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公开(公告)号：KR102262763B1
公开(公告)日：2021-06-10
申请号：KR1020190130751
申请日：2019-10-21
Applicant: 한국식품연구원
IPC: A61K36/9066 , A61K36/488 , A61K36/899 , A61P25/20 , A23L33/105 , A23K10/30
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公开(公告)号：KR1020210047415A
公开(公告)日：2021-04-30
申请号：KR1020190130750
申请日：2019-10-21
Applicant: 한국식품연구원
IPC: A61K36/9066 , A61P43/00 , A23L33/105
Abstract: 본발명은강황추출물을유효성분으로포함하는 GABAA 수용체효능제의부작용경감용약학조성물, 강황추출물과 GABAA 수용체효능제의복합물을유효성분으로포함하는수면장애예방또는치료용약학조성물, 및강황추출물을유효성분으로포함하는 GABAA 수용체효능제의부작용개선용건강기능식품조성물에관한것이다. 본발명의강황추출물을유효성분으로하는 GABAA 수용체효능제의부작용경감용약학조성물은종래 GABAA 수용체효능제의부작용이발생하지않는다. 또한, 본발명의강황추출물을유효성분으로하는 GABAA 수용체효능제의부작용경감용약학조성물또는 GABAA 수용체효능제의부작용개선용건강기능식품조성물은 GABAA 수용체효능제의부작용을경감시킬수 있다. 또한본 발명의강황추출물및 GABAA 수용체효능제를유효성분으로하는수면장애예방또는치료용약학조성물은, 수면의양은증가시키나수면의질을저하시켜다양한부작용의원인이될 수있는 GABAA 수용체효능제의함량을줄임으로써 GABAA 수용체효능제의부작용을경감시킬수 있다.
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公开(公告)号：KR1020120123625A
公开(公告)日：2012-11-09
申请号：KR1020110040222
申请日：2011-04-28
Applicant: 제주대학교 산학협력단 , 제주어류양식수산업협동조합 , 한국식품연구원
Abstract: PURPOSE: Flatfish paste having excellent palatability, and a producing method thereof are provided to produce functional fried, steamed, or roasted fish cake using the paste. CONSTITUTION: A producing method of flatfish paste comprises the following steps: washing and dehydrating flatfish; mixing 100 parts of flatfish by weight, 3-5 parts of sorbitol by weight, 3-5 parts of sugar by weight, 0.1-0.25 parts of polyphosphate by weight, and 0.1-0.25 parts of pyrophosphate by weight, and grinding the mixture; rapidly freezing the ground mixture at 23-27 deg. C below zero; thawing the obtained flatfish surimi, finely grinding the surimi before adding salt, and eluting salt-soluble protein from the surimi; mixing 100 parts of flatfish surimi by weight, 8-12 parts of starch by weight, and 7-10 parts of water by weight; and molding the mixture before frying, steaming, or roasting. [Reference numerals] (AA) Thawing; (BB) Grinding meat; (CC) Adding salt and additional materials; (DD) Molding; (EE) Steaming; (FF) Calcinating; (GG) Cooling; (HH) Finished product
Abstract translation: 目的：提供具有优异适口性的鲽鱼酱及其制造方法，以使用该糊料制造功能性的油炸，蒸或烤鱼饼。 构成：鲽鱼酱的生产方法包括以下步骤：鲽鱼的洗涤和脱水; 混合100重量的鲽鱼，3-5重量份的山梨糖醇，3-5重量份的糖，0.1-0.25重量份的多磷酸盐，和0.1-0.25重量份的焦磷酸盐，并研磨该混合物; 在23-27度快速冷冻研磨混合物。 C低于零; 解冻所获得的鲽鱼，在加盐前精细研磨鱼糜，并从鱼糜中洗脱出盐溶性蛋白质; 混合100份鲽鱼重量，8-12份重量的淀粉和7-10份重量的水; 并在油炸，蒸煮或焙烧之前将混合物成型。 （附图标记）（AA）解冻; （BB）磨肉; （CC）添加盐和其他材料; （DD）成型; （EE）蒸汽; （FF）煅烧; （GG）冷却; （HH）成品
