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公开(公告)号：KR1020150053528A
公开(公告)日：2015-05-18
申请号：KR1020130135588
申请日：2013-11-08
Applicant: 한국과학기술연구원
CPC classification number: A61L27/14 , A61F2/06 , A61L27/26 , A61L2420/00
Abstract: 본발명은본 발명에의하면체내에서정상적인물리적스트레스하에서는코팅된고분자탄성체에의해원할한수축과팽창이가능하며, 다른요인에의해내압이급격히높아지더라도섬유구조물에의해팽창에의한저항력이극대화될수 있게설계됨으로써혈관의파열및 찢어짐현상을억제할수 있는인공혈관용구조물및 제조방법에관한것이다.
Abstract translation: 本说明书公开了一种人造血支架及其制造方法，其能够在人体的正常身体应力下由于涂覆的聚合物弹性体而使其收缩膨胀，并通过设计为使血管破裂和撕裂最大化 即使当内部压力由于其他因素而迅速增加时，通过纤维结构膨胀的阻力。 根据本发明的一个实施方案，提供了具有包含生物相容性材料的特定形式的纤维结构和包含涂覆在纤维结构上的多孔可生物降解弹性体的人造血液支架。
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公开(公告)号：KR101386399B1
公开(公告)日：2014-04-29
申请号：KR1020120012801
申请日：2012-02-08
Applicant: 한국과학기술연구원
CPC classification number: Y02P20/544
Abstract: 본 발명은 다공성 생분해성 고분자 지지체를 제조하는 방법에 관한 것으로서, 초임계 유체 공정에 유기용매를 적용하여 다공성 생분해성 고분자 지지체를 제조하는 것을 특징으로 하며, 본 발명에 따르면 생체온도 범위의 공정에서 다공성 및 다공의 균일도가 향상되고 내부 연결성이 양호해진 생분해성 고분자 지지체의 제조가 가능하고, 이는 단백질 등 다양한 생리활성 물질을 함유한 조직재생능이 향상된 조직 공학용 지지체 제작에 매우 유용하다.
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公开(公告)号：KR101348096B1
公开(公告)日：2014-01-09
申请号：KR1020120032697
申请日：2012-03-29
Applicant: 한국과학기술연구원
Abstract: 본 발명은 친수성 아미노산과 소수성 아미노산이 순차적으로 결합된 자가조립 펩타이드와 콜라겐 모사 펩타이드가 결합된 줄기세포의 연골 분화 유도 활성을 가지는 폴리펩타이드에 관한 것으로, 소재 자체에 면역반응이 없고, 생체 복원 후 무해하게 분해되는 소재로서 콜라겐 모사 펩타이드로 인하여 줄기세포가 연골 분화하는데 적합한 환경을 조성함으로써, 연골 분화 활성을 증진시키고, 이로 인하여 연골 조직의 재생을 달성할 수 있도록 한다.
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14.发明授权
公开(公告)号：KR101344719B1
公开(公告)日：2013-12-26
申请号：KR1020110071672
申请日：2011-07-19
Applicant: 한국과학기술연구원
Abstract: 본발명은줄기세포가접종된탄성스캐폴드에응력(Strain)을가하면서줄기세포를평활근세포로분화시키는방법및 상기방법에의해분화된평활근세포를함유하는혈관질환또는창상치료를위한조직공학용평활근세포패치에관한것이다. 본발명은기계적응력과생화학인자의인간지방줄기세포의평활근세포분화에미치는시너지효과를증명하였고기계-활성조직공학에있어서줄기세포의유용한응용법을제공한다.
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公开(公告)号：KR101265492B1
公开(公告)日：2013-05-20
申请号：KR1020110107237
申请日：2011-10-19
Applicant: 한국과학기술연구원
CPC classification number: C12N5/069 , A61K35/28 , A61K35/30 , A61K35/44 , A61K35/51 , A61K35/545 , C12N2501/115 , C12N2506/1384 , C12N2513/00 , C12N2533/52 , C12N2533/54 , C12N2533/70
Abstract: 본발명은줄기세포를 3차원세포집합체(cell cluster) 형태로배양하여혈관세포로분화시키는방법및 생체내 혈관신생을위한상기 3차원세포집합체의용도에관한것이다. 구체적으로, 본발명은 1) 줄기세포를표면이소수성을띠는배양용기혹은성장인자가고정화된배양용기에접착시켜배양하는단계; 2) 배양된줄기세포의밀도가증가함에따라줄기세포가배양용기로부터탈착되어 3차원세포집합체를형성하는단계; 및 3) 3차원세포집합체형태로증식하면서줄기세포가혈관세포로분화되는단계를포함하는, 줄기세포를혈관세포로분화시키는방법및 상기방법에의해줄기세포로부터분화된혈관세포로구성된 3차원세포집합체를혈관신생을위한세포치료제로사용하는용도에관한것이다.
