公开(公告)号：EP0970083A1

公开(公告)日：2000-01-12

申请号：EP98907359.8

申请日：1998-02-05

Applicant: Abbott Laboratories

Inventor： WASICAK, James, T. ,  GARVEY, David, S. ,  HOLLADAY, Mark, W. ,  LIN, Nan-Horng ,  RYTHER, Keith, B.

IPC: C07D487/04 ,  A61K31/44

CPC classification number: C07D487/04

Abstract: 7a-Substituted hexahydro-1H-pyrrolizine compounds having formula (I), wherein A is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：EP0950057A1

公开(公告)日：1999-10-20

申请号：EP97952392.0

申请日：1997-12-10

Applicant: Abbott Laboratories

Inventor： HOLLADAY, Mark, W. ,  ARNERIC, Stephen, P. ,  BAI, Hao ,  DART, Michael, J. ,  LIN, Nan-Horng ,  LYNCH, John, K. ,  OR, Yat, Sun ,  RYTHER, Keith, B. ,  SULLIVAN, James, P. ,  WASICAK, James, T. ,  EHRLICH, Paul, P.

IPC: A61P25 ,  A61K31 ,  A61P29 ,  C07D205 ,  C07D401 ,  C07D405

CPC classification number: C07D401/12 ,  A61K31/4427 ,  A61K31/485 ,  C07D205/04 ,  Y02P20/55 ,  A61K2300/00

Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

公开(公告)号：EP1047690A1

公开(公告)日：2000-11-02

申请号：EP98964167.5

申请日：1998-12-18

Applicant: Abbott Laboratories

Inventor： HOLLADAY, Mark, W. ,  ABREO, Melwyn, A. ,  GUNN, David, E. ,  LIN, Nan-Horng ,  GARVEY, David, S. ,  RYTHER, Keith ,  LEBOLD, Suzanne, A. ,  ELLIOTT, Richard, L. ,  HE, Yun ,  WASIAK, James, T. ,  BAI, Hao ,  DART, Michael, J. ,  EHRLICH, Paul, P. ,  LI, Yihong ,  KINCAID, John, F. ,  SCHKERYANTZ, Jeffrey, M. ,  LYNCH, John, K.

IPC: C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D487/04 ,  C07D455/02 ,  A61K31/44 ,  A61K31/40 ,  A61K31/425 ,  A61K31/50 ,  A61K31/505 ,  A61K31/47

CPC classification number: C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D455/02 ,  C07D487/04

Abstract: Novel compounds having formulas (I), (II) or (III) or pharmaceutically-acceptable salts or prodrugs thereof, which are useful for controlling synaptic transmission; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to controlling synaptic transmission in human or veterinary patients.

公开(公告)号：EP0934308A1

公开(公告)日：1999-08-11

申请号：EP97927830.0

申请日：1997-06-04

Applicant: Abbott Laboratories

Inventor： LIN, Nan-Horng ,  HE, Yun ,  HOLLADAY, Mark, W. ,  RYTHER, Keith ,  LI, Yihong ,  BAI, Hao

IPC: C07D401 ,  C07D405 ,  C07D409

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14

Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds of formula (I) or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission. Key intermediates and processes using this key intermediates to produce compounds of formula (I) with the variables defined in the specification are also described.

公开(公告)号：EP1198456B1

公开(公告)日：2007-09-19

申请号：EP00955327.2

申请日：2000-08-02

Applicant: ABBOTT LABORATORIES

Inventor： ALTENBACH, Robert, J. ,  BAI, Hao ,  BRIONI, Jorge, D. ,  CARROLL, William, A. ,  GOPALAKRISHNAN, Murali ,  GREGG, Robert, J. ,  HOLLADAY, Mark, W. ,  HUANG, Peggy, P. ,  KINCAID, John, F. ,  KORT, Michael, E. ,  KYM, Philip, R. ,  LYNCH, John, K. ,  PEREZ-MEDRANO, Arturo ,  ZHANG, Henry, Q.

