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公开(公告)号：AU779638B2
公开(公告)日：2005-02-03
申请号：AU2522100
申请日：2000-03-31
Applicant: AGENCY IND SCIENCE TECHN
Inventor： OISHI AKIHIRO , TAGUCHI YOICHI , FUJITA KENICHI , IKEDA YOSHIKAZU , MASUDA TAKASHI , ISHIGAMI YUTAKA , NAKAYAMA KAZUO , KINUGASA SHINICHI , NAKAHARA HISAE
IPC: C08G63/08 , C08G63/78 , C08G63/82 , C08L101/16
Abstract: A process of producing a polyester or copolyester, wherein at least one cyclic lactone of the following formula (I): wherein n is an integer of 1-4 provided that n is not 2 when only one cyclic lactone is used, is polymerized under a pressure of at least 200 MPa in the absence of any catalyst or in the presence of a metal-free polyesterification catalyst.
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公开(公告)号：JPH10130623A
公开(公告)日：1998-05-19
申请号：JP30246596
申请日：1996-10-28
Applicant: AGENCY IND SCIENCE TECHN
Inventor： ISHIGAMI YUTAKA , TOKUNAGA SHUZO , KOU KIYOUCHIN , KAJIUCHI TOSHIO , SAI EIKOKU , TOMIKAWA AKIO
Abstract: PROBLEM TO BE SOLVED: To clean soil polluted by a heavy metal by bringing the soil into contact with an aq. soln. of a metal ion scavenger comprising saponin obtd. from fruits of high deciduous trees of the family Aesculus turbinata to cause heavy metal ions to migrate into the aq. soln. SOLUTION: A saponin having three saccharide groups and one carboxyl group is obtd. from fruits of trees of the family Aesculus turbinata. The saccharide groups include residues of glucuronic acid, glucose, and xylose. The saponin is called escin and is solid at normal temp. Escin has not only a metal-ion- scavenging capablity but also a function as a dispersant capable of converting a heavy metal salt of huminic acid or a metal oxide into fine particles and dispersing them. Therefore, escin can clean soil polluted by a harmful heavy metal, such as Cd, Cu, Zn, or Pb. The polluted soil is cleaned by putting it into and stirring it in a 0.8-7wt.% aq. soln. of escin. A heavy metal caught in the soln. is adjusted to a pH of 2.5 or lower and is recoverd.
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公开(公告)号：JPH0474116A
公开(公告)日：1992-03-09
申请号：JP18848590
申请日：1990-07-16
Applicant: AGENCY IND SCIENCE TECHN , LINTEC CORP
Inventor： GAMA YASUO , ISHIGAMI YUTAKA , OKABE HIDEAKI , KAMAGAMI SABURO , KAIZE HISAYASU
Abstract: PURPOSE:To obtain a liposome capable of releasing included drug according to the reducting condition and pH condition of outer aqueous phase and having excellent affinity to keratin by including N,N'-diacylcystine in wall membrane. CONSTITUTION:The wall membrane material of the objective lipsome is composed of a mixture of phospholipid molecule and N,N'-diacylcystine and, as necessary, added with cholesterol to reinforce a bimolecular membrane and dicetyl phosphate,stearylamine, etc., as a charge substance. The acyl group of the N,N'-diacylcystine has a C-number of 8-22, preferably 10-18 and the amount of the diacylcystine is 5-40 mol%, preferably 10-30 mol% based on total wall membrane. When the above liposome containing insulin as a drug component is administered, glucose is dehydrogenated with enzyme in the body activated by the increase of glucose and, as a result, cystine is reduced and insulin is released by the destruction of liposome. Accordingly, the objective liposome is useful as a remedy for diabetes.