Abstract translation: 本发明涉及一种通过以三维细胞簇的形式培养它们并使用三维细胞簇进行血管发生来将干细胞分化为血管细胞的方法。 具体而言，本发明教导了将干细胞分化为血管细胞的方法，包括通过将干细胞粘附到具有疏水性的表面的培养板上或培养板上固定有生长因子培养干细胞，其中培养的干细胞 随着其密度增加而随培养板分离，形成三维细胞簇，并以三维细胞簇的形式生长，同时分化为血管细胞。 还公开了通过上述方法将由干细胞分化的血管细胞组成的三维细胞簇用作血管发生的细胞治疗剂。
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Patent Agency Ranking
公开(公告)号：KR1020120126769A
公开(公告)日：2012-11-21
申请号：KR1020110044812
申请日：2011-05-12
Applicant: 한국과학기술연구원
CPC classification number: C08J3/205 , C08J9/0066 , C08J9/12 , C08J9/30 , C08J2203/08 , C08J2367/04 , C08J2467/04 , Y02P20/544
Abstract: PURPOSE: A manufacturing method of a clay/polymer composite is provided to provide a clay/biodegradable polymer stereoisomeric nanocomposite with excellent thermal and mechanical stability by using a supercritical fluid-organic solvent system by which is simple and economic. CONSTITUTION: A manufacturing method of a clay/polymer composite comprises: a step of accepting clay, biodegradable single phase D-type/L-type stereoisomer polymer and organic solvent in a reactor; a step of forming stereoisomeric nanocomposite by accepting a super critical fluid into the reactor and forming a clay/polymer composite in which clay is dispersed in the stereoisomer; and a step of collecting the clay/polymer composite. The clay/polymer composite has a particle form or porous form.
Abstract translation: 目的：提供粘土/聚合物复合材料的制造方法，通过使用简单经济的超临界流体 - 有机溶剂系统，提供具有优异的热和机械稳定性的粘土/可生物降解聚合物立体异构纳米复合材料。 构成：粘土/聚合物复合材料的制造方法包括：在反应器中接受粘土，可生物降解的单相D型/ L型立体异构体聚合物和有机溶剂的步骤; 通过将超临界流体接收到反应器中并形成其中粘土分散在立体异构体中的粘土/聚合物复合材料形成立体异构纳米复合材料的步骤; 和收集粘土/聚合物复合材料的步骤。 粘土/聚合物复合物具有颗粒形式或多孔形式。
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17.发明公开
公开(公告)号：KR1020100122778A
公开(公告)日：2010-11-23
申请号：KR1020090041846
申请日：2009-05-13
Applicant: 한국과학기술연구원
CPC classification number: C12N5/0068 , C07K14/47 , C07K14/50 , C07K14/503 , C07K17/14 , C07K2319/00 , C12N5/0663 , C12N2501/115 , C12N2533/50
Abstract: PURPOSE: A fibroblast growth factor(FGF) having adhesion activity and a method for culturing stem cells using the same are provided to maintain biological activity of FGF and to effectively culture the stem cells. CONSTITUTION: A method for culturing stem cells using immortalized FGF comprises: a step of preparing a recombinant protein of FGF-polypeptide linker having adhesion activity to stem cells; a step of fixing the recombinant protein on hydrophobic surface using amino terminal of polyepeptide linker; and a step of adhering the stem cells on the culture container in which recombinant protein is fixed and culturing.
