公开(公告)号：WO2003068790A3

公开(公告)日：2003-08-21

申请号：PCT/US2003/004117

申请日：2003-02-11

Applicant: ABBOTT LABORATORIES

Inventor： MA, Zhenkun ,  CLARK, Richard ,  DJURIC, Stevan ,  WANG, Sanyi

IPC: C07H17/08

Abstract: Antibacterial compounds having formula (I), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections using the compounds are disclosed.

公开(公告)号：WO1998009978A1

公开(公告)日：1998-03-12

申请号：PCT/US1997015506

申请日：1997-09-02

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  OR, Yat, Sun ,  MA, Zhenkun ,  CLARK, Richard, F. ,  CHU, Daniel, T. ,  PLATTNER, Jacob, J.

IPC: C07H17/08

CPC classification number: C07H17/08 ,  Y02P20/55

Abstract: Antimicrobial compounds having formula (II), (III), (IV), (IV-A) or (V) as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compunds.

Abstract translation: 具有式（II），（III），（IV），（IV-A）或（V）的抗微生物化合物及其药学上可接受的盐，酯或前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 以及制备肥料的过程。

公开(公告)号：WO1997042204A1

公开(公告)日：1997-11-13

申请号：PCT/US1997004622

申请日：1997-03-21

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  OR, Yat, Sun ,  CHU, Daniel, T. ,  CLARK, Richard, F. ,  MA, Zhenkun

IPC: C07H17/08

CPC classification number: C07H17/08

Abstract: Antimicrobial compounds having formula (II), (III), (IV), (V), (VI), (VII), (VIII) and (IX) as well as the pharmaceutically acceptable salts, esters and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.

Abstract translation: 具有式（II），（III），（IV），（V），（VI），（VII），（VIII）和（IX）的抗微生物化合物及其药学上可接受的盐，酯和前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。

公开(公告)号：WO1996039407A1

公开(公告)日：1996-12-12

申请号：PCT/US1996008991

申请日：1996-06-05

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  CHU, Daniel, T. ,  LI, Qun ,  COOPER, Curt, S. ,  FUNG, Anthony, K., L. ,  LEE, Cheuk, M. ,  PLATTNER, Jacob, J. ,  MA, Zhenkun ,  WANG, Wei-Bo

IPC: C07D471/04

CPC classification number: C07D471/04 ,  A61K38/00 ,  C07D213/61 ,  C07D213/68 ,  C07D455/02 ,  C07K5/06026

Abstract: Antibacterial compounds having formula (I) and the pharmaceutically acceptable salts, esters and amides thereof, selected preferred examples of which include those compounds wherein A is =CR -; R is cycloalkyl of from three to eight carbon atoms or substituted phenyl; R is selected from the group consisting of (a), (b), (c) and (d); R is halogen; R is hydrogen, loweralkyl, a pharmaceutically acceptable cation, or a prodrug ester group; R is hydrogen, loweralkyl, halo(loweralkyl), or -NR R ; and R is halogen, loeralkyl, halo(loweralkyl), hydroxy-substituted loweralkyl, loweralkoxy(loweralkyl), loweralkoxy, or amino(loweralkyl), as well as pharmaceutical compositions containing such compounds and the use of the same in the treatment of bacterial infections.

Abstract translation: 具有式（I）的抗菌化合物及其药学上可接受的盐，酯和酰胺，其选择的优选实例包括其中A = CR 6 - 的那些化合物; R 1是3至8个碳原子的环烷基或取代的苯基; R 2选自（a），（b），（c）和（d）; R 3是卤素; R 4是氢，低级烷基，药学上可接受的阳离子或前药酯基; R 5是氢，低级烷基，卤代（低级烷基）或-NR 13 R 14; 和R 6是卤素，低级烷基，卤代（低级烷基），羟基取代的低级烷基，低级烷氧基（低级烷基），低级烷氧基或氨基（低级烷基），以及含有这些化合物的药物组合物及其在治疗中的用途 的细菌感染。

公开(公告)号：WO2003093288A1

公开(公告)日：2003-11-13

申请号：PCT/US2003/012970

申请日：2003-04-25

Applicant: ABBOTT LABORATORIES

Inventor： CLARK, Richard, F. ,  DJURIC, Stevan, M. ,  MA, Zhenkun ,  PHAN, Ly ,  RUPP, Michael, J.

