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公开(公告)号：CA3087354C
公开(公告)日：2023-01-03
申请号：CA3087354
申请日：2019-01-18
Applicant: ARRAY BIOPHARMA INC
Inventor： BLAKE JAMES F , DAI DONGHUA , HAAS JULIA , JIANG YUTONG , KOLAKOWSKI GABRIELLE R , MCFADDIN ELIZABETH A , MCKENNEY MEGAN L , METCALF ANDREW T , MORENO DAVID A , PRIGARO BRETT , RAMANN GINELLE A , REN LI
IPC: C07D487/04 , A61K31/519 , A61P35/00
Abstract: ABSTRACT Provided herein are compounds of the Formula I: NH2 Ri N LI RY and tautomers, stereoisomers and pharmaceutically acceptable salts and solvates thereof, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders. 1 Date recue / Date received 2021-12-16
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公开(公告)号：UA125032C2
公开(公告)日：2021-12-29
申请号：UAA201904246
申请日：2017-10-10
Applicant: ARRAY BIOPHARMA INC
Inventor： ANDREWS STEVEN W , ARONOW SEAN , BLAKE JAMES F , BRANDHUBER BARBARA J , COLLIER JAMES , COOK ADAM , HAAS JULIA , JIANG YUTONG , KOLAKOWSKI GABRIELLE R , MCFADDIN ELIZABETH A , MCKENNEY MEGAN L , MCNULTY OREN T , METCALF ANDREW T , MORENO DAVID A , RAMANN GINELLE A , TANG TONY P , REN LI , WALLS SHANE M
Abstract: ВданомудокументізапропонованісполукиФормулиІ: абоїхфармацевтичноприйнятнасіль, абосольват, деА, В, X1, X2, X3, X4, кільце D, Е, Ra, Rb, n і m маютьзначення, наведенів описі, якіявляютьсобоюінгібітори RET-кіназиі корисніприлікуванніі профілактицізахворювань, якіможутьлікуватисяінгібітором RET-кінази, включаючизахворюваннятарозлади, пов'язаніз RET.
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公开(公告)号：EA037208B1
公开(公告)日：2021-02-19
申请号：EA201990939
申请日：2017-10-10
Applicant: ARRAY BIOPHARMA INC
Inventor： ANDREWS STEVEN W , ARONOW SEAN , BLAKE JAMES F , BRANDHUBER BARBARA J , COLLIER JAMES , COOK ADAM , HAAS JULIA , JIANG YUTONG , KOLAKOWSKI GABRIELLE R , MCFADDIN ELIZABETH A , MCKENNEY MEGAN L , MCNULTY OREN T , METCALF ANDREW T , MORENO DAVID A , RAMANN GINELLE A , TANG TONY P , REN LI , WALLS SHANE M
IPC: C07D471/04 , A61K31/437 , A61P35/00
Abstract: Вданномдокументепредложенысоединенияформулы Iилиихфармацевтическиприемлемаясоль, где A, B, X1, X2, X3, X4, кольцо D, E, Ra, Rb, n и m имеютзначения, приведенныев описании, которыеявляютсяингибиторами RET киназыи полезныприлечениии профилактикезаболеваний, которыемогутлечитьсяингибитором RET киназы, включаязаболеванияи расстройства, связанныес RET.
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公开(公告)号：TN2019000107A1
公开(公告)日：2020-10-05
申请号：TN2019000107
申请日：2017-10-10
Applicant: ARRAY BIOPHARMA INC
Inventor： KOLAKOWSKI GABRIELLE R , MCFADDIN ELIZABETH A , MCKENNEY MEGAN L , JIANG YUTONG , ARONOW SEAN , COOK ADAM , MORENO DAVID A , RAMANN GINELLE A , ANDREWS STEVEN W , TANG TONY P , BRANDHUBER BARBARA J , COLLIER JAMES , MCNULTY OREN T , REN LI , BLAKE JAMES F , METCALF ANDREW T , WALLS SHANE M , HAAS JULIA
IPC: A61P35/00 , A61K31/437 , C07D471/04
Abstract: Provided herein are compounds of the Formula (I), or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X 1 , X 2 , X 3 , X 4 , Ring D, E, R a , R b , n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
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公开(公告)号：AU2017342027A1
公开(公告)日：2019-05-23
申请号：AU2017342027
申请日：2017-10-10
Applicant: ARRAY BIOPHARMA INC
