公开(公告)号：WO1994017839A1

公开(公告)日：1994-08-18

申请号：PCT/US1994001377

申请日：1994-02-07

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  LEE, Raphael, C.

IPC: A61L25/00

CPC classification number: A61L26/008 ,  A61L26/0066 ,  A61L2300/432

Abstract: A method for improving the size and appearance of a scar associated with a fibromatosis, a keloid, or a hypertrophic wound healing disorder comprises stimulating collagenase activity in the scar. Preferably, stimulating collagenase activity is accomplished by covering said scar with a thermal insulating material that elevates the surface temperature of the scar. Further disclosed is a method for improving the size and appearance of a scar by covering said scar with a thermal insulating material that elevates the surface temperature of the scar and that contains a therapeutically effective amount of a medicament.

Abstract translation: 用于改善与纤维瘤病，瘢痕疙瘩或肥厚性伤口愈合障碍相关的瘢痕的大小和外观的方法包括刺激瘢痕中的胶原酶活性。 优选地，通过用提高瘢痕的表面温度的绝热材料覆盖所述疤痕来实现刺激胶原酶活性。 进一步公开的是通过用提高瘢痕的表面温度并含有治疗有效量的药物的绝热材料覆盖所述疤痕来改善瘢痕的尺寸和外观的方法。

公开(公告)号：WO1993015745A1

公开(公告)日：1993-08-19

申请号：PCT/US1993001327

申请日：1993-02-12

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  LEE, Raphael, C.

IPC: A61K31/77

CPC classification number: A61K31/785 ,  A61K31/77 ,  Y10S424/13 ,  Y10S514/917 ,  Y10S514/975 ,  A61K31/70 ,  A61K31/685 ,  A61K2300/00

Abstract: Novel methods for prophylaxis and treatment of tissue damage resulting from cell membrane permeabilization are disclosed. Compositions comprising a surface active copolymer are employed to prevent permeabilization or to promote membrane repair. Methods for enhancement of cell survival following membrane permeabilization in vitro are also disclosed, along with methods for increasing the efficacy of transfection of cells with foreign exogenous macromolecules, in particular DNA, also involving treatment of permeabilized cells with a surface active copolymer. Also disclosed are novel methods for prophylaxis and treatment of tissue damage, and for enhancement of cell survival and transfection efficacy, using a surface active copolymer in combination with high energy phosphate compounds which are capable of recharging cellular energy stores and thereby potentiating cell repair and survival. Compositions comprising surface active copolymers for intravenous, intramuscular, and topical use are also disclosed, along with novel compositions comprising a combination of a surface active copolymer and a high energy phosphate compound.

Abstract translation: 公开了用于预防和治疗由细胞膜透化引起的组织损伤的新方法。 包含表面活性共聚物的组合物用于防止透化或促进膜修复。 还公开了在体外膜透化后增强细胞存活的方法，以及用于增加用外源外源大分子特别是DNA转染细胞的功效的方法，还涉及用表面活性共聚物处理透化细胞。 还公开了用于预防和治疗组织损伤以及用于增强细胞存活和转染功效的新方法，其中使用表面活性共聚物与高能量磷酸盐化合物组合，其能够再次充电细胞能量储存并从而增强细胞修复和存活 。 还公开了包含静脉内，肌肉内和局部使用的表面活性共聚物的组合物，以及包含表面活性共聚物和高能磷酸盐化合物的组合的新型组合物。

公开(公告)号：WO1994002130A1

公开(公告)日：1994-02-03

申请号：PCT/US1993006804

申请日：1993-07-20

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  ARCH DEVELOPMENT CORPORATION

Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  ARCH DEVELOPMENT CORPORATION ,  LEE, Raphael, C.

IPC: A61K31/275

CPC classification number: A61K31/57 ,  A61K31/135 ,  A61K31/275 ,  A61K31/44 ,  A61K31/54 ,  A61K31/55 ,  A61K33/24 ,  A61K2300/00

Abstract: This invention pertains to a method for controlling wound scar production by administering a calcium antagonist, alone or in a combination with or followed by a steroid, to the wound site. The method can be used to minimize wound scars, such as hypertrophic wound healing disorders, keloids and burn scar contractures in humans or other mammals, particularly those individually prone to excessive scarring. Calcium antagonist treatment can also be used to control diseases associated with excessive scarring, such as cirrhosis of the liver, constructive pericarditis, Dupuytren's disease of the hand, plantar fibrosis of the foot, and various other fibromatoses.

Abstract translation: 本发明涉及一种通过向伤口部位施用单独或与类固醇组合或与之结合的钙拮抗剂来控制伤口瘢痕产生的方法。 该方法可以用于最小化人或其它哺乳动物，特别是单独容易发生过度瘢痕形成的伤口瘢痕，例如增生性伤口愈合障碍，瘢痕疙瘩和烧伤瘢痕挛缩。 钙拮抗剂治疗也可用于控制与过度瘢痕形成相关的疾病，如肝硬化，建构性心包炎，手杜邦氏病，脚足底纤维化和各种其他纤维瘤病。