의료용 접착제 조성물
    12.
    发明公开
    의료용 접착제 조성물 有权
    医用胶组合物

    公开(公告)号:KR1020120050354A

    公开(公告)日:2012-05-18

    申请号:KR1020100111804

    申请日:2010-11-10

    Abstract: PURPOSE: A medical adhesive composition is provided to use poly-gamma-glutamic acid, thereby having edible, water-soluble, anionic, biodegradable properties. CONSTITUTION: A medical adhesive composition comprises poly-gamma-glutamic acid or salt thereof, and sugar or sugar alcohol. The poly-gamma-glutamic acid salt is selected from sodium polyglutamate, polyglutamic acid potassium salt, polyglutamic acid calcium salt, and polyglutamic acid ammonium sat, and polyglutamic acid zinc salt. The molecular weight of the poly-gamma-glutamic acid and salt thereof is 1-15,000 kDa. The salt is selected fructose, glucose, mannose, sucrose, maltose, trehalose, oligosaccharide, starch and maltodextrin. The sugar alcohol is selected from xylitol, lactitol, isomalt, sorbitol, maltitol, and glycerol.

    Abstract translation: 目的:提供一种医用粘合剂组合物,以使用聚-γ-谷氨酸,从而具有食用,水溶性,阴离子,可生物降解的特性。 构成:医用粘合剂组合物包含聚-γ-谷氨酸或其盐,以及糖或糖醇。 聚-γ-谷氨酸盐选自聚谷氨酸钠,聚谷氨酸钾盐,聚谷氨酸钙盐和聚谷氨酸铵sat,以及聚谷氨酸锌盐。 聚-γ-谷氨酸及其盐的分子量为1-15,000kDa。 选择果糖,葡萄糖,甘露糖,蔗糖,麦芽糖,海藻糖,寡糖,淀粉和麦芽糖糊精。 糖醇选自木糖醇,乳糖醇,异麦芽酮糖醇,山梨糖醇,麦芽糖醇和甘油。

    암억제 단백질을 발현하는 알파바이러스계 발현 벡터, 이의 제조 방법 및 용도
    17.
    发明公开
    암억제 단백질을 발현하는 알파바이러스계 발현 벡터, 이의 제조 방법 및 용도 有权
    表达抑癌基因蛋白的ALPHAVIRUS表达载体及其制备方法及其用途

    公开(公告)号:KR1020020067833A

    公开(公告)日:2002-08-24

    申请号:KR1020010008201

    申请日:2001-02-19

    CPC classification number: C12N15/86 C07K14/4703 C07K14/4746 C12N5/0693

    Abstract: PURPOSE: An Alphavirus expression vector capable of expressing a cancer-inhibiting protein, its producing method and its use are provided, thereby effectively inhibiting and preventing the growth of a cancer cell. CONSTITUTION: The Alphavirus expression vector capable of expressing a cancer-inhibiting protein contains a first cancer-inhibiting gene which is operably linked under operation of a first subgenomic promoter, a second cancer-inhibiting gene which is operably linked under operation of a second subgenomic promoter, and a third cancer-inhibiting gene which is operably linked under operation of a third subgenomic promoter, in which the cancer-inhibiting gene is selected from pRb/p110 or its homologue p107 and p120, p53 protein, p21 protein, p21 protein(WAF-1), bak, BRCA1, BRCA2, PTEN, APC, DCC, NF-1, NF-2, WT-1, MEN-I, MEN-II, zac1, p73, VHL, FCC and MCC; and the Alphavirus is Sindbis virus or Semliki Forest virus(SFV).

    Abstract translation: 目的:提供能够表达癌抑制蛋白的甲病毒表达载体及其制备方法及其用途,从而有效抑制和预防癌细胞的生长。 构成:能够表达癌症抑制蛋白的甲病毒载体表达载体含有第一癌抑制基因,其在第一亚基因组启动子的操作下可操作地连接,第二癌抑制基因在第二亚基因组启动子的操作下可操作地连接 ,以及第三癌抑制基因,其在第三亚基因组启动子的操作下可操作地连接,其中所述癌抑制基因选自pRb / p110或其同源物p107和p120,p53蛋白,p21蛋白,p21蛋白(WAF -1),bak,BRCA1,BRCA2,PTEN,APC,DCC,NF-1,NF-2,WT-1,MEN-1,MEN-II,zac1,p73,VHL,FCC和MCC; 甲病毒属于辛德毕斯病毒或辛格利奇森林病毒(SFV)。

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