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    APOLIPOPROTEIN B mRNA EDITING PROTEIN COMPOSITIONS AND METHODS
    11.
    发明申请
    APOLIPOPROTEIN B mRNA EDITING PROTEIN COMPOSITIONS AND METHODS 审中-公开
    APOLIPOPROTEIN B mRNA编码蛋白质组合物和方法

    公开(公告)号：WO1994018316A2

    公开(公告)日：1994-08-18

    申请号：PCT/US1994001422

    申请日：1994-02-08

    Applicant: ARCH DEVELOPMENT CORPORATION

    Inventor： ARCH DEVELOPMENT CORPORATION ,  TENG, Babie ,  DAVIDSON, Nicholas ,  BURANT, Charles, F.

    IPC: C12N09/78

    CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K14/775

    Abstract: The present invention provides a protein that edits apo B RNA. A polynucleotide that comprises a DNA sequence that encodes an apo B RNA editing protein and an expression vector comprising such a polynucleotide are also provided. Processes for producing an apo B RNA editing protein, editing apo B RNA and altering apo B protein production are also provided.

    Abstract translation: 本发明提供编码载脂蛋白B RNA的蛋白质。 还提供了包含编码载脂蛋白B RNA编辑蛋白的DNA序列和包含这种多核苷酸的表达载体的多核苷酸。 还提供了生产载脂蛋白B RNA编辑蛋白，编辑载脂蛋白B RNA和改变载脂蛋白B蛋白质生产的方法。

    METHOD FOR THE IMPROVEMENT OF SCAR SIZE AND APPEARANCE
    12.
    发明申请
    METHOD FOR THE IMPROVEMENT OF SCAR SIZE AND APPEARANCE 审中-公开
    改善眼睛尺寸和外观的方法

    公开(公告)号：WO1994017839A1

    公开(公告)日：1994-08-18

    申请号：PCT/US1994001377

    申请日：1994-02-07

    Applicant: ARCH DEVELOPMENT CORPORATION

    Inventor： ARCH DEVELOPMENT CORPORATION ,  LEE, Raphael, C.

    IPC: A61L25/00

    CPC classification number: A61L26/008 ,  A61L26/0066 ,  A61L2300/432

    Abstract: A method for improving the size and appearance of a scar associated with a fibromatosis, a keloid, or a hypertrophic wound healing disorder comprises stimulating collagenase activity in the scar. Preferably, stimulating collagenase activity is accomplished by covering said scar with a thermal insulating material that elevates the surface temperature of the scar. Further disclosed is a method for improving the size and appearance of a scar by covering said scar with a thermal insulating material that elevates the surface temperature of the scar and that contains a therapeutically effective amount of a medicament.

    Abstract translation: 用于改善与纤维瘤病，瘢痕疙瘩或肥厚性伤口愈合障碍相关的瘢痕的大小和外观的方法包括刺激瘢痕中的胶原酶活性。 优选地，通过用提高瘢痕的表面温度的绝热材料覆盖所述疤痕来实现刺激胶原酶活性。 进一步公开的是通过用提高瘢痕的表面温度并含有治疗有效量的药物的绝热材料覆盖所述疤痕来改善瘢痕的尺寸和外观的方法。

    HIGH TEMPERATURE SUPERCONDUCTING FAULT CURRENT LIMITER
    15.
    发明申请
    HIGH TEMPERATURE SUPERCONDUCTING FAULT CURRENT LIMITER 审中-公开
    高温超导故障电流限制

    公开(公告)号：WO1994003955A1

    公开(公告)日：1994-02-17

    申请号：PCT/US1993007135

    申请日：1993-07-28

    Applicant: ARCH DEVELOPMENT CORPORATION

    Inventor： ARCH DEVELOPMENT CORPORATION ,  HULL, John

    IPC: H02H09/02

    CPC classification number: H02H9/023 ,  H01L39/16 ,  Y02E40/69 ,  Y10S505/85

    Abstract: A fault current limiter (10) for an electrical circuit (14). The fault current limiter (10) includes a high temperature superconductor (12) in the electrical circuit (14). The high temperature superconductor (12) is cooled below its critical temperature to maintain the superconducting electrical properties during operation as the fault current limiter (10).

