公开(公告)号：EP0821665A1

公开(公告)日：1998-02-04

申请号：EP96912978.0

申请日：1996-04-18

Applicant: Abbott Laboratories

Inventor： ARENDSEN, David, L. ,  BAKER, William, R. ,  FAKHOURY, Stephen, A. ,  FUNG, K., L., Anthony ,  GARVEY, David, S. ,  MCCLELLAN, William, J. ,  O'CONNOR, Stephen, J. ,  PRASAD, Rajnandan, N. ,  ROCKWAY, Todd, W. ,  ROSENBERG, Saul, H. ,  STEIN, Herman, H. ,  SHEN, Wang ,  STOUT, David, M. ,  SULLIVAN, Gerard, M. ,  AUGERI, David, J.

IPC: A61K31 ,  A61P3 ,  A61P9 ,  A61P31 ,  A61P35 ,  A61P43 ,  C07C233 ,  C07C235 ,  C07D271 ,  C07D285 ,  C07D333

CPC classification number: C07C235/82 ,  C07C233/58 ,  C07C233/59 ,  C07C233/60 ,  C07C235/40 ,  C07C2601/04 ,  C07D333/20

Abstract: The present invention provides a compound of formula (I) or (II) or a pharmaceutically acceptable salt thereof, which is useful for inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squalene production resulting in the inhibition of cholesterol biosynthesis, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.

公开(公告)号：EP1904047A2

公开(公告)日：2008-04-02

申请号：EP06774553.9

申请日：2006-07-07

Applicant: ABBOTT LABORATORIES

Inventor： WENDT, Michael, D. ,  SHEN, Wang ,  DICKMAN, Daniel, A. ,  DING, Hong ,  THOMAS, Sheela, A. ,  AUGERI, David ,  ELMORE, Steven, W.

IPC: A61K31/192 ,  C07C15/12 ,  A61P35/00

CPC classification number: C07C311/41 ,  C07C63/48 ,  C07C63/49 ,  C07C65/26 ,  C07C65/28 ,  C07C205/58 ,  C07C229/52 ,  C07C229/56 ,  C07C233/81 ,  C07C311/13 ,  C07C311/18 ,  C07C311/21 ,  C07C311/37 ,  C07C311/44 ,  C07C323/20 ,  C07C323/25 ,  C07C323/62 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/10 ,  C07C2603/18 ,  C07C2603/74 ,  C07D207/30 ,  C07D213/53 ,  C07D215/12 ,  C07D215/48 ,  C07D333/34

Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-I protein, compositions containing the compounds and methods of treating diseases during which are expressed the Mcl- 1 protein are disclosed.

公开(公告)号：EP1904047B1

公开(公告)日：2013-01-02

申请号：EP06774553.9

申请日：2006-07-07

Applicant: ABBOTT LABORATORIES

Inventor： WENDT, Michael, D. ,  SHEN, Wang ,  DICKMAN, Daniel, A. ,  DING, Hong ,  THOMAS, Sheela, A. ,  AUGERI, David ,  ELMORE, Steven, W.

IPC: A61K31/192 ,  C07C15/12 ,  A61P35/00

CPC classification number: C07C311/41 ,  C07C63/48 ,  C07C63/49 ,  C07C65/26 ,  C07C65/28 ,  C07C205/58 ,  C07C229/52 ,  C07C229/56 ,  C07C233/81 ,  C07C311/13 ,  C07C311/18 ,  C07C311/21 ,  C07C311/37 ,  C07C311/44 ,  C07C323/20 ,  C07C323/25 ,  C07C323/62 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/10 ,  C07C2603/18 ,  C07C2603/74 ,  C07D207/30 ,  C07D213/53 ,  C07D215/12 ,  C07D215/48 ,  C07D333/34