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11.发明公开
公开(公告)号：KR1020010015512A
公开(公告)日：2001-02-26
申请号：KR1020000063394
申请日：2000-10-27
Applicant: 한국과학기술연구원
IPC: A61K36/725 , A61K36/752 , A61P3/06 , A61P9/12
Abstract: PURPOSE: A composition containing the extract of jujube and the extract of citrus rind is provided for improving lipid metabolism and lowering blood pressure, so that it can prevent liver diseases, hypertension, arteriosclerosis, hyperlipemia and cancer. CONSTITUTION: The composition contains 0.1 to 5g/weight kg/day of the extract of jujube and 0.1 to 10g/weight kg/day of the extract of citrus rind in a weight ratio of 1:1 to 100:1, in which the extract of jujube is produced by adding 2 to 5 liter of 70 to 95% ethanol into 1 kg of jujube, and extracting them at 50 to 60deg.C for 1 to 24 hours, or by adding 2 to 5 liter of water into 1 kg of citrus rind, and extracting them at 70 to 121deg.C for 30 minutes to 12 hours; the extract of citrus rind is produced by drying citrus rind, adding 3 to 30 liter of 20 to 95% ethanol into 1kg of dried rind, extracting them at 25 to 80deg.C for 1 to 12 hours, filtering the extract, and condensing it under reduced pressure, wherein citrus includes orange, lemon, tangerine, grapefruit or citron.
Abstract translation: 目的：提供含有枣提取物和柑橘皮提取物的组合物，用于改善脂质代谢和降低血压，从而可以预防肝脏疾病，高血压，动脉硬化，高脂血症和癌症。 构成：组合物以1：1〜100：1的重量比含有0.1〜5g / kg的枣提取物和0.1〜10g / kg的柑橘皮提取物，其中提取物 通过向1kg的枣中加入2〜5升的70〜95％的乙醇，在50〜60℃下提取1〜24小时，或者将2〜5升的水加入1kg的 柑橘皮，70〜121℃，30分钟〜12小时提取; 柑橘皮提取物是通过干燥柑橘皮制成的，将3〜30升20〜95％乙醇加入1kg干燥的皮中，在25〜80℃下提取1〜12小时，过滤提取物，冷凝 在减压下，其中柑橘包括橙，柠檬，橘子，葡萄柚或柚子。
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公开(公告)号：KR1020010015494A
公开(公告)日：2001-02-26
申请号：KR1020000058704
申请日：2000-10-06
Applicant: 한국과학기술연구원
IPC: A23L1/29
Abstract: PURPOSE: A hypotensive composition containing a bioflavonoid compound is provided to use itself as a therapeutic agent for glycosemia or as a health food. CONSTITUTION: A hypotensive composition comprises an effective amount, preferably, 0.01-50 wt.% of bioflavonoid of formula (1) and a pharmaceutical acceptable carrier thereof. The flavonoids consist in citrus fruits such as orange, lemon, citron, grapefruit and the like. The composition containing the flavonoid compounds is useful to treat glycosemia. To drop the blood sugar level, the flavonoid compound of formula (1) can be added to foods, for example meats, beverages, snacks, chocolates etc. In the formula (1), R1 is OH, rutinosyl or rhaminosyl group; R2 is H, OH or rutinosyl group; R3 is H or OH group; R4 is OH or methoxy group; X is single bond or double bond.
