公开(公告)号：JP2003102474A

公开(公告)日：2003-04-08

申请号：JP2002274149

申请日：2002-09-19

Applicant: ARCH DEV CORP

Inventor： LEIDEN JEFFREY M ,  BARR ELIAV

IPC: C12N15/09 ,  A61K31/7088 ,  A61K35/76 ,  A61K38/00 ,  A61K38/22 ,  A61K45/00 ,  A61K48/00 ,  A61P9/10 ,  C07K14/47 ,  C12N5/10 ,  C12N15/12 ,  C12N15/861 ,  C12P21/00 ,  C12R1/91

Abstract: PROBLEM TO BE SOLVED: To provide a specific gene expression to cardiac muscle and to coronary vascular smooth muscle. SOLUTION: This method is used for expression of a gene product in a cardiac muscle cell and comprises (a) a step for infusing an adenovirus vector construct comprising a coding sequence that encodes the gene product into the blood flow of a coronary artery or a coronary sinus perfusing the cardiac muscle cell wherein the vector drives expression of the gene product in the muscle cell and (b) a step for obtaining expression of the gene product in the cardiac muscle cell.

公开(公告)号：DE69333886T2

公开(公告)日：2006-07-27

申请号：DE69333886

申请日：1993-11-16

Applicant: ARCH DEV CORP

Inventor： LEIDEN JEFFREY M ,  BARR ELIAV

IPC: C12N15/09 ,  C12N15/86 ,  A61K31/7088 ,  A61K35/76 ,  A61K38/00 ,  A61K38/22 ,  A61K45/00 ,  A61K48/00 ,  A61P9/10 ,  C07K14/47 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63 ,  C12N15/861 ,  C12P21/00 ,  C12R1/91

Abstract: The present invention relates to the use of adenovirus-mediated gene transfer to regulate function in cardiac and vascular smooth muscle cells. A recombinant adenovirus comprising a DNA sequence that codes for a gene product is delivered to a cardiac or vascular smooth muscle cell and the cell is maintained until that gene product is expressed. Delivery is direct injection into a muscle cell or infusing a pharmaceutical composition containing an adenovirus vector construct intravascularly.

公开(公告)号：AT212665T

公开(公告)日：2002-02-15

申请号：AT94901544

申请日：1993-11-16

Applicant: ARCH DEV CORP

Inventor： LEIDEN JEFFREY M ,  BARR ELIAV

IPC: C12N15/09 ,  A61K31/7088 ,  A61K35/76 ,  A61K38/00 ,  A61K38/22 ,  A61K45/00 ,  A61K48/00 ,  A61P9/10 ,  C07K14/47 ,  C12N5/10 ,  C12N15/12 ,  C12N15/861 ,  C12P21/00 ,  C12R1/91 ,  C12N15/63 ,  C12N15/86 ,  C07K2/00

Abstract: The present invention relates to the use of adenovirus-mediated gene transfer to regulate function in cardiac and vascular smooth muscle cells. A recombinant adenovirus comprising a DNA sequence that codes for a gene product is delivered to a cardiac or vascular smooth muscle cell and the cell is maintained until that gene product is expressed. Delivery is direct injection into a muscle cell or infusing a pharmaceutical composition containing an adenovirus vector construct intravascularly.

公开(公告)号：AU694097B2

公开(公告)日：1998-07-16

申请号：AU5609394

申请日：1993-11-16

Applicant: ARCH DEV CORP

Inventor： LEIDEN JEFFREY M ,  BARR ELIAV

IPC: C12N15/09 ,  A61K31/7088 ,  A61K35/76 ,  A61K38/00 ,  A61K38/22 ,  A61K45/00 ,  A61K48/00 ,  A61P9/10 ,  C07K14/47 ,  C12N5/10 ,  C12N15/12 ,  C12N15/861 ,  C12P21/00 ,  C12R1/91 ,  C12N15/63 ,  C12N15/86

Abstract: The present invention relates to the use of adenovirus-mediated gene transfer to regulate function in cardiac and vascular smooth muscle cells. A recombinant adenovirus comprising a DNA sequence that codes for a gene product is delivered to a cardiac or vascular smooth muscle cell and the cell is maintained until that gene product is expressed. Delivery is direct injection into a muscle cell or infusing a pharmaceutical composition containing an adenovirus vector construct intravascularly.

公开(公告)号：AU5609394A

公开(公告)日：1994-06-08

申请号：AU5609394

申请日：1993-11-16

Applicant: ARCH DEV CORP

Inventor： LEIDEN JEFFREY M ,  BARR ELIAV

IPC: C12N15/09 ,  A61K31/7088 ,  A61K35/76 ,  A61K38/00 ,  A61K38/22 ,  A61K45/00 ,  A61K48/00 ,  A61P9/10 ,  C07K14/47 ,  C12N5/10 ,  C12N15/12 ,  C12N15/861 ,  C12P21/00 ,  C12R1/91 ,  C12N15/63 ,  C12N15/86 ,  C07K15/00

Abstract: The present invention relates to the use of adenovirus-mediated gene transfer to regulate function in cardiac and vascular smooth muscle cells. A recombinant adenovirus comprising a DNA sequence that codes for a gene product is delivered to a cardiac or vascular smooth muscle cell and the cell is maintained until that gene product is expressed. Delivery is direct injection into a muscle cell or infusing a pharmaceutical composition containing an adenovirus vector construct intravascularly.

