公开(公告)号：KR1020100060673A

公开(公告)日：2010-06-07

申请号：KR1020080119366

申请日：2008-11-28

Applicant: 한림제약(주)

Inventor： 박세완 ,  이근혁 ,  류종현 ,  김재신 ,  박진하 ,  곽은영

IPC: A61K36/87 ,  A61P27/02

CPC classification number: A61K36/87 ,  A61K9/0048

Abstract: PURPOSE: A pharmaceutical composition of eye drop liquids and solutions or gels containing Vitis vinifera seed extract and antioxidant is provided to maintain physical and chemical stability. CONSTITUTION: A pharmaceutical composition of eye drop liquids and solutions or gels contains 0.1-30 weight% of Vitis vinifera seed extract, ascorbic acid or salt thereof, sodium bisulfate, potassium metabisulphite, or L-threonine, or antioxidant of salt thereof. The Vitis vinifera seed extract contains 80-130 of procyanidolic value(PCV); 30% or less (+)catechin and (-) epicatechin; and 95-105% of proanthocyanidine.

Abstract translation: 目的：提供含有葡萄种子提取物和抗氧化剂的滴眼液和溶液或凝胶的药物组合物，以维持物理和化学稳定性。 构成：滴眼液和溶液或凝胶的药物组合物含有0.1-30重量％的葡萄籽种子提取物，抗坏血酸或其盐，硫酸氢钠，偏亚硫酸氢钾或L-苏氨酸或其盐的抗氧化剂。 葡萄籽提取物含有原花青素含量（PCV）80-130; 30％以下（+）儿茶素和（ - ）表儿茶素; 和95-105％的原花青素。