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公开(公告)号：KR1020140114622A
公开(公告)日：2014-09-29
申请号：KR1020130029119
申请日：2013-03-19
Applicant: 전남대학교산학협력단
Abstract: The present invention provides a method for producing various kinds of low toxic hydrogel using natural polymers and hydrogel produced through the same, wherein the low toxic hydrogel has a rapid absorbing speed and a high absorbing amount. Alginic acid hydrogel and k-carageenan/karaya gum hydrogel exhibiting rapid swelling properties can be applied to a diaper or a hygiene product. CMC hydrogel and amide pectin hydrogel having a slow swelling speed but exhibiting a high horizontal swelling degree can be utilized as a vegetation mat. The hydrogel produced in the present invention can be applied in various fields by producing pores and adjusting a composition rate using various natural polymers.
Abstract translation: 本发明提供了使用天然聚合物和通过其制备的水凝胶来生产各种低毒水凝胶的方法，其中低毒水凝胶具有快速吸收速度和高吸收量。 表现出快速溶胀性能的海藻酸水凝胶和k-角叉菜胶/刺梧桐树胶水凝胶可以应用于尿布或卫生用品。 具有缓慢溶胀速度但具有高水平膨胀度的CMC水凝胶和酰胺果胶水凝胶可用作植被垫。 本发明中生产的水凝胶可以通过使用各种天然聚合物产生孔隙和调节组成比来应用于各种领域。
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公开(公告)号：KR101310614B1
公开(公告)日：2013-09-24
申请号：KR1020100122102
申请日：2010-12-02
Applicant: 전남대학교산학협력단 , (주) 켐포트
Abstract: 본 발명은 소수성 불포화지방산과 수용성 키토산의 정전기적 상호작용(electrostatic interaction)을 이용한 나노입자 제조와 종양모델 마우스를 이용한 EPR(enhanced permeability retention: 종양부위에 흡수되는 나노입자의 양과 그 위치에 머무는 시간을 향상시키는 효과)실험을 통해 종양 조직에 효과적으로 축적되며 불포화지방산의 도입으로 암세포에 대한 치료 특성을 갖는 주사제용 및 경구용 항암제의 제조에 관한 새로운 발명이다. 본 발명의 나노입자는 불포화지방산의 캡슐화가 가능하고 불포화지방산의 악취와 산패를 막음으로써 식품-의약품으로의 개발을 가능케 하는 새로운 발명이다. 소수성 불포화지방산과 수용성 키토산의 나노입자는 수용액상에서 구의 형태를 가지며 110-330nm의 크기를 형성한다. 광학영상(optical image)을 위해 제조된 나노입자에 Cy7을 표지시켜 동물실험을 통하여 확인하였다.
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公开(公告)号：KR1020120061163A
公开(公告)日：2012-06-13
申请号：KR1020100122102
申请日：2010-12-02
Applicant: 전남대학교산학협력단 , (주) 켐포트
CPC classification number: A61K9/5161 , A61K47/61 , B82Y5/00 , B82Y40/00 , G01N33/54346 , G01N33/574
Abstract: PURPOSE: An unsaturated fatty acid-chitosan composite which forms self-assembled nano-particles and a manufacturing method thereof are provided to manufacture the self-assembled nano-particles without adding emulsifier by using electrostatic interaction between water-soluble chitosan and unsaturated fatty acid. CONSTITUTION: An unsaturated fatty acid-chitosan composite which forms self-assembled nano-particles comprises water-soluble chitosan which is represented by chemical formula 1 and unsaturated fatty acid which is combined by applying electrostatic interaction to the water-soluble chitosan. In the chemical formula 1, n indicates an integer of 10-10,000. An end part of the unsaturated fatty acid is esterified by combining end part of carboxyl group with alkyl group having 1-10 carbons. Oxygen of the ester takes part in the electrostatic interaction.
