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    PRODUCTION OF METHYL-ALPHA-D-GLUCOSIDE-6-MONOFATTY ACID ESTER
    12.
    发明专利
    PRODUCTION OF METHYL-ALPHA-D-GLUCOSIDE-6-MONOFATTY ACID ESTER 失效

    公开(公告)号：JPH03109395A

    公开(公告)日：1991-05-09

    申请号：JP24860389

    申请日：1989-09-25

    Applicant: AGENCY IND SCIENCE TECHN

    Inventor： GAMA YASUO ,  KAMATA TOSHIHIRO ,  ISHIGAMI YUTAKA

    IPC: C07H13/06 ,  C07H1/00 ,  C07H15/04

    Abstract: PURPOSE:To simply obtain the title ester useful as a nonionic surfactant having protein solubilizing ability by treating methyl-alpha-D-glucoside and fatty acid with oxidation-reduction condensing method. CONSTITUTION:(A) Methyl-alpha-D-glucoside expressed by formula I and (B) fatty acid are treated by oxidation-reduction condensation method (2,2'- dipyridyldisulfide/triphenylphosphin) to provide the ester expressed by formula II (R is fatty acid residue). Furthermore, the above-mentioned reaction is preferably carried out using the ingredient B at an amount of 1.2-1.5mol based on 1mol ingredient A and using pyridine as the reaction solvent at 100 deg.C for 8-10hr.

    LIPOSOME
    15.
    发明专利
    LIPOSOME 失效

    公开(公告)号：JPS63182029A

    公开(公告)日：1988-07-27

    申请号：JP1312287

    申请日：1987-01-22

    Applicant: AGENCY IND SCIENCE TECHN ,  SHINETSU CHEMICAL CO

    Inventor： ISHIGAMI YUTAKA ,  GAMA YASUO ,  NAGAHORA HITOSHI ,  MOTOMIYA TATSUHIKO ,  YAMAGUCHI MUNEO

    IPC: C12N15/09 ,  A61K8/14 ,  A61K8/60 ,  A61K9/127 ,  A61Q19/00 ,  B01J13/02 ,  C07H15/10 ,  C12N1/00 ,  C12N15/00 ,  C12P19/44

    Abstract: PURPOSE:To obtain liposome which is fine, stable and capable of use for biological applications by forming a wall film consisting of substance selected from among rhamnolipid A, rhamnolipid B and their neutral salts. CONSTITUTION:Rhamnolipid A and rhamnolipid B shown in a formula I and a formula II are a microbe-derived biosurfactant and are one kind of glycolipids. These perform the conversion of a molecular association type reversible among micell-droplet-lamella-vehicle (closed follicle) which is dependent on pH. In other words, a micell is formed at pH not less than 6.8 (complete neutral salt) and a lamella-shape is formed at 6.5-6.0pH and they are converted into a vehicle at 5.8-4.3pH. Liposome is formed from rhamnolipid A and rhamnolipid B by a well-known method by utilizing these properties. The obtained liposome is fine and stable and can be used for biological applications.

    POLYBASIC ACID POLYOXYALKYLENE GLYCOL ESTER TYPE SURFACE ACTIVE AGENT
    16.
    发明专利
    POLYBASIC ACID POLYOXYALKYLENE GLYCOL ESTER TYPE SURFACE ACTIVE AGENT 失效

    公开(公告)号：JPS61146330A

    公开(公告)日：1986-07-04

    申请号：JP26597884

    申请日：1984-12-17

    Applicant: AGENCY IND SCIENCE TECHN

    Inventor： ISHIGAMI YUTAKA ,  YAMAZAKI SHINSUKE ,  GAMA YASUO

    IPC: B01F17/42 ,  B01F17/44 ,  C07C69/675 ,  C07C235/06

    Abstract: PURPOSE:To improve solubilizing power and emulsifying and dispersing effects for solid fine powder and several substances by prepg. a surface active agent from at least one compd. selected from three kinds of compds. expressed by the specified general formulas. CONSTITUTION:The surface active agent is prepd. from at least one compd. selected from compds. expressed by formula I (wherein X and X are polyoxyalkylene group, alkylamino group, alkoxy group, etc.; one of X and X is polyoxyalkylene group), from compds. expressed by formula II (wherein Y , Y and Y are polyoxyalkylene group, alkylamino group, etc.; at least one of the three is polyoxyalkylene group), and from compds. expressed by formula III (wherein Z , Z and Z are polyoxyalkylene group, alkylamino group, etc.; at least one of the three is polyoxyalkylene group).

    DERIVATIVE OF 1,2-BENZISOTHIAZOLIN-3-ONE AND ITS PREPARATION
    17.
    发明专利
    DERIVATIVE OF 1,2-BENZISOTHIAZOLIN-3-ONE AND ITS PREPARATION 失效

    公开(公告)号：JP2001019684A

    公开(公告)日：2001-01-23

    申请号：JP19513699

    申请日：1999-07-08

    Applicant: AGENCY IND SCIENCE TECHN

    Inventor： SHIMIZU MASAO ,  SHIBUYA ISAO ,  GAMA YASUO ,  SHIBAUE MOTONARI ,  TAKAGI TOSHIYUKI

    IPC: C07D275/04 ,  A61K31/428 ,  A61K31/431 ,  A61P31/04 ,  C07D417/12

    Abstract: PROBLEM TO BE SOLVED: To obtain a derivative of 1,2-benzothiazolin-3-one having various bioactivities, producible in an industrially profitable method overcoming a defect of using toxic chlorine gas for preparation of a starting raw material. SOLUTION: This compound is expressed by formula I (R1 to R4 are each H or a substituent; Ar is an aromatic substituent), e.g. a compound expressed by formula II. The compound of formula I is obtained, for example, in a method, etc., reacting (A) a 1,2-benzisothiazoline-3-one compound of formula III having no substituent at the 2-position, and (B) a sulfenamide compound of the formula: Ar-S-NH2 having N-S bond which is relatively easy to cleave, in (C) a reaction solvent if necessary, preferably at 50-150 deg.C, more preferably at 80-120 deg.C, for 2-12 hours. Ethyl 2-sulfenamoylbenzoate, isopropyl 2-sulfenamoylbenzoate, ethyl 2-sulfenamoylpyridine-3-carboxylate, etc., are enumerated as the component B.

