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    11.
    发明专利
    未知

    公开(公告)号：DE69821009T2

    公开(公告)日：2004-11-18

    申请号：DE69821009

    申请日：1998-09-01

    Applicant: ABBOTT LAB

    Inventor： OR SUN ,  CLARK F ,  CHU T ,  PLATTNER J

    IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

    Abstract: Novel multicyclic erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having a formula (I) (II), (III), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention.

    LIGAND ANALOG-IRREVERSIBLE ENZYME INHIBITOR CONJUGATES AND METHODS FOR USE
    14.
    发明专利
    LIGAND ANALOG-IRREVERSIBLE ENZYME INHIBITOR CONJUGATES AND METHODS FOR USE 未知

    公开(公告)号：ZA80371B

    公开(公告)日：1981-03-25

    申请号：ZA80371

    申请日：1980-01-22

    Applicant: ABBOTT LAB

    Inventor： HERRIN T ,  VOSS H ,  PLATTNER J

    IPC: C07F9/40 ,  C12Q1/46 ,  G01N33/532 ,  G01N33/542 ,  G01N

    Abstract: The present invention encompasses a method for determining ligands in test samples comprising intermixing with the test sample a ligand analog-irreversible enzyme inhibitor conjugate and a binding protein bindable to the ligand and the ligand analog-irreversible enzyme inhibitor conjugate and wherein the amount of ligand analog-irreversible enzyme inhibitor conjugate bound by the binding protein is related to the amount of ligand in the test sample, said binding protein inactivating the irreversible enzyme inhibitor when bound to the ligand analog portion of the conjugate; intermixing an enzyme which is irreversibly inhibited by the ligand analog-irreversible enzyme inhibitor conjugate unbound by the binding protein; and intermixing substrate to the enzyme and monitoring the enzyme substrate reaction. The invention also includes ligand analog-irreversible enzyme inhibitor conjugates useful as reagents in practicing the method. Methods and reagents of the present are particularly useful in determining drugs, hormones, and the like in biological fluids.

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