公开(公告)号：KR100521841B1

公开(公告)日：2005-10-17

申请号：KR1020020002032

申请日：2002-01-14

Applicant: 재단법인서울대학교산학협력재단 ,  주식회사 팜트리

Inventor： 서영거 ,  신동윤 ,  박선현 ,  이도상

IPC: C07D311/78

Abstract: 본 발명은 하기 화학식 1로 표시되는 오르토-나프토피라노퀴논 유도체, 제조방법 및 이를 포함하는 약학적 조성물에 관한 것으로, 상기 화합물은 항균 및 항진균 효과가 우수하고 독성이 적어 항균제 및 항진균제로 유용하게 사용될 수 있다.
화학식 1

(상기 식에서, A, B, R
1 및 R
2 는 명세서 내에서 정의한 바와 같다)

公开(公告)号：KR1020080037374A

公开(公告)日：2008-04-30

申请号：KR1020060104404

申请日：2006-10-26

Applicant: 재단법인서울대학교산학협력재단

Inventor： 서영거 ,  구본웅 ,  김진관 ,  김미경

IPC: C07C251/48 ,  C07D261/04

Abstract: A 2-ethoxypropionic acid derivative or its pharmaceutically acceptable salt, its preparation method, and an agent for treating or preventing diabetes containing the derivative or salt are provided to improve the effect for treating or preventing diabetes by the dual acting to PPAR(peroxisome proliferator-activated receptor) alpha or gamma. A 2-ethoxypropionic acid derivative is represented by the formula 1, 2 or 3, wherein X is H, a halogen atom, a substituted or unsubstituted C1-C4 alkyl group, a substituted or unsubstituted C5-C7 aryl group, OH, a substituted or unsubstituted C1-C5 alkoxy group, or a substituted or unsubstituted C1-C5 alkylsulfonyl group; Z is a specific group containing a nitrogen atom; n is an integer of 0-5 and is determined by Z; and R1 and R2 are H, or a substituted or unsubstituted C1-C4 alkyl group.

Abstract translation: 提供2-乙氧基丙酸衍生物或其药学上可接受的盐，其制备方法和用于治疗或预防含有衍生物或盐的糖尿病的药物，以改善通过双重作用于PPAR（过氧化物酶体增殖物 - 活化受体）α或γ。 2-乙氧基丙酸衍生物由式1,2或3表示，其中X为H，卤素原子，取代或未取代的C 1 -C 4烷基，取代或未取代的C 5 -C 7芳基，OH，取代的 或未取代的C1-C5烷氧基，或取代或未取代的C1-C5烷基磺酰基; Z是含有氮原子的特定基团; n是0-5的整数，由Z决定; 并且R 1和R 2是H或取代或未取代的C 1 -C 4烷基。

公开(公告)号：KR1020020019136A

公开(公告)日：2002-03-12

申请号：KR1020000052253

申请日：2000-09-05

Applicant: 재단법인서울대학교산학협력재단

Inventor： 서영거 ,  김영호 ,  박형섭 ,  문주연 ,  김석호

IPC: C07C69/12

Abstract: PURPOSE: Provided are diterpene derivatives which are synthesized from the material extracted from Acanthopanax Koreanum, and antiphlogistics containing the derivatives. CONSTITUTION: The diterpene derivatives are represented by the formula 1, wherein R1 is a vinyl group or phenylethyl group; and R2 is carboxyl group, carboxy homoallyl group, carboxy pentadienyl group, carboxy hexyl group, carboxy hexatrienyl group, carboxy heptadienyl group, carboxy methyl butadienyl group, carboxy dimethyl pentadienyl group, carboxy methyl pentadienyl group, carboxy methyl pentenyl group, carboxy methyl pentyl group, carbamoyl pentadienyl group, (N-methoxy)carbamoyl pentadienyl group, (N-pipsyl)carbamoyl pentadienyl group, (N-methanesulfonyl)carbamoyl pentadienyl group, or (N-chloropyridine)carbamoyl pentadienyl group.

Abstract translation: 目的：提供由从刺五加提取的材料合成的二萜衍生物和含衍生物的消炎药。 构成：二萜衍生物由式1表示，其中R1是乙烯基或苯基乙基; 羧基高辛烯基，羧基戊二烯基，羧基己基，羧基己三烯基，羧基庚二烯基，羧甲基丁二烯基，羧基二甲基戊二烯基，羧基甲基戊二烯基，羧甲基戊烯基，羧基甲基戊基 ，氨基甲酰基戊二烯基，（N-甲氧基）氨基甲酰基戊二烯基，（N-哌啶基）氨基甲酰基戊二烯基，（N-甲磺酰基）氨基甲酰基戊二烯基或（N-氯吡啶）氨基甲酰基戊二烯基。