公开(公告)号：WO2005049593A2

公开(公告)日：2005-06-02

申请号：PCT/US2004/036770

申请日：2004-11-03

Applicant: ABBOTT LABORATORIES ,  BRUNCKO, Milan ,  ELMORE, Steven ,  KUNZER, Aaron, R. ,  LYNCH, Christopher, L. ,  WANG, Xilu ,  WENDT, Michael, D.

Inventor： BRUNCKO, Milan ,  ELMORE, Steven ,  KUNZER, Aaron, R. ,  LYNCH, Christopher, L. ,  WANG, Xilu ,  WENDT, Michael, D.

IPC: C07D295/14

CPC classification number: C07D277/74 ,  C04B35/632 ,  C07C323/25 ,  C07C2601/16 ,  C07D205/04 ,  C07D207/16 ,  C07D211/46 ,  C07D211/60 ,  C07D211/74 ,  C07D213/70 ,  C07D213/75 ,  C07D233/06 ,  C07D233/84 ,  C07D239/06 ,  C07D263/58 ,  C07D277/36 ,  C07D295/13 ,  C07D295/192 ,  C07D307/64 ,  C07D335/02 ,  C07D401/12 ,  C07D403/04 ,  C07D409/12 ,  C07D487/04 ,  C07D487/08

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which are expressed one or more than one of an anti apoptotic protein family member.

Abstract translation: 公开了抑制抗凋亡蛋白质家族成员的活性的化合物，含有该化合物的组合物和该化合物用于制备用于治疗疾病的药物的用途，在该疾病期间表达一种或多种抗 - 凋亡蛋白家族成员。

公开(公告)号：WO2007008627A3

公开(公告)日：2007-01-18

申请号：PCT/US2006/026424

申请日：2006-07-07

Applicant: ABBOTT LABORATORIES ,  WENDT, Michael, D. ,  SHEN, Wang ,  DICKMAN, Daniel, A. ,  DING, Hong ,  THOMAS, Sheela, A. ,  AUGERI, David ,  ELMORE, Steven, W.

Inventor： WENDT, Michael, D. ,  SHEN, Wang ,  DICKMAN, Daniel, A. ,  DING, Hong ,  THOMAS, Sheela, A. ,  AUGERI, David ,  ELMORE, Steven, W.

IPC: A61K31/192 ,  C07C15/12 ,  A61P35/00

Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-I protein, compositions containing the compounds and methods of treating diseases during which are expressed the Mcl- 1 protein are disclosed.

公开(公告)号：WO2011068561A1

公开(公告)日：2011-06-09

申请号：PCT/US2010/036919

申请日：2010-06-01

Applicant: ABBOTT LABORATORIES ,  BRUNCKO, Milan ,  DING, Hong ,  DOHERTY, George A. ,  ELMORE, Steven, W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron ,  MANTEI, Robert, A. ,  McCLELLAN, William, J. ,  PARK, Chang, H. ,  PARK, Cheol-Min ,  PETROS, Andrew, M. ,  SONG, Xiaohong ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard, M. ,  TAO, Zhi-Fu ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael, D. ,  HANSEN, Todd, M.

Inventor： BRUNCKO, Milan ,  DING, Hong ,  DOHERTY, George A. ,  ELMORE, Steven, W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron ,  MANTEI, Robert, A. ,  McCLELLAN, William, J. ,  PARK, Chang, H. ,  PARK, Cheol-Min ,  PETROS, Andrew, M. ,  SONG, Xiaohong ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard, M. ,  TAO, Zhi-Fu ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael, D. ,  HANSEN, Todd, M.

IPC: C07D405/12 ,  A61K31/404 ,  A61P35/00 ,  C07D209/32 ,  C07D211/96 ,  C07D213/64 ,  C07D215/20 ,  C07D217/16 ,  C07D235/26 ,  C07D249/04 ,  C07D295/14 ,  C07D309/14 ,  C07D401/12 ,  C07D295/125 ,  C07D231/56 ,  C07D405/14

CPC classification number: C07D401/12 ,  A61K31/407 ,  A61K31/495 ,  A61K31/496 ,  A61K31/501 ,  A61K31/5377 ,  A61K45/06 ,  C07D209/08 ,  C07D209/32 ,  C07D211/58 ,  C07D211/96 ,  C07D213/64 ,  C07D215/20 ,  C07D217/16 ,  C07D231/56 ,  C07D235/26 ,  C07D241/04 ,  C07D249/04 ,  C07D295/125 ,  C07D295/14 ,  C07D295/155 ,  C07D309/04 ,  C07D309/14 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/06 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

Abstract: Disclosed are compounds (I) which inhibit the activity of anti-apoptotic Bc1-2 or Bc1 xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti apoptotic Bc1-2 protein.

