations thereof and the compound containing the functional group is mercaptopropyltrimethoxysilane, mercaptopropyltriethoxysilane, aminopropyltrimethoxysilane, aminopropyltriethoxysilane, phosphinopropyl triethoxysilane, cyanopropyltrimethoxysilane, cyanopropyltriethoxysilane and combinations thereof.
Abstract translation: 目的：提供一种由钯纳米颗粒组成的中空钯催化剂的制备方法。 方法：该方法包括以下步骤：（a）使钯化合物前体在由官能团衍生的二氧化硅表面上反应制备钯和二氧化硅的复合物; 和（b）通过使用蚀刻剂从钯和二氧化硅的复合物中除去二氧化硅，其中钯化合物前体选自乙酰丙酮钯，乙酸钯，氯化钯，溴化钯，碘化钯，氯钯酸，硫酸钯 硝酸钯及其组合，含有官能团的化合物为巯基丙基三甲氧基硅烷，巯基丙基三乙氧基硅烷，氨基丙基三甲氧基硅烷，氨基丙基三乙氧基硅烷，膦酰基丙基三乙氧基硅烷，氰基丙基三甲氧基硅烷，氰基丙基三乙氧基硅烷及其组合。
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15.发明公开크기분리 과정 없이 균일하고 결정성이 우수한 금속,합금, 금속 산화물, 및 복합금속 산화물 나노입자를제조하는 방법 有权金属，合金，金属氧化物和复合金属氧化物纳米粒子的生产过程，具有均匀和优异的结晶度，没有尺寸分离过程
公开(公告)号：KR1020030030728A
公开(公告)日：2003-04-18
申请号：KR1020010063077
申请日：2001-10-12
Applicant: 재단법인서울대학교산학협력재단
Inventor： 현택환
CPC classification number: B82Y30/00 , B22F1/0018 , B22F9/305 , B22F2998/00 , B82Y25/00 , C01B13/36 , C01B13/366 , C01P2004/04 , C01P2004/32 , C01P2004/52 , C01P2004/64 , C01P2006/42 , G11B5/70605 , H01F1/0054 , H01F1/009 , B22F1/0085
Abstract: PURPOSE: Provided is a production process of metal, alloy, metal oxide and complex metal oxide nanoparticles which adjusts concentration of surfactants, amount of solvent, reaction time and reaction temperature to produce the nanoparticles as wanted size. CONSTITUTION: The production process of metal, metal oxide and complex metal oxide nanoparticles comprises the steps of: (i) reacting metal precursors to the surfactants in solvent to prepare a metal-surfactant complex compound, in which metal and the surfactants are combined; (ii) executing pyrolysis of the metal-surfactant complex compound to form uniform metal nanoparticles; (iii) distributing the metal nanoparticles to the solvent, adding oxidant to the solution and forming metal oxide nanoparticles.
Abstract translation: 目的：提供金属，合金，金属氧化物和复合金属氧化物纳米颗粒的生产工艺，调整表面活性剂的浓度，溶剂用量，反应时间和反应温度，以生产纳米颗粒作为所需尺寸。 构成：金属，金属氧化物和复合金属氧化物纳米粒子的制备方法包括以下步骤：（i）将金属前体与溶剂中的表面活性剂反应，制备金属与表面活性剂结合的金属 - 表面活性剂络合物; （ii）执行金属 - 表面活性剂络合物的热解以形成均匀的金属纳米颗粒; （iii）将金属纳米颗粒分配到溶剂中，向溶液中加入氧化剂并形成金属氧化物纳米颗粒。
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Patent Agency Ranking
公开(公告)号：KR101197898B1
公开(公告)日：2012-11-05
申请号：KR1020060030850
申请日：2006-04-05
Applicant: 재단법인서울대학교산학협력재단
Abstract: 본 발명은 균일한 두께를 가지는 얇은 카드뮴 셀레나이드(CdSe) 나노 리본 및 그 제조 방법에 관한 것이다. 보다 상세하게는, 본 발명은 발광파장의 반가폭 (Full Width at Half Maximum)이 좁은 청색광을 발광하는 균일한 두께를 가진 CdSe 나노 리본과, 상기 CdSe 나노 리본을 포함하는 청색광 발광 반도체 소자 그리고, 상기 CdSe 나노 리본을 저온에서 제조하는 방법에 대한 것이다.
나노 리본-
公开(公告)号：KR1020090041964A
公开(公告)日：2009-04-29
申请号：KR1020070107780
申请日：2007-10-25
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: D01F9/08 , B01J23/745 , B01J35/0013 , B01J35/002 , B01J37/086 , B01J37/16 , B82Y25/00 , B82Y30/00
Abstract: A method for manufacturing goethite nanotube is provided to be used as a catalyst in a heavy metal absorption process and used for a medical field such as a drug carrier. A method for manufacturing goethite nanotube comprises a step of reacting a reducing agent to a reversed-micelle mixture containing an organic solvent, iron-surfactant composite, surfactant and water. The organic solvents are one or more solvents or mixed solvent selected from the group consisting of toluene, xylene, mesitylene, benzene, pyridine, tetrahydrofuran(THF), pentane, hexane, heptane, octane, nonane, decane, undecane, dodecane, tridecane, pentadecane, tetradecane and hexadecane. The iron-surfactant composite is one or more composite or their mixture selected from the group consisting of iron-C1 carboxylic acid composite to iron-C18 carboxylic acid composite.
