公开(公告)号：EP1028320A2

公开(公告)日：2000-08-16

申请号：EP00108051.4

申请日：1994-09-22

Applicant: ABBOTT LABORATORIES

Inventor： Clark, Frederick L. ,  Clemens, John M. ,  Hance, Robert B. ,  Hendrick, Kendall B. ,  Tayi, Apparao ,  Kanewske, William J. III ,  Lagocki, Peter A. ,  Martin, Richard R. ,  McDowell, Douglas D. ,  Merriam, Richard A. ,  Moore, Larry W. ,  Oleksak, Carl M. ,  Pennington, Charles D. ,  Raymoure, William J. ,  Rumbaugh, William D. ,  Schmidt, Linda S. ,  Schrier, Paul R. ,  Smith B, Jane ,  Spronk, Adrian M. ,  Walker, Edna S. ,  Vaught, James A. ,  Vickstrom Richard L. ,  Walker, Donny Ray ,  Watkins, William E. III ,  Winter, Gary E. ,  Wohlford, Robert A. ,  Clift, Gilbert ,  Cloonan, Kevin M. ,  Mitchell, James E. ,  Stanton, Alyn K. ,  Yost, David A. ,  Hills, David B.

IPC: G01N35/02

CPC classification number: G01N35/0092 ,  B01F11/0022 ,  B01L3/5025 ,  B29C45/00 ,  G01N21/6445 ,  G01N21/6452 ,  G01N21/76 ,  G01N33/5302 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2021/6482 ,  G01N2035/00148 ,  G01N2035/00356 ,  G01N2035/0405 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0446 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: The present invention relates to a method of operating an automated, continuous and random access analytical system capable of simultaneously effecting multiple assays in a plurality of liquid samples, comprising the following steps: introducing sample cups, reagent packs, and reaction vessels for performing said assays onto concentric carousels of a front end carousel, the reaction vessels being introduced to an outer carousel; identifying the reagent packs and sample cups; scheduling the assays; aligning the sample cups and reagent packs with a reaction vessel at a kitting station by rotating the respective carousels; kitting a unit dose disposable in a reaction vessel having multiple independent open chambers in accordance with the scheduled assay by transfer of the sample from the sample cup to a reaction vessel chamber and transfer of specific reagents to separate reaction vessel chambers from the reagent pack; transferring the kitted reaction vessel to a process carousel which is maintained under controlled environment conditions; pipetting the sample and various reagents into a reaction well of the reaction vessel, the amounts of reagent, sequencing of transfer and time spacing therebetween being predetermined by assay scheduling; incubating the pipetted sample and reagent mix; identifying and transferring the incubated mixture in the reaction well to one of at least two assay analytical stations; performing an analysis by reading the prepared reaction mixture and calibrating the reading; and recording the resulting assay reading analysis.

Abstract translation: 本发明涉及的方法在自动化的，连续的和随机存取的分析能够同时 - 影响多个测定在液体样品的复数，包括以下步骤系统中操作：将样品杯，试剂包，并且反应容器用于进行所述测定 到前端转盘的同心旋转木马，反应容器被引入到在传送带外; 标识试剂袋和样品杯; 调度所述测定法; 通过旋转respectivement转盘对准样品杯和试剂袋与在备料站的反应容器; 备料的单位剂量在具有雅舞蹈多个独立的开放腔室与从所述样品杯的样品转移至反应容器腔室和特定的试剂从试剂包单独的反应容器室的传送被调度的测定的反应容器中一次性; 被控制的环境条件下保持转移环成套的反应容器中的处理转盘所有; 吸移样本和各种试剂到反应容器中的反应孔试剂，量，转移和时间通过测定调度被预先确定之间的间隔有的测序; 孵育所述移液样品和试剂混合物; 在反应识别和传递环保温的混合物以及至少两个化验分析站中的一个; 通过读取制备的反应混合物中，并校准读出执行的分析; 并记录所得到的测定读数的分析。