IPC: C07H17/08

CPC classification number: C07H17/08

Abstract: Antibacterial compounds with improved pharmacokinetic profiles having formula (I), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis and treatment of bacterial infections using the compounds are disclosed.

Abstract translation: 具有式（I）的改进的药代动力学特征的抗菌化合物及其前体药物的盐，前药和盐，用于制备该方法中使用的化合物和中间体的方法，含有该化合物的组合物，以及用于预防和治疗细菌感染的方法 公开了这些化合物。

公开(公告)号：EP1501845A1

公开(公告)日：2005-02-02

申请号：EP03721887.2

申请日：2003-04-25

Applicant: Abbott Laboratories

Inventor： CLARK, Richard, F. ,  DJURIC, Stevan, M. ,  MA, Zhenkun ,  PHAN, Ly ,  RUPP, Michael, J.

IPC: C07H17/08 ,  A61K31/7048 ,  A61P31/04

CPC classification number: C07H17/08

Abstract: Antibacterial compounds with improved pharmacokinetic profiles having formula (I), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis and treatment of bacterial infections using the compounds are disclosed.

公开(公告)号：EP1499326A1

公开(公告)日：2005-01-26

申请号：EP03719889.2

申请日：2003-04-23

Applicant: Abbott Laboratories

Inventor： MA, Zhenkun ,  DJURIC, Stevan ,  FLORJANCIC, Alan, S. ,  YONG, Hong ,  GU, YUGUI

IPC: A61K31/7048 ,  C07H17/08

CPC classification number: C07H17/08

Abstract: Antibacterial compounds having formula (I) and formula (II), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates employed in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections in a fish or a mammal using the compounds are disclosed.

公开(公告)号：EP1206476B1

公开(公告)日：2006-01-04

申请号：EP00955256.3

申请日：2000-07-26

Applicant: ABBOTT LABORATORIES

Inventor： OR, Yat Sun ,  KEYES, Robert F. ,  MA, Zhenkun

IPC: C07H17/08 ,  A61K31/70 ,  A61P31/04

CPC classification number: C07H17/08

Abstract: Compounds of formula (I), formula (II), formula (III), and formula (IV) or pharmaceutically acceptable salts or prodrugs thereof, are antibacterial agents. Compositions containing the compounds, processes for making the compounds, synthetic intermediates employed in the processes, and methods for treatment and prevention of bacterial infections are disclosed.

公开(公告)号：EP1501847A2

公开(公告)日：2005-02-02

申请号：EP03733878.7

申请日：2003-04-24

Applicant: Abbott Laboratories

Inventor： CLARK, Richard ,  DJURIC, Stevan ,  MA, Zhenkun ,  WANG, Sanyi

IPC: C07H17/08

CPC classification number: C07H17/08

Abstract: Antibacterial compounds having formula (I) and formula (II), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections using the compounds are disclosed.

Abstract translation: 具有式（I）和式（II）的抗菌化合物及其盐，前药和前药的盐，制备用于该方法的化合物和中间体的方法，含有该化合物的组合物，以及预防或治疗细菌感染 公开了使用这些化合物。

公开(公告)号：EP1233971A2

公开(公告)日：2002-08-28

申请号：EP00982357.6

申请日：2000-12-01

Applicant: ABBOTT LABORATORIES

Inventor： PHAN, Ly, Tam ,  OR, Yat, Sun ,  MA, Zhenkun

IPC: C07H17/00

CPC classification number: C07H17/08

Abstract: The present invention relates to 6-O-alkyl-2-nor-2-substituted ketolide compound or a derivative thereof, a composition comprising the compound and a suitable carrier, a method of preparing the compound, and a method of treatment and prevention of in mammals comprising administering said compound.