Abstract translation: 目的：提供含有生物类黄酮化合物的低血压组合物作为糖血症的治疗剂或作为保健食品。 构成：低血压组合物包含有效量，优选0.01-50重量％的式（1）的生物类黄酮及其药学上可接受的载体。 黄酮类化合物包括橙子，柠檬，柚子，葡萄柚等柑橘类水果。 含有类黄酮化合物的组合物可用于治疗糖血症。 为了降低血糖水平，式（1）的类黄酮化合物可以加入到食品中，例如肉类，饮料，小吃，巧克力等。在式（1）中，R 1是OH，芸香酰基或脱氨基糖基; R2是H，OH或芸香糖基; R3是H或OH基; R4是OH或甲氧基; X是单键或双键。
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13.发明公开디오스민을 포함하는 동맥경화증 및 고지혈증의 예방 및치료용 조성물 失效含有二氢DI UL UL UL UL UL A A A A A A A A A A A A A A A A A A A A A A A A
公开(公告)号：KR1020010007625A
公开(公告)日：2001-01-26
申请号：KR1020000058789
申请日：2000-10-06
Applicant: 한국과학기술연구원
IPC: A61K31/70
Abstract: PURPOSE: A composition containing diosmin is provided for preventing and treating ateriosclerosis and hyperlipemia, thereby adhesion of macrophage-lipid complex on inner layer of artery is strongly inhibited, the amounts of cholesterol and fat in serum is decreased, and the activity of ACAT and HMG-CoA reductase is inhibited. CONSTITUTION: The amount of cholesterol in serum can be decreased by inhibiting the activities of acyl CoA:cholesterol-o-acyltransferase(ACAT) in liver, cholesterol ester transfer protein(CETP) transferring cholesterol between lipid proteins, 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA) relating to biosynthesis of cholesterol in liver. Diosmin(C28H32O15, M.W. 608.55) may be obtained from vegetables and oranges or be synthesized. The composition containing an effective amount of diosmin, that is, 0.1 to 500 mg/kg, preferably 1 to 100 mg/kg a day, is orally or topically administrated into a patient and the dose thereof may be variable by patient's age, weight, sex, health, diet, severity of disease, and so on. The composition containing diosmin may be added into foods and drinks in an amount of 0.01 to 10 wt.%, preferably 0.1 to 5 wt.% of diosmin.
Abstract translation: 目的：提供含有diosmin的组合物，用于预防和治疗动脉硬化和高脂血症，从而强烈抑制巨噬细胞 - 脂质复合物对动脉内层的粘附，血清中胆固醇和脂肪的含量降低，ACAT和HMG的活性 -CoA还原酶被抑制。 构成：通过抑制肝脏中酰基CoA：胆固醇 - 邻 - 酰基转移酶（ACAT），胆固醇酯转移蛋白（CETP）在脂质蛋白，3-羟基-3-甲基戊二醛之间转运胆固醇的活性，可以降低血清中的胆固醇含量 辅酶A（HMG-CoA）涉及胆固醇在肝脏中的生物合成。 Diosmin（C28H32O15，M.W. 608.55）可以从蔬菜和橙子中获得或被合成。 将包含有效量的二糖苷的组合物，即每天0.1至500mg / kg，优选1至100mg / kg，口服或局部施用于患者，其剂量可以根据患者的年龄，体重， 性别，健康，饮食，疾病严重程度等。 含有diosmin的组合物可以以diosmin的0.01〜10重量％，优选0.1〜5重量％的量添加到食品和饮料中。
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公开(公告)号：KR1020000026393A
公开(公告)日：2000-05-15
申请号：KR1019980043909
申请日：1998-10-20
Applicant: 한국과학기술연구원
IPC: A61K31/35
CPC classification number: A61K31/352 , A61K31/7034 , A61K31/704
Abstract: PURPOSE: A composition for increasing serum high density lipoprotein containing bioflavonoids is provided which is useful for preventing and treating diseases of cardiac circulatory organs. CONSTITUTION: The medical composition for increasing high density lipoprotein consists of(i) an effective amount of bioflavonoids of the following general formula(I) or a plant extract containing thereof, where each R¬1-R¬9 is independently hydrogen, hydroxy, alkoxy having 1-9 carbon atoms(optionally, which is able to include hydroxy, alkoxy having 1-5 carbon atoms, aryloxy or phenyl group which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido), cycloalkyloxy having 5-9 carbon atoms which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido, cycloalkylcarbonyloxy having 5-9 carbon atoms which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido, acyloxy having 2-10 or 16-18 carbon atoms(optionally, which is able to include hydroxy, alkoxy having 1-5 carbon atoms, aryloxy or phenyl group which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido), or rutinosyl, and X is either a single bond or a double bond; and (ii) a medically acceptable carrier.
