公开(公告)号：EP1380842A2

公开(公告)日：2004-01-14

申请号：EP03021136.1

申请日：1993-03-24

Applicant: Abbott Laboratories

Inventor： Clark, Frederic L. ,  Clift, Gilbert ,  Hendrick, Kendall B. ,  Kanewske, William J.III ,  Lagocki, Peter A. ,  Martin, Richard R. ,  Mitchell, James E. ,  Moore, Larry W ,  Pennington, Charles D. ,  Walker, Edna S. ,  Smith, Jane B. ,  Tayi, Apparao ,  Vaught, James A. ,  Yost, David A ,  Merriam, Richard A. ,  Walker, Donny Ray ,  McDowell, Douglas D. ,  Rumbaugh, William A. ,  Clemens, John M.

IPC: G01N35/02

CPC classification number: G01N35/0095 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2300/042 ,  B01L2300/043 ,  B29C45/00 ,  B29K2995/0032 ,  B29L2023/22 ,  G01N21/03 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2035/00168 ,  G01N2035/00277 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: A test sample container assembly for loading a plurality of test samples onto a test sample carousel of an automated analytical system and an automated, continuous and random access analytical system containing such test sample container assembly and capable of simultaneously effecting multiple assays of a plurality of liquid samples are disclosed. The test sample container assembly comprises (i) a housing with two parallel curved sides, said sides having the same radius of curvature as the test sample carousel, (ii) a top shelf with at least two openings for receiving test sample containers, (iii) a bottom parallel to and spaced apart from the top shelf defining with the curved surfaces therebetween a cavity, and (iv) wherein said bottom portion and said curved surfaces define a cavity therebetween wherein the at least two openings provide a predefined vertical alignment and the test sample container openings are presented in a plane parallel with the plane of the assembly shelf.

Abstract translation: 一种用于将多个测试样品加载到自动分析系统的测试样品转盘上的测试样品容器组件和包含这种测试样品容器组件并且能够同时进行多种液体的多种测定的自动化，连续和随机存取分析系统 样品被公开。 测试样品容器组件包括（i）具有两个平行弯曲侧面的壳体，所述侧部具有与测试样品转盘相同的曲率半径，（ii）具有用于接收测试样品容器的至少两个开口的顶架，（iii ）平行于所述顶架的间隔开的底部，其间具有空腔之间的弯曲表面，以及（iv）其中所述底部部分和所述弯曲表面在其间限定了空腔，其中所述至少两个开口提供预定垂直对准，并且 测试样品容器开口呈现在与组装架平面平行的平面内。

公开(公告)号：EP1028320A2

公开(公告)日：2000-08-16

申请号：EP00108051.4

申请日：1994-09-22

Applicant: ABBOTT LABORATORIES

Inventor： Clark, Frederick L. ,  Clemens, John M. ,  Hance, Robert B. ,  Hendrick, Kendall B. ,  Tayi, Apparao ,  Kanewske, William J. III ,  Lagocki, Peter A. ,  Martin, Richard R. ,  McDowell, Douglas D. ,  Merriam, Richard A. ,  Moore, Larry W. ,  Oleksak, Carl M. ,  Pennington, Charles D. ,  Raymoure, William J. ,  Rumbaugh, William D. ,  Schmidt, Linda S. ,  Schrier, Paul R. ,  Smith B, Jane ,  Spronk, Adrian M. ,  Walker, Edna S. ,  Vaught, James A. ,  Vickstrom Richard L. ,  Walker, Donny Ray ,  Watkins, William E. III ,  Winter, Gary E. ,  Wohlford, Robert A. ,  Clift, Gilbert ,  Cloonan, Kevin M. ,  Mitchell, James E. ,  Stanton, Alyn K. ,  Yost, David A. ,  Hills, David B.

