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    METHODS AND COMPOSITIONS FOR IMMUNIZATION AGAINST VIRUS
    3.
    发明申请
    METHODS AND COMPOSITIONS FOR IMMUNIZATION AGAINST VIRUS 审中-公开
    用于免疫病毒的方法和组合物

    公开(公告)号：WO2010111687A3

    公开(公告)日：2012-07-05

    申请号：PCT/US2010028968

    申请日：2010-03-26

    Applicant: ACADEMIA SINICA ,  WONG CHI-HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

    Inventor： WONG CHI-HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

    IPC: A61K39/12

    CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K2039/55505 ,  C07K16/1018 ,  C07K2317/76 ,  C12N7/00 ,  C12N2740/11034 ,  C12N2740/16034 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16171 ,  C12N2770/24134

    Abstract: Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.

    Abstract translation: 提供了包含部分糖基化的病毒糖蛋白的免疫原性组合物，其用作抗病毒疫苗。 使用单糖，二糖或三糖基化的病毒表面糖蛋白和多肽配制的疫苗甚至可以跨毒株提供有效和广泛的防病毒保护。 公开了包含单糖基化血凝素多肽和由其产生的疫苗的药物组合物及其用于预防或治疗病毒感染的方法。 公开了用于流感病毒HA，NA和M2，RSV蛋白F，G和SH，登革病毒糖蛋白M或E，丙型肝炎病毒糖蛋白E1或E2和HIV糖蛋白gp120和gp41的方法和组合物。

    Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
    4.
    发明专利
    Compositions and methods relating to universal glycoforms for enhanced antibody efficacy 未知

    公开(公告)号：AU2021200644A1

    公开(公告)日：2021-03-04

    申请号：AU2021200644

    申请日：2021-02-02

    Applicant: ACADEMIA SINICA

    Inventor： WU CHUNG-YI ,  MA CHE ,  WONG CHI-HUEY

    IPC: C07K16/28

    Abstract: The present disclosure relates to glycoproteins, particularly monoclonal antibodies, comprising a gly-coengineered Fc region, wherein said Fe region comprises an optimized N glycan having the structure of Sia2(a2 - 6)Gal2GlcNAc2Man 3GlcNAc2 . The glycoengineered Fe region binds FcyRIIA or FeyRIIIA with a greater affinity, relative to comparable monoclonal antibodies comprising the wild-type Fe region. The monoclonal antibodies of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by FcyR is desired, e.g., cancer, autoimmune, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC.

    COMPOSITIONS AND METHODS RELATING TO UNIVERSAL GLYCOFORMS FOR ENHANCED ANTIBODY EFFICACY
    7.
    发明专利
    COMPOSITIONS AND METHODS RELATING TO UNIVERSAL GLYCOFORMS FOR ENHANCED ANTIBODY EFFICACY 未知

    公开(公告)号：CA2950423A1

    公开(公告)日：2015-12-03

    申请号：CA2950423

    申请日：2015-05-27

    Applicant: ACADEMIA SINICA

    Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  MA CHE

    IPC: C07K16/28

    Abstract: The present disclosure relates to glycoproteins, particularly monoclonal antibodies, comprising a glycoengineered Fc region, wherein said Fc region comprises an optimized N-glycan having the structure of Sia2(a2-6)Gal2GlcNAc2Man3GlcNAc2. The glycoengineered Fc region binds Fc?RIIA or Fc?RIIIA with a greater affinity, relative to comparable monoclonal antibodies comprising the wild-type Fc region. The monoclonal antibodies of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by Fc?R is desired, e.g., cancer, autoimmune, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC.

    Métodos para producir partículas de virus con glucosilación simplificada de proteínas de superficie
    8.
    发明专利
    Métodos para producir partículas de virus con glucosilación simplificada de proteínas de superficie 未知

    公开(公告)号：CO6781543A2

    公开(公告)日：2013-10-31

    申请号：CO13111806

    申请日：2013-05-03

    Applicant: ACADEMIA SINICA

    Inventor： WONG CHI HUEY ,  MA CHE ,  TSENG YUNG-CHIEH

    IPC: C12P21/06

    Abstract: Se proporcionan métodos para producción de partículas de virus con glucosilación simplificada en proteínas estructurales o de superficie. Cuando se utilizan como objetivos para producción de vacunas, la naturaleza conservada de dichos sitios genera vacunas que son más sensibles a mutaciones víricas. Se describe el uso de inhibidores de glucosilación para producción de virus con perfiles de glucosilación simplificados. Se proporciona una descripción de ejemplo de los virus de la influenza y métodos para producción de partículas de virus de influenza monoglucosilada. Se proporcionan métodos para producción de formas monoglucosiladas de virus de influenza A, NIBRG-14 (H5N1).

    métodos para produzir partículas virais com glicosilação simplificada de proteínas de superfície.
    10.
    发明专利
    métodos para produzir partículas virais com glicosilação simplificada de proteínas de superfície. 未知

    公开(公告)号：BR112013011198A2

    公开(公告)日：2016-07-05

    申请号：BR112013011198

    申请日：2011-11-04

    Applicant: ACADEMIA SINICA

    Inventor： MA CHE ,  WONG CHI-HUEY ,  TSENG YUNG-CHIEH

    IPC: C12N15/09 ,  C12P21/06

    Abstract: métodos para produzir partículas virais com glicosilação simplificada de proteínas de superfície. os métodos para a produção de partículas de vírus com a glicosilação simplificada em proteínas estruturais ou de superfície são fornecidos. quando usados como alvos para a produção de vacinas, a natureza conservada de tais locais gera vacinas que são menos sensíveis às mutações virais. o uso de inibidores de glicosilação para a produção de vírus com perfis de glicosilação simplificados são divulgados. uma divulgação exemplar dos vírus influenza e métodos para a produção de partículas de vírus influenza monoglicosilado ser fornecido. os métodos para a produção de formas de monoglicosilado de vírus influenza a, nibrg-14 (h5n1) são fornecidos.

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