Abstract translation: 目的：提供一种用于增加血清高密度脂蛋白含有生物类黄酮的组合物，可用于预防和治疗心脏循环系统疾病。 构成：用于增加高密度脂蛋白的医药组合物包括（i）有效量的以下通式（I）的生物类黄酮或含有它们的植物提取物，其中每个R 1 -R 9独立地是氢，羟基， 具有1-9个碳原子的烷氧基（任选地，其可以包括羟基，具有1-5个碳原子的烷氧基，芳氧基或被一至三个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基取代的苯基） ），具有5-9个碳原子的环烷氧基，其被一至三个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基取代，具有5-9个碳原子的环烷基羰基氧基，被一至三个选自羟基， 烷氧基，芳氧基，卤素，硝基和酰氨基，具有2-10或16-18个碳原子的酰氧基（任选地，其可以包括羟基，具有1-5个碳原子的烷氧基，芳氧基或被一个 至三个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基）或芸香糖基，X为单键或双键; 和（ii）医学上可接受的载体。
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公开(公告)号：KR1019990079922A
公开(公告)日：1999-11-05
申请号：KR1019980012818
申请日：1998-04-10
Applicant: 한국과학기술연구원
IPC: A61K36/725 , A61K36/752 , A61P3/06 , A61P9/12
Abstract: 본 발명은 대추 추출물 및 감귤류 과피 추출물을 포함하는 지질대사 개선 및 혈압강하용 조성물에 관한 것으로, 본 발명의 조성물은 의약용 및 식품용 조성물을 포함한다. 대추 추출물 및 감귤류 과피 추출물을 포함하는 본 발명의 조성물은, 동물에 투여되었을 때 간 질환, 고혈압증, 동맥경화증, 고지혈증 등의 성인병 및 암 예방 등의 효과를 나타낼 수 있다.
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Patent Agency Ranking
公开(公告)号：KR1019990079683A
公开(公告)日：1999-11-05
申请号：KR1019980012411
申请日：1998-04-08
Applicant: 한국과학기술연구원
Abstract: 본 발명은 감귤류의 과피 분말 또는 과피 추출물을 포함하는 기능성 건강식품에 관한 것으로, 감귤류의 과피 분말 또는 과피 추출물을 각종 식품에 첨가함으로써 항산화, 혈압강하, 혈중 콜레스테롤 강하, 항암 작용, 간기능 개선 등의 효과를 얻을 수 있으며, 이는 건강식품으로 유용하게 사용될 수 있다.
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公开(公告)号：KR100291144B1
公开(公告)日：2001-05-15
申请号：KR1020000058789
申请日：2000-10-06
Applicant: 한국과학기술연구원
IPC: A61K31/70
Abstract: 본 발명은 디오스민(diosmin)을 포함하는 동맥경화증 및 고지혈증의 예방 및 치료용 조성물에 관한 것으로, 디오스민은 동물에게 투여되었을 때 동맥내피에 대식세포-지질 복합체가 침착되는 것을 강력히 억제할 뿐만 아니라, ACAT 및 HMG-CoA 환원효소의 활성을 억제하고, 혈중 콜레스테롤 및 중성지질의 농도를 감소시키므로, 동맥경화증 및 고지혈증의 예방 및 치료제로서 유용하게 사용될 수 있다.
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18.发明公开탄닌 또는 탄닌 유래 페놀성 화합물을 포함하는동맥경화증, 고지혈증 및 지방간의 예방 및 치료용 식품조성물 无效食品复合材料用于预防和治疗阿片样物质，高胆固醇和包括鞣制或鞣制酚醛化合物的肝硬化
公开(公告)号：KR1020010030556A
公开(公告)日：2001-04-16
申请号：KR1020000062335
申请日：2000-10-23
Applicant: 한국과학기술연구원
Abstract: PURPOSE: Food composites including tannin or tannin-derived phenolics are provided to prevent and treat arteriosclerosis, hyperlipidemia and hepatic steatosis by dosing tannin, gallic acid or/and ellagic acid. CONSTITUTION: Tannin, gallic acid or/and ellagic acid is/are added to a food or a drink to prevent and treat arteriosclerosis. Tannin(C76H52O46) is extracted from acorns, persimmons and walnut shells. Gallic acid(C7H6O5) and ellagic acid(C14H6O8) are the decomposition products of tannin and have anticancer activities. The amount of the tannin-derived phenolics is from 0.01wt.% to 20wt.% according to the weight, age, gender, health status, diet, dosage time and method, excretory rate and disease level of patients.