IPC: G01N35/02

CPC classification number: G01N35/0092 ,  B01F11/0022 ,  B01L3/5025 ,  B29C45/00 ,  G01N21/6445 ,  G01N21/6452 ,  G01N21/76 ,  G01N33/5302 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2021/6482 ,  G01N2035/00148 ,  G01N2035/00356 ,  G01N2035/0405 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0446 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: The present invention relates to a method of operating an automated, continuous and random access analytical system capable of simultaneously effecting multiple assays in a plurality of liquid samples, comprising the following steps: introducing sample cups, reagent packs, and reaction vessels for performing said assays onto concentric carousels of a front end carousel, the reaction vessels being introduced to an outer carousel; identifying the reagent packs and sample cups; scheduling the assays; aligning the sample cups and reagent packs with a reaction vessel at a kitting station by rotating the respective carousels; kitting a unit dose disposable in a reaction vessel having multiple independent open chambers in accordance with the scheduled assay by transfer of the sample from the sample cup to a reaction vessel chamber and transfer of specific reagents to separate reaction vessel chambers from the reagent pack; transferring the kitted reaction vessel to a process carousel which is maintained under controlled environment conditions; pipetting the sample and various reagents into a reaction well of the reaction vessel, the amounts of reagent, sequencing of transfer and time spacing therebetween being predetermined by assay scheduling; incubating the pipetted sample and reagent mix; identifying and transferring the incubated mixture in the reaction well to one of at least two assay analytical stations; performing an analysis by reading the prepared reaction mixture and calibrating the reading; and recording the resulting assay reading analysis.

Abstract translation: 本发明涉及的方法在自动化的，连续的和随机存取的分析能够同时 - 影响多个测定在液体样品的复数，包括以下步骤系统中操作：将样品杯，试剂包，并且反应容器用于进行所述测定 到前端转盘的同心旋转木马，反应容器被引入到在传送带外; 标识试剂袋和样品杯; 调度所述测定法; 通过旋转respectivement转盘对准样品杯和试剂袋与在备料站的反应容器; 备料的单位剂量在具有雅舞蹈多个独立的开放腔室与从所述样品杯的样品转移至反应容器腔室和特定的试剂从试剂包单独的反应容器室的传送被调度的测定的反应容器中一次性; 被控制的环境条件下保持转移环成套的反应容器中的处理转盘所有; 吸移样本和各种试剂到反应容器中的反应孔试剂，量，转移和时间通过测定调度被预先确定之间的间隔有的测序; 孵育所述移液样品和试剂混合物; 在反应识别和传递环保温的混合物以及至少两个化验分析站中的一个; 通过读取制备的反应混合物中，并校准读出执行的分析; 并记录所得到的测定读数的分析。

公开(公告)号：EP0387697A3

公开(公告)日：1991-11-13

申请号：EP90104414.9

申请日：1990-03-08

Applicant: ABBOTT LABORATORIES

Inventor： Yost, David A. ,  Dolan, Peggy Anne ,  Pennington, Charles D.

IPC: C12Q1/52 ,  C12Q1/32 ,  C12Q1/26

CPC classification number: C12Q1/52 ,  C12Q1/32

Abstract: A method and reagent system for determining the amount of an aminotransferase present in a biological test sample. The aminotransferase is determined by contacting a test sample containing an aminotransferase with its corresponding amino acid, a ketoacid, a dehydrogenase or a reductase, and a reduced form of thionicotinamide adenine dinculeotide or an analog thereof to form a liquid mixture thereof. The visible absorbance of the liquid mixture is measured and correlated to the amount of aminotransferase present in the test sample. The method and reagent system of the present invention are particularly useful for determining alanine aminotransferase and aspartate aminotransferase.