Abstract translation: 目的：提供具有粘附活性的成纤维细胞生长因子（FGF）和使用其的培养干细胞的方法，以维持FGF的生物学活性并有效培养干细胞。 构成：使用永生化FGF培养干细胞的方法包括：制备对干细胞具有粘附活性的FGF-多肽接头重组蛋白的步骤; 使用多肽接头的氨基末端将重组蛋白质固定在疏水表面上的步骤; 以及将干细胞粘附在重组蛋白质固定培养的培养容器上的步骤。
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公开(公告)号：KR1020080078096A
公开(公告)日：2008-08-27
申请号：KR1020070017662
申请日：2007-02-22
Applicant: 한국과학기술연구원
CPC classification number: C04B41/87 , C01F7/001 , C01P2004/64 , C04B41/0072
Abstract: A method for forming an alumina coating layer is provided to prevent the agglomeration and inhomogeneous dispersion of particles within a polyphase alumina coating layer formed on a substrate, and to produce the alumina coating layer in a simple process and at a low cost. A method for forming an alumina coating layer includes a step of coating a substrate with ammonium aluminum carbonate hydroxide, followed by heat-treating the coated substrate. The substrate is powder or film. The substrate is made of a ceramic or metallic material. The ammonium aluminum carbonate hydroxide is prepared by mixing an aqueous solution containing an aluminum salt with an aqueous solution of ammonium bicarbonate. A molar ratio of the aluminum salt and ammonium bicarbonate ranges from 1:25 to 1:2. Further, the aluminum salt is selected from NH4Al(SO4)2, aluminum nitrate, aluminum sulfide and aluminium chloride.
Abstract translation: 提供一种形成氧化铝涂层的方法，以防止在形成于基底上的多相氧化铝涂层内的颗粒的聚集和不均匀分散，并以简单的工艺和低成本生产氧化铝涂层。 形成氧化铝涂层的方法包括用碳酸铝铵氢氧化物涂覆基材，然后对涂覆的基材进行热处理的步骤。 基材是粉末或薄膜。 基板由陶瓷或金属材料制成。 通过将含有铝盐的水溶液与碳酸氢铵水溶液混合来制备氢氧化铝铵。 铝盐和碳酸氢铵的摩尔比为1:25至1:2。 此外，铝盐选自NH 4 Al（SO 4）2，硝酸铝，硫化铝和氯化铝。
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公开(公告)号：KR100837357B1
公开(公告)日：2008-06-12
申请号：KR1020070013980
申请日：2007-02-09
Applicant: 한국과학기술연구원
CPC classification number: C01F7/30 , C01P2004/64 , C01P2006/22
Abstract: A method for manufacturing alumina powders using microwaves is provided to produce the multi-phase alumina powders having nano particle size without causing a secondary cohesion among powders. A method for manufacturing alumina powders using microwaves includes the steps of: microwave-synthesizing a precursor of alumina added with alpha-alumina, gamma-alumina, or theta-alumina as a nucleation accelerator; and subjecting the precursor to thermal decomposition and phase transformation to produce the alumina powder. The precursor of alumina is ammonium aluminum carbonate hydroxide. The microwave synthesis is carried out under an atmosphere of air, nitrogen, argon, hydrogen, or a mixture thereof. Further, the ammonium aluminum carbonate hydroxide is manufactured by mixing a water solution comprising an aluminum salt with ammonium bicarbonate solution comprising the nucleation accelerator.
Abstract translation: 提供使用微波制造氧化铝粉末的方法，以制造具有纳米粒径的多相氧化铝粉末，而不会引起粉末之间的二次内聚力。 使用微波制造氧化铝粉末的方法包括以下步骤：微波合成添加有α-氧化铝，γ-氧化铝或θ-氧化铝的氧化铝前体作为成核促进剂; 并对该前体进行热分解和相变以产生氧化铝粉末。 氧化铝的前体是氢氧化铝铝酸铵。 微波合成在空气，氮气，氩气，氢气或其混合物的气氛下进行。 此外，通过将包含铝盐的水溶液与包含成核促进剂的碳酸氢铵溶液混合来制造氢氧化铝铵。
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公开(公告)号：KR102226056B1
公开(公告)日：2021-03-11
申请号：KR1020190025067
申请日：2019-03-05
Applicant: 한국과학기술연구원
Abstract: 본발명은생체피부와유사한인공표피층, 인공진피층및 이를포함하는인공피부에관한것으로, 생체피부와유사한물성을갖는인공표피층, 생체피부와유사한생물학적특성을갖는인공진피층및 상기인공표피층및 인공진피층이적층된인공피부를포함함으로써, 인체상관성이높은인공피부모델을제공한다.
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