-
公开(公告)号：KR101431987B1
公开(公告)日：2014-08-22
申请号：KR1020130109692
申请日：2013-09-12
Applicant: 중앙대학교 산학협력단 , 대전대학교 산학협력단 , 강릉원주대학교산학협력단 , 충남대학교산학협력단
CPC classification number: A61K31/16 , A23L33/10 , A23V2002/00 , A23V2200/318 , A61K8/42 , A61Q19/00
Abstract: The present invention relates to a composition including pellitorine as an active ingredient for alleviating contact dermatitis. A pellitorine compound which is an active ingredient of the composition according to the present invention is secreted in the early stage of various strong inflammatory diseases so as to control the secretion of IL-1beta which is cytokine promoting an inflammatory response and also control the proliferation of T cells and the secretion of IL-2, IL-4, or IFN-gamma which is cytokine secreted from T cells so that immunity can be regulated. Moreover, the compound exhibits activities in controlling the secretion of IL-1beta, inhibiting the decomposition cleavage of caspase-1, having no cytotoxicity, and decreasing skin thickness in contact dermatitis in an experiment using a contact dermatitis animal model as an animal model. Accordingly, it is expected that the composition of the present invention can be usefully used as a pharmaceutical composition, a cosmetic composition, or a functional food composition for preventing or treating inflammatory skin diseases like contact dermatitis.
Abstract translation: 本发明涉及包含扑地酮作为缓和接触性皮炎的活性成分的组合物。 作为本发明组合物的活性成分的倍他尼汀化合物在各种强烈炎症性疾病的早期阶段被分泌，以便控制作为促进炎性反应的细胞因子的IL-1β的分泌，并且还可以控制 T细胞和从T细胞分泌的细胞因子的IL-2，IL-4或IFN-γ的分泌，从而可以调节免疫。 此外，在使用接触性皮炎动物模型作为动物模型的实验中，该化合物显示出控制IL-1β分泌的活性，抑制无细胞毒性的胱天蛋白酶-1的分解切割和减少接触性皮炎的皮肤厚度。 因此，预期本发明的组合物可有效地用作药物组合物，化妆品组合物或用于预防或治疗炎性皮肤疾病如接触性皮炎的功能性食品组合物。
-
公开(公告)号：KR101142452B1
公开(公告)日：2012-05-08
申请号：KR1020090101226
申请日：2009-10-23
Applicant: (주)지노믹트리 , 충남대학교산학협력단
CPC classification number: C12Q1/6827 , C12Q1/6886 , C12Q2565/501
Abstract: The present invention relates to a method for detecting the methylation of a breast cancer-specific methylation marker gene for breast cancer diagnosis, and more particularly, to a method which involves detecting methylation of a breast cancer-specific methylation marker gene which is methylated specifically in a breast cancer cell, and provides information for the diagnosis of breast cancer or the stage of progression of breast cancer. When the methylation detection method of the present invention is used together with a diagnosis composition, a kit, and a nucleic acid chip, more accurate and quicker early diagnosis of breast cancer can be facilitated as compared to conventional methods, the stage of progression of breast cancer can be checked, and a non-invasive serum sample is made available, to thereby diagnose breast cancer in a more simple and accurate manner.
-
公开(公告)号：KR1020090071998A
公开(公告)日：2009-07-02
申请号：KR1020070139958
申请日：2007-12-28
Applicant: 충남대학교산학협력단
Abstract: A composition for skin external preparation, which contains colostrums as an active ingredient is provided to improve skin condition by having anti-alergic effect, anti-inflammatory effect, promotion effect of keratin differentiation, and skin moisturization. A composition of skin external preparation comprises 0.001-30 weight% of colostrums based on the total weight as an active ingredient. The composition has the effect of anti-allergy, anti-inflammation, keratin differentiation, skin moisturization, skin barrier strengthening, improvement of wrinkle care. The composition comprises only colostrums, or further comprises excipient, diluents, or anti-oxidant. The composition is used in a form of skin softener, lotion, nutrition cream, spray, granule, essence, powder, syrup, liquid, aerosol, ointment, suspension, capsule, or pill. The excipient is used by mixing with glycerin, starch, water, alcohol, propylene glycol, or saline solution.
