公开(公告)号：KR1020000026393A

公开(公告)日：2000-05-15

申请号：KR1019980043909

申请日：1998-10-20

Applicant: 한국과학기술연구원

Inventor： 복성해 ,  현병화 ,  이철호 ,  최양규 ,  정태숙 ,  최명숙 ,  문석식 ,  권용국 ,  이은숙 ,  김성규 ,  문옥성 ,  이새봄 ,  안병태 ,  박용복

IPC: A61K31/35

CPC classification number: A61K31/352 ,  A61K31/7034 ,  A61K31/704

Abstract: PURPOSE: A composition for increasing serum high density lipoprotein containing bioflavonoids is provided which is useful for preventing and treating diseases of cardiac circulatory organs. CONSTITUTION: The medical composition for increasing high density lipoprotein consists of(i) an effective amount of bioflavonoids of the following general formula(I) or a plant extract containing thereof, where each R¬1-R¬9 is independently hydrogen, hydroxy, alkoxy having 1-9 carbon atoms(optionally, which is able to include hydroxy, alkoxy having 1-5 carbon atoms, aryloxy or phenyl group which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido), cycloalkyloxy having 5-9 carbon atoms which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido, cycloalkylcarbonyloxy having 5-9 carbon atoms which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido, acyloxy having 2-10 or 16-18 carbon atoms(optionally, which is able to include hydroxy, alkoxy having 1-5 carbon atoms, aryloxy or phenyl group which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido), or rutinosyl, and X is either a single bond or a double bond; and (ii) a medically acceptable carrier.

Abstract translation: 目的：提供一种用于增加血清高密度脂蛋白含有生物类黄酮的组合物，可用于预防和治疗心脏循环系统疾病。 构成：用于增加高密度脂蛋白的医药组合物包括（i）有效量的以下通式（I）的生物类黄酮或含有它们的植物提取物，其中每个R 1 -R 9独立地是氢，羟基， 具有1-9个碳原子的烷氧基（任选地，其可以包括羟基，具有1-5个碳原子的烷氧基，芳氧基或被一至三个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基取代的苯基） ），具有5-9个碳原子的环烷氧基，其被一至三个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基取代，具有5-9个碳原子的环烷基羰基氧基，被一至三个选自羟基， 烷氧基，芳氧基，卤素，硝基和酰氨基，具有2-10或16-18个碳原子的酰氧基（任选地，其可以包括羟基，具有1-5个碳原子的烷氧基，芳氧基或被一个 至三个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基）或芸香糖基，X为单键或双键; 和（ii）医学上可接受的载体。

公开(公告)号：KR100363180B1

公开(公告)日：2003-01-24

申请号：KR1019980043909

申请日：1998-10-20

Applicant: 한국과학기술연구원

Inventor： 복성해 ,  현병화 ,  이철호 ,  최양규 ,  정태숙 ,  최명숙 ,  문석식 ,  권용국 ,  이은숙 ,  김성규 ,  문옥성 ,  이새봄 ,  안병태 ,  박용복

IPC: A61K31/35

Abstract: PURPOSE: A composition for increasing serum high density lipoprotein containing bioflavonoids is provided which is useful for preventing and treating diseases of cardiac circulatory organs. CONSTITUTION: The medical composition for increasing high density lipoprotein consists of(i) an effective amount of bioflavonoids of the following general formula(I) or a plant extract containing thereof, where each R¬1-R¬9 is independently hydrogen, hydroxy, alkoxy having 1-9 carbon atoms(optionally, which is able to include hydroxy, alkoxy having 1-5 carbon atoms, aryloxy or phenyl group which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido), cycloalkyloxy having 5-9 carbon atoms which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido, cycloalkylcarbonyloxy having 5-9 carbon atoms which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido, acyloxy having 2-10 or 16-18 carbon atoms(optionally, which is able to include hydroxy, alkoxy having 1-5 carbon atoms, aryloxy or phenyl group which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido), or rutinosyl, and X is either a single bond or a double bond; and (ii) a medically acceptable carrier.