Abstract translation: 公开了抑制抗凋亡Bc1-2或Bc1 xL蛋白活性的化合物（I），含有该化合物的组合物和治疗其中表达抗凋亡Bc1-2蛋白的疾病的方法。

公开(公告)号：WO2010083442A1

公开(公告)日：2010-07-22

申请号：PCT/US2010/021245

申请日：2010-01-15

Applicant: ABBOTT LABORATORIES ,  KUNZER, Aaron, R. ,  ELMORE, Steven, W. ,  HEXAMER, Laura ,  PARK, Cheol-Min ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard, M. ,  WANG, Gary, T. ,  WANG, Xilu ,  WENDT, Michael, D.

Inventor： KUNZER, Aaron, R. ,  ELMORE, Steven, W. ,  HEXAMER, Laura ,  PARK, Cheol-Min ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard, M. ,  WANG, Gary, T. ,  WANG, Xilu ,  WENDT, Michael, D.

IPC: C07C311/51 ,  C07D207/36 ,  C07D211/96 ,  C07D231/18 ,  C07D261/10 ,  C07D275/03 ,  C07D277/36 ,  C07D333/34 ,  C07D285/135 ,  C07D295/155 ,  C07D285/125 ,  C07D295/26 ,  A61K31/18 ,  A61P35/00

CPC classification number: C07D277/54 ,  C07C311/00 ,  C07C311/51 ,  C07D207/36 ,  C07D211/96 ,  C07D231/18 ,  C07D261/10 ,  C07D275/03 ,  C07D277/36 ,  C07D277/60 ,  C07D285/125 ,  C07D285/135 ,  C07D295/155 ,  C07D295/26 ,  C07D333/34 ,  C07D333/36 ,  C07D333/42 ,  C07D333/62 ,  C07D409/12 ,  C07D413/04 ,  C07D413/06 ,  C07D417/14 ,  C07D487/04 ,  C07D513/04

Abstract: Disclosed are compounds of Formula (1), in which A 1 , Z 1 , Z 1A , Z 2 , Z 2A , L 1 and Z 3 are as defined in the claims, which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and their use in treating diseases during which anti-apoptotic Bcl-2 protein is expressed.

Abstract translation: 公开了式（1）的化合物，其中A1，Z1，Z1A，Z2，Z2A，L1和Z3如权利要求中所定义，其抑制抗凋亡Bcl-2蛋白的活性，含有这些化合物的组合物及其 用于治疗抗凋亡Bcl-2蛋白表达的疾病。

公开(公告)号：WO2008131000A2

公开(公告)日：2008-10-30

申请号：PCT/US2008/060472

申请日：2008-04-16

Applicant: ABBOTT LABORATORIES ,  ELMORE, Steven, W. ,  SOUERS, Andrew, J. ,  BRUNCKO, Milan ,  SONG, Xiaohong ,  WANG, Xilu ,  HASVOLD, Lisa, A. ,  WANG, Le ,  KUNZER, Aaron, R. ,  PARK, Cheol-min ,  WENDT, Michael, D. ,  TAO, Zhi-fu

Inventor： ELMORE, Steven, W. ,  SOUERS, Andrew, J. ,  BRUNCKO, Milan ,  SONG, Xiaohong ,  WANG, Xilu ,  HASVOLD, Lisa, A. ,  WANG, Le ,  KUNZER, Aaron, R. ,  PARK, Cheol-min ,  WENDT, Michael, D. ,  TAO, Zhi-fu

IPC: C07D209/34 ,  C07D401/12 ,  C07D413/06 ,  C07D417/04 ,  A61P35/00 ,  A61K31/404

CPC classification number: C07D209/42 ,  A61K31/5377 ,  C07D209/34 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D491/113

Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.

Abstract translation: 公开了抑制抗细胞凋亡Mcl-1蛋白活性的化合物，含有该化合物的组合物以及治疗涉及过表达或未调节的Mcl-1蛋白的疾病的方法。

公开(公告)号：WO1998024791A1

公开(公告)日：1998-06-11

申请号：PCT/US1997022279

申请日：1997-12-04

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  MEYER, Michael, D. ,  ALTENBACH, Robert, J. ,  BASHA, Fatima ,  CARROLL, William, A. ,  DRIZIN, Irene ,  KERWIN, James, F. ,  WENDT, Michael, D. ,  HAIGHT, Anthony, R. ,  ZHANG, Weijiang

IPC: C07D491/04

CPC classification number: C07D491/04

Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 adrenoreceptors and treating BPH.

Abstract translation: 本发明涉及式（I）化合物及其药学上可接受的盐，其中W是双环杂环体系。 该化合物是α-1肾上腺素能拮抗剂，可用于治疗BPH; 还公开了α-1拮抗剂组合物和拮抗α-1肾上腺素受体并治疗BPH的方法。

公开(公告)号：WO1996022992A1

公开(公告)日：1996-08-01

申请号：PCT/US1996000072

申请日：1996-01-11

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  MEYER, Michael, D. ,  ALTENBACH, Robert, J. ,  BASHA, Fatima, Z. ,  CARROLL, William, A. ,  DRIZIN, Irene ,  KERWIN, James, F., Jr. ,  LEBOLD, Suzanne, A. ,  LEE, Edmund, L. ,  ELMORE, Steven, W. ,  SIPPY, Kevin, B. ,  TIETJE, Karin, R. ,  WENDT, Michael, D. ,  YAMAMOTO, Diane, M.