    Abstract translation: 一种用于电路（14）的故障限流器（10）。 故障限流器（10）包括电路（14）中的高温超导体（12）。 高温超导体（12）被冷却到其临界温度以下，以在运行期间保持超导电性能作为故障限流器（10）。

    METHODS AND COMPOSITIONS FOR GENE, TUMOR, AND VIRAL INFECTION THERAPY, AND PREVENTION OF PROGRAMMED CELL DEATH (APOPTOSIS)
    17.
    发明申请
    METHODS AND COMPOSITIONS FOR GENE, TUMOR, AND VIRAL INFECTION THERAPY, AND PREVENTION OF PROGRAMMED CELL DEATH (APOPTOSIS) 审中-公开
    用于基因，肿瘤和病毒感染治疗的方法和组合物，以及预防编程性细胞死亡（APOPTOSIS）

    公开(公告)号：WO1993019591A1

    公开(公告)日：1993-10-14

    申请号：PCT/US1993001801

    申请日：1993-02-26

    Applicant: ARCH DEVELOPMENT CORPORATION

    Inventor： ARCH DEVELOPMENT CORPORATION ,  ROIZMAN, Bernard ,  CHOU, Joany

    IPC: A01K63/00

    CPC classification number: G01N33/5011 ,  A61K38/162 ,  A61K39/12 ,  A61K39/245 ,  A61K48/00 ,  C07K14/005 ,  C12N15/86 ,  C12N2710/16622 ,  C12N2710/16634 ,  C12N2710/16643 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5058 ,  G01N33/5073 ,  G01N2510/00

    Abstract: The present invention relates to methods of treatment of programmed cell death (apoptosis) through the use of the HSV-1 gene gamma 134.5 or the product of its expression, ICP34.5. The gene and its expression have been demonstrated to be required for HSV-1 neurovirulence, and in particular, to act as an inhibitor of neuronal programmed cell death which allows for viral replication. Use of the gene therapy, or the protein itself, can be expected to result in inhibition of programmed cell death in various neurodegenerative diseases. This invention also relates to novel vectors for gene therapy, including modified herpes virus. Methods are presented for conducting assays for substances capable of mimicing, potentiating or inhibiting the expression of gamma 134.5 or the activity of ICP34.5. Also, methods are disclosed for the treatment of tumorogenic diseases, including cancer, and for treatment of herpes and other viral infections using inhibitors of gamma 134.5 expression or ICP34.5 activity.

    Abstract translation: 本发明涉及通过使用HSV-1基因γ134.5或其表达产物ICP34.5来治疗程序性细胞死亡（细胞凋亡）的方法。 已经证明该基因及其表达是HSV-1神经毒力所必需的，特别是作为允许病毒复制的神经元程序性细胞死亡的抑制剂。 可以预期使用基因治疗或蛋白质本身会导致各种神经变性疾病中程序性细胞死亡的抑制。 本发明还涉及用于基因治疗的新载体，包括改良的疱疹病毒。 提出了用于进行能够模拟，增强或抑制γ134.5的表达或ICP34.5的活性的物质的测定的方法。 此外，公开了用于治疗肿瘤发生疾病（包括癌症）的方法，以及使用γ134.5表达或ICP34.5活性抑制剂治疗疱疹和其它病毒感染的方法。

    METHODS AND COMPOSITIONS OF A POLYMER (POLOXAMER) FOR CELL REPAIR
    18.
    发明申请
    METHODS AND COMPOSITIONS OF A POLYMER (POLOXAMER) FOR CELL REPAIR 审中-公开
    聚合物（POLOXAMER）用于细胞修复的方法和组合物

    公开(公告)号：WO1993015745A1

    公开(公告)日：1993-08-19

    申请号：PCT/US1993001327

    申请日：1993-02-12

    Applicant: ARCH DEVELOPMENT CORPORATION

    Inventor： ARCH DEVELOPMENT CORPORATION ,  LEE, Raphael, C.

    IPC: A61K31/77

    CPC classification number: A61K31/785 ,  A61K31/77 ,  Y10S424/13 ,  Y10S514/917 ,  Y10S514/975 ,  A61K31/70 ,  A61K31/685 ,  A61K2300/00

    Abstract: Novel methods for prophylaxis and treatment of tissue damage resulting from cell membrane permeabilization are disclosed. Compositions comprising a surface active copolymer are employed to prevent permeabilization or to promote membrane repair. Methods for enhancement of cell survival following membrane permeabilization in vitro are also disclosed, along with methods for increasing the efficacy of transfection of cells with foreign exogenous macromolecules, in particular DNA, also involving treatment of permeabilized cells with a surface active copolymer. Also disclosed are novel methods for prophylaxis and treatment of tissue damage, and for enhancement of cell survival and transfection efficacy, using a surface active copolymer in combination with high energy phosphate compounds which are capable of recharging cellular energy stores and thereby potentiating cell repair and survival. Compositions comprising surface active copolymers for intravenous, intramuscular, and topical use are also disclosed, along with novel compositions comprising a combination of a surface active copolymer and a high energy phosphate compound.