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公开(公告)号：JPH01106842A
公开(公告)日：1989-04-24
申请号：JP26337387
申请日：1987-10-19
Applicant: AGENCY IND SCIENCE TECHN
Inventor： KAMATA TOSHIHIRO , ISHIGAMI YUTAKA , WASADA NOBUHIDE
Abstract: NEW MATERIAL:A 2-n-decyl-3-hydroxy-n-tetradecanoic acid expressed by the formula (OR is OH or alcohol residue) or ester thereof. USE:A raw material for immunological activator having low toxicity and powerful cell activating action or biodegradable surfactants having well balanced lipophilicity and hydrophilicity. PREPARATION:A lauric acid ester is thermally condensed in the presence of sodium hydride to provide a compound expressed by formula II (OR is alcohol residue). The ketone grope of the resultant compound is then reduced to afford the compound expressed by formula I (OR is alcohol residue), which is, as desired, treated with an alkali to provide the compound expressed by formula I (OR is OH). Furthermore, although such compounds consist of a mixture of the syn- and anti-isomers, the mixture can be separated into the respective isomers by a syn-anti-isomer separating technique, such as thin-layer chromatography.
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公开(公告)号：JPH0892279A
公开(公告)日：1996-04-09
申请号：JP22544894
申请日：1994-09-21
Applicant: AGENCY IND SCIENCE TECHN
Inventor： MOHAMADO OSUMAN , ISHIGAMI YUTAKA , ISHIZUKA YASUKO
Abstract: PURPOSE: To obtain a new amphipathic straight-chain surfactin exhibiting large surface-active action, having water soluble property or oil soluble property according to pH and useful as a extracting agent for biological substances, a biosurfactant and a surfactant, etc. CONSTITUTION: This straight-chain surfactin is expressed by formula I. Furthermore, the straight-chain surfactin of formula I is obtained by charging, e.g. a cycloheptapeptide type surfactin of formula II into a glass bottle having a lid, adding 2N NH4 OH thereto, allowing the surfactin to stand at 37 deg.C for 4 days, further blowing nitrogen gas thereinto to remove ammonia, adding diethyl ether thereto to remove a soluble part, distilling diethyl ether away and drying the residue under reduced pressure.
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Patent Agency Ranking
公开(公告)号：JPH03261799A
公开(公告)日：1991-11-21
申请号：JP6080190
申请日：1990-03-12
Applicant: AGENCY IND SCIENCE TECHN
Inventor： SASAKI MAKOTO , MATSUZAKI SANAE , NIWA YOSHIO , ISHIKAWA KEIICHIRO , IKEDA YOSHIKAZU , ISHIGAMI YUTAKA
Abstract: NEW MATERIAL:A cyclic peptide pyrenacyl ester expressed by the formula. USE:A medium for research such as peptide type environmental probes, molecular aggregates, various media and biomembranes, etc. PREPARATION:For example, the carboxyl group of the terminal leucine residues in 3-hydroxy-13-methyltetradecanoyl-L-glutamyl-L-leucyl-D-leucyl-L-valyl-L- aspartyl-D-leucyl-L-leucylpeptide and-3-hydroxyl group are subjected to cyclodehydration to provide surfactin composed of an amphiphatic cyclic peptide having a lactone structure, which is then dissolved in acetonitrile and reacted with 1-bromoacetylpyrene in the presence of diisopropylethylamine to afford a crude product. The resultant crude product is subsequently purified by silica gel column chromatography to afford surfactin pyrenacyl ester expressed by the formula.
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公开(公告)号：JPH01283295A
公开(公告)日：1989-11-14
申请号：JP11116988
申请日：1988-05-06
Applicant: AGENCY IND SCIENCE TECHN
Inventor： GAMA YASUO , ISHIGAMI YUTAKA
Abstract: NEW MATERIAL:(2-O-alpha-decenoyl-alpha-L-rhamnopyranocyl-beta-hydroxydecan oyl-beta- hydroxydecanoic acid)-pyrenacyl ester expressed by the formula. USE:The aimed material is a fluorescent material of glucolipid type and useful for fluorescent probe material and research of biomembrane or liposome. PREPARATION:For instance, potassium salt or sodium salt of rhamnolipid and 1-bromoacetylpyrene are subjected to desalting reaction in hydrous alcohol or hydrous acetonitrile.