Abstract translation: 提供含有初乳作为活性成分的皮肤外用剂组合物，通过具有抗过敏作用，抗炎作用，促进角蛋白分化作用和皮肤保湿来改善皮肤状况。 皮肤外用制剂的组合物含有作为活性成分的总重量的0.001-30重量％的初乳。 该组合物具有抗过敏，抗炎，角蛋白分化，皮肤保湿，增强皮肤屏障，改善皱纹护理的作用。 组合物仅包含初乳，或者还包括赋形剂，稀释剂或抗氧化剂。 该组合物以皮肤柔软剂，洗剂，营养霜，喷雾剂，颗粒剂，精华剂，粉剂，糖浆剂，液体剂，气溶胶剂，软膏剂，悬浮剂，胶囊剂或丸剂的形式使用。 赋形剂与甘油，淀粉，水，醇，丙二醇或盐溶液混合使用。
-
Patent Agency Ranking
公开(公告)号：KR1020110127108A
公开(公告)日：2011-11-24
申请号：KR1020110115895
申请日：2011-11-08
Applicant: (주)지노믹트리 , 충남대학교산학협력단
CPC classification number: C12Q1/6886 , C12N15/117 , C12Q1/6837 , C12Q1/6858 , C12Q2600/154
Abstract: PURPOSE: A method for detecting breast cancer using breast cancer-specific biomarker is provided to enable early diagnosis of breast cancer and to ensure simplicity and accuracy. CONSTITUTION: A method for detecting methylation of a biomarker for diagnosing breast cancer or progression comprises: a step of isolating DNA from a clinical sample; and a step of detecting methylation of TF gene(NM_001063, transferrin) from the isolated DNA. The clinical sample is tissue, sputum, cells, blood, plasma, or urine derived from a patient with cancer or possibility of cancer. A nucleic acid chip for diagnosing breast cancer contains a probe which is hybridiable with a fragment containing CpG of a promoter of the TF gene(NM_001063, iron binding transport protein, transferrin) under a severe condition.
Abstract translation: 目的：提供使用乳腺癌特异性生物标志物检测乳腺癌的方法，以便早期诊断乳腺癌并确保简单性和准确性。 构成：用于检测用于诊断乳腺癌或进展的生物标志物的甲基化的方法包括：从临床样品中分离DNA的步骤; 以及从分离的DNA检测TF基因（NM_001063，转铁蛋白）甲基化的步骤。 临床样本是来自患有癌症或癌症可能性的患者的组织，痰，细胞，血液，血浆或尿液。 用于诊断乳腺癌的核酸芯片含有在严重条件下与含有TF基因启动子（NM_001063，铁结合转运蛋白，转铁蛋白）的CpG的片段可杂交的探针。
-
公开(公告)号：KR1020110044510A
公开(公告)日：2011-04-29
申请号：KR1020090101226
申请日：2009-10-23
Applicant: (주)지노믹트리 , 충남대학교산학협력단
CPC classification number: C12Q1/6827 , C12Q1/6886 , C12N15/11 , C12Q1/6837 , C12Q2565/501 , C12Q2600/154
Abstract: PURPOSE: A method for detecting methylation of a breast cancer-specific methylated marker is provided to quickly and accurately detect methylation. CONSTITUTION: A method for methylation of a breast cancer-specific methylated marker comprises: a step of preparing a clinical sample containing DNA; a step of detecting CpG island methylation of OTP(NM_032109, Orthopedia Homeobox) from the DNA. The CpG island methylation is detected at an intron site of OTP gene. The intron of OTP gene has a base sequence of sequence number 1. A composition for diagnosing breast cancer contains GpG island of OTP gene.