IPC: C07D495/04

CPC classification number: C07D403/06 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D491/04 ,  C07D491/14 ,  C07D495/04 ,  C07D495/14

Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

Abstract translation: 本发明涉及式（I）化合物及其药学上可接受的盐，其中W是三环杂环体系; 其是α-1肾上腺素能拮抗剂，可用于治疗BPH; 还公开了α-1拮抗剂组合物和拮抗α-1受体并治疗BPH的方法。

公开(公告)号：WO2010083441A2

公开(公告)日：2010-07-22

申请号：PCT/US2010/021243

申请日：2010-01-15

Applicant: ABBOTT LABORATORIES ,  HEXAMER, Laura ,  DING, Hong ,  ELMORE, Steven, W. ,  KUNZER, Aaron, R. ,  SONG, Xiaohong ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard, M. ,  TAO, Zhi-fu ,  WENDT, Michael, D.

Inventor： HEXAMER, Laura ,  DING, Hong ,  ELMORE, Steven, W. ,  KUNZER, Aaron, R. ,  SONG, Xiaohong ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard, M. ,  TAO, Zhi-fu ,  WENDT, Michael, D.

IPC: C07D209/08 ,  C07D213/71 ,  C07D231/56 ,  C07D235/04 ,  C07D265/02 ,  C07D285/14

CPC classification number: C07D295/155 ,  C07D209/08 ,  C07D213/71 ,  C07D231/56 ,  C07D235/04 ,  C07D265/02 ,  C07D285/14 ,  C07D311/14

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：WO2010065865A2

公开(公告)日：2010-06-10

申请号：PCT/US2009/066790

申请日：2009-12-04

Applicant: ABBOTT LABORATORIES ,  BRUNCKO, Milan ,  DING, Hong ,  DOHERTY, George, A. ,  ELMORE, Steven, W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron, R. ,  MANTEI, Robert, A. ,  MCCLELLAN, William, J. ,  PARK, Chang, H. ,  PARK, Cheol-min ,  PETROS, Andrew, M. ,  SONG, Xiaohong ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard, M. ,  TAO, Zhi-fu ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael, D.

Inventor： BRUNCKO, Milan ,  DING, Hong ,  DOHERTY, George, A. ,  ELMORE, Steven, W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron, R. ,  MANTEI, Robert, A. ,  MCCLELLAN, William, J. ,  PARK, Chang, H. ,  PARK, Cheol-min ,  PETROS, Andrew, M. ,  SONG, Xiaohong ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard, M. ,  TAO, Zhi-fu ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael, D.

IPC: C07D405/12 ,  A61K31/404 ,  A61P35/00

CPC classification number: C07D405/12 ,  C07D209/32 ,  C07D211/96 ,  C07D213/64 ,  C07D215/20 ,  C07D217/16 ,  C07D231/56 ,  C07D235/26 ,  C07D249/04 ,  C07D295/125 ,  C07D295/14 ,  C07D309/14 ,  C07D401/12 ,  C07D417/12

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.

Abstract translation: 公开了抑制抗凋亡Bcl-2或Bcl-xL蛋白的活性的化合物，含有该化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。

公开(公告)号：WO2010065824A2

公开(公告)日：2010-06-10

申请号：PCT/US2009/066722

申请日：2009-12-04

Applicant: ABBOTT LABORATORIES ,  BRUNCKO, Milan ,  DAI, Yujia ,  DING, Hong ,  DOHERTY, George, A. ,  ELMORE, Steven, W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron, R. ,  MANTEI, Robert, A. ,  MCCLELLAN, William, J. ,  PARK, Chang, H. ,  PARK, Cheol-Min ,  PETROS, Andrew, M. ,  SONG, Xiaohong ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard, M. ,  TAO, Zhi-Fu ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael, D.

Inventor： BRUNCKO, Milan ,  DAI, Yujia ,  DING, Hong ,  DOHERTY, George, A. ,  ELMORE, Steven, W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron, R. ,  MANTEI, Robert, A. ,  MCCLELLAN, William, J. ,  PARK, Chang, H. ,  PARK, Cheol-Min ,  PETROS, Andrew, M. ,  SONG, Xiaohong ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard, M. ,  TAO, Zhi-Fu ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael, D.

IPC: A61P35/00 ,  A61K31/496 ,  C07D403/12

CPC classification number: C07D405/12 ,  C07D209/08 ,  C07D211/58 ,  C07D213/74 ,  C07D213/84 ,  C07D231/56 ,  C07D235/06 ,  C07D277/24 ,  C07D295/30 ,  C07D309/04 ,  C07D401/14 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。