公开(公告)号：KR101117301B1

公开(公告)日：2012-06-12

申请号：KR1020090110173

申请日：2009-11-16

Applicant: 한국인스팜(주)

Inventor： 김용재 ,  백흠영 ,  오규철 ,  윤호근 ,  이정민 ,  전우진 ,  황권택 ,  성혜미 ,  유양희 ,  김경미

IPC: A61K36/9066 ,  A61P1/16 ,  A61P25/32 ,  A23L1/30

Abstract: PURPOSE: A composition containing fermented Curcuma aromatica Salisb. extract is provided to remove DPPH radical and ABTS radical and to suppress liver damage. CONSTITUTION: A pharmacetucialc composition for preventing and treating alcoholic liver diseases contains fermented Curcuma aromatica Salisb. extract as an active ingredient. The Curcuma aromatica Salisb. is fermented by Aspergillus sp. fungi at 150°C and 2090% of relative humidity for 1 hour to 1 week. The fermented Curcuma aromatica Salisb. extract is obtained by isolating with water including purified water, methanol, ethanol, or mixture solvent thereof. A health food for preventing and treating alcoholic liver diseases contains the ffermented Curcuma aromatica Salisb. extract as an active ingredient.

公开(公告)号：KR101059075B1

公开(公告)日：2011-08-24

申请号：KR1020090123470

申请日：2009-12-11

Applicant: 한국인스팜(주)

Inventor： 김용재 ,  백흠영 ,  오규철 ,  윤호근 ,  이정민 ,  전우진 ,  황권택 ,  배동혁 ,  유양희 ,  김경미

IPC: A61K36/73 ,  A61P1/16 ,  A61P25/32 ,  A23L1/30

Abstract: 본 발명은 비파엽 추출물을 함유하는 조성물에 관한 것으로, 본 발명의 비파엽 추출물은 통상의 추출 공정을 통하여 수득한 비파엽 추출물이 DPPH 라디칼 소거능면에서 상대적으로 높은 소거 활성을 나타낼 뿐만 아니라, 지질과산화 억제능을 보였고, 알코올성 간 손상 모델에서 강력한 간 손상 억제 효능을 나타내어, 본 발명의 비파엽 추출물은 알코올성 간질환의 치료 및 예방용 조성물로 유용하게 이용될 수 있다.
비파엽, DPPH, 지질과산화 억제능, 알코올성 간 손상

Abstract translation: 本发明涉及含有bipayeop提取物，本发明的提取物bipayeop不仅表现出在表面上的bipayeop提取由常规的提取方法获得的DPPH自由基清除活性相对较高的清除活性组合物，它表现出脂质过氧化作用的抑制能力 时，它显示在酒精性肝损伤模型中的强大的肝损伤的抑制效果，本发明的bipayeop提取物可以是作为酒精性肝病的预防和治疗的组合物是有用的。

公开(公告)号：KR1020110066710A

公开(公告)日：2011-06-17

申请号：KR1020090123470

申请日：2009-12-11

Applicant: 한국인스팜(주)

Inventor： 김용재 ,  백흠영 ,  오규철 ,  윤호근 ,  이정민 ,  전우진 ,  황권택 ,  배동혁 ,  유양희 ,  김경미

IPC: A61K36/73 ,  A61P1/16 ,  A61P25/32 ,  A23L1/30

CPC classification number: A61K36/73 ,  A61K2236/331 ,  A61K2236/333 ,  Y10S514/811 ,  Y10S514/894

Abstract: PURPOSE: A composition containing Eriobotryae Folium extract is provided to ensure high DPPH radical removal activity and to treat and prevent alcoholic liver diseases. CONSTITUTION: A pharmaceutical composition for preventing and treating alcoholic liver diseases contains Eriobotryae Folium extract as an active ingredient. The Eriobotryae Folium extract is isolated using water, low alcohol of C1-C4, or mixture solvent thereof. A health food for preventing and treating alcoholic liver diseases contains Eriobotryae Folium extract as an active ingredient. The health food is used in the form of powder, granule, tablet, capsule, or beverage.

Abstract translation: 目的：提供含有Eriobotryae叶提取物的组合物，以确保高DPPH自由基去除活性，并治疗和预防酒精性肝病。 构成：用于预防和治疗酒精性肝病的药物组合物含有叶柄叶提取物作为活性成分。 使用水，C1-C4的低级醇或其混合溶剂分离叶面提取物。 一种用于预防和治疗酒精性肝病的保健食品含有叶柄叶提取物作为活性成分。 保健食品以粉末，颗粒，片剂，胶囊或饮料的形式使用。

公开(公告)号：KR1020110053590A

公开(公告)日：2011-05-24

申请号：KR1020090110173

申请日：2009-11-16

Applicant: 한국인스팜(주)

Inventor： 김용재 ,  백흠영 ,  오규철 ,  윤호근 ,  이정민 ,  전우진 ,  황권택 ,  성혜미 ,  유양희 ,  김경미

IPC: A61K36/9066 ,  A61P1/16 ,  A61P25/32 ,  A23L1/30

Abstract: PURPOSE: A composition containing fermented Curcuma aromatica Salisb. extract is provided to remove DPPH radical and ABTS radical and to suppress liver damage. CONSTITUTION: A pharmacetucialc composition for preventing and treating alcoholic liver diseases contains fermented Curcuma aromatica Salisb. extract as an active ingredient. The Curcuma aromatica Salisb. is fermented by Aspergillus sp. fungi at 150°C and 2090% of relative humidity for 1 hour to 1 week. The fermented Curcuma aromatica Salisb. extract is obtained by isolating with water including purified water, methanol, ethanol, or mixture solvent thereof. A health food for preventing and treating alcoholic liver diseases contains the ffermented Curcuma aromatica Salisb. extract as an active ingredient.