Abstract translation: 目的：提供一种检测乳腺癌特异性甲基化标记甲基化的方法，以快速，准确地检测甲基化。 构成：乳腺癌特异性甲基化标记的甲基化方法包括：制备含有DNA的临床样品的步骤; 从DNA中检测OTP（NM_032109，Orthopedia Homeobox）的CpG岛甲基化的步骤。 在OTP基因的内含子位点检测到CpG岛甲基化。 OTP基因的内含子具有序列号1的碱基序列。用于诊断乳腺癌的组合物含有OTP基因的GpG岛。
-
16.发明公开포공영, 어성초, 감초 및 유근피의 혼합 추출물을 유효성분으로 함유하는 피부 보습 개선용 화장료 조성물 无效化妆品组合物，用于皮肤保湿，其中包括蒲公英的提取物。达拉斯泰特心af鱼腥草甘草的樟子松根皮
公开(公告)号：KR1020160121636A
公开(公告)日：2016-10-20
申请号：KR1020150050118
申请日：2015-04-09
Applicant: 충남대학교산학협력단 , 동국대학교 경주캠퍼스 산학협력단
IPC: A61K8/97 , A61K36/288 , A61K36/78 , A61K36/236 , A61Q19/00
Abstract: 본발명은포공영(H. Dahlstedt), 어성초(Heartleaf), 감초(Fischer) 및유근피(root bark of)의혼합추출물을유효성분으로함유하는피부보습개선용화장료조성물에관한것으로, 포공영, 어성초, 감초및 유근피의혼합추출물이세포독성을나타내지않고, 피부각질세포막을구성하는단백질인인볼루크린(involucrin) 및로리크림(loricrin)의발현을증가시키며, 세포증식을촉진하고, 마우스에처리하였을때 피부의수분손실을억제함을확인함으로써, 본발명의포공영, 어성초, 감초및 유근피의혼합추출물이피부보습개선용화장료조성물로유용하게사용될수 있음을확인하였다.
-
公开(公告)号：KR101587635B1
公开(公告)日：2016-01-22
申请号：KR1020150029188
申请日：2015-03-02
Applicant: (주)지노믹트리 , 충남대학교산학협력단
CPC classification number: C12Q1/6886 , C12Q1/686 , C12Q2521/331 , C12Q2600/154 , G01N33/53 , G01N2800/046
Abstract: 본발명은갑상선암 (thyroid cancer) 또는갑상선암진행단계진단을위한갑상선암특이적메틸화마커유전자의메틸화검출방법, 갑상선암특이적메틸화마커유전자의메틸화를검출할수 있는갑상선암또는갑상선암진행단계진단용조성물, 이를포함하는키트및 핵산칩에관한것으로, 보다구체적으로는갑상선암세포에서특이적으로메틸화되는갑상선암특이적마커유전자의메틸화를검출하여갑상선암또는갑상선암진행단계진단을위한정보를제공하는방법, 및갑상선암특이적마커유전자의메틸화여부를검출할수 있는물질을포함하는갑상선암또는갑상선암진행단계진단용조성물, 이를포함하는키트및 핵산칩에관한것이다.
Abstract translation: 本发明涉及甲状腺癌特异性甲基化标记基因甲基化检测方法，用于诊断甲状腺癌或其进展; 用于诊断甲状腺癌的组合物或其检测甲状腺癌特异性甲基化标记基因甲基化的进展; 以及包含该组合物的试剂盒和核酸芯片。 更具体地，本发明涉及通过检测在甲状腺癌细胞中特异性甲基化的甲状腺癌特异性标志物基因的甲基化来提供信息诊断甲状腺癌或其进展的方法。 用于诊断甲状腺癌或其进展的组合物，其包含能够检测甲状腺癌特异性标志物基因是否被甲基化的物质; 以及包含该组合物的试剂盒和核酸芯片。
-
公开(公告)号：KR101191947B1
公开(公告)日：2012-10-17
申请号：KR1020110115895
申请日：2011-11-08
Applicant: (주)지노믹트리 , 충남대학교산학협력단
Abstract: 본 발명은 유방암 특이적인 바이오마커를 이용한 유방암의 검출방법에 관한 것으로, 보다 구체적으로는, 유방암 특이적 발현감소 유전자인
CHL1
유전자{NM_006614, cell adhesion molecule with homology to L1CAM (close homolog of L1)}
또는
TF
유전자(NM_001063, 철이온 결합 수송 단백질, 트랜스페린)의 프로모터 부위의 메틸화된 CpG 섬을 포함하는 유방암 또는 그 진행단계 진단용 바이오마커 및 상기 바이오마커를 이용한 유방암 및 그 진행단계의 검출방법에 관한 것이다.
본 발명의 바이오마커를 이용하면, 통상적인 방법보다 정확하고 빠르게 유방암의 조기 진단이 가능하며, 비침습적 시료인 혈청을 샘플로 이용할 수 있어, 보다 간편하고 정확하게 유방암을 진단할 수 있다.
-
-
-
-
-
-
-
Search Results
18
records
(took 0.021 seconds)