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公开(公告)号：JPS63104644A
公开(公告)日：1988-05-10
申请号：JP24833686
申请日：1986-10-21
Applicant: AGENCY IND SCIENCE TECHN , SHINETSU CHEMICAL CO
Inventor： ISHIGAMI YUTAKA , GAMA YASUO , NAGAHORA HITOSHI , MOTOMIYA TATSUHIKO
IPC: A61K47/12 , A61K8/11 , A61K8/14 , A61K8/36 , A61K8/365 , A61K8/41 , A61K8/49 , A61K9/127 , A61K47/16 , A61K47/22 , B01F17/32 , B01F17/38 , B01J13/02 , C07C59/245 , C07D307/33
Abstract: PURPOSE:To provide surface activity and a low-degree gel forming action to the title liposome by forming the liposome having a wall membrane consisting of the neutralization salt by an alkylamine of spiculisporic acid and/or the ring-opening product of its lactone ring. CONSTITUTION:The liposome having a wall membrane consisting of the neutralization salt by a 4-20C alkylamine of spiculisporic acid and/or the ring-opening product of its lactone ring, is formed. In the case of S-acid and O-acid, since a decyl group is chemically bonded to the acids, octylamine is preferably used to ionically bond two chains more to the O-acid to obtain the chemical structure to form the liposome. The obtained liposome having surface activity and a low-degree gel forming action as well as the capability to form liposome having a microscopic sphaerite structure, hence liposome is formed on the acidic side, micelles are formed on the alkaline side, and the molecule assembling configulations are reversely changed.
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公开(公告)号：JPS6377535A
公开(公告)日：1988-04-07
申请号：JP22279786
申请日：1986-09-19
Applicant: AGENCY IND SCIENCE TECHN , TOYO BIYUUT KK
Inventor： ISHIGAMI YUTAKA , GAMA YASUO , UJI YOSHITAKA , MASUI KATSUNOBU , SHIBAYAMA YUJI
IPC: A61K9/06 , A23L29/10 , A61K8/06 , A61K8/36 , A61K8/60 , A61K8/73 , A61K8/99 , A61K9/107 , A61K47/00 , A61Q19/00 , B01F17/56 , B01J13/00 , C07H15/10 , C11D1/04 , C11D3/38 , C12N1/00 , C12P19/44
Abstract: PURPOSE:To obtain the titled composition improved in decomposition property, safety and stability by adding a rhamnolipid combined with alpha-decenoic acid or its salt as an emulsifying agent to a water phase component of and an oil phase component thus, preparing the emulsified composition. CONSTITUTION:The emulsified composition is prepared by adding the rhamnolipid combined with alpha-decenoic acid or its salt as the emulsifying agent to a water phase component such as water, monohydric alcohols, polyglycerin, glucose and maltose, etc., and an oil phase component such as hydrocarbons, ester oils and waxes, etc. The water phase component, the oil phase component and the rhamnolipid or its salt are preferably mixed in the respective proportion of 15-95wt% to 1-75wt% and 0.1-15wt%. Further, the emulsified composition may be added with
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公开(公告)号：JPS6230546A
公开(公告)日：1987-02-09
申请号：JP17062785
申请日：1985-07-31
Applicant: AGENCY IND SCIENCE TECHN , TOYO BIYUUT KK
Inventor： ISHIGAMI YUTAKA , UJI YOSHITAKA , MASUI KATSUNOBU , SHIBAYAMA YUJI
IPC: B01J13/00 , A61K8/00 , A61K8/06 , A61K8/30 , A61K8/36 , A61K8/365 , A61K8/49 , A61K9/10 , A61K9/107 , A61Q19/00 , B01F17/32 , B01F17/38 , C11D1/04
Abstract: PURPOSE:To enable the emulsification in an acidic region, by preparing a polybasic acid type bio-surfactant emulsified composition by a method wherein one or more kind of four specific compounds is compounded and the pH value of the obtained compound is adjusted to 7.0 or less. CONSTITUTION:At least one component among four components of 4,5- dicarboxy-4-pentadecanolide (spiculisporic acid) (hereinbelow, referred to as S-acid), 4,5-dicarboxy-4-pentadecanolide salt, 3-hydroxy-1,3,4-tetradecane tricar boxylic acid (hereinbelow, referred to as O-acid) prepared by opening the lactone ring of 4,5-dicarboxy-4-pentadecanolide and a salt thereof is compounded and the pH value of the obtained compound is adjusted to 7.0 or less to prepare a polybasic acid type bio-surfactant emulsified composition. As a method for adjusting the pH value to 7.0 or less, there is a method for preliminarily adjusting the amount of the base used in the saponification or neutralization of S-acid and O-acid.
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