Abstract translation: 目的：含有发酵姜黄的组合物。 提取提取物以去除DPPH自由基和ABTS基团并抑制肝损伤。 构成：用于预防和治疗酒精性肝病的药物组合物含有发酵姜黄。 提取物作为活性成分。 姜黄姜 被曲霉菌发酵。 真菌在150℃和2090％的相对湿度下1小时至1周。 发酵姜黄香草Salisb。 通过用包括净化水，甲醇，乙醇或其混合溶剂的水分离获得提取物。 一种用于预防和治疗酒精性肝病的保健食品含有发酵姜黄。 提取物作为活性成分。

公开(公告)号：KR1020110005387A

公开(公告)日：2011-01-18

申请号：KR1020090062900

申请日：2009-07-10

Applicant: 한국인스팜(주)

Inventor： 김용재 ,  백흠영 ,  오규철 ,  윤호근 ,  김미정 ,  이정민 ,  전우진 ,  황권택

IPC: A61K36/73 ,  A61P25/28 ,  A23L1/30 ,  A61P25/16

CPC classification number: A61K36/73 ,  A23V2200/322 ,  A61K2236/331 ,  A61K2236/333

Abstract: PURPOSE: A composition containing Eriobotryae Folium extract for preventing and treating neurodegenerative diseases is provided to protect brain cells and to ensure radical removal ability. CONSTITUTION: A pharmaceutical composition for preventing and treating neurodegenerative diseases contains 0.1-95% weight(w/w%) of Eriobotryae Folium extract as an active ingredient. The Eriobotryae Folium extract is obtained using water, methanol, ethanol, butanol or a mixture solvent thereof. A health food for preventing and treating neurodegenerative diseases contains the Eriobotryae Folium extract as an active ingredient. The health food is used in the form of a powder, granule, tablet, capsule or beverage.

Abstract translation: 目的：提供含有Eriobotryae叶提取物的预防和治疗神经退行性疾病的组合物，以保护脑细胞并确保自由基清除能力。 构成：用于预防和治疗神经退行性疾病的药物组合物含有0.1-95％重量（w / w％）的Eriobotryae Folium提取物作为活性成分。 使用水，甲醇，乙醇，丁醇或它们的混合溶剂，得到鸢尾叶提取物。 一种用于预防和治疗神经退行性疾病的保健食品含有叶柄叶提取物作为活性成分。 保健食品以粉末，颗粒，片剂，胶囊或饮料的形式使用。

公开(公告)号：KR1020110000951A

公开(公告)日：2011-01-06

申请号：KR1020090058304

申请日：2009-06-29

Applicant: 한국인스팜(주)

Inventor： 김윤철 ,  정길생 ,  김용재 ,  백흠영 ,  오규철

IPC: A61K36/69 ,  A61P25/28 ,  A23L1/30

CPC classification number: A61K36/69 ,  A23V2200/322 ,  A61K2236/331 ,  A61K2236/333

Abstract: PURPOSE: A composition with an activity of protecting brain cells is provided to ensure antioxidative activity and to prevent and treat neurodegenerative brain cells. CONSTITUTION: A pharmaceutical composition for preventing and treating neurodegenerative brain diseases contains acid hydrolytic fraction of Polygalae Radix crude extract as an active ingredient. The crude extract is isolated using water, methanol, ethanol, butanol or mixture solvent thereof. A method for preparing the acid hydrolytic fraction comprises: a step of extracting dried Polygalae Radix with polar solvent by heating, ultrasonic extraction, reflux extraction to obtain Polygalae Radix crude extract; a step of adding hydrochloric acid, nitric acid, diluted sulfuric acid or acetic acid; a step of heating at 50-100°C for 12-48 hours; a step of adding sodium hydroxide, potassium hydroxide, potassium carbonate and sodium hydrogen carbonate; and a step of fractioning the acid hydrolysate solution with ether, chloroform, ethyl acetate and acetone by solvent-solvent distribution.

Abstract translation: 目的：提供具有保护脑细胞活性的组合物，以确保抗氧化活性，并预防和治疗神经退行性脑细胞。 构成：用于预防和治疗神经退行性脑疾病的药物组合物含有Polygalae Radix粗提物的酸水解部分作为活性成分。 粗提物用水，甲醇，乙醇，丁醇或其混合溶剂分离。 一种制备酸性水解馏分的方法，包括：通过加热，超声提取，回流提取，用极性溶剂萃取干燥的Polygalae Radix获得Polygalae Radix粗提物的步骤; 加入盐酸，硝酸，稀硫酸或乙酸的步骤; 在50-100℃下加热12-48小时的步骤; 加入氢氧化钠，氢氧化钾，碳酸钾和碳酸氢钠的步骤; 并通过溶剂 - 溶剂分配用乙醚，氯仿，乙酸乙酯和丙酮分级酸水解产物溶液的步骤。