公开(公告)号：AU2016204276A1

公开(公告)日：2016-07-14

申请号：AU2016204276

申请日：2016-06-23

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  MA CHE ,  TSENG YUNG-CHIEH

IPC: C12P21/06 ,  C12N15/09

Abstract: Methods for production of virus particles with simplified glycosylation on structural or surface proteins are provided. When used as targets for vaccine production, the conserved nature of such sites generates vaccines that are less sensitive to viral mutations. Use of glycosylation inhibitors for production of viruses with simplified glycosylation profiles are disclosed. An exemplary disclosure of influenza viruses and methods for production of mono-glycosylated influenza virus particles is provided. Methods for production of mono-glycosylated forms of influenza A virus, NIBRG-1 4 (H5N1) are provided.

公开(公告)号：AU2011323141B2

公开(公告)日：2016-04-07

申请号：AU2011323141

申请日：2011-11-04

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  MA CHE ,  TSENG YUNG-CHIEH

IPC: C12P21/06 ,  C12N15/09

Abstract: Methods for production of virus particles with simplified glycosylation on structural or surface proteins are provided. When used as targets for vaccine production, the conserved nature of such sites generates vaccines that are less sensitive to viral mutations. Use of glycosylation inhibitors for production of viruses with simplified glycosylation profiles are disclosed. An exemplary disclosure of influenza viruses and methods for production of mono-glycosylated influenza virus particles is provided. Methods for production of mono-glycosylated forms of influenza A virus, NIBRG-14 (H5N1) are provided.

公开(公告)号：AU2011323141A1

公开(公告)日：2013-06-27

申请号：AU2011323141

申请日：2011-11-04

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  MA CHE ,  TSENG YUNG-CHIEH

IPC: C12P21/06 ,  C12N15/09

Abstract: Methods for production of virus particles with simplified glycosylation on structural or surface proteins are provided. When used as targets for vaccine production, the conserved nature of such sites generates vaccines that are less sensitive to viral mutations. Use of glycosylation inhibitors for production of viruses with simplified glycosylation profiles are disclosed. An exemplary disclosure of influenza viruses and methods for production of mono-glycosylated influenza virus particles is provided. Methods for production of mono-glycosylated forms of influenza A virus, NIBRG-14 (H5N1) are provided.

公开(公告)号：EP2635693A4

公开(公告)日：2014-05-07

申请号：EP11838917

申请日：2011-11-04

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  MA CHE ,  TSENG YUNG-CHIEH

IPC: C12P21/06 ,  C12N15/09

CPC classification number: C12P21/005 ,  A61K39/12 ,  A61K39/145 ,  C07K14/005 ,  C12N7/00 ,  C12N2760/16111 ,  C12N2760/16121 ,  C12N2760/16123 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12Y302/01096 ,  G01N2333/00 ,  G01N2333/11 ,  Y02P20/52

Abstract: Methods for producing virus particles with simplified glycosylation on structural or surface proteins, such as mono-glycosylated forms of influenza A virus, NIBRG-14 (H5N1). When used as targets for vaccine production, the conserved nature of such sites generates vaccines that are less sensitive to viral mutations. Such methods may include the use of glycosylation inhibitors for production of viruses with simplified glycosylation profiles.

Abstract translation: 用于在结构或表面蛋白上产生简单糖基化的病毒颗粒的方法，例如甲型流感病毒的单糖基化形式，NIBRG-14（H5N1）。 当用作疫苗生产的目标时，这些位点的保守性质产生对病毒突变较不敏感的疫苗。 这样的方法可以包括使用糖基化抑制剂来生产具有简化的糖基化谱的病毒。