Abstract translation: 提供一种制造针铁矿纳米管的方法，用作重金属吸收方法中的催化剂并用于药物载体等医疗领域。 制造针铁矿纳米管的方法包括使还原剂与含有有机溶剂，铁 - 表面活性剂复合物，表面活性剂和水的反胶束混合物反应的步骤。 有机溶剂是一种或多种溶剂或选自甲苯，二甲苯，均三甲苯，苯，吡啶，四氢呋喃（THF），戊烷，己烷，庚烷，辛烷，壬烷，癸烷，十一烷，十二烷，十三烷， 十五烷，十四烷和十六烷。 铁 - 表面活性剂复合物是一种或多种复合材料或它们的混合物，其选自铁-C1羧酸复合物与铁-C18羧酸复合物。
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公开(公告)号：KR1020090038337A
公开(公告)日：2009-04-20
申请号：KR1020070103783
申请日：2007-10-15
Applicant: 재단법인서울대학교산학협력재단 , 아주대학교산학협력단
CPC classification number: C07F9/2408 , C07F9/2458
Abstract: A bio-compatible suspension stabilizer for dispersing inorganic nano-particles in an aqueous medium is provided to modify surfaces of the inorganic nano-particles to have hydrophilic properties and easily allow ligand having in vivo activity to be accepted. A bio-compatible suspension stabilizer for dispersing inorganic nano-particles in an aqueous medium is phosphin oxide represented by the formula 1. A method for producing the phosphin oxide comprises the following steps of: dissolving a bio-compatible polymer in an organic solvent to prepare a bio-compatible polymer organic solvent; adding phosphin oxide having a leaving group into the prepared bio-compatible polymer organic solvent to bond the phosphin oxide with the bio-compatible polymer; reacting a compound having a functional group in order to induce the functional group which can be bonded with the functional ligand at a position of the leaving group of the bio-compatible polymer.
Abstract translation: 提供了用于将无机纳米颗粒分散在水性介质中的生物相容性悬浮稳定剂，以将无机纳米颗粒的表面改性为具有亲水性，并容易地允许具有体内活性的配体。 用于将无机纳米颗粒分散在水性介质中的生物相容的悬浮稳定剂是由式1表示的氧化膦。氧化膦的制备方法包括以下步骤：将生物相容性聚合物溶解在有机溶剂中以制备 生物相容性聚合物有机溶剂; 在制备的生物相容性聚合物有机溶剂中加入具有离去基团的氧化膦，将氧化膦与生物相容的聚合物键合; 使具有官能团的化合物反应以诱导可在生物相容性聚合物的离去基团的位置处与官能配体结合的官能团。
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公开(公告)号：KR1020080007195A
公开(公告)日：2008-01-17
申请号：KR1020070084853
申请日：2007-08-23
Applicant: 재단법인서울대학교산학협력재단
IPC: C07C15/16 , C07C49/303 , C07C15/18 , B82B3/00
Abstract: A method for preparing biaryl compounds is provided to produce biaryl compounds with high yield at low catalyst amount and low reaction temperature. A method for preparing biaryl compounds includes a step of using palladium nanoparticles as a Suzuki coupling reaction catalyst. The palladium nanoparticles are prepared by the steps of: (a) dissolving polyethyleneoxide-polypropyleneoxide-polyethyleneoxide block copolymers in distilled water to prepare a block copolymer solution; and (b) adding a palladium precursor compound to the block copolymer solution and stirring the admixture.
Abstract translation: 提供了一种制备联芳基化合物的方法，以低催化剂量和低反应温度产生高收率的联芳基化合物。 制备联芳基化合物的方法包括使用钯纳米颗粒作为Suzuki偶联反应催化剂的步骤。 通过以下步骤制备钯纳米颗粒：（a）将聚环氧乙烷 - 聚环氧丙烷 - 聚环氧乙烷嵌段共聚物溶解在蒸馏水中以制备嵌段共聚物溶液; 和（b）向嵌段共聚物溶液中加入钯前体化合物并搅拌混合物。
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公开(公告)号：KR1020070099737A
公开(公告)日：2007-10-10
申请号：KR1020060030850
申请日：2006-04-05
Applicant: 재단법인서울대학교산학협력재단
Abstract: Cadmium selenide nanoribbons having a uniform thickness are provided to emit a blue light having a narrow full width at half maximum of the electroluminescent wavelength and be manufactured at low temperature of 100°C or below. Cadmium selenide nanoribbons having a uniform thickness grow along a crystal face(0001) and are surrounded by crystal faces(1100,1120). A method for manufacturing cadmium selenide semiconductor nanoribbons comprising the cadmium selenide nanoribbons includes the steps of: (i) adding CdCl2 to a C3-C10 alkyl amine, heating and stirring the admixture to form a Cd-alkylamine complex; (ii) adding Se to a C3-C10 alkyl amine, stirring the admixture, and introducing carbon monoxide into the admixture to form a Se precursor; (iii) mixing the Cd-alkylamine complex with the Se precursor and heating the mixture; and (iv) growing nanoribbons while keeping a solution containing the Cd-alkylamine complex and the Se precursor at suitable temperature for growth of nanocrystals.
Abstract translation: 提供具有均匀厚度的硒化镉纳米带，以发射具有电致发光波长半个全宽的全宽的蓝光，并在100℃或更低的低温下制造。 具有均匀厚度的硒化镉纳米带沿着晶面（0001）生长并被晶面包围（1100,1120）。 包含硒化镉纳米带的硒化镉半导体纳米带的制造方法包括以下步骤：（ⅰ）将CCl 2加入到C 3 -C 10烷基胺中，加热搅拌混合物以形成镉 - 烷基胺络合物; （ii）向C 3 -C 10烷基胺中加入Se，搅拌混合物，并将一氧化碳引入混合物中以形成Se前体; （iii）将Cd-烷基胺配合物与Se前体混合并加热该混合物; 和（iv）生长纳米带，同时保持包含Cd-烷基胺络合物和Se前体的溶液在合适的温度下生长纳米晶体。
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