Abstract translation: 目的：提供包括单宁或单宁衍生物酚类的食品复合材料，以预防和治疗单宁，没食子酸或鞣花酸的动脉硬化，高脂血症和肝脂肪变性。 构成：将单宁，没食子酸或/和鞣花酸加入到食物或饮料中以预防和治疗动脉硬化。 单宁（C76H52O46）从橡子，柿子和核桃壳中提取。 没食子酸（C7H6O5）和鞣花酸（C14H6O8）是单宁的分解产物，具有抗癌活性。 根据体重，年龄，性别，健康状况，饮食，剂量时间和方法，患者的排泄率和病情水平，单宁衍生物酚类的含量为0.01重量％〜20重量％。
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公开(公告)号：KR1020010015510A
公开(公告)日：2001-02-26
申请号：KR1020000062334
申请日：2000-10-23
Applicant: 한국과학기술연구원
IPC: A61K31/366
Abstract: PURPOSE: A composition containing tannin, gallic acid or ellagic acid is provided for preventing and treating arteriosclerosis, hyperlipemia and liver diseases. CONSTITUTION: When tannin, gallic acid or ellagic acid are administrated into an animal body, they prevent the deposition of macrophage-lipid complex within the inner surface of arterial duct, decrease the concentration of GOT(glutamate-oxaloacetate transaminase), GPT(glutamate-pyruvate transaminase), gammaGTP(gamma-glutamyl transpeptidase), and lipid in serum, and strongly inhibit the damage of liver cells and the progress of fatty liver. The composition contains an effective of ellagic acid displaying an anticancer activity, that is 0.1 mg to 500 mg/weight kg a day. The composition is preferably administrated into an animal body 5 times a day in a dosage of 1 mg to 100 mg/weight kg.
Abstract translation: 目的：提供含有单宁，没食子酸或鞣花酸的组合物，用于预防和治疗动脉硬化，高脂血症和肝脏疾病。 构成：当将单宁，没食子酸或鞣花酸施用于动物体内时，可防止巨噬细胞 - 脂质复合物在动脉管内表面沉积，降低GOT（谷氨酸 - 草酰乙酸转氨酶）浓度，GPT（谷氨酸 - 丙酮酸转氨酶），γGTP（γ-谷氨酰转肽酶）和血清中的脂质，并且强烈地抑制肝细胞的损伤和脂肪肝的进展。 组合物含有显示抗癌活性的有效的鞣花酸，即每天0.1mg至500mg /重量kg。 组合物优选以1mg至100mg / kg kg的剂量每天施用5次。
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公开(公告)号：KR1020010015495A
公开(公告)日：2001-02-26
申请号：KR1020000058705
申请日：2000-10-06
Applicant: 한국과학기술연구원
IPC: A23L1/29
Abstract: PURPOSE: A pharmaceutical composition containing one of rutin and Quercetin or the mixture is provided to prevent and treat hyperlipidemia, arteriosclerosis and liver diseases. CONSTITUTION: The rutin is extracted from buckwheat or leaves, stems and flowers of the buckwheat by leaving the materials at a base of pH10-12 by using calcium hydroxide, neutralizing and settling the materials, or by using 20-97% alcohol or water at a high temperature and pressure. The buckwheat and the leaves, stems and flowers also can be dried and pulverized to get powdered buckwheat. The resulting buckwheat flour or buckwheat extract containing 0.01-10wt% of the rutin, quercetin or the mixture of them is added to tomato ketchup, sauce and juice, ramen, noodle, bread, cookies and cracker, soup and gravies, ground beef, or dairy products to get functional foods.
Abstract translation: 目的：提供含有芦丁和槲皮素之一或混合物的药物组合物，用于预防和治疗高脂血症，动脉硬化和肝脏疾病。 构成：通过使用氢氧化钙将材料置于pH10-12的碱性条件下，从荞麦或荞麦的荞麦或叶子，茎和花中提取芦丁，中和和沉淀材料，或通过使用20-97％的酒精或水 高温高压。 荞麦和叶子，茎和花也可以干燥和粉碎以得到荞麦粉。 将含有0.01-10重量％的芦丁，槲皮素或其混合物的荞麦面粉或荞麦提取物加入番茄酱，酱汁和果汁，拉面，面条，面包，饼干和饼干，汤和肉汁，碎牛肉或 乳制品获得功能性食品。
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