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公开(公告)号：KR1020150131951A
公开(公告)日：2015-11-25
申请号：KR1020150051619
申请日：2015-04-13
Applicant: 포항공과대학교 산학협력단
CPC classification number: A61L24/0031 , A61L24/0015 , A61L24/08 , A61L27/20 , A61L27/52 , A61L27/54 , A61L27/60 , C08L5/08
Abstract: 본발명은표면처리된나노섬유을포함하는생체접착성하이드로젤, 이의제조방법, 및이의용도에관한것으로, 본발명을통하여제공되는표면처리된나노섬유를이용한하이드로젤은, 우수한생체접착력을가지므로, 생체접착제, 조직공학용지지체, 또는약물전달용담체등으로폭넓게응용될수 있다.
Abstract translation: 本发明涉及包含表面处理的纳米纤维的生物粘合剂水凝胶，其制备方法及其用途。 使用本发明的表面处理纳米纤维的水凝胶具有优异的生物粘附性，因此可以广泛地应用于生物粘合剂，组织工程用支持体或药物输送用载体。
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公开(公告)号：KR1020140035251A
公开(公告)日：2014-03-21
申请号：KR1020130106599
申请日：2013-09-05
Applicant: 포항공과대학교 산학협력단
CPC classification number: D04H1/4266 , A61L27/22 , A61L27/26 , A61L27/3637 , A61L27/56 , D04H1/4282 , D04H1/728 , D10B2509/00
Abstract: The present invention relates to a nanofibers tissue engineering scaffold comprising mussels coating proteins and Fe3+ ions and a manufacturing method thereof. More specifically, the present invention relates to a nanofibers tissue engineering scaffold which the surface of the nanofibers is coated by bioactive substances, the mussels adhesive proteins is a nanofibers tissue engineering scaffold which more than 20% of the total tyrosine residues are modified to DOPA.
Abstract translation: 本发明涉及包含贻贝涂层蛋白质和Fe3 +离子的纳米纤维组织工程支架及其制造方法。 更具体地，本发明涉及纳米纤维表面被生物活性物质包被的纳米纤维组织工程支架，贻贝粘合蛋白是纳米纤维组织工程支架，其中20％以上的酪氨酸残基被修饰为DOPA。
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公开(公告)号：KR1020140027031A
公开(公告)日：2014-03-06
申请号：KR1020130096424
申请日：2013-08-14
Applicant: 포항공과대학교 산학협력단
CPC classification number: A61L27/52 , A61K9/06 , A61K38/18 , A61K47/42 , A61L2430/00
Abstract: The present invention relates to a mussel adhesive protein-based bioadhesive hydrogel and a manufacturing method thereof. More specifically, to a hydrogel formed by combination of a DOPA (3, 4-dihydroxyphenylalanine) residue included in a mussel adhesive protein and Fe3+ ions. In addition, the present invention relates to a hydrogel formed as a DOPA residue contained in a mussel adhesive protein is oxidized.
Abstract translation: 本发明涉及一种基于贻贝粘合蛋白的生物粘附性水凝胶及其制造方法。 更具体地说，涉及通过组合包含在贻贝粘合蛋白质中的DOPA（3,4-二羟基苯丙氨酸）残基和Fe 3+离子形成的水凝胶。 此外，本发明涉及由贻贝粘合蛋白中所含的DOPA残基形成的水凝胶被氧化。
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公开(公告)号：KR1020130033996A
公开(公告)日：2013-04-04
申请号：KR1020120107890
申请日：2012-09-27
Applicant: 포항공과대학교 산학협력단
CPC classification number: A61L27/20 , A61L27/50 , A61L2430/10 , A61L2430/12 , C08B37/003 , C08L5/08 , Y10T442/60
Abstract: PURPOSE: A chitosan and/or chitin composite is provided to improve strength in a wet condition and to provide an artificial tendon and ligament for being used in a wet condition. CONSTITUTION: A composite comprises chitosan, chitin, or a mixture thereof; and one or more compounds selected from catechol, dopamine, DOPA, and methylcatechol. The one or more compounds selected from catechol, dopamine, DOPA, and methylcatechol has a crosslinked structure by a covalent bond or non-covalent bond. The composite has a Young's modulus of 500-10,000MPa at relative humidity of 40-50% and a Young's modulus of 180-5,000MPa at relative humidity of 90-100%.