公开(公告)号：DE69333886D1

公开(公告)日：2006-03-02

申请号：DE69333886

申请日：1993-11-16

Applicant: ARCH DEV CORP

Inventor： LEIDEN JEFFREY M ,  BARR ELIAV

IPC: C12N15/09 ,  A61K31/7088 ,  A61K35/76 ,  A61K38/00 ,  A61K38/22 ,  A61K45/00 ,  A61K48/00 ,  A61P9/10 ,  C07K14/47 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63 ,  C12N15/86 ,  C12N15/861 ,  C12P21/00 ,  C12R1/91

Abstract: The present invention relates to the use of adenovirus-mediated gene transfer to regulate function in cardiac and vascular smooth muscle cells. A recombinant adenovirus comprising a DNA sequence that codes for a gene product is delivered to a cardiac or vascular smooth muscle cell and the cell is maintained until that gene product is expressed. Delivery is direct injection into a muscle cell or infusing a pharmaceutical composition containing an adenovirus vector construct intravascularly.

公开(公告)号：AU4502096A

公开(公告)日：1996-06-06

申请号：AU4502096

申请日：1995-11-13

Applicant: ARCH DEV CORP

Inventor： LEIDEN JEFFREY M ,  BARR ELIAV

IPC: A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/82 ,  C12N15/12 ,  C12N15/86

公开(公告)号：CA2149771A1

公开(公告)日：1994-05-26

申请号：CA2149771

申请日：1993-11-16

Applicant: ARCH DEV CORP

Inventor： LEIDEN JEFFREY M ,  BARR ELIAV

IPC: C12N15/09 ,  A61K31/7088 ,  A61K35/76 ,  A61K38/00 ,  A61K38/22 ,  A61K45/00 ,  A61K48/00 ,  A61P9/10 ,  C07K14/47 ,  C12N5/10 ,  C12N15/12 ,  C12N15/861 ,  C12P21/00 ,  C12R1/91 ,  C12N15/86

Abstract: 2149771 9411506 PCTABS00032 The present invention relates to the use of adenovirus-mediated gene transfer to regulate function in cardiac and vascular smooth muscle cells. A recombinant adenovirus comprising a DNA sequence that codes for a gene product is delivered to a cardiac or vascular smooth muscle cell and the cell is maintained until that gene product is expressed. Delivery is direct injection into a muscle cell or infusing a pharmaceutical composition containing an adenovirus vector construct intravascularly.

公开(公告)号：AT307212T

公开(公告)日：2005-11-15

申请号：AT99109240

申请日：1993-11-16

Applicant: ARCH DEV CORP

Inventor： LEIDEN JEFFREY M ,  BARR ELIAV

IPC: C12N15/09 ,  A61K31/7088 ,  A61K35/76 ,  A61K38/00 ,  A61K38/22 ,  A61K45/00 ,  A61K48/00 ,  A61P9/10 ,  C07K14/47 ,  C12N5/10 ,  C12N15/12 ,  C12N15/861 ,  C12P21/00 ,  C12R1/91 ,  C12N15/86 ,  C12N15/63

Abstract: The present invention relates to the use of adenovirus-mediated gene transfer to regulate function in cardiac and vascular smooth muscle cells. A recombinant adenovirus comprising a DNA sequence that codes for a gene product is delivered to a cardiac or vascular smooth muscle cell and the cell is maintained until that gene product is expressed. Delivery is direct injection into a muscle cell or infusing a pharmaceutical composition containing an adenovirus vector construct intravascularly.

公开(公告)号：DE69331526T2

公开(公告)日：2002-10-24

申请号：DE69331526

申请日：1993-11-16

Applicant: ARCH DEV CORP

Inventor： LEIDEN M ,  BARR ELIAV

IPC: C12N15/09 ,  A61K31/7088 ,  A61K35/76 ,  A61K38/00 ,  A61K38/22 ,  A61K45/00 ,  A61K48/00 ,  A61P9/10 ,  C07K14/47 ,  C12N5/10 ,  C12N15/12 ,  C12N15/861 ,  C12P21/00 ,  C12R1/91 ,  C12N15/63 ,  C12N15/86 ,  C07K2/00

Abstract: The present invention relates to the use of adenovirus-mediated gene transfer to regulate function in cardiac and vascular smooth muscle cells. A recombinant adenovirus comprising a DNA sequence that codes for a gene product is delivered to a cardiac or vascular smooth muscle cell and the cell is maintained until that gene product is expressed. Delivery is direct injection into a muscle cell or infusing a pharmaceutical composition containing an adenovirus vector construct intravascularly.