Abstract translation: 用于确定生物测试样品中存在的氨基转移酶的量的方法和试剂系统。 通过使包含氨基转移酶的测试样品与其相应的氨基酸，酮酸，脱氢酶或还原酶和还原形式的硫酰胺腺嘌呤丁卡肽或其类似物接触来测定氨基转移酶，以形成其液体混合物。 测量液体混合物的可见吸光度并与测试样品中存在的氨基转移酶的量相关。 本发明的方法和试剂系统特别可用于测定丙氨酸氨基转移酶和天冬氨酸氨基转移酶。

公开(公告)号：EP0387697A2

公开(公告)日：1990-09-19

申请号：EP90104414.9

申请日：1990-03-08

Applicant: ABBOTT LABORATORIES

Inventor： Yost, David A. ,  Dolan, Peggy Anne ,  Pennington, Charles D.

IPC: C12Q1/52 ,  C12Q1/32 ,  C12Q1/26

CPC classification number: C12Q1/52 ,  C12Q1/32

Abstract: A method and reagent system for determining the amount of an aminotransferase present in a biological test sample. The aminotransferase is determined by contacting a test sample containing an aminotransferase with its corresponding amino acid, a ketoacid, a dehydrogenase or a reductase, and a reduced form of thionicotinamide adenine dinculeotide or an analog thereof to form a liquid mixture thereof. The visible absorbance of the liquid mixture is measured and correlated to the amount of aminotransferase present in the test sample. The method and reagent system of the present invention are particularly useful for determining alanine aminotransferase and aspartate aminotransferase.

Abstract translation: 用于确定生物测试样品中存在的氨基转移酶的量的方法和试剂系统。 通过使包含氨基转移酶的测试样品与其相应的氨基酸，酮酸，脱氢酶或还原酶和还原形式的硫酰胺腺嘌呤丁卡肽或其类似物接触来测定氨基转移酶，以形成其液体混合物。 测量液体混合物的可见吸光度并与测试样品中存在的氨基转移酶的量相关。 本发明的方法和试剂系统特别可用于测定丙氨酸氨基转移酶和天冬氨酸氨基转移酶。

公开(公告)号：EP1450161A3

公开(公告)日：2006-05-24

申请号：EP04010901.9

申请日：1993-03-24

Applicant: ABBOTT LABORATORIES

Inventor： Clark, Frederic L. ,  Clift, Gilbert ,  Hendrick, Kendall B. ,  Kanewske, William J. III. ,  Lagocki, Peter A. ,  Martin, Richard R. ,  Mitchell, James E. ,  Moore, Larry W. ,  Pennington, Charles D. ,  Walker, Edna S. ,  Smith, Jane B. ,  Tayi, Apparao ,  Vaught, James A. ,  Yost, David A. ,  Winter, Gary E. ,  Hance, Robert B. ,  Stanton, Alyn K. ,  Oleksak, Carl M. ,  Watkins, William E. III. ,  Vickstrom, Richard L. ,  Cloonan, Kevin M. ,  Wohlford Robert A. ,  Hills, David B. Jr. ,  Schrier, Paul R. ,  Rumbaugh, William

IPC: G01N35/02 ,  B65B7/00

CPC classification number: G01N21/0303 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/043 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/026 ,  G01N35/1004 ,  G01N2001/007 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: A method for controlling evaporation and contamination of reagents used in automated diagnostic systems is disclosed as well as an apparatus for opening and closing reagent containers contained within a reagent pack having cover and cap means for such controlling of evaporation and contamination. The method comprises (a) moving reagent packs containing reagents in closed reagent containers mounted in a reagent pack carousel to an opening and closing station, (b) forcing open the evaporatively closed reagent containers contained in the reagent pack by the opening and closing station, (c) locking in an open position the reagent containers cover and cap which is affixed to the reagent containers, (d) moving the locked open reagent containers from the opening and closing station on the reagent pack carousel to a position wherein the system has access to the reagents, (e) withdrawing reagents from the reagent containers for system use, (f) returning the reagent pack and reagent containers on the reagent pack carousel to the opening and closing station, (g) unlocking the lock open cover and cap of the reagent containers, (h) force closing the cover and cap of the reagent containers of the reagent pack, and (i) removing the reagent pack from the opening and closing station.

