-
公开(公告)号：KR1020140056517A
公开(公告)日：2014-05-12
申请号：KR1020120120159
申请日：2012-10-29
Applicant: 대진대학교 산학협력단 , 충남대학교산학협력단
IPC: C12N15/53 , C12N15/63 , C12N9/02 , A61K31/711
Abstract: The present invention relates to a method for reinforcing a barrier function of a cell, by reinforcing the function or increasing gene expression by having an NADPH-quinone-oxidoreductase-1 (NQO1) gene or a protein expressed therefrom, as a target molecule. More specifically, the present invention is based on a cell barrier function relating to worsening of an inflammation of a large intestine epithelial cell of a human or a mammal, and an NQO1 gene adjusting the cell barrier function, to suppress the worsening of the inflammation caused by a loss of the barrier function of the large intestine epithelial cell and provide a treatment for effectively treating various acute and chronic enteritis diseases.
Abstract translation: 本发明涉及通过使NADPH-醌 - 氧化还原酶-1（NQO1）基因或其表达的蛋白质作为靶分子来增强功能或增加基因表达来增强细胞的屏障功能的方法。 更具体地，本发明是基于与人或哺乳动物的大肠上皮细胞的炎症恶化有关的细胞屏障功能和调节细胞屏障功能的NQO1基因，以抑制炎症恶化 通过损失大肠上皮细胞的屏障功能，并提供有效治疗各种急性和慢性肠炎疾病的治疗方法。
-
公开(公告)号：KR101301486B1
公开(公告)日：2013-08-29
申请号：KR1020120043311
申请日：2012-04-25
Applicant: 충남대학교산학협력단
IPC: A01K67/027 , C12N5/071 , G01N33/15
CPC classification number: A01K67/027 , C12N5/0602 , G01N33/15
Abstract: PURPOSE: A Parkinson's disease model mouse, a preparation method thereof, and a screening method for Parkinson's disease using the same are provided to be utilized for pathological mechanism researches. CONSTITUTION: A Parkinson's disease model mouse lacks a CR6-interacting factor 1 gene in the dopamine type neuron cells. A preparation method of the Parkinson's disease model mouse comprises the following steps: obtaining a CRIF1 heterozygous knockout first generation mouse having CRIF1 loxp/+ and DAT-Cre m/+ genotypes by crossing a CRIF1 loxp/loxp mouse and a DAT-Cre mouse; obtaining a second generation mouse by crossing the heterozygous knockout mouse and a CRIF1 loxp/loxp mouse; and selecting a CRIF1 homozygous knockout mouse having CRIF1 loxp/loxp and DAT-Cre m/+ genotypes from the second generation mouse.
Abstract translation: 目的：提供帕金森氏病模型小鼠及其制备方法和使用该方法的帕金森病筛选方法，用于病理机制研究。 构成：帕金森病模型小鼠在多巴胺型神经元细胞中缺少CR6相互作用因子1基因。 帕金森病模型小鼠的制备方法包括以下步骤：通过杂交CRIF1 loxp / loxp小鼠和DAT-Cre小鼠获得具有CRIF1 loxp / +和DAT-Cre m / +基因型的CRIF1杂合敲除第一代小鼠; 通过杂交敲除小鼠和CRIF1 loxp / loxp小鼠杂交获得第二代小鼠; 并从第二代小鼠中选择具有CRIF1 loxp / loxp和DAT-Cre m / +基因型的CRIF1纯合敲除小鼠。
-
公开(公告)号：KR101065806B1
公开(公告)日：2011-09-19
申请号：KR1020090005382
申请日：2009-01-22
Applicant: 충남대학교산학협력단
Abstract: 본 발명은 단백질을 세포내에서 미토콘드리아로 이동시키는 것에 의해 미토콘드리아의 기능과 안정성을 효과적으로 조절할 수 있는 서열번호 5의 도메인 단백질 및 이를 암호화하는 유전자에 관한 것이다.
본 발명의 도메인 단백질은 CRIF1 또는 이종 단백질과 융합된 형태로 CRIF1 또는 이종 단백질을 미토콘드리아로 이동시키는 표적서열로 작용하므로, 미토콘드리아의 기능이상을 동반하는 신경 및 근육 퇴행성 질환, 대사성증후군, 암등에
약리적 활성을 나타내는 물질(화학물질, 단백질 또는 유전자 포함)을 미토콘드리아에서 직접 작용할 수 있도록 한다.
미토콘드리아, 표적 서열, 도메인 단백질-
公开(公告)号：KR1020100092086A
公开(公告)日：2010-08-20
申请号：KR1020090011273
申请日：2009-02-12
Applicant: 충남대학교산학협력단
CPC classification number: A61K38/16 , A61K48/00 , C07K14/47 , Y10S514/866 , Y10S514/907
Abstract: PURPOSE: A composition for preventing and treating diseases accompanying mitochondrial dysfunction is provided to use in researching mediate which performs signal transduction between the mitochondria and nucleus. CONSTITUTION: A composition for preventing and treating diseases accompanying mitochondrial dysfunction contains CRIF1(CR6(Gadd45gamma) Interacting Factor 1) protein, DNA encoding the same or mRNA of the protein. The disease includes neurodegenerative diseases or anaplasia muscle disease. The diseases are cancer, diabetes, or metabolic syndrome. The cancer is colon cancer, thyroid cancer, or prostate cancer.
