公开(公告)号：DE69734678T2

公开(公告)日：2006-08-17

申请号：DE69734678

申请日：1997-05-06

Applicant: ABBOTT LAB

Inventor： OR SUN ,  CLARK F ,  MA ZHENKUN ,  GRIESGRABER GEORGE ,  LI LEPING ,  CHU T

IPC: C07H17/08 ,  A61K31/70

公开(公告)号：DE69734678D1

公开(公告)日：2005-12-22

申请号：DE69734678

申请日：1997-05-06

Applicant: ABBOTT LAB

Inventor： OR SUN ,  CLARK F ,  MA ZHENKUN ,  GRIESGRABER GEORGE ,  LI LEPING ,  CHU T

IPC: C07H17/08 ,  A61K31/70

公开(公告)号：DE69626040T2

公开(公告)日：2004-01-22

申请号：DE69626040

申请日：1996-11-06

Applicant: ABBOTT LAB

Inventor： OR SUN ,  CHU T ,  ELLIOTT L ,  PIREH DAISY

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08

Abstract: A compound selected from groups (I), (II), and (III), wherein A, B, V, W, X and R are specifically defined; pharmaceutical compositions thereof; a method of treating or preventing bacterial infections by administering therapeutically effective pharmaceutical compositions thereof; and a process for the preparation thereof.

公开(公告)号：DE69631609T2

公开(公告)日：2005-01-05

申请号：DE69631609

申请日：1996-10-17

Applicant: ABBOTT LAB

Inventor： OR SUN ,  PHAN TAM ,  CHU T ,  SPINA P ,  HALLAS ROBERT ,  ELLIOTT L

IPC: C07H17/00 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08

Abstract: Compounds, or pharmaceutically acceptable salts and esters thereof, of formulae (I); (II); (III) or (IV) wherein A, B, D and E, R , R and Z are specifically defined, having antibacterial activity, pharmaceutical compositions containing said compounds, treatment of antibacterial infections with such compositions, and processes for the preparation of the compounds.

公开(公告)号：DE69723848T2

公开(公告)日：2004-07-01

申请号：DE69723848

申请日：1997-04-25

Applicant: ABBOTT LAB

Inventor： ELLIOTT L ,  OR SUN ,  CHU T ,  GRIESGRABER W ,  PLATTNER J ,  PIREH DAISY

IPC: A61K31/04 ,  A61K31/70 ,  A61K31/7048 ,  A61K31/7052 ,  C07H17/08

Abstract: Novel 3-descladinose-2,3-anhydroerythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity selected from the group consisting of: (a) (I), (b) (II), (c) (III), and (d) (IV), pharmaceutical compositions comprising a therapeutically effective amount of a compound of formulas (I)-(IV) of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formulas (I)-(IV) of the invention.

公开(公告)号：DE69821964D1

公开(公告)日：2004-04-01

申请号：DE69821964

申请日：1998-09-16

Applicant: ABBOTT LAB

Inventor： OR SUN ,  MA ZHENKUN ,  CHU T

IPC: A61K31/7042 ,  A61K31/7048 ,  A61K31/7052 ,  A61P31/04 ,  C07H17/00 ,  C07H17/08 ,  A61K31/70

Abstract: Novel 3'-N-modified 6-O-substituted erythromycin ketolide compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I), (II), (III), (IV) or (V), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention.

公开(公告)号：DE69821009D1

公开(公告)日：2004-02-12

申请号：DE69821009

申请日：1998-09-01

Applicant: ABBOTT LAB

Inventor： OR SUN ,  CLARK F ,  CHU T ,  PLATTNER J

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

Abstract: Novel multicyclic erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having a formula (I) (II), (III), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention.

公开(公告)号：DE69723848D1

公开(公告)日：2003-09-04

申请号：DE69723848

申请日：1997-04-25

Applicant: ABBOTT LAB

Inventor： ELLIOTT L ,  OR SUN ,  CHU T ,  GRIESGRABER W ,  PLATTNER J ,  PIREH DAISY

IPC: A61K31/04 ,  A61K31/70 ,  A61K31/7048 ,  A61K31/7052 ,  C07H17/08

Abstract: Novel 3-descladinose-2,3-anhydroerythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity selected from the group consisting of: (a) (I), (b) (II), (c) (III), and (d) (IV), pharmaceutical compositions comprising a therapeutically effective amount of a compound of formulas (I)-(IV) of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formulas (I)-(IV) of the invention.

