公开(公告)号：WO2012019315A1

公开(公告)日：2012-02-16

申请号：PCT/CN2010/001213

申请日：2010-08-10

Applicant: ABBOTT LABORATORIES ,  ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD ,  BAYBURT, Erol, K. ,  CLAPHAM, Bruce ,  COX, Phil, B. ,  DAANEN, Jerome, F. ,  GOMTSYAN, Arthur ,  KORT, Michael, E. ,  KYM, Philip, R. ,  VOIGHT, Eric, A.

Inventor： BAYBURT, Erol, K. ,  CLAPHAM, Bruce ,  COX, Phil, B. ,  DAANEN, Jerome, F. ,  GOMTSYAN, Arthur ,  KORT, Michael, E. ,  KYM, Philip, R. ,  VOIGHT, Eric, A.

IPC: C07D213/30 ,  C07D239/26 ,  C07D405/06 ,  C07D405/08 ,  A61K31/4402 ,  A61K31/4433 ,  A61K31/505 ,  A61P25/00 ,  A61P29/00

CPC classification number: C07D213/30 ,  C07D213/50 ,  C07D239/26 ,  C07D401/12 ,  C07D405/12

Abstract: Disclosed herein are modulators of TRPV3 of formula (I), wherein G 1 , X 1 , X 2 , X 3 , X 4 , X 5 , G 2 , Z 1 , R a , R b , u, and p are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.

Abstract translation: 本文公开了式（I）的TRPV3的调节剂，其中G1，X1，X2，X3，X4，X5，G2，Z1，Ra，Rb，u和p如说明书中所定义。 还提出了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和障碍的方法。

公开(公告)号：WO2012129491A1

公开(公告)日：2012-09-27

申请号：PCT/US2012/030317

申请日：2012-03-23

Applicant: ABBOTT LABORATORIES ,  CLAPHAM, Bruce ,  COX, Philip, B. ,  DART, Michael, J. ,  GOMTSYAN, Arthur ,  JINKERSON, Tammie, K. ,  KEDDY, Ryan, G. ,  KORT, Michael, E. ,  KYM, Philip, R. ,  MATULENKO, Mark ,  SCHMIDT, Robert, G., Jr. ,  VILLAMIL, Clara, I. ,  VOIGHT, Eric, A. ,  WOLLER, Kevin, R.

Inventor： CLAPHAM, Bruce ,  COX, Philip, B. ,  DART, Michael, J. ,  GOMTSYAN, Arthur ,  JINKERSON, Tammie, K. ,  KEDDY, Ryan, G. ,  KORT, Michael, E. ,  KYM, Philip, R. ,  MATULENKO, Mark ,  SCHMIDT, Robert, G., Jr. ,  VILLAMIL, Clara, I. ,  VOIGHT, Eric, A. ,  WOLLER, Kevin, R.

IPC: C07D401/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  A61K31/44 ,  A61K31/505 ,  C07D211/06 ,  C07D239/28 ,  C07D239/30 ,  A61P25/00

CPC classification number: C07D213/61 ,  A61K31/44 ,  A61K31/505 ,  C07D211/06 ,  C07D213/38 ,  C07D213/64 ,  C07D213/643 ,  C07D213/74 ,  C07D239/26 ,  C07D239/28 ,  C07D239/30 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/10 ,  C07D417/12

Abstract: Disclosed herein are modulators of TRPV3 of formula (I) wherein X 1 , X 2 , R 1 , R 2 , R x , and n are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.

Abstract translation: 本文公开了式（I）的TRPV3的调节剂，其中X1，X2，R1，R2，Rx和n如说明书中所定义。 还提出了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和障碍的方法。

公开(公告)号：WO2002062762A2

公开(公告)日：2002-08-15

申请号：PCT/US2002/005252

申请日：2002-01-17

Applicant: ABBOTT LABORATORIES

Inventor： ALTENBACH, Robert, J. ,  BAI, Hao ,  BRIONI, Jorge, D. ,  CARROLL, William, A. ,  GOPALAKRISHNAN, Murali ,  GREGG, Robert, J. ,  HOLLADAY, Mark, W. ,  HUANG, Peggy, P. ,  KINCAID, John, F. ,  KORT, Michael, E. ,  KYM, Philip, R. ,  LYNCH, John, K. ,  PEREZ-MEDRANO, Arturo ,  ZHANG, Henry, Q.