Abstract translation: 目的：提供壳聚糖和/或几丁质复合材料，以提高湿润条件下的强度，并提供用于湿润条件的人造腱和韧带。 构成：复合材料包含壳聚糖，几丁质或其混合物; 和一种或多种选自邻苯二酚，多巴胺，DOPA和甲基儿茶酚的化合物。 一种或多种选自儿茶酚，多巴胺，DOPA和甲基儿茶酚的化合物通过共价键或非共价键具有交联结构。 该复合材料的相对湿度为40-50％时的杨氏模量为500-10,000MPa，相对湿度为90-100％时的杨氏模量为180-5,000MPa。
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Patent Agency Ranking
公开(公告)号：KR101783448B1
公开(公告)日：2017-09-29
申请号：KR1020150051619
申请日：2015-04-13
Applicant: 포항공과대학교 산학협력단
CPC classification number: A61L24/0031 , A61L24/0015 , A61L24/08 , A61L27/20 , A61L27/52 , A61L27/54 , A61L27/60 , C08L5/08
Abstract: 본발명은표면처리된나노섬유을포함하는생체접착성하이드로젤, 이의제조방법, 및이의용도에관한것으로, 본발명을통하여제공되는표면처리된나노섬유를이용한하이드로젤은, 우수한생체접착력을가지므로, 생체접착제, 조직공학용지지체, 또는약물전달용담체등으로폭넓게응용될수 있다.
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公开(公告)号：KR1020160110723A
公开(公告)日：2016-09-22
申请号：KR1020150033808
申请日：2015-03-11
Applicant: 포항공과대학교 산학협력단
Abstract: 본발명은아스파탐(aspartame)을첨가하여아스파르트산-페닐알라닌모티프를갖는 RGD 펩타이드를제조하는방법, 아스파탐을포함하는 RGD 펩타이드제조용조성물및 키트에관한것이다. 본발명은아스파탐을이용하여아스파르트산-페닐알라닌모티프를갖는 RGD 펩타이드를저비용, 고효율로합성할수 있고, 제조된 RGD 펩타이드는 RGD 펩타이드의세포부착능증가효과를나타내므로생물학적활성을갖는 RGD 펩타이드를간단하고저렴하게합성하는데유용하게사용될수 있다.
Abstract translation: 本发明涉及通过添加阿斯巴甜来制备具有天冬氨酸 - 苯丙氨酸基序的RGD肽的方法。 本发明还涉及用于制备包含阿斯巴甜的RGD肽的试剂盒和组合物。 使用本发明的阿斯巴甜能够以低成本和高效率合成具有天冬氨酸 - 苯丙氨酸基序的RGD肽，并且由此产生的RGD肽也显示RGD肽中的细胞附着性改善。 因此，阿斯巴甜可以用于以简单且经济的方式合成生物活性RGD肽。
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公开(公告)号：KR1020150124919A
公开(公告)日：2015-11-06
申请号：KR1020150059920
申请日：2015-04-28
Applicant: 포항공과대학교 산학협력단
CPC classification number: A61K8/19 , A61K8/0241 , A61K8/24 , A61K8/25 , A61K8/29 , A61K8/368 , A61K8/602 , A61K2800/412 , A61K2800/413 , A61K2800/92 , A61Q11/00
Abstract: 본발명은구강도포용조성물과그 제조방법에관한것으로, 보다상세하게는, 특정한루이스염기및 특정한루이스산의착화합물을포함하는구강도포용조성물과그 제조방법에관한것이다. 본발명의구강도포용조성물은내구성, 인체안전성, 및도포용이성이우수하여, 효과적으로시린이증상을치료할수 있고, 시린이증상이나타나기전에적용시, 시린이증상을방지할수 있다.
Abstract translation: 本发明涉及一种口服用组合物及其制备方法，更具体地涉及含有特定路易斯碱和特定路易斯酸的络合物的口服用组合物及其制造方法。 本发明的口服用组合物具有优异的耐久性，对人体的安全性和涂布能力，因此可以有效地治疗牙齿敏感症状，并且可以在牙齿敏感症状之前施用时防止牙齿敏感症状。
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20.发明公开
公开(公告)号：KR1020140117293A
公开(公告)日：2014-10-07
申请号：KR1020140034299
申请日：2014-03-24
Applicant: 포항공과대학교 산학협력단
Inventor： 황동수 , 오동엽 , 프라자테리스티아에카비안티 , 이진우 , 예영진
CPC classification number: A61L27/12 , A61F2002/5093 , A61L2430/10 , C12N2501/815 , C12N2533/72
Abstract: The present invention relates to a composite including hydroxyapatite, chitosan, chitin, or a derivative of the same, and catechol or a derivative of the same; an organic reinforcing material composition including the composite, a product manufactured with the organic reinforcing material composition, and a method to manufacture the composite. The composite provided in the present invention is a material with catechol or an added catechol derivative, which has characteristics of being harmless to a human body, shows strong mechanical strength to be used as various biomaterials such as an artificial sinew, an artificial ligament, and an artificial dental material; and is useful for various kinds of required materials, without limitations.
Abstract translation: 本发明涉及包含羟基磷灰石，壳聚糖，壳多糖或其衍生物的复合材料，以及儿茶酚或其衍生物; 包含所述复合材料的有机增强材料组合物，使用所述有机增强材料组合物制造的产品以及所述复合材料的制造方法。 本发明提供的复合材料是具有儿茶酚衍生物或添加的儿茶酚衍生物的材料，具有对人体无害的特性，显示出很强的机械强度，可用作各种生物材料如人造丝，人造韧带和 人造牙科材料; 并且对于各种所需材料是有用的，没有限制。
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