Abstract translation: 目的：提供一种用于预防和治疗伴随线粒体功能障碍的疾病的组合物，用于研究在线粒体和细胞核之间进行信号转导的介质。 构成：用于预防和治疗伴随线粒体功能障碍的疾病的组合物含有CRIF1（CR6（Gadd45gamma）相互作用因子1）蛋白，编码该蛋白的相同或mRNA的DNA。 该疾病包括神经退行性疾病或肛裂肌病。 这些疾病是癌症，糖尿病或代谢综合征。 癌症是结肠癌，甲状腺癌或前列腺癌。
-
公开(公告)号：KR102164525B1
公开(公告)日：2020-10-12
申请号：KR1020190017660
申请日：2019-02-15
Applicant: 충남대학교산학협력단
IPC: C12Q1/6886 , G01N33/574
-
Patent Agency Ranking
公开(公告)号：KR102097008B1
公开(公告)日：2020-04-03
申请号：KR1020180103488
申请日：2018-08-31
Applicant: 충남대학교산학협력단
IPC: C12Q1/6886 , G01N33/574
-
17.发明公开근감소증 (Sarcopenia) 동물 모델과 그 제조 방법 및 이를 이용한 근감소증 치료제의 스크리닝 방법 无效Sarcopiaia Sarconia模型小鼠的制备方法和使用它们的sarconia的筛选方法
公开(公告)号：KR1020170001021A
公开(公告)日：2017-01-04
申请号：KR1020150090349
申请日：2015-06-25
Applicant: 충남대학교산학협력단
IPC: A01K67/027
Abstract: 본발명의근감소증동물모델은출생시에는성비및 외형에이상이없으면서성장에따라근세포의양, 운동량및 운동력이감소하여근감소증고유의증상을나타내므로근감소증진행경과, 병리학적기전연구의동물모델및 근감소증예방및 치료제의스크리닝에유용하게이용될수 있다.
-
公开(公告)号：KR1020160122685A
公开(公告)日：2016-10-24
申请号：KR1020160132868
申请日：2016-10-13
Applicant: 충남대학교산학협력단
IPC: A61K38/17 , A61K48/00 , A61K38/16 , A61K39/395 , A61K38/00
CPC classification number: A61K38/17 , A61K38/00 , A61K38/16 , A61K39/395 , A61K48/00
Abstract: 본발명은 CRIF1 단백질또는이를코딩하는유전자를포함하는심혈관질환예방또는치료용약학조성물, CRIF1 단백질을이용한심혈관질환진단용키트, 및 CRIF1 단백질을이용한심혈관질환의진단에필요한정보제공방법에관한것이다. 본발명에따르면, CRIF1 결핍으로유도된미토콘드리아기능장애가 ROS 생성을자극하여, 내피세포활성화를초래하고 p66shc에의한내피세포활성화를부분적으로매개함을확인하였다. 따라서 CRIF1 단백질또는유전자는내피세포기능장애와관련된혈관질환의진단및 치료에효과적으로이용될수 있다.
-
公开(公告)号：KR1020100086164A
公开(公告)日：2010-07-30
申请号：KR1020090005382
申请日：2009-01-22
Applicant: 충남대학교산학협력단
Abstract: PURPOSE: A mitochondria targeting domain is provided to transfer functional protein CRIF1 or foreign protein-fused CRIF1 to mitochondria and to target mitochondria by a material for treating mitochondria malfunction. CONSTITUTION: A mitochondria targeting domain is represented by sequence number 5. A gene encoding the domain is DNA, RNA, or PNA. The gene is denoted by base sequence number 10. The domain transfers CRIF1 protein and foreign protein to the mitochondria.
Abstract translation: 目的：提供线粒体靶向结构域，以将功能蛋白CRIF1或外源蛋白融合CRIF1转移至线粒体，并通过用于治疗线粒体功能障碍的材料靶向线粒体。 构成：线粒体靶向结构域由序列号5表示。编码结构域的基因是DNA，RNA或PNA。 该基因由碱基序列号10表示。结构域将CRIF1蛋白和外来蛋白转移至线粒体。
-
公开(公告)号：KR101727506B1
公开(公告)日：2017-05-04
申请号：KR1020160089470
申请日：2016-07-14
Applicant: 충남대학교산학협력단
IPC: A61K38/18 , A23L1/305 , C07K14/495 , C12N15/86
Abstract: 본발명은 GDF15 단백질또는이를암호화하는폴리뉴클레오티드를유효성분으로함유하는지방간의예방또는치료용약학적조성물에관한것으로, GDF15(Growth differentiation factor 15) 단백질또는이를암호화하는폴리뉴클레오티드가비만동물모델인 ob/ob 마우스모델에투여되었을때, 몸무게증가억제효과를보였고, 간조직과지방조직에서지방세포생성(lipogenesis)이감소되었으며. 지방분해에관여하는유전자와미토콘드리아기능의향상과관련된유전자의발현및 베타산화(beta-oxidation)관련유전자발현이증가될뿐만아니라시험관내()에서재조합 GDF15 단백질을농도별로근육세포와간세포에처리하였을때 미토콘드리아산소소모량과지방의분해(lipolysis)를증가시켜미토콘드리아의기능을향상시킴을최종확인함으로써, GDF15 단백질또는이를암호화하는폴리뉴클레오티드는미토콘드리아기능을향상시켜지방간의예방또는치료용약학적조성물로써유용하게사용될수 있다.
-
-
-
-
-
-
-
-
-
Search Results
24
records
(took 0.021 seconds)