IPC: C07D213/75

CPC classification number: C07D213/40 ,  A61K31/17 ,  A61K31/275 ,  A61K31/4406 ,  C07C233/78 ,  C07C233/83 ,  C07C271/22 ,  C07C275/28 ,  C07C275/30 ,  C07C279/28 ,  C07C279/36 ,  C07C335/16 ,  C07C335/18 ,  C07D209/08 ,  C07D213/74 ,  C07D213/75 ,  C07D213/82 ,  C07D215/38 ,  C07D233/42 ,  C07D233/84 ,  C07D235/06 ,  C07D239/42 ,  C07D333/20 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Compounds of formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

Abstract translation: 式（I）化合物可用于治疗用钾通道开放剂预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中开放钾通道的方法。

公开(公告)号：WO2007137107A2

公开(公告)日：2007-11-29

申请号：PCT/US2007/069112

申请日：2007-05-17

Applicant: ABBOTT LABORATORIES ,  IYENGAR, Rajesh, R. ,  ZHAO, Gang ,  FREEMAN, Jennifer, C. ,  GAO, Ju ,  JUDD, Andrew, S. ,  KYM, Philip, R. ,  LYNCH, John, K. ,  MULHERN, Mathew, M. ,  SOUERS, Andrew, J.

Inventor： IYENGAR, Rajesh, R. ,  ZHAO, Gang ,  FREEMAN, Jennifer, C. ,  GAO, Ju ,  JUDD, Andrew, S. ,  KYM, Philip, R. ,  LYNCH, John, K. ,  MULHERN, Mathew, M. ,  SOUERS, Andrew, J.

IPC: C07C211/22 ,  C07C275/30 ,  C07C279/18 ,  C07C335/16 ,  C07D213/55 ,  C07D213/75

CPC classification number: C07C335/22 ,  C07C229/46 ,  C07C275/30 ,  C07C275/32 ,  C07C275/38 ,  C07C279/28 ,  C07C2601/08 ,  C07C2601/14 ,  C07D213/55 ,  C07D213/75 ,  C07D277/30 ,  C07D333/22 ,  C07D333/36 ,  C07D401/04 ,  C07D401/12 ,  C07D409/12 ,  C07D409/14

Abstract: The present invention relates to compounds of formula (I) wherein R 1 , R 3 , X, Q, Z, A, D, m, and n are defined herein. Pharmaceutical compositions and methods for treating DGAT-1 related diseases or conditions are also disclosed.

Abstract translation: 本发明涉及式（I）化合物，其中R 1，R 3，X，Q，Z，A，D，m和n如本文所定义。 还公开了治疗DGAT-1相关疾病或病症的药物组合物和方法。

公开(公告)号：WO2004000869A1

公开(公告)日：2003-12-31

申请号：PCT/US2003/019157

申请日：2003-06-17

Applicant: ABBOTT LABORATORIES

Inventor： VON GELDERN, Thomas, W. ,  LINK, James, T. ,  TU, Noah ,  KYM, Philip, R. ,  LAI, Chunqiu ,  RICHARDS, Steven, J. ,  JACOBSON, Peer, B. ,  BISHOP, Richard, D. ,  GATES, Bradley, D.

IPC: C07J41/00

CPC classification number: C07J41/0083 ,  C07J41/0061

Abstract: This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in the regulation of metabolism, especially lowering serum glucose levels, insulin levels, or lipid levels, and/or decreasing body weight.

Abstract translation: 本发明涉及作为肝脏选择性糖皮质激素受体拮抗剂的新型化合物，制备这些化合物的方法，以及使用这些化合物来调节代谢的方法，特别是降低血清葡萄糖水平，胰岛素水平或脂质水平，和/或 减轻体重。

公开(公告)号：WO2003105850A1

公开(公告)日：2003-12-24

申请号：PCT/US2003/018959

申请日：2003-06-17

Applicant: ABBOTT LABORATORIES

Inventor： COLLINS, Christine, A. ,  GAO, Ju ,  KYM, Philip, R. ,  LEWIS, Jared, C. ,  SOUERS, Andrew, J. ,  VASUDEVAN, Anil ,  WODKA, Dariusz

IPC: A61K31/47

CPC classification number: C07D215/38 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D411/12 ,  C07D413/12

Abstract: The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, which antagonize the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor and are useful for the prevention or treatment of eating disorders, weight gain and obesity.

