公开(公告)号：KR1020140047645A

公开(公告)日：2014-04-22

申请号：KR1020140037956

申请日：2014-03-31

Applicant: 한국과학기술연구원

Inventor： 강기성 ,  함정엽 ,  김수남 ,  권학철 ,  정봉철 ,  이우정 ,  박순혜

IPC: A61K36/258 ,  A61K31/704 ,  A61P7/02 ,  A61P29/00 ,  A61P25/00

CPC classification number: A61K36/258 ,  A23L33/105 ,  A23L33/175 ,  A61K31/198 ,  A61K31/704 ,  A61K2236/333

Abstract: The present invention relates to an extract of processed Panax genus plant obtained by maillard browning reaction of Panax genus extract with at least one amino acid selected from the group consisting of valine, arginine, and alanine at 100-130°C for 0.5-12 hours; a method for manufacturing the same; and a composition comprising the extract for anti-cancer, neuroprotection, inhibition of platelet aggregation, antioxidant, anti-inflammatory, renal protection, or anti-fatigue. The present invention also provides an extract of processed Panax genus plant obtained by maillard browning reaction of Panax genus extrac with at least one amino acid selected from the group consisting of leucine and glutamine at 100-130°C for 0.1-12 hours; a method for manufacturing the same; and an anti-cancer composition comprising the extract.

Abstract translation: 本发明涉及通过将亚麻提取物与选自缬氨酸，精氨酸和丙氨酸的至少一种氨基酸在100-130℃下进行0.5-12小时的美拉德褐变反应而获得的加工番荔枝属植物提取物 ; 其制造方法; 以及包含用于抗癌，神经保护，抑制血小板聚集，抗氧化，抗炎，肾脏保护或抗疲劳的提取物的组合物。 本发明还提供了将Panax属提取物的玉米褐变反应与100-130℃下选自亮氨酸和谷氨酰胺的至少一种氨基酸进行0.1-12小时的经加工的Panax属植物提取物; 其制造方法; 以及包含所述提取物的抗癌组合物。

公开(公告)号：KR1020140022588A

公开(公告)日：2014-02-25

申请号：KR1020120088843

申请日：2012-08-14

Applicant: 한국과학기술연구원

Inventor： 함정엽 ,  정봉철 ,  김희진 ,  최필주 ,  최화정 ,  김태정 ,  송재형 ,  송중호 ,  박순혜

IPC: A61K36/04 ,  A61P31/12 ,  A61P31/00

CPC classification number: A61K36/04 ,  A61K2236/39

Abstract: The present invention provides a composition having antiviral activities which include neorhodomela extracts as an active ingredient. In addition, the present invention provides a method for isolating polybromocatechol which comprises the steps of: obtaining the extract by extracting the neorhodomela using organic solvents and vacuum distilling the same; obtaining fraction extracts by fractioning the organic solvent extracts obtained from the previous step using polar difference of solvents; and isolating and purifying the fraction extract obtained from the previous step using chromatography. According to the present invention, the antiviral substances can be provided which is safe, have enhanced inhibition ability for human rhino virus, and has low toxicity by being derived from a natural product. In addition, the polybromocatechol compound can easily be isolated from the neorhodomela so that the present invention can provide a pharmaceutical composition which can be used for preventing and treating viral diseases. [Reference numerals] (AA) Neorhodomela; (BB) Ethylacetate extracts; (CC) Repeat butanol fraction for two times; (DD) Butanol extracts; (EE) Water extracts; (FF) Silicagel column chromatography Hex;EA;MeOH gradient (F1-F7); (GG) Reverse phase fraction HPLC C-18 DBTHR 10 ml/min, 280 nm, 10-100% acetonitrile gradient (0.02% TFA); (HH) Compound 1a; (II) Compound 2b; (JJ) Compound 1c; (KK) Compound 1d; (LL) Reverse phase fraction HPLCC-18 velocity of flow 4 ml/min, 280 nm 40% acetonitrile (0.02% TFA); (MM) Compound 2a; (NN) Mixture; (OO) Compound 1b