    Abstract translation: 公开了用于预防和治疗由细胞膜透化引起的组织损伤的新方法。 包含表面活性共聚物的组合物用于防止透化或促进膜修复。 还公开了在体外膜透化后增强细胞存活的方法，以及用于增加用外源外源大分子特别是DNA转染细胞的功效的方法，还涉及用表面活性共聚物处理透化细胞。 还公开了用于预防和治疗组织损伤以及用于增强细胞存活和转染功效的新方法，其中使用表面活性共聚物与高能量磷酸盐化合物组合，其能够再次充电细胞能量储存并从而增强细胞修复和存活 。 还公开了包含静脉内，肌肉内和局部使用的表面活性共聚物的组合物，以及包含表面活性共聚物和高能磷酸盐化合物的组合的新型组合物。

    IMPROVED FLOATING BEARING PROSTHETIC KNEE
    19.
    发明申请
    IMPROVED FLOATING BEARING PROSTHETIC KNEE 审中-公开
    改进的浮动轴承预制卡通

    公开(公告)号：WO1992008424A1

    公开(公告)日：1992-05-29

    申请号：PCT/US1991008520

    申请日：1991-11-14

    Applicant: ARCH DEVELOPMENT CORPORATION

    Inventor： ARCH DEVELOPMENT CORPORATION ,  POTTENGER, Lawrence ,  DRAGANICH, Louis, F.

    IPC: A61F02/38

    CPC classification number: A61F2/3868 ,  A61F2/3886

    Abstract: A semiconstrained prosthetic knee for surgical replacement of a dysfunctional knee includes a tibial platform (22), a movable bearing element (16), and a femoral component (12). The femoral component (12) includes a polycentric convex bearing which slidably engages a movable bearing (16). The superior surface of the bearing element (16) is designed to congruently slidably engage the inferior surface of the bearing portion of the femoral component (12). The inferior surface of the femoral component (12) is generally convex with two or more offset portions of varying radii of curvature matching complementary superior surfaces of the bearing element (16). The inferior surface of the femoral component (12) may have more than one radius of curvature at different points along the convex surface. The superior surface of the tibial platform (22) is generally flat and includes at least one protrusion for controlling the movement of the bearing element (16).

    Abstract translation: 用于外科替代功能不全膝盖的半限制假肢膝盖包括胫骨平台（22），可移动轴承元件（16）和股骨部件（12）。 股骨部件（12）包括可滑动地接合可移动轴承（16）的多中心凸起轴承。 轴承元件（16）的上表面被设计成一致地滑动地接合股骨部件（12）的轴承部分的下表面。 股骨组件（12）的下表面通常是凸起的，具有两个或更多个具有不同曲率半径的偏移部分，其匹配支承元件（16）的互补的上表面。 股骨组件（12）的下表面可以在沿着凸表面的不同点处具有多于一个的曲率半径。 胫骨平台（22）的上表面大致平坦，并且包括用于控制支承元件（16）的运动的至少一个突出部。

    BACTERIAL SUCROSE SYNTHASE COMPOSITIONS AND METHODS OF USE
    20.
    发明申请
    BACTERIAL SUCROSE SYNTHASE COMPOSITIONS AND METHODS OF USE 审中-公开
    细菌枯草芽孢杆菌合成酶及其使用方法

    公开(公告)号：WO1998003637A1

    公开(公告)日：1998-01-29

    申请号：PCT/US1997012736

    申请日：1997-07-21

    Applicant: ARCH DEVELOPMENT CORPORATION ,  HASELKORN, Robert ,  BUIKEMA, William, J. ,  BAUER, Christopher, C.

    Inventor： ARCH DEVELOPMENT CORPORATION

    IPC: C12N09/10

    CPC classification number: C12N9/1062 ,  C12N15/8245 ,  C12N15/8261 ,  Y02A40/146

    Abstract: The present invention provides isolated and purified polynucleotides that encode bacterial polypeptides that participate in the utilization of sucrose. Isolated bacterial sucrose synthase compositions and methods of use are provided. Processes for altering sucrose synthase activity, altering the starch and/or sucrose content of bacterial and/or plant cells, methods of identifying sucrose synthase-encoding nucleic acid segments, and compositions comprising sucrose synthase peptides and antibodies are also disclosed.

    Abstract translation: 本发明提供编码参与蔗糖利用的细菌多肽的分离和纯化的多核苷酸。 提供了分离的细菌蔗糖合成酶组合物和使用方法。 还公开了改变蔗糖合酶活性，改变细菌和/或植物细胞的淀粉和/或蔗糖含量，鉴定蔗糖合酶编码核酸片段的方法，以及包含蔗糖合成酶和抗体的组合物的方法。

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