公开(公告)号：KR1020010017936A

公开(公告)日：2001-03-05

申请号：KR1019990033693

申请日：1999-08-16

Applicant: 한국화학연구원

Inventor： 구정 ,  조선행 ,  정제교 ,  강길선 ,  이해방

IPC: A61K31/35

CPC classification number: A61K31/352 ,  A61K47/58

Abstract: PURPOSE: A bio-availibility-improved ipriflavone preparation for oral is provided, which increases solubility to body fluid and effective blood concentration in the gastrointestines by smaller quantity of drug and less administration frequency than existing ipriflavone preparation, so decreases inconvenience of use, and increases bio-availibility. CONSTITUTION: A process for the preparation of bio-availibility-improved ipriflavone preparation for oral comprises: dissolving ipriflavone raw preparation in acetone; meanwhile, dissolving polyvinylpyrolidone in a mixed solution of acetone/ethanol(1:1, v/v) evenly; adding the prepared ipriflavone solution and polyvinylpyrolidone solution in a spray-dryer, and spraying to ipriflavone to be dispersed in polyvinylpyrolidone(ipriflavone:polyvinylpyrolidone=50:50 in weight part); drying by ventilation to get ipriflavone preparation of 10μm size(influx air temperature is 50deg.C, jet air pressure is 30psi, rate of spray solution is 12ml/min).

Abstract translation: 目的：提供一种生物可用性改善的异胡酮酮口服制剂，其通过较少量的药物和较少的给药频率比现有的异黄酮制剂增加对体液的溶解度和有效的血液浓度，从而减少使用的不便，并增加 生物可否订购。 构成：用于口服制备生物可利用性改良的异黄酮制剂的方法包括：将异黄酮原料制备于丙酮中; 同时将聚乙烯吡咯烷酮溶解在丙酮/乙醇（1：1，v / v）的混合溶液中; 将制备的异黄酮溶液和聚乙烯吡咯烷酮溶液加入喷雾干燥器中，喷雾至异黄酮分散在聚乙烯吡咯烷酮（异丙酮：聚乙烯吡咯烷酮= 50:50重量份）中; 通风通风干燥，得到异黄酮制剂10μm（流入气温50℃，喷气压30psi，喷雾速率为12ml / min）。