公开(公告)号：EP1450163A9

公开(公告)日：2004-12-29

申请号：EP04010902.7

申请日：1993-03-24

Applicant: ABBOTT LABORATORIES

Inventor： Clark, Frederic L. ,  Clift, Gilbert ,  Hendrick, Kendall B. ,  Kanewske, William J. III. ,  Lagocki, Peter A. ,  Martin, Richard R. ,  Mitchell, James E. ,  Moore, Larry W. ,  Pennington, Charles D. ,  Walker, Edna S. ,  Smith, Jane B. ,  Tayi, Apparao ,  Vaught, James A. ,  Yost, David A. ,  Rumbaugh, William ,  Winter, Gary E. ,  Hance, Robert B. ,  Stanton, Alyn K. ,  Oleksak, Carl M. ,  Watkins, William E. III. ,  Vickstrom, Richard L. ,  Cloonan, Kevin M. ,  Wohlford Robert A. ,  Hills, David B. Jr. ,  Schrier, Paul R.

IPC: G01N35/02 ,  G01N35/10 ,  F04B53/00

CPC classification number: G01N21/0303 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/043 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/026 ,  G01N35/1004 ,  G01N2001/007 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: A bubble flushing aspirating and dispensing syringe having precision and volumetric accuracy, particularly for use in an automated, continuous and random access analytical system, is disclosed. The syringe comprises a piston (124) within a bore (128), the bore having seal means at a first end and a closed end (130) at a second end, wherein the piston forms an annulus (138) with the bore wall and seal means, and is capable of reciprocating therein. Fluid inlet (134) and fluid outlet (136) means are in communication with the annulus (138) and bore, the fluid inlet and fluid outlet means being located between the seal means and the bore closed end. A fluid source is in communication with the inlet means and a fluid conduit is in communication with the outlet means and an open-ended release tip. A drive means is connected to the piston for reciprocating the piston within the bore. As a result, fluid from the inlet, when connected to a fluid supply, flows through the annulus (138) around the sides of the piston and out through the fluid outlet to the open-ended tip, thereby creating a cross-flow pattern in the annulus (138) around the piston as it reciprocates in the bore to flush bubbles through the outlet.

公开(公告)号：EP1450163A8

公开(公告)日：2004-11-10

申请号：EP04010902.7

申请日：1993-03-24

Applicant: ABBOTT LABORATORIES

Inventor： Clark, Frederic L. ,  Clift, Gilbert ,  Hendrick, Kendall B. ,  Kanewske, William J. III. ,  Lagocki, Peter A. ,  Martin, Richard R. ,  Mitchell, James E. ,  Moore, Larry W. ,  Pennington, Charles D. ,  Walker, Edna S. ,  Smith, Jane B. ,  Tayi, Apparao ,  Vaught, James A. ,  Yost, David A. ,  Rumbaugh, William ,  Winter, Gary E. ,  Hance, Robert B. ,  Stanton, Alyn K. ,  Oleksak, Carl M. ,  Watkins, William E. III. ,  Vickstrom, Richard L. ,  Cloonan, Kevin M. ,  Wohlford Robert A. ,  Hills, David B. Jr. ,  Schrier, Paul R.

IPC: G01N35/02 ,  G01N35/10 ,  F04B53/00

CPC classification number: G01N21/0303 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/043 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/026 ,  G01N35/1004 ,  G01N2001/007 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: A bubble flushing aspirating and dispensing syringe having precision and volumetric accuracy, particularly for use in an automated, continuous and random access analytical system, is disclosed. The syringe comprises a piston (124) within a bore (128), the bore having seal means at a first end and a closed end (130) at a second end, wherein the piston forms an annulus (138) with the bore wall and seal means, and is capable of reciprocating therein. Fluid inlet (134) and fluid outlet (136) means are in communication with the annulus (138) and bore, the fluid inlet and fluid outlet means being located between the seal means and the bore closed end. A fluid source is in communication with the inlet means and a fluid conduit is in communication with the outlet means and an open-ended release tip. A drive means is connected to the piston for reciprocating the piston within the bore. As a result, fluid from the inlet, when connected to a fluid supply, flows through the annulus (138) around the sides of the piston and out through the fluid outlet to the open-ended tip, thereby creating a cross-flow pattern in the annulus (138) around the piston as it reciprocates in the bore to flush bubbles through the outlet.