Abstract translation: 目的：提供一种用于增加含血清高密度脂蛋白的生物类黄酮的组合物，其用于预防和治疗心脏循环器官疾病。 组成：用于增加高密度脂蛋白的药物组合物由（i）有效量的下列通式（I）的生物类黄酮或含有其的植物提取物组成，其中每个R 1 -R 1不是9独立地是氢，羟基， 具有1-9个碳原子的烷氧基（任选地，其能够包括羟基，具有1-5个碳原子的烷氧基，芳氧基或被1-3个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基 ），被一至三个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基取代的具有5-9个碳原子的环烷氧基，具有5-9个碳原子的环烷氧基，其被1-3个选自羟基， 烷氧基，芳氧基，卤素，硝基和酰氨基，具有2-10或16-18个碳原子的酰氧基（任选地，其可以包括羟基，具有1-5个碳原子的烷氧基，芳氧基或被取代的苯基 y选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的1至3个取代基）或芸香糖基，X为单键或双键; 和（ii）医学上可接受的载体。

公开(公告)号：KR1020010015490A

公开(公告)日：2001-02-26

申请号：KR1020000056166

申请日：2000-09-25

Applicant: 한국과학기술연구원

Inventor： 복성해 ,  현병화 ,  이철호 ,  최양규 ,  정태숙 ,  최명숙 ,  문석식 ,  권용국 ,  이은숙 ,  김성규 ,  문옥성 ,  이새봄 ,  안병태

IPC: A23L1/29

Abstract: PURPOSE: A food or drink composition including a bioflavonoid of formula(I) or extract of vegetables or citrus fruits containing the bioflavonoid is provided. This composition prevents hypertension, arteriosclerosis and a stroke of paralysis by increasing the plasma high density lipoprotein level in the body. CONSTITUTION: The composition for increasing plasma high density lipoprotein(HDL) level comprises a bioflavonoid of formula(I), wherein i) R1 to R9 are each independently hydrogen; hydroxy group; C1-9 alkoxy group optionally substituted with one or more substituents selected from the group consisting of hydroxy, C1-5 alkoxy, aryloxy, and phenyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; a C5-9 cycloalkyloxy group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; C5-9 cycloalkylcarbonyloxy group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; C2-10 or C16-18 acyloxy group optionally substituted with one or more substituents selected from the group consisting of a hydroxy, C1-5 alkoxy, aryloxy, and phenyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen and nitro group; rutinosyl group; or rhaminosyl group, and ii) X is a single or double bond. The bioflavonoid of formula(I) or extract of vegetables or citrus fruits containing the bioflavonoid can be added to various foods or drinks.

Abstract translation: 目的：提供包含式（I）的生物类黄酮或含有生物类黄酮的蔬菜或柑橘类水果提取物的食品或饮料组合物。 该组合物通过增加体内血浆高密度脂蛋白水平来预防高血压，动脉硬化和瘫痪中风。 构成：用于增加血浆高密度脂蛋白（HDL）水平的组合物包含式（I）的生物类黄酮，其中i）R 1至R 9各自独立地为氢; 羟基; 任选地被一个或多个选自羟基，C 1-5烷氧基，芳氧基和被1至3个选自羟基，烷氧基，芳氧基，卤素取代基的取代基取代的取代基取代的C1-9烷氧基 ，硝基和酰氨基; 被1至3个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基取代的C5-9环烷氧基; 被1至3个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基取代的C 5-9环烷基羰基氧基; 任选被一个或多个选自羟基，C 1-5烷氧基，芳氧基和被1至3个选自下组取代的取代基的苯基取代的C 2-10或C16-18酰氧基：羟基， 烷氧基，芳氧基，卤素和硝基; 芸香酰基; 或rhaminosyl基，和ii）X是单键或双键。 式（I）的生物类黄酮或含有生物类黄酮的蔬菜或柑橘类水果的提取物可以添加到各种食品或饮料中。