Abstract translation: 本发明提供具有抗病毒活性的组合物，其包括作为活性成分的新罗莫拉提取物。 此外，本发明提供了一种分离多溴邻苯二酚的方法，其包括以下步骤：通过使用有机溶剂提取新方法得到提取物，并真空蒸馏该方法; 通过使用极性差的溶剂分馏从前一步骤获得的有机溶剂提取物获得级分提取物; 并使用色谱分离和纯化从前一步骤获得的级分提取物。 根据本发明，可以提供抗病毒物质，其是安全的，具有增强的人犀牛病毒的抑制能力，并且通过衍生自天然产物具有低毒性。 此外，多溴代邻苯二酚化合物可以容易地从新方法中分离出来，从而本发明可以提供可用于预防和治疗病毒性疾病的药物组合物。 （AA）Neorhodomela; （BB）乙酸乙酯提取物; （CC）重复丁醇级分2次; （DD）丁醇提取物; （EE）水提取物; （FF）硅胶柱色谱法Hex; EA; MeOH梯度（F1-F7）; （GG）反相级分HPLC C-18 DBTHR 10ml / min，280nm，10-100％乙腈梯度（0.02％TFA）; （HH）化合物1a; （II）化合物2b; （JJ）化合物1c; （KK）化合物1d; （LL）反相级分HPLCC-18流速4ml / min，280nm 40％乙腈（0.02％TFA）; （MM）化合物2a; （NN）混合物; （OO）化合物1b

公开(公告)号：KR1020130132264A

公开(公告)日：2013-12-04

申请号：KR1020130036448

申请日：2013-04-03

Applicant: 한국과학기술연구원

Inventor： 함정엽 ,  강기성 ,  정봉철 ,  권학철 ,  박순혜 ,  최필주 ,  김수남 ,  양현옥

IPC: A61K36/258 ,  A61K31/56 ,  A61K9/48 ,  A61K9/20

CPC classification number: A61K36/258 ,  A61K31/704 ,  A61K2236/37 ,  A61K2300/00

Abstract: The present invention provides Panax spp. plant extract which includes 90% or more of Rg3, Rk1, and Rg5 based on the weight of ginsenoside Rb1, Rc, Rb2, Rd, Rg3, Rk1 and Rg5 obtained by making microwave reaction with Panax spp. plant or the extract, a method for preparing the same, a pharmaceutical composition for improving anti-cancer agent side effects selected from immune degradation and anti-cancer agent tolerance, antioxidant, anti-cancer, antiinflammatory, brain function or cognitive skills, blood vessel relaxation, platelet coagulation suppression, dermatitis, or psoriasis and a composition for health supplement. [Reference numerals] (AA) Voltage (mV);(BB) Time (minute)

Abstract translation: 本发明提供了Panax spp。 基于通过与Panax spp进行微波反应获得的人参皂甙Rb1，Rc，Rb2，Rd，Rg3，Rk1和Rg5的重量，含有90％以上的Rg3，Rk1和Rg5的植物提取物。 植物或提取物，其制备方法，用于改善选自免疫降解和抗癌药耐受性，抗氧化剂，抗癌，抗炎，脑功能或认知技能的抗癌剂副作用的药物组合物，血管 松弛，血小板凝血抑制，皮炎或银屑病以及健康补充剂的组合物。 （标号）（AA）电压（mV）;（BB）时间（分钟）

公开(公告)号：KR101303916B1

公开(公告)日：2013-09-05

申请号：KR1020110107369

申请日：2011-10-20

Applicant: 한국과학기술연구원

Inventor： 함정엽 ,  김태정 ,  송중호 ,  박순혜

IPC: C07F19/00 ,  C07F1/06 ,  C07F5/02

Abstract: 본 발명은 하기 화학식 1로 나타내어지는 포타슘 스티레닐트리플루오로보레이트 유도체 및 그 제조방법을 제공한다.
[화학식 1]

