公开(公告)号：AT212665T

公开(公告)日：2002-02-15

申请号：AT94901544

申请日：1993-11-16

Applicant: ARCH DEV CORP

Inventor： LEIDEN JEFFREY M ,  BARR ELIAV

IPC: C12N15/09 ,  A61K31/7088 ,  A61K35/76 ,  A61K38/00 ,  A61K38/22 ,  A61K45/00 ,  A61K48/00 ,  A61P9/10 ,  C07K14/47 ,  C12N5/10 ,  C12N15/12 ,  C12N15/861 ,  C12P21/00 ,  C12R1/91 ,  C12N15/63 ,  C12N15/86 ,  C07K2/00

Abstract: The present invention relates to the use of adenovirus-mediated gene transfer to regulate function in cardiac and vascular smooth muscle cells. A recombinant adenovirus comprising a DNA sequence that codes for a gene product is delivered to a cardiac or vascular smooth muscle cell and the cell is maintained until that gene product is expressed. Delivery is direct injection into a muscle cell or infusing a pharmaceutical composition containing an adenovirus vector construct intravascularly.

公开(公告)号：AU2394200A

公开(公告)日：2000-07-31

申请号：AU2394200

申请日：1999-12-28

Applicant: ARCH DEV CORP

Inventor： LEIDEN JEFFREY M ,  SVENSSON ERIC

IPC: C12N15/09 ,  A61K31/711 ,  A61K35/76 ,  A61K38/00 ,  A61K38/04 ,  A61K48/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  C12N15/864 ,  A01N43/04 ,  A61K31/70 ,  C12N15/00 ,  C12N15/63

公开(公告)号：AU694097B2

公开(公告)日：1998-07-16

申请号：AU5609394

申请日：1993-11-16

Applicant: ARCH DEV CORP

Inventor： LEIDEN JEFFREY M ,  BARR ELIAV

IPC: C12N15/09 ,  A61K31/7088 ,  A61K35/76 ,  A61K38/00 ,  A61K38/22 ,  A61K45/00 ,  A61K48/00 ,  A61P9/10 ,  C07K14/47 ,  C12N5/10 ,  C12N15/12 ,  C12N15/861 ,  C12P21/00 ,  C12R1/91 ,  C12N15/63 ,  C12N15/86

Abstract: The present invention relates to the use of adenovirus-mediated gene transfer to regulate function in cardiac and vascular smooth muscle cells. A recombinant adenovirus comprising a DNA sequence that codes for a gene product is delivered to a cardiac or vascular smooth muscle cell and the cell is maintained until that gene product is expressed. Delivery is direct injection into a muscle cell or infusing a pharmaceutical composition containing an adenovirus vector construct intravascularly.

公开(公告)号：AU5609394A

公开(公告)日：1994-06-08

申请号：AU5609394

申请日：1993-11-16

Applicant: ARCH DEV CORP

Inventor： LEIDEN JEFFREY M ,  BARR ELIAV

IPC: C12N15/09 ,  A61K31/7088 ,  A61K35/76 ,  A61K38/00 ,  A61K38/22 ,  A61K45/00 ,  A61K48/00 ,  A61P9/10 ,  C07K14/47 ,  C12N5/10 ,  C12N15/12 ,  C12N15/861 ,  C12P21/00 ,  C12R1/91 ,  C12N15/63 ,  C12N15/86 ,  C07K15/00

Abstract: The present invention relates to the use of adenovirus-mediated gene transfer to regulate function in cardiac and vascular smooth muscle cells. A recombinant adenovirus comprising a DNA sequence that codes for a gene product is delivered to a cardiac or vascular smooth muscle cell and the cell is maintained until that gene product is expressed. Delivery is direct injection into a muscle cell or infusing a pharmaceutical composition containing an adenovirus vector construct intravascularly.