    PRODUCTION OF KETENEIMIDE COMPOUND
    18.
    发明专利
    PRODUCTION OF KETENEIMIDE COMPOUND 失效

    公开(公告)号：JP2000256296A

    公开(公告)日：2000-09-19

    申请号：JP5571299

    申请日：1999-03-03

    Applicant: AGENCY IND SCIENCE TECHN

    Inventor： SHIMIZU MASAO ,  SHIBUYA ISAO ,  GAMA YASUO

    IPC: C07D311/82 ,  C07C249/02 ,  C07C251/16

    Abstract: PROBLEM TO BE SOLVED: To produce the subject compound in high yield under mild conditions by reacting a specific thioamide compound with a dehydrosulfurizing agent comprising a specified haloiminium salt. SOLUTION: (A) A thioamide compound represented by formula I (Ar1 and Ar2 are each an aryl and Ar1 and Ar2 may each be bonded) is reacted with (B) a dehydrosulfurizing agent comprising a haloiminium salt represented by formula II (R1 and R2 are each a lower alkyl; X is a halogen; Y is a counteranion; and (n) is 0 or 1) in the presence of (C) a base (e.g. triethylamine) and (D), as necessary, in a reactional solvent, preferably at -30 to +100 deg.C, more preferably 0-60 deg.C for 30 min to 3 h to produce the objective compound (e.g. a compound represented by formula IV). 2-Chloro-1,3-dimethylimidazolinium chloride, 2-chloro-1,3-dimethyl-3,4,5,6-tetrahydropyrimidinium chloride, etc. are cited as the component B.

    PRODUCTION OF QUINAZOLINE DERIVATIVE OR SALT THEREOF
    19.
    发明专利
    PRODUCTION OF QUINAZOLINE DERIVATIVE OR SALT THEREOF 失效

    公开(公告)号：JP2000229950A

    公开(公告)日：2000-08-22

    申请号：JP3384399

    申请日：1999-02-12

    Applicant: AGENCY IND SCIENCE TECHN

    Inventor： SHIBUYA ISAO ,  GAMA YASUO ,  SHIMIZU MASAO ,  OISHI AKIHIRO

    IPC: C07D239/94 ,  B01J27/10 ,  C07B61/00 ,  C07D239/70 ,  C07D239/95

    Abstract: PROBLEM TO BE SOLVED: To efficiently obtain in a simple operation the subject compound useful as an intermediate material for medicaments, agrochemicals, etc., by desulfurization reaction between an arylthiocarbamoyl compound and a disubstituted cyanamide compound in the presence of a metal salt. SOLUTION: This compound of formula II is obtained by desulfurization reaction between an N-arylthiocarbamoyl compound of formula I (R1 is an inert substituent; R2 is a hydrocarbon group; and (n) is 0-4) and an N,N- disubstituted cyanamide compound of the formula: NC-N-(R3)2 (R3 is a hydrocarbon group) in the presence of a metal salt (e.g. a silver salt of a strong acid such as perchloric acid, trifluoromethanesulfonic acid, trifluoroacetic acid or fluoroboric acid). The above reaction is carried out preferably as follows: >=2 equivalents, based on the compound of formula I, of the disubstituted cyanamide is dissolved in an organic solvent such as acetonitrile, dioxane, benzene, toluene or N,N-dimethylformamide followed by addition of >=2 equivalents of the metal salt, and the resulting system is agitated at room temperature and also, as necessary, heated.

    PRODUCTION OF 1,3-BENZODIOXAN-4-ONE COMPOUND
    20.
    发明专利
    PRODUCTION OF 1,3-BENZODIOXAN-4-ONE COMPOUND 失效

    公开(公告)号：JPH11209369A

    公开(公告)日：1999-08-03

    申请号：JP1031098

    申请日：1998-01-22

    Applicant: AGENCY IND SCIENCE TECHN

    Inventor： SHIBUYA ISAO ,  GAMA YASUO ,  SHIMIZU MASAO

    IPC: C07D319/08 ,  C07D493/10 ,  C07D495/10

    Abstract: PROBLEM TO BE SOLVED: To obtain the subject compound in a high yield by subjecting a salicylic acid compound and an arylthioketone compound to a desulfurizing condensation reaction in the presence of a desulfurizing agent and a base. SOLUTION: This method for producing a 1,3-benzodioxan-4-one compound of formula III (for example, a compound of formula IV) comprises subjecting (A) a salicylic acid compound of formula I [R is H or a substituent; (n) is 1-4] and (B) (i) an arylthioketone compound of formula II (Ar and Ar are each an aryl) to a desulfurizing condensation reaction in the presence of (ii) a desulfurizing agent (for example, Cu) and (iii) a base (for example, an organic carboxylic acid alkali metal salt). In the reaction, the component Bii is preferably used in an amount of at least 1 equivalent per equivalent of the component Bi, and the component Biii is preferably used in an amount of at least 2 equivalents per equivalent of the component A.

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