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11.发明授权4각 고리 질소 화합물, 이를 포함하는 우울증, 정신 질환, 조루증, 또는 신경병증성 통증의 예방 또는 치료용 약학 조성물, 및 상기 약학 조성물을 포함하는 제제 有权用于治疗或预防呕吐，精神疾病，预防性呕吐或包括其的神经病性疼痛的药物组合物和包含其的药物的四组分循环氮化合物
公开(公告)号：KR101426408B1
公开(公告)日：2014-08-07
申请号：KR1020130017607
申请日：2013-02-19
Applicant: 한국과학기술연구원
IPC: C07D205/04 , A61K31/397 , A61P25/00
CPC classification number: C07D205/04 , C07D417/12
Abstract: The present invention relates to a 4-membered cyclic nitrogen compound which can be used as a therapeutic agent or a preventive agent for depression, mental disease, premature ejaculation, or neuropathic pain by preventing re-uptake of certain neurotransmitters with high efficiency; a pharmaceutical composition which can inhibit serotonin and dopamine or norepinephrine re-uptake and has a high therapeutic or prophylactic effect against depression, mental disease, premature ejaculation, or neuropathic pain; and a pharmaceutical formulation comprising the same.
Abstract translation: 本发明涉及一种4元环状氮化合物，其可以通过防止某些神经递质以高效率的再摄取而用作治疗剂或抑郁症，精神疾病，早泄或神经性疼痛的预防剂。 能够抑制5-羟色胺和多巴胺或去甲肾上腺素再吸收并对抑郁，精神疾病，早泄或神经性疼痛具有高治疗或预防作用的药物组合物; 和含有该制剂的药物制剂。
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公开(公告)号：KR1020130026292A
公开(公告)日：2013-03-13
申请号：KR1020110089820
申请日：2011-09-05
Applicant: 한국과학기술연구원
IPC: C07D205/04 , A61K31/397 , A61P25/24
CPC classification number: C07D403/06 , C07D205/04
Abstract: PURPOSE: A novel azetidine derivative and an anti-depression composition containing the same are provided to effectively suppress reuptake of dopamine, serotonin, and norepinephrine with reduced side effects. CONSTITUTION: An anti-depression composition contains a novel azeditine derivative of chemical formula 1 or a pharmaceutically acceptable salt thereof. In chemical formula 1: R_1 is hydrogen or methyl; R_2 is hydrogen, C1-C5 linear or branched alkyl, -COC_6H_5, or substituted or non-substituted phenyl or benzyl; R_3 is a substituted or non-substituted C6-C12 aromatic compound; and X is halogen.
Abstract translation: 目的：提供一种新的氮杂环丁烷衍生物和含有它们的抗抑郁组合物，以有效抑制多巴胺，5-羟色胺和去甲肾上腺素的再摄取，副作用降低。 构成：抗抑郁组合物含有化学式1的新颖的氮杂衍生物或其药学上可接受的盐。 在化学式1中：R 1是氢或甲基; R 2是氢，C 1 -C 5直链或支链烷基，-COC 6 H 5或取代或未取代的苯基或苄基; R 3是取代或未取代的C 6 -C 12芳族化合物; X为卤素。
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13.发明公开
公开(公告)号：KR1020140026879A
公开(公告)日：2014-03-06
申请号：KR1020120092596
申请日：2012-08-23
Applicant: 한국과학기술연구원
IPC: C07D207/04 , C07D211/10 , A61K31/402 , A61P25/00
Abstract: The present invention relates to: a novel 2-naphthyl propan-2-ol compound which can be used for treating or preventing depression or specific metal illnesses by preventing re-uptake of certain neurotransmitters in a high efficiency; a pharmaceutical composition which can inhibit re-uptake of dopamine and norepinephrine at the same time and has a high therapeutic effect or preventive effect for depression or certain metal illnesses; a medicine comprising the pharmaceutical composition; and a food comprising the novel 2-naphthyl propan-2-ol compound.
Abstract translation: 本发明涉及一种新型2-萘基丙-2-醇化合物，其可以通过预防某些神经递质的高效率再摄取而用于治疗或预防抑郁或特异性金属疾病。 可以同时抑制多巴胺和去甲肾上腺素的再吸收并对抑郁或某些金属疾病具有高治疗效果或预防效果的药物组合物; 包含药物组合物的药物; 和包含新型2-萘基丙-2-醇化合物的食品。
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