公开(公告)号：DE69733422T2

公开(公告)日：2006-05-04

申请号：DE69733422

申请日：1997-09-02

Applicant: ABBOTT LAB

Inventor： OR SUN ,  MA ZHENKUN ,  CLARK F ,  CHU T ,  PLATTNER J

IPC: C07H17/08 ,  A61K31/70 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/00

Abstract: 6-Substituted ketolides of e.g. formula (II) or (III), and their salts, esters and prodrugs are new: Y + Z = X; X = OH, =NOR1 or =NOC(R5)(R6)OR1; or one of Y and Z = H; and the other = H, OH, protected OH or NR7R8; R1 = 1-12C alkyl (optionally substituted), 3-12C cycloalkyl or SiR2R3R4; R2-R4 = 1-12C alkyl or aryl; R5, R6 = H or 1-12C alkyl (optionally substituted), or R5 + R6 = 3-12C cycloalkyl; R7, R8 = H or 1-6C alkyl; or NR7R8 = 3-7 membered ring which, when the ring is 5-7 membered may optionally contain O, NH, N(1-6C alkyl), N(aryl), N(aryl-1-6C alkyl), N (substituted aryl-1-6C alkyl), N(heteroaryl), N(heteroaryl-1-6C alkyl), N(substituted heteroaryl-1-6C alkyl), S or S(O)n; n = 1 or 2; Ra = H or OH; Rc = H or hydroxy protecting group; R9 = 1-6C alkyl (optionally substituted), 3-7C cycloalkyl or optionally substituted aryl or heteroaryl; M = CONH, NHCO, NH, N=, NMe, NHCOO, NHCONH, OCONHY, OCOO, O, S(O)n, COO, OCO or CO; R = methyl (substituted by CN, F, CO2R10, S(O)nR10, NHCOR10, NHCONR11R12, aryl, substituted aryl, heteroaryl or substituted heteroaryl); 2-10C alkyl (optionally substituted), 3C alkenyl (substituted by halo, CHO, CO2R10, COR9, CONR11R12, CN, optionally substituted aryl or heteroaryl, 3-7C cycloalkyl or 1-12C alkyl substituted by heteroaryl); 4-10C alkenyl (optionally substituted), or 3-10C alkynyl optionally substituted); R10 = 1-3C alkyl (optionally aryl substituted), or heteroaryl substituted 1-3C alkyl; R11, R12 = H or 1-3C alkyl (optionally substituted); A, B, D, E = H, 1-6C alkyl (optionally substituted by optionally substituted), 3-7C cycloalkyl, optionally substituted aryl or heteroaryl, heterocycloalkyl or 1-6C alkyl substituted by MR9; provided that \- 2 of A, B, D and E = H; or any one pair of substituents, consisting of AB, AD, AE, BD, BE or DE taken with the atoms to which they are attached, form a 3- to 7-membered ring optionally containing O, NH, N(1-6C alkyl), N(aryl-1-6C alkyl), N(substituted aryl-1-6C alkyl), N(heteroaryl-1-6C alkyl), N(substituted heteroaryl-1-6C alkyl), S, S(O)n, CONH, CONR12, NHCO, NR12CO or C(=NH)NH.

公开(公告)号：DE69821964T2

公开(公告)日：2004-12-30

申请号：DE69821964

申请日：1998-09-16

Applicant: ABBOTT LAB

Inventor： OR SUN ,  MA ZHENKUN ,  CHU T

IPC: A61K31/7042 ,  A61K31/7048 ,  A61K31/7052 ,  A61P31/04 ,  C07H17/00 ,  C07H17/08 ,  A61K31/70

Abstract: Novel 3'-N-modified 6-O-substituted erythromycin ketolide compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I), (II), (III), (IV) or (V), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention.