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公开(公告)号：JPS6398392A
公开(公告)日：1988-04-28
申请号：JP24319686
申请日：1986-10-15
Applicant: AGENCY IND SCIENCE TECHN , MEIJI SEIKA KAISHA
Inventor： NAKAHARA HARUROU , YOKOCHI TOSHIHIRO , KAMISAKA YASUSHI , SUZUKI OSAMU , HIRUTA OSAMU
Abstract: PURPOSE:To exclusively produce the titled substance in high conversion, by treating gamma-linolenic acid with soybean lipoxygenase in a system of an organic solvent and an aqueous solution in the presence of an anionic surfactant. CONSTITUTION:gamma-Linolenic acid is dissolved in a binary phase system composed of an organic solvent (e.g., hexane, heptane, etc.) and an aqueous solution. The aqueous solution is a boric acid buffer solution of 6.5pH. gamma-Linolenic acid is treated with soybean lipoxygenase in the above binary phase system in the presence of an anionic surfactant such as sodium polyoxyethylene alkyl ether acetate, sarcosinate L-N, etc., to convert the gamma-linolenic acid to 9-hydroperoxy-gamma- linolenic acid. The objective product is recovered by adding hydrochloric acid to the reaction mixture, extracting the oil-soluble fraction with ethyl acetate, subjecting the extract to dehydrochlorination and dehydration and developing by a reversed phase thin-layer chromatography.
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公开(公告)号：JPS6296432A
公开(公告)日：1987-05-02
申请号：JP23614185
申请日：1985-10-22
Applicant: AGENCY IND SCIENCE TECHN
Inventor： SUZUKI OSAMU , YOKOCHI TOSHIHIRO , NAKANE TAKASHI
IPC: A61K31/20 , A23L1/30 , A61K8/04 , A61K8/30 , A61K8/36 , A61K8/37 , A61K8/60 , A61K8/72 , A61K8/73 , A61K31/23 , A61K47/40 , A61P3/06 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/02 , A61P15/00 , A61P37/08 , A61Q19/00 , C07C53/126 , C07C69/22 , C08B37/16 , C11B15/00
Abstract: PURPOSE:To obtain a composition containing a higher fatty acid or its ester and having excellent dispersibility in water, by adding a higher fatty acid or its ester in liquid state to cyclodextrin and mixing the product. CONSTITUTION:A water-dispersible composition containing a higher fatty acid or its ester is produced by adding a higher fatty acid (e.g. gamma-linolenic acid) or its ester in liquid state to cyclodextrin and mixing the product. A higher fatty acid or its ester is an oily substance immiscible with water. The oily substance can be uniformly dispersed in various aqueous solutions or aqueous slurries and in some oily substances by converting the substance to the present composition. Accordingly, the present composition can be utilized in various fields taking advantage of the physiological activity or pharmacological activity of the higher fatty acid or its ester. The amount of the higher fatty acid or its ester is 1-30pts.wt. per 100pts.wt. of cyclodextrin.
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公开(公告)号：JPS61227790A
公开(公告)日：1986-10-09
申请号：JP6766985
申请日：1985-03-30
Applicant: AGENCY IND SCIENCE TECHN , NITTO ELECTRIC IND CO
Inventor： SUZUKI OSAMU , YOKOCHI TOSHIHIRO , NINOMIYA YASUO , KOMATA TETSUO
Abstract: PURPOSE:To enable the extraction of glyceride oil in high yield, without causing the contamination with impurities, by adjusting the water content of microbial cells separated from a medium below a specific level and extracting the cells with an organic solvent. CONSTITUTION:Glyceride oil existing in microbial cells separated from a medium is extracted after drying the cell to a water-content of
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公开(公告)号：JPS61149054A
公开(公告)日：1986-07-07
申请号：JP27015984
申请日：1984-12-21
Applicant: AGENCY IND SCIENCE TECHN , RIKEN VITAMIN CO
Inventor： SUZUKI OSAMU , YOKOCHI TOSHIHIRO , MUROI KOJI
Abstract: PURPOSE:To provide the titled composition effective to prevent the health disturbance and trophopathy of cat, by adding the cell of microorganism of Mortierella genus containing an oil or fat containing gamma-linoleic acid. CONSTITUTION:A microbial strain belonging to Mortierella genus and capable of producing lipid having high gamma-linoleic acid content (e.g. Mortierella isabellina) is cultured in a hydrocarbon medium or a molasses medium, etc. to obtain the cell of Mortierella containing 20-50wt% oil or fat containing gamma-linoleic acid. The microbial cells are added to a cat food in an amount to give a gamma- linoleic acid content of 0.01-1.0wt%.