(상기 화학식 1에서,
Ar은 페닐 ( ), 바이페닐 ( ), 나프틸 ( ), 펜옥시페닐 ( ), 피리딜 ( ), 퓨라닐 ( ) 및 티오페닐 ( )로 이루어진 군으로부터 선택되는 어느 하나 이상이고,
R
1 은 C
1 -C
8 알킬기, C
1 -C
4 알킬옥시기, 불소, 염소 및 수소로 이루어진 군으로부터 선택되는 어느 하나 이상이며,
R
2 는 기 (R
4 는 C
1 -C
8 알킬기, C
1 -C
4 알킬옥시기, 불소, 염소 및 수소로 이루어진 군으로부터 선택되는 어느 하나 이상임), C
1 -C
8 알킬기, C
6 -C
12 시클로알킬기, C
6 -C
12 아릴알킬기, C
2 -C
9
알킬에테르기, 기 (R
5 는 C
1 -C
8 알킬기 또는 수소), 기 (R
6 는 C
1 -C
8 알킬기, 디메틸아민기, 페닐기 및 수소로 이루어진 군으로부터 선택되는 어느 하나 이상임), 시안기 및 수소로 이루어진 군으로부터 선택되는 어느 하나 이상이고,
R
3 는 C
1 -C
8 알킬기, 페닐기 및 수소로 이루어진 군으로부터 선택되는 어느 하나 이상이며,
n은 1 내지 4의 정수이고, m은 1 내지 4의 정수이다.)

公开(公告)号：KR101260047B1

公开(公告)日：2013-05-06

申请号：KR1020130007651

申请日：2013-01-23

Applicant: 한국과학기술연구원

Inventor： 함정엽 ,  강기성 ,  정봉철 ,  권학철 ,  박순혜 ,  최필주 ,  김수남 ,  양현옥

IPC: A61K36/258 ,  A61K9/48 ,  A61K9/20 ,  A61K9/16

CPC classification number: A61K36/258 ,  A61K31/704 ,  A61K2236/37 ,  A61K2300/00

Abstract: PURPOSE: A Panax species plant extract having the increased content of ginsenoside Rg5 and Rk1 by microwave irradiation, a manufacturing method thereof, and a composition containing the processed Panax species plant extract are provided to enhance an effect of Rg5 and Rk1 compared to an extract by simple thermal-processing. CONSTITUTION: A manufacturing method of a Panax species plant extract comprises: a step of irradiating Panax species plants or an extract thereof with microwaves. The Panax species plant or the extract contains more than 90% of Rg3, Rk1, and Rg5 to the weight of ginsenoside Rb1, Rc, Rb2, Rd, Rg3, Rk1 and Rg5. The microwave irradiation is performed at 150-190 deg. C for 30-90 minutes while pressurizing. The microwave irradiation is performed under 2-100 atmospheric pressure. The Panax species plant extract has a ratio of ginsenoside (Rg5+Rk1)/(Rg3) of 2 or greater. [Reference numerals] (AA) Voltage(mv); (BB) Time(minutes)

Abstract translation: 目的：提供通过微波照射提高人参皂甙Rg5和Rk1含量增加的Panax种植物提取物，其制备方法和含有加工的Panax种植物提取物的组合物，以提高Rg5和Rk1与提取物相比的作用 简单的热处理。 构成：人参植物提取物的制造方法包括：将微生物种类植物或其提取物照射到微波的步骤。 人参植物或提取物含有人参皂甙Rb1，Rc，Rb2，Rd，Rg3，Rk1和Rg5重量的Rg3，Rk1和Rg5的90％以上。 微波照射在150-190度进行。 C加压30-90分钟。 微波照射在2-100大气压下进行。 人参植物提取物的人参皂甙（Rg5 + Rk1）/（Rg3）的比值为2以上。 （附图标记）（AA）电压（mv）; （BB）时间（分钟）