Inventor： ANDREWS STEVEN W , ARONOW SEAN , BLAKE JAMES F , BRANDHUBER BARBARA J , COLLIER JAMES , COOK ADAM , HAAS JULIA , JIANG YUTONG , KOLAKOWSKI GABRIELLE R , MCFADDIN ELIZABETH A , MCKENNEY MEGAN L , MCNULTY OREN T , METCALF ANDREW T , MORENO DAVID A , RAMANN GINELLE A , TANG TONY P , REN LI , WALLS SHANE M
IPC: C07D471/04 , A61K31/437 , A61P35/00
Abstract: Provided herein are compounds of the Formula I: (I) or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X
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Patent Agency Ranking
公开(公告)号：CA3039912A1
公开(公告)日：2018-04-19
申请号：CA3039912
申请日：2017-10-10
Applicant: ARRAY BIOPHARMA INC
Inventor： ANDREWS STEVEN W , ARONOW SEAN , BLAKE JAMES F , BRANDHUBER BARBARA J , COLLIER JAMES , COOK ADAM , HAAS JULIA , JIANG YUTONG , KOLAKOWSKI GABRIELLE R , MCFADDIN ELIZABETH A , MCKENNEY MEGAN L , MCNULTY OREN T , METCALF ANDREW T , MORENO DAVID A , RAMANN GINELLE A , TANG TONY P , REN LI , WALLS SHANE M
IPC: C07D471/04 , A61K31/437 , A61P35/00
Abstract: Provided herein are compounds of the Formula I: (I) or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
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公开(公告)号：MD3523302T2
公开(公告)日：2022-12-31
申请号：MDE20190907
申请日：2017-10-10
Applicant: ARRAY BIOPHARMA INC
Inventor： ANDREWS STEVEN W , ARONOW SEAN , BLAKE JAMES F , BRANDHUBER BARBARA J , COLLIER JAMES , COOK ADAM , HAAS JULIA , JIANG YUTONG , KOLAKOWSKI GABRIELLE R , MCFADDIN ELIZABETH A , MCKENNEY MEGAN L , MCKNULTY OREN T , METCALF ANDREW T , MORENO DAVID A , RAMANN GINELLE A , TANG TONY P , REN LI , WALLS SHANE M
IPC: C07D471/04 , A61K31/437 , A61P35/00
Abstract: Sunt furnizaţi aici compuşi cu Formula I:sau o sare aceptabilă farmaceutic a acestora, în care A, B, X1, X2, X3, X4, inelul D, E, Ra, Rb, n şi m au semnificaţiile date în specificaţie, care sunt inhibitori de kinază RET şi sunt utili în tratamentul şi prevenirea bolilor care pot fi tratate cu un inhibitor de kinază RET, incluzând bolile şi tulburările asociate cu RET.
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公开(公告)号：HRP20221154T1
公开(公告)日：2022-12-09
申请号：HRP20221154
申请日：2017-10-10
Applicant: ARRAY BIOPHARMA INC
Inventor： ANDREWS STEVEN W , ARONOW SEAN , BLAKE JAMES F , BRANDHUBER BARBARA J , COLLIER JAMES , COOK ADAM , HAAS JULIA , JIANG YUTONG , KOLAKOWSKI GABRIELLE R , MCFADDIN ELIZABETH A , MCKENNEY MEGAN L , MCKNULTY OREN T , METCALF ANDREW T , MORENO DAVID A , RAMANN GINELLE A , TANG TONY P , REN LI , WALLS SHANE M
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公开(公告)号：SI3523302T1
公开(公告)日：2022-09-30
申请号：SI201731196
申请日：2017-10-10
Applicant: ARRAY BIOPHARMA INC
Inventor： ANDREWS STEVEN W , ARONOW SEAN , BLAKE JAMES F , BRANDHUBER BARBARA J , COLLIER JAMES , COOK ADAM , HAAS JULIA , JIANG YUTONG , KOLAKOWSKI GABRIELLE R , MCFADDIN ELIZABETH A , MCKENNEY MEGAN L , MCKNULTY OREN T , METCALF ANDREW T , MORENO DAVID A , RAMANN GINELLE A , TANG TONY P , REN LI , WALLS SHANE M
IPC: C07D471/00 , A61K31/00 , A61P35/00
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公开(公告)号：RS63510B1
公开(公告)日：2022-09-30
申请号：RSP20220783
申请日：2017-10-10
Applicant: ARRAY BIOPHARMA INC
Inventor： ANDREWS STEVEN W , ARONOW SEAN , BLAKE JAMES F , BRANDHUBER BARBARA J , COLLIER JAMES , COOK ADAM , HAAS JULIA , JIANG YUTONG , KOLAKOWSKI GABRIELLE R , MCFADDIN ELIZABETH A , MCKENNEY MEGAN L , MCKNULTY OREN T , METCALF ANDREW T , MORENO DAVID A , RAMANN GINELLE A , TANG TONY P , REN LI , WALLS SHANE M
IPC: C07D471/04 , A61K31/437 , A61P35/00
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