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14.发明公开
公开(公告)号：KR1020120078898A
公开(公告)日：2012-07-11
申请号：KR1020110000197
申请日：2011-01-03
Applicant: 한국식품연구원
IPC: A61K31/12 , A61K36/484 , A23L33/00 , A61P25/20
CPC classification number: Y02A50/415
Abstract: PURPOSE: A composition containing isoliquiritigenin for activating GABAA-benzodiazepine receptors is provided to enhance deep sleep, sedation, and anti-anxiety. CONSTITUTION: A composition for activating GABAA-benzodiazepine receptors contains a compound of chemical formula 1. A composition for deep sleep, sedation, anti-anxiety, or anti-convulsion contains the compound of chemical formula 1. A functional food for deep sleep, sedation, anti-anxiety, or anti-convulsion contains the compound of chemical formula 1. The functional food contains Glycyrrhiza uralensis Fischer extract. The extract is prepared by extracting Glycyrrhiza uralensis Fischer with 28-32% ethanol at 38-42 Deg.C for 10-14 hours.
Abstract translation: 目的：提供含有用于激活GABA A - 苯并二氮杂受体的异iqu igen素的组合物，以增强深度睡眠，镇静和抗焦虑。 组成：用于激活GABAA-苯并二氮杂受体的组合物含有化学式1的化合物。用于深度睡眠，镇静，抗焦虑或抗惊厥的组合物含有化学式1的化合物。用于深度睡眠，镇静的功能性食物 ，抗焦虑或抗惊厥含有化学式1的化合物。功能性食品含有甘草黄芪提取物。 提取物采用28-32％乙醇在38-42℃下提取甘草10-7小时。
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公开(公告)号：KR101020245B1
公开(公告)日：2011-03-09
申请号：KR1020100079596
申请日：2010-08-18
Applicant: 한국식품연구원
IPC: A61K36/484 , A61P25/20 , A61P25/00
Abstract: PURPOSE: A composition containing Glycyrrhizae radix extract and Albizia julibrissin DURAZZ. extract is provided to reduce sleep latency and to enhance sleep duration. CONSTITUTION: A composition for improving sleeping contains Glycyrrhizae radix extract or Albizia julibrissin DURAZZ. extract as an active ingredient. The Glycyrrhizae radix extract is obtained by extracting Glycyrrhizae radix using 26-32% ethanol at 38-44°C for 10-14 hours. The Albizia julibrissin DURAZZ. extract is obtained by extracting Albizia julibrissin DURAZZ. with 52-62% ethanol at 18-60°C for 22-60 hours. The mixture ratio of Glycyrrhizae radix extract or Albizia julibrissin DURAZZ. extract is 2.5-3.5:0.5-1.5. A functional food for improving sleeping contains the Glycyrrhizae radix extract or Albizia julibrissin DURAZZ. extract as an active ingredient.