Abstract translation: 目的：提供一种形成自组装纳米颗粒的不饱和脂肪酸 - 壳聚糖复合物及其制备方法，通过使用水溶性壳聚糖和不饱和脂肪酸之间的静电相互作用，不加入乳化剂来制造自组装纳米颗粒。 构成：形成自组装纳米颗粒的不饱和脂肪酸 - 壳聚糖复合物包括由化学式1表示的水溶性壳聚糖和通过向水溶性壳聚糖施加静电相互作用而组合的不饱和脂肪酸。 在化学式1中，n表示10〜10000的整数。 通过将羧基的末端与具有1-10个碳的烷基结合，将不饱和脂肪酸的末端部分酯化。 酯的氧气参与静电相互作用。
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公开(公告)号：KR1020110088702A
公开(公告)日：2011-08-04
申请号：KR1020100008326
申请日：2010-01-29
Applicant: 전남대학교산학협력단 , (주) 켐포트
CPC classification number: A61K9/1271 , A61K9/1277 , A61K31/202 , A61K47/36 , Y10S514/857
Abstract: PURPOSE: An EPA-containing liposome which is coated with thiol chitosan and a method for preparing the same are provided to maximize stability, efficiency, and absorption rate. CONSTITUTION: A method for preparing EPA-containing liposome coated with thiol chitosan comprises: a step of adding a volatile organic solvent to a mixture to prepare a phospholipid solution; a step of evaporating and concentrating the phosphlipid solution to prepare a thin film; a step of adding thiol chitosan solution to the thin film; and a step of hydrating thin film to prepare liposome.
Abstract translation: 目的：提供涂有巯基壳聚糖的含EPA脂质体及其制备方法，以使稳定性，效率和吸收速度最大化。 构成：包含硫醇壳聚糖的含EPA脂质体的制备方法包括：向混合物中加入挥发性有机溶剂以制备磷脂溶液的步骤; 蒸发并浓缩磷脂溶液以制备薄膜的步骤; 向薄膜中添加硫醇壳聚糖溶液的步骤; 以及水合薄膜以制备脂质体的步骤。
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公开(公告)号：KR101706608B1
公开(公告)日：2017-02-27
申请号：KR1020160134288
申请日：2016-10-17
Applicant: 전남대학교산학협력단
CPC classification number: A61L27/3604 , A61L27/20 , A61L27/3687 , A61L27/3691 , A61L2430/02
Abstract: 본발명은해양소재인민어부레추출물및 젤란검혼합물로제조한막에 D-PBS를처리하여제조한차폐막에관한것으로, 생체적합성, 조직재생, 조직재건, 조직치료, 효소에의한분해저항, 물리적강도등이매우좋아다양한분야에서활용될수 있다.
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Patent Agency Ranking
公开(公告)号：KR101576246B1
公开(公告)日：2015-12-10
申请号：KR1020140052956
申请日：2014-04-30
Applicant: 전남대학교산학협력단
Abstract: 본발명은생체조직간의유착을효과적으로방지할수 있는나노섬유시트와이의제조방법에관한것으로서, 더욱상세하게는수용성키토산과친수성고분자인폴리에틸렌옥사이드(PEO)를전기방사하여균일한나노섬유로형성되고표면적이넓으며독성이없는부직포형태의나노섬유시트와이의제조방법에관한것이다. 본발명의나노섬유시트의제조방법은수용성키토산과폴리에틸렌옥사이드(poly ethylene oxide)를물에용해시켜고분자용액을수득하는단계와, 상기고분자용액을전기방사하는단계를포함한다.
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公开(公告)号：KR1020090123111A
公开(公告)日：2009-12-02
申请号：KR1020080049030
申请日：2008-05-27
Applicant: 전남대학교산학협력단
IPC: A01N65/08
Abstract: PURPOSE: An antimicrobial agent containing essential oil loaded in polymeric beads is provided to effectively and safely enhance anti-microbial activity. CONSTITUTION: An antimicrobial agent contains essential oil loaded in polymeric bead as an active ingredient. The polymeric bead is alginate bead. The essential oil is essential oil of tea tree, chamomile or eucalypus. The microbial is Staphylococcus aureus. A method for producing the antimicrobial agent comprises: a step of homogenizing essential oil and polymer solution(0.1-10% w/v of polymer) in a volume ratio of 1:100-1,000; and a step of dropping mixture solution into bead forming solution, washing and drying. The bead forming solution is calcium chloride, magnesium chloride or calciumsulfate solution.