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公开(公告)号：JPH09284A
公开(公告)日：1997-01-07
申请号：JP9931796
申请日：1996-03-28
Applicant: AGENCY IND SCIENCE TECHN
Inventor： YOKOCHI TOSHIHIRO , NAKAHARA HARUROU , HIGASHIHARA TAKANORI
Abstract: PROBLEM TO BE SOLVED: To provide a process for producing oil and fat containing docosahexaenoic acid and docosahexaenoic acid in a higher yield than that of the conventional processes by using a microorganism having high ability to produce docosahexaenoic acid in no need of complicated process in extremely high efficiency. SOLUTION: Schizochytrium SR21 strain is a microorganism having the ability to produce oil and fat containing docosahexaenoic acid and the content of the docosahexaenoic acid is
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Patent Agency Ranking
公开(公告)号：JPS6425708A
公开(公告)日：1989-01-27
申请号：JP14976188
申请日：1988-06-16
Applicant: AGENCY IND SCIENCE TECHN , RIKEN VITAMIN CO
Inventor： SUZUKI OSAMU , YOKOCHI TOSHIHIRO , MUROI KOJI
IPC: A61K8/30 , A61K8/36 , A61K8/67 , A61K8/96 , A61K8/99 , A61K47/00 , A61K47/44 , A61Q1/00 , A61Q1/04 , A61Q1/06 , A61Q1/10 , A61Q1/12 , A61Q19/00
Abstract: PURPOSE:To obtain the titled composition, containing a gamma-linolenic acid- containing fat and oil extracted from fungal cells of the genus Mortierella, annually producible and available at a low cost and having excellent skin touch and simultaneously producing various effects originating from the gamma-linolenic acid. CONSTITUTION:A cosmetic or dermal composition obtained by containing a gamma-linolenic acid-containing fat and oil extracted from cells of fungi which are molds belonging to the genus Mortierella. This composition can be applied in the form of a water-in-oil type or oil-in-water type emulsion system, e.g. milky lotion, lotion, shampoo or shaving foam, or more concentrated emulsion system, e.g. facial pack. In this case, the fat and oil of the fungal cells can be contained in an amount of 1-20wt.%. The above-mentioned composition may consists essentially of an oily phase or aqueous phase and is applicable in the form of a solid, e.g. makeup product. In this case the composition can be contained in amount of about 1-30wt%.
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公开(公告)号：JPS63119687A
公开(公告)日：1988-05-24
申请号：JP25560487
申请日：1987-10-09
Applicant: AGENCY IND SCIENCE TECHN
Inventor： SUZUKI OSAMU , YOKOCHI TOSHIHIRO
Abstract: PURPOSE:To produce a neutral lipid and polar lipid in high productivity, by culturing a microorganism belonging to Mortierella genus. CONSTITUTION:A microbial strain selected from Mortierella isabellina, M. vinacea, M. ramanniana vas. anglispora or M. nana, e.g. Mortierella isabellina IFO 7884 is inoculated in a medium containing a carbohydrate as a carbon source and cultured under aerobic condition at 4.0-6.0pH for about 2-15 days. The objective neutral lipid and polar lipid can be separated from the cultured microbial cell.
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公开(公告)号：JPS6265689A
公开(公告)日：1987-03-24
申请号：JP20552785
申请日：1985-09-18
Applicant: AGENCY IND SCIENCE TECHN , NITTO ELECTRIC IND CO
Inventor： NAKANE TAKASHI , YAGISHITA HIROSHI , YOKOCHI TOSHIHIRO , SUZUKI OSAMU , NINOMIYA YASUO , HIGUCHI TOSHIO
Abstract: PURPOSE:To obtain refined glyceride oil effectively removing a gum such as phospholipid, diglyceride, free fatty acid, etc., by extracting crude glyceride oil composition from microorganism, diluting the composition with an organic solvent and contacting with a semipermeable membrane under pressure. CONSTITUTION:A crude glyceride oil composition extracted from microorganism, e.g. from the microbial cell of Mortierella genus is diluted with an organic solvent and the solution is made to contact with one surface of a semipermeable membrane under pressure. The liquid permeated to the other surface of the membrane is collected and the organic solvent is removed therefrom to obtain a glyceride oil having decreased amount of foreign materials. The semipermeable membrane is preferably made of a polyimide polymer, e.g. a polymer having the recurring unit of formula I [R is bivalent aromatic group including the group of formula II [X is -CH2-, -O-, etc.) and formula III (Y is -CH3, etc.) or unit of formula IV (R and R are vibalent aromatic group), especially preferably a polyimide composed of the recurring units of formula V and formula VI.
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公开(公告)号：JPS61225300A
公开(公告)日：1986-10-07
申请号：JP6766785
申请日：1985-03-30
Applicant: AGENCY IND SCIENCE TECHN , NITTO ELECTRIC IND CO
Inventor： SUZUKI OSAMU , YOKOCHI TOSHIHIRO , NINOMIYA YASUO , USHIYAMA KEIICHI
IPC: C11D9/50
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公开(公告)号：JPS61192292A
公开(公告)日：1986-08-26
申请号：JP3313085
申请日：1985-02-21
Applicant: AGENCY IND SCIENCE TECHN
Inventor： SUZUKI OSAMU , YOKOCHI TOSHIHIRO
Abstract: PURPOSE:To obtain easily a concentrate of gamma-linolenic acid-containing glyceride, by dissolving a lipid component of a mold belonging to the genus Mortierella in a specific solvent, and concentrating the cooling crystallization residue of the solution. CONSTITUTION:A lipid component of a mold belonging to the genus Mortierella is dissolved in at least one selected from hexane, acetone, ethyl alcohol, and petroleum ether, the prepared solution is cooled, crystal is precipitated in the solution, the crystal is separated, the noncrystalline part is concentrated, to give a concentrate of gamma-linolenic acid-containing glyceride.
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