Abstract translation: 目的：一种含甘草提取物和合欢树的组合物DURAZZ。 提取物以减少睡眠潜伏期并增强睡眠持续时间。 构成：用于改善睡眠的组合物含有甘草提取物或合欢树。 提取物作为活性成分。 甘草提取物通过使用26-32％乙醇在38-44℃下提取甘草12小时获得。 合欢树合欢DURAZZ。 提取物是通过提取合欢树提取物得到的。 用52-62％乙醇在18-60℃下加热22-60小时。 甘草提取物或合欢芽孢杆菌DURAZZ的混合比例。 提取物为2.5-3.5:0.5-1.5。 用于改善睡眠的功能性食物含有甘草提取物或合欢树合欢菊DURAZZ。 提取物作为活性成分。
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Patent Agency Ranking
公开(公告)号：KR1020210047414A
公开(公告)日：2021-04-30
申请号：KR1020190130749
申请日：2019-10-21
Applicant: 한국식품연구원
IPC: A61K36/9066 , A61K31/12 , A61P25/20 , A23L33/105 , A23K10/30
Abstract: 본발명은강황추출물을유효성분으로함유하는수면장애의예방, 개선또는치료용조성물에관한것이다. 본발명의강황추출물은종래수면유도제로사용되는의약인레돌민또는디아제팜과거의동일한수준또는향상된수준으로입면시간의감소, 수면지속시간의증가및 논렘수면의증가효과를제공한다. 또한, 본발명의강황추출물은종래히스타민수용체길항제로알려진피릴아민말리에이트염의수면효과가히스타민수용체효능제인 2-피리딜에틸아민디히드로클로라이드에의해완전히억제되는것과마찬가지기작으로수면효과가억제되어, 천연항히스타민제로서작용한다. 또한, 천연물인강황으로부터유래한것이어서장기간사용하여도인지장애(cognitive impairment), 내성또는의존성이형성되는부작용이없다. 따라서, 본발명의강황추출물을유효성분으로포함하는수면장애예방, 개선또는치료용조성물은경쟁력있는식품조성물및 의약조성물의제조에매우유용하다.
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公开(公告)号：KR101457442B1
公开(公告)日：2014-11-10
申请号：KR1020120121346
申请日：2012-10-30
Applicant: 한국식품연구원
IPC: A61K31/685 , A61P11/06 , A61P1/04
CPC classification number: A61K31/575 , A23L33/105 , A23V2002/00 , A61K9/4866 , A61K36/88 , A23V2200/314 , A23V2200/32 , A23V2200/322 , A23V2250/21
Abstract: 본 발명은 감마오리자놀의 히스타민 수용체 길항제로서의 신규 용도를 제공한다. 감마오리자놀은 천연 항히스타민제로 사용되어, 알레르기성 비염; 염증성 장질환; 천식; 기관지염; 구토; 위 및 십이지장 궤양; 위식도 역류; 수면장애; 불안; 및 우울증의 예방 또는 치료에 이용될 수 있음은 물론 향상된 입면시간의 감소, 수면시간의 증가 및 논렘수면 시간의 증가 효과가 있다. 감마오리자놀은 쌀겨에서 유래되는 천연물로서 장기간 사용하여도 인지장애(cognitive impairment), 내성 또는 의존성이 형성되는 부작용이 없다.
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公开(公告)号：KR1020140118971A
公开(公告)日：2014-10-08
申请号：KR1020140122634
申请日：2014-09-16
Applicant: 한국식품연구원
IPC: A61K31/685 , A61P25/20
CPC classification number: A61K31/215 , A23L33/10 , A23L33/105 , A23V2002/00 , A23V2200/322 , A23V2250/21 , A61K36/899
Abstract: The present invention provides a novel use as histamine receptor antagonists of gamma-oryzanol. The gamma-oryzanol is used as a natural anti-histamine agent, thereby can be used for preventing or treating allergic rhinitis, inflammatory bowel disease, asthma, bronchitis, vomiting, stomach and duodenal ulcers, gastroesophageal reflux, sleep disorders, anxiety, and depression; and have effects of reducing a hypnagogue time, increasing a sleep time, and increasing a non-REM sleep time. The gamma-oryzanol is a natural product derived from rice bran which has no side effects such as cognitive impairment, tolerance, or dependence even for a long-term use.
Abstract translation: 本发明提供作为γ-谷维素的组胺受体拮抗剂的新用途。 γ-谷维素被用作天然的抗组胺药物，从而可用于预防或治疗过敏性鼻炎，炎症性肠病，哮喘，支气管炎，呕吐，胃和十二指肠溃疡，胃食管反流，睡眠障碍，焦虑和抑郁 ; 并具有减少嗜睡时间，增加睡眠时间以及增加非REM睡眠时间的效果。 γ-谷维素是来自米糠的天然产物，即使对于长期使用也没有副作用，例如认知障碍，耐受性或依赖性。
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