Abstract translation: 公开了一种具有精确度和体积精确度的泡冲洗抽吸和分配注射器，特别用于自动化，连续和随机进入分析系统。 所述注射器包括在孔（128）内的活塞（124），所述孔在第一端具有密封装置而在第二端具有封闭端（130），其中所述活塞与所述孔壁形成环带（138），以及 密封装置，并且能够在其中往复运动。 流体入口（134）和流体出口（136）装置与环形空间（138）和孔连通，流体入口和流体出口装置位于密封装置和孔封闭端之间。 流体源与入口装置连通并且流体导管与出口装置和开放式释放末端连通。 驱动装置连接到活塞，用于使活塞在孔内往复运动。 结果，来自入口的流体在连接到流体供应源时流过环绕活塞侧面的环形空间（138）并且通过流体出口流出到开放式末端，由此在流体出口处形成交叉流动模式 当活塞在孔内往复运动时围绕活塞的环形空间（138）以通过出口冲洗气泡。

公开(公告)号：EP1443329A2

公开(公告)日：2004-08-04

申请号：EP04010960.5

申请日：1994-09-22

Applicant: Abbott Laboratories

Inventor： Clark, Frederick L. ,  Clemens, John M. ,  Hance, Robert B. ,  Hendrick, Kendall B. ,  Tayi, Apparao ,  Kanewske, William J. III ,  Lagocki, Peter A. ,  Martin, Richard R. ,  McDowell, Douglas D. ,  Merriam, Richard A. ,  Moore, Larry W. ,  Oleksak, Carl M. ,  Pennington, Charles D. ,  Raymoure, William J. ,  Rumbaugh, William D. ,  Schmidt, Linda S. ,  Schrier, Paul R. ,  Smith, Jane B. ,  Spronk, Adrian M. ,  Walker, Edna S. ,  Vaught, James A. ,  Vickstrom, Richard L. ,  Walker, Donny Ray ,  Watkins, William E. III ,  Winter, Gary E. ,  Wohlford, Robert A. ,  Clift, Gilbert ,  Cloonan, Kevin M. ,  Mitchell, James E. ,  Stanton, Alyn K. ,  Yost, David A. ,  Hills, David B.

IPC: G01N35/02 ,  G01N33/53

CPC classification number: G01N35/0092 ,  B01F11/0022 ,  B01L3/5025 ,  B29C45/00 ,  G01N21/6445 ,  G01N21/6452 ,  G01N21/76 ,  G01N33/5302 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2021/6482 ,  G01N2035/00148 ,  G01N2035/00356 ,  G01N2035/0405 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0446 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: The present invention relates to a method for simultaneously performing at least two assays, said assays comprising a plurality of activities, for a plurality of liquid samples on a continuous analytical system, said method comprising the steps of: combining an aliquot of a first liquid sample with at least one reagent in a first reaction container to form a first assay reaction mixture for said first liquid sample; combining an aliquot of a second liquid sample with at least one reagent in a second reaction container to form a second assay reaction mixture for said second liquid sample; incubating said first and said second assay reaction mixtures at least one time; performing activities associated with each assay other than said combining and said incubating on the first and second assay reaction mixtures to complete each assay, said other activities including analyzing the incubated assay reaction mixtures; and scheduling the steps of said combining, said incubating, and said performing activities other than said combining and said incubating associated with each of the assays according to a predetermined protocol, said protocol specifying: (a) what activities are to be performed for a given assay; (b) an order in which said activities of (a) are to be performed; (c) at least one incubation period between said activities of (a), said at least one incubation period comprising a nominal period of time for the performance of an incubating step between activities of (a) and a specified window of time for varying the duration of the nominal period between activities of (a) to optimize performance; (d) how said activities of (a) are to be performed; and (e) duration of said activities of (a).