IPC: C07D213/74 ,  C07C335/18 ,  C07C335/16 ,  C07C279/28 ,  C07C279/30 ,  C07D209/08 ,  C07D235/06 ,  C07D401/12 ,  C07D239/42 ,  C07D401/04 ,  C07D233/42 ,  C07D407/12 ,  C07C275/30 ,  C07D215/38 ,  A61K31/47 ,  A61K31/44 ,  A61K31/17 ,  A61K31/155

CPC classification number: C07D213/74 ,  A61K31/17 ,  C07C233/78 ,  C07C233/83 ,  C07C271/22 ,  C07C275/28 ,  C07C275/30 ,  C07C279/28 ,  C07C279/36 ,  C07C335/16 ,  C07C335/18 ,  C07D209/08 ,  C07D215/38 ,  C07D233/42 ,  C07D235/06 ,  C07D239/42 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12

Abstract: Compounds of formula (I), are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：EP0934308B1

公开(公告)日：2004-08-11

申请号：EP97927830.6

申请日：1997-06-04

Applicant: Abbott Laboratories

Inventor： LIN, Nan-Horng ,  HE, Yun ,  HOLLADAY, Mark, W. ,  RYTHER, Keith ,  LI, Yihong ,  BAI, Hao

IPC: C07D401/12 ,  C07D401/14 ,  C07D407/14 ,  C07D409/14 ,  A61K31/44 ,  A61K31/445 ,  A61K31/465 ,  A61K31/505

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14

公开(公告)号：EP1242422A1

公开(公告)日：2002-09-25

申请号：EP00980801.5

申请日：2000-11-17

Applicant: ABBOTT LABORATORIES

Inventor： HOLLADAY, Mark, W. ,  CARROLL, William, A. ,  DRIZIN, Irene ,  YI, Lin ,  ZHANG, Henry, Q.

IPC: C07D487/04 ,  C07D495/14 ,  C07D491/14 ,  A61K31/505 ,  A61P9/12

CPC classification number: C07D487/04 ,  C07D491/14 ,  C07D495/14

Abstract: Compounds of formula (I), are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：EP1198456A2

公开(公告)日：2002-04-24

申请号：EP00955327.2

申请日：2000-08-02

Applicant: Abbott Laboratories

Inventor： ALTENBACH, Robert, J. ,  BAI, Hao ,  BRIONI, Jorge, D. ,  CARROLL, William, A. ,  GOPALAKRISHNAN, Murali ,  GREGG, Robert, J. ,  HOLLADAY, Mark, W. ,  HUANG, Peggy, P. ,  KINCAID, John, F. ,  KORT, Michael, E. ,  KYM, Philip, R. ,  LYNCH, John, K. ,  PEREZ-MEDRANO, Arturo ,  ZHANG, Henry, Q.

IPC: C07D213/74

CPC classification number: C07D213/74 ,  A61K31/17 ,  C07C233/78 ,  C07C233/83 ,  C07C271/22 ,  C07C275/28 ,  C07C275/30 ,  C07C279/28 ,  C07C279/36 ,  C07C335/16 ,  C07C335/18 ,  C07D209/08 ,  C07D215/38 ,  C07D233/42 ,  C07D235/06 ,  C07D239/42 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12

Abstract: Compounds of formula (I), are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：EP1194429A1

公开(公告)日：2002-04-10

申请号：EP00941678.5

申请日：2000-06-23

Applicant: Abbott Laboratories

Inventor： CARROLL, William, A. ,  CHEN, Yiyuan ,  HOLLADAY, Mark, W. ,  KORT, Michael, E. ,  KYM, Philip, R. ,  SULLIVAN, James, P. ,  TANG, Rui ,  YI, Lin ,  ZHANG, Henry, Q.

IPC: C07D495/04 ,  C07D215/36 ,  C07D221/04 ,  A61K31/44

CPC classification number: C07D221/04 ,  C07C45/00 ,  C07C45/298 ,  C07C45/41 ,  C07C45/63 ,  C07C45/71 ,  C07C205/44 ,  C07D215/36 ,  C07D495/04 ,  C07D495/14 ,  C07C47/565 ,  C07C47/55 ,  C07C49/753

Abstract: Compounds having formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：EP0846114A1

公开(公告)日：1998-06-10

申请号：EP96914786.0

申请日：1996-05-28

Applicant: Abbott Laboratories

Inventor： HOLLADAY, Mark, W. ,  LIN, Nan-Horng ,  RYTHER, Keith, B. ,  HE, Yun

IPC: A61K31 ,  A61P25 ,  C07D401 ,  C07D403 ,  C07D417

CPC classification number: C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds having formula (I), wherein * is a chiral center and n, X, R1, R2, A andB are specifically defined, which are useful in controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions therof; and use of said compositions to selectively control synaptic transmission in mammals.