公开(公告)号：HUE035188T2

公开(公告)日：2018-05-02

申请号：HUE10859431

申请日：2010-11-12

Applicant: ACADEMIA SINICA

Inventor： LIN YUN-LIAN ,  CHERN YIJUANG ,  FANG JIM-MIN ,  LIN JUNG-HSING ,  HUANG NAI-KUEI

IPC: A61K31/56 ,  A61P11/06

公开(公告)号：AU2014340114A1

公开(公告)日：2016-05-26

申请号：AU2014340114

申请日：2014-10-22

Applicant: ACADEMIA SINICA

Inventor： FANG JIM-MIN ,  LIN YUN-LIAN ,  LIN JUNG-HSIN ,  LIN CHUN-JUNG ,  CHERN YIJUANG ,  HUANG NAI-KUEI ,  WANG HUNG-LI ,  TU BENJAMIN PANG-HSIEN ,  CHEN CHIH-CHENG

IPC: C07D498/02 ,  C07D515/02

Abstract: Compounds for use in prevention and treatment of neurodegenerative disease and pain are disclosed. In one embodiment of the invention, the compound is selected from the group consisting of

公开(公告)号：EP2849566A4

公开(公告)日：2015-08-19

申请号：EP13746079

申请日：2013-02-11

Applicant: ACADEMIA SINICA

Inventor： CHEN CHIH-CHENG ,  LIN YUN-LIAN ,  FANG JIM-MIN ,  CHERN YIJUANG ,  LIN CHIA-CHING JOHN ,  CHEN WEI-NAN ,  LIN CHUN-JUNG

IPC: A01N43/04 ,  A61K31/70 ,  A61P25/04 ,  A61P29/02

CPC classification number: A61K31/7076 ,  A61K36/8988 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention provides a new use of adenosine analogs for the treatment of pain through activation of neurokinin 1 (NK1) receptor signaling pathway, thereby inducing the activation of activation of M-type potassium channel to induce outward currents. A method and pharmaceutical composition for treating pain comprising an adenonsine analog that activates NK1 receptor signaling, thereby inducing outward current are also provided.

Abstract translation: 本公开提供了腺苷类似物用于通过激活神经激肽1（NK1）受体信号传导途径治疗疼痛的新用途，从而诱导M型钾通道的活化以诱导向外的电流。 还提供了用于治疗疼痛的方法和药物组合物，其包含激活NK1受体信号传导的腺苷类似物，从而诱导外向电流。

公开(公告)号：EP2498774A4

公开(公告)日：2013-04-17

申请号：EP10859431

申请日：2010-11-12

Applicant: ACADEMIA SINICA

Inventor： LIN YUN-LIAN ,  CHERN YIJUANG ,  FANG JIM-MIN ,  LIN JUNG-HSING ,  HUANG NAI-KUEI

IPC: C07H19/167 ,  A61K31/426 ,  A61K31/56 ,  A61P11/06

CPC classification number: A61K31/7076 ,  C07H19/167