Abstract translation: 本发明涉及一种用于同时进行至少两种测定的方法，所述测定法包括多个活性，对于连续分析系统上的多个液体样品，所述方法包括以下步骤：将等分试样的第一液体样品 与第一反应容器中的至少一种试剂形成用于所述第一液体样品的第一测定反应混合物; 将第二液体样品的等分试样与第二反应容器中的至少一种试剂组合以形成用于所述第二液体样品的第二测定反应混合物; 至少一次孵育所述第一和所述第二测定反应混合物; 执行与所述组合以外的每个测定相关的活动，并且在第一和第二测定反应混合物上孵育以完成每个测定，所述其它活性包括分析培养的测定反应混合物; 并且根据预定协议安排所述组合，所述孵育和所述执行活动之外的所述组合和所述孵化与每个测定相关联的步骤，所述协议规定：（a）将对给定的 法; （b）执行（a）的活动的命令; （c）所述活动之间的至少一个潜伏期（a），所述至少一个潜伏期包括在（a）的活动与指定的时间窗口之间执行孵化步骤的标称时间段，以改变 活动之间的名义期间的持续时间（a）优化业绩; （d）如何执行（a）的活动; （e）（a）所述活动的持续时间。

公开(公告)号：EP1380843A2

公开(公告)日：2004-01-14

申请号：EP03021137.9

申请日：1993-03-24

Applicant: Abbott Laboratories

Inventor： Clark, Frederic L. ,  Clift, Gilbert ,  Hendrick, Kendall B. ,  Kanewske, William J.III ,  Lagocki, Peter A. ,  Martin, Richard R. ,  Mitchell, James E. ,  Moore, Larry W ,  Pennington, Charles D. ,  Walker, Edna S. ,  Smith, Jane B. ,  Tayi, Apparao ,  Vaught, James A. ,  Yost, David A ,  Merriam, Richard A. ,  Walker, Donny Ray ,  McDowell, Douglas D. ,  Rumbaugh, William A. ,  Clemens, John M.

IPC: G01N35/02

CPC classification number: G01N35/0095 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2300/042 ,  B01L2300/043 ,  B29C45/00 ,  B29K2995/0032 ,  B29L2023/22 ,  G01N21/03 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2035/00168 ,  G01N2035/00277 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: A liquid level sensing device for sensing the level of a liquid in a container and an automated, continuous and random access analytical system containing such liquid level sensing device and capable of simultaneously effecting multiple assays of a plurality of liquid samples are disclosed. The liquid level sensing device comprises: (a) means for producing an electrical sinusoidal signal; (b) means for evaluating the amount of signal as it propagates from a probe to a sense antenna; (c) circuit means for creating an electrical signal wherein said electrical signal changes when a probe contacts liquid; (d) signal processing means for enhancing the electrical signal and for degrading and suppressing signals not associated with the probe contacting said liquid; (e) decision circuit means for causing a basic digital output indicating either the presence or absence of liquid; and (f) means for utilizing the digital signal for controlling motion, and wherein said sensing device detects signal change and rate of signal change.

Abstract translation: 公开了一种用于感测容器中的液体水平的液面感测装置和包含这种液位感测装置并且能够同时进行多个液体样品的多次测定的自动连续和随机存取分析系统。 液位检测装置包括：（a）产生电正弦信号的装置; （b）用于在从探头传播到感测天线时评估信号量的装置; （c）用于产生电信号的电路装置，其中当探针接触液体时，所述电信号改变; （d）信号处理装置，用于增强电信号并降低和抑制与所述探头接触的所述液体不相关的信号; （e）用于使基本数字输出指示液体存在或不存在的判定电路装置; 和（f）用于利用数字信号来控制运动的装置，并且其中所述感测装置检测信号变化和信号变化率。