Abstract translation: 目的：提供一种含有载于聚合物珠粒中的精油的抗微生物剂，以有效和安全地增强抗微生物活性。 构成：抗微生物剂含有载于聚合物珠中的精油作为活性成分。 聚合物珠粒是藻酸盐珠粒。 精油是茶树，洋甘菊或桉树油的精油。 微生物是金黄色葡萄球菌。 制备抗微生物剂的方法包括：以1：100-1,000的体积比均匀化精油和聚合物溶液（0.1-10％w / v的聚合物）的步骤; 以及将混合溶液滴加到珠形成溶液中，洗涤和干燥的步骤。 珠形成溶液是氯化钙，氯化镁或硫酸钙溶液。
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公开(公告)号：KR101874321B1
公开(公告)日：2018-07-05
申请号：KR1020180023845
申请日：2018-02-27
Applicant: 전남대학교산학협력단
IPC: C08J9/228 , C08J5/18 , C08L67/04 , C08G63/91 , C08J9/40 , C08J7/12 , C08J7/02 , A61L27/28 , A61L27/18
CPC classification number: C08J9/228 , A61L27/18 , A61L27/28 , C08G63/912 , C08J5/18 , C08J7/02 , C08J7/12 , C08J9/40 , C08L67/04
Abstract: 본발명은다공성폴리락트산멤브레인및 이의제조방법에관한것이다. 보다구체적으로, 폴리락트산의표면활성을증가시켜골 치유효과를높일수 있는다공성폴리락트산멤브레인및 이의제조방법에관한것이다.
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公开(公告)号：KR1020150042363A
公开(公告)日：2015-04-21
申请号：KR1020130120764
申请日：2013-10-10
Applicant: 전남대학교산학협력단
CPC classification number: A61K47/40 , A61K9/06 , A61K31/353 , A61K47/32 , A61K47/36 , A61K2121/00 , Y10S514/886
Abstract: 본발명은카테킨을함유하는창상피복제용하이드로겔조성물과이의제조방법에관한것으로서, 더욱상세하게는나노화시킨카테킨입자를폴리비닐알콜과펙틴조성의하이드로겔에첨가하여창상보호및 치료에효과적인창상피복제용하이드로겔조성물과이의제조방법에관한것이다. 본발명의카테킨을함유하는창상피복제용하이드로겔조성물은카테킨입자가하이드로겔에함유된다. 그리고본 발명의카테킨을함유하는창상피복제용하이드로겔조성물의제조방법은나노크기의카테킨입자를형성시키는제 1단계와, 물에폴리비닐알콜과펙틴을용해시켜혼합용액을수득하는제 2단계와, 혼합용액에상기카테킨입자를첨가하여하이드로겔을형성시키는제 3단계를포함한다.
Abstract translation: 本发明涉及包含用于敷料的儿茶素的水凝胶组合物及其制造方法，更具体地，涉及一种用于伤口敷料的水凝胶组合物，其通过将纳米儿茶素颗粒加入到水凝胶中而有效保护和治疗伤口 聚乙烯醇和果胶，及其制造方法。 含有本发明伤口敷料儿茶素的水凝胶组合物在水凝胶中含有儿茶素颗粒。 包含本发明的伤口敷料儿茶素的水凝胶组合物的制造方法包括形成纳米级儿茶素颗粒的第一步骤，通过将聚乙烯醇和果胶溶解在水中获得混合溶液的第二步骤，第三步 通过在混合溶液中加入儿茶素颗粒形成水凝胶。
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公开(公告)号：KR1020140114617A
公开(公告)日：2014-09-29
申请号：KR1020130029109
申请日：2013-03-19
Applicant: 전남대학교산학협력단
Abstract: Provided are a pharmaceutical or cosmetic composition and an application-type gel, which prepare a curcumin-containing gel by adding curcumin to gel formulations for transdermal delivery to check an effect of treating wound, and treat skin wound containing the same. Through in vitro anti-inflammatory experiments and in vivo animal experiments, the present invention can check an increase of reepithelialisation tendency on a wounded area when using the curcumin-containing gel, thus is capable of being used for preparing the application-type gel which promotes wound healing.
Abstract translation: 提供了一种药物或化妆品组合物和应用型凝胶，其通过将姜黄素加入用于透皮递送的凝胶制剂中以制备含有姜黄素的凝胶，以检查治疗伤口的作用，并治疗含有其的皮肤伤口。 通过体外抗炎实验和体内动物实验，本发明可以在使用含有姜黄素的凝胶时检查受伤区域上皮再生倾向的增加，因此能够用于制备促进的应用型凝胶 伤口愈合。
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