Abstract translation: 本发明涉及通过黑色素浓缩激素受体拮抗黑色素浓缩激素（MCH）的作用的式（I）化合物或其治疗上合适的盐或前药，并且可用于预防或治疗饮食 疾病，体重增加和肥胖。

公开(公告)号：WO2007137103A2

公开(公告)日：2007-11-29

申请号：PCT/US2007/069104

申请日：2007-05-17

Applicant: ABBOTT LABORATORIES ,  KYM, Philip, R. ,  ZHAO, Gang

Inventor： KYM, Philip, R. ,  ZHAO, Gang

CPC classification number: C07C275/42 ,  C07C2601/08 ,  C07C2601/14 ,  C07D213/75 ,  C07D317/66 ,  C07D333/36

Abstract: The present invention relates to compounds of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , m, n, p and q are defined herein. Pharmaceutical compositions and methods for treating DGAT-1 related diseases or conditions are also disclosed.

Abstract translation: 本发明涉及式（I）的化合物，其中R 1，R 2，R 3，R 4， >，R 5，R 6，m，n，p和q在本文中定义。 还公开了治疗DGAT-1相关疾病或病症的药物组合物和方法。

公开(公告)号：WO2003070244A1

公开(公告)日：2003-08-28

申请号：PCT/US2003/005510

申请日：2003-02-21

Applicant: ABBOTT LABORATORIES

Inventor： KYM, Philip, R. ,  HARTANDI, Kresna ,  GAO, Ju ,  PHELAN, Kathleen, M. ,  AKRITOPOULOU-ZANZE, Irini ,  COLLINS, Christine, A. ,  VASUDEVAN, Anil ,  VERZAL, Mary, K.

IPC: A61K31/4706

CPC classification number: C07D401/12 ,  C07D215/46 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders. The present invention is directed to the compouds of formula (I).

Abstract translation: 本发明涉及黑色素浓缩激素（MCH）通过黑色素浓缩激素受体的作用的拮抗作用，其可用于预防或治疗进食障碍，体重增加，肥胖，生殖和性行为异常，甲状腺激素 分泌，利尿和水/电解质体内平衡，感觉加工，记忆，睡眠，唤醒，焦虑，抑郁，癫痫发作，神经变性和精神疾病。 本发明涉及式（I）的化合物。

公开(公告)号：WO2002070507A2

公开(公告)日：2002-09-12

申请号：PCT/US2002/004541

申请日：2002-01-16

Applicant: ABBOTT LABORATORIES

Inventor： KYM, Philip, R. ,  LANE, Benjamin, C. ,  PRATT, John, K. ,  VON GELDERN, Tom ,  WINN, Martin ,  PATEL, Jyoti, R. ,  ARENDSEN, David, L. ,  AKRITOPOULOU-ZANZE, Irini ,  ASHWORTH, Kimba, L. ,  HARTANDI, Kresna ,  BRENNEMAN, Jehrod

IPC: C07D311/80

CPC classification number: C07D407/04 ,  C07D311/80 ,  C07D409/04

Abstract: Compounds of formula (I) are useful for treating type (II) diabetes, obesity, hyperglycemia, inadequate glucose clearance, hyperinsulinemia, hypertriglyceridemia, and high-circulating glucocorticoid levels, preparations of the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract translation: 式（I）化合物可用于治疗II型糖尿病，肥胖症，高血糖症，葡萄糖清除不足，高胰岛素血症，高甘油三酯血症和高循环糖皮质激素水平，所述化合物的制剂，含有 化合物和使用这些化合物的治疗方法。

公开(公告)号：EP1208095A1

公开(公告)日：2002-05-29

申请号：EP00959835.0

申请日：2000-09-01

Applicant: Abbott Laboratories

Inventor： KYM, Philip, R. ,  LANE, Benjamin, C. ,  PRATT, John, K. ,  VON GELDERN, Tom

IPC: C07D311/80 ,  A61K31/352 ,  A61P3/10

CPC classification number: C07D311/80

Abstract: The instant invention relates to compounds of formula (I) which are useful as antagonists of the glucocorticoid receptor and for treating diabetes in a mammal. In addition, any glucocorticoid receptor antagonist(s) is useful for the treatment of diabetes.