公开(公告)号：EP1205756A2

公开(公告)日：2002-05-15

申请号：EP02001046.8

申请日：1994-09-22

Applicant: Abbott Laboratories

Inventor： Clark, Frederick L. ,  Clemens, John M. ,  Hance, Robert B. ,  Hendrick, Kendall B. ,  Tayi, Apparao ,  Kanewske, William J., III ,  Lagocki, Peter A. ,  Martin, Richard R. ,  McDowell, Douglas D. ,  Merriam, Richard A. ,  Moore, Larry W. ,  Oleksak, Carl M. ,  Pennington, Charles D. ,  Raymoure, William J. ,  Rumbaugh, William D. ,  Schmidt, Linda S. ,  Schrier, Paul R. ,  Smith, Jane B. ,  Spronk, Adrian M. ,  Walker, Edna S. ,  Vaught, James A. ,  Vickstrom, Richard L. ,  Walker, Donny Ray ,  Watkins, William E., III ,  Winter, Gary E. ,  Wohlford, Robert A. ,  Clift, Gilbert ,  Cloonan, Kevin M. ,  Mitchell, James E. ,  Stanton, Alyn K. ,  Yost, David A. ,  Hills, David B.

IPC: G01N35/10

CPC classification number: G01N35/0092 ,  B01F11/0022 ,  B01L3/5025 ,  B29C45/00 ,  G01N21/6445 ,  G01N21/6452 ,  G01N21/76 ,  G01N33/5302 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2021/6482 ,  G01N2035/00148 ,  G01N2035/00356 ,  G01N2035/0405 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0446 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: The invention relates to an automated liquid level sensing system for detecting the presence of liquid in a container, said liquid level sensing system comprising: a vertically oriented, electrically conductive probe positioned above said container; means for vertically moving said probe into and out of said container; a signal source electrically connected to said probe, said signal source energizing said probe with an electrical signal and causing said probe to transmit said electrical signal; a receiving antenna positioned below said container for receiving said transmitted electrical signal; means for analyzing said received electrical signal for indications that said probe has contacted liquid in said container; means for transferring said received electrical signal from said receiving antenna to said analyzing means; and means for indicating that liquid has been detected. Further, the invention also provides for a method for automatically detecting the presence of liquid in a container, said method comprising the steps of: vertically positioning an electrically conductive probe above said container; vertically moving said probe into and out of said container; electrically connecting a signal source to said probe, said signal source energizing said probe with an electrical signal and causing said probe to transmit said electrical signal; positioning a receiving antenna below said container for receiving said transmitted electrical signal; analyzing said received electrical signal for indications that said probe has contacted liquid in said container; transferring said received electrical signal from said receiving antenna to said analyzing means; and indicating that liquid has been detected.

Abstract translation: 本发明涉及一种用于检测容器中液体存在的自动液位传感系统，所述液位传感系统包括：位于所述容器上方的垂直取向的导电探头; 垂直移动所述探针进出所述容器的装置; 信号源，其电连接到所述探针，所述信号源用电信号激励所述探针并且使所述探针传送所述电信号; 位于所述容器下方的接收天线，用于接收所述发射的电信号; 用于分析所述接收到的电信号以用于指示所述探针已经接触所述容器中的液体的装置; 用于将所述接收的电信号从所述接收天线传送到所述分析装置的装置; 以及用于指示已检测到液体的装置。 此外，本发明还提供了一种用于自动检测容器中液体存在的方法，所述方法包括以下步骤：在所述容器上方垂直放置导电探针; 垂直移动所述探针进出所述容器; 将信号源电连接到所述探头，所述信号源用电信号激励所述探头并使所述探头传送所述电信号; 将接收天线定位在所述容器下方用于接收所述传输的电信号; 分析所述接收的电信号以指示所述探针已接触所述容器中的液体; 将所述接收的电信号从所述接收天线传送到所述分析装置; 并指示已检测到液体。