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    SYSTEM AND METHOD OF ASSESSMENT OF MOOD DISORDERS USING EEG
    11.
    发明授权
    SYSTEM AND METHOD OF ASSESSMENT OF MOOD DISORDERS USING EEG 有权
    系统和方法符合条件的精神障碍脑电图使用

    公开(公告)号：EP1460933B1

    公开(公告)日：2008-12-17

    申请号：EP03703709.0

    申请日：2003-01-06

    Applicant: ASPECT MEDICAL SYSTEMS, INC.

    Inventor： GREENWALD, Scott, D. ,  SMITH, Charles, P. ,  SIGL, Jeffrey, C. ,  DEVLIN, Philip, H.

    IPC: A61B5/048

    CPC classification number: A61B5/4839 ,  A61B5/048 ,  A61B5/16 ,  A61B5/4088 ,  G06K9/00523

    Abstract: The present invention is a system and method that produces features and indices that indicate the presence or absence of a disease or condition, or of the progression of a disease or condition. The system and method of the present invention also produce features and indices that predict responsiveness to medication from a premedication baseline. The system and method of the present invention further incorporates a testing methodology to improve the performance characteristics of the features or indices. To obtain such features and indices, time domain, power spectrum, bispectrum and higher order spectrum values are derived from biopotential signals taken from the subject being tested.

    SYSTEM AND METHOD OF ASSESSMENT OF AROUSAL, PAIN AND STRESS DURING ANESTHESIA AND SEDATION
    14.
    发明公开
    SYSTEM AND METHOD OF ASSESSMENT OF AROUSAL, PAIN AND STRESS DURING ANESTHESIA AND SEDATION 审中-公开
    方法蜡条件，疼痛和压力水平在麻醉过程中评估

    公开(公告)号：EP1489964A1

    公开(公告)日：2004-12-29

    申请号：EP03746093.8

    申请日：2003-04-01

    Applicant: Aspect Medical Systems, Inc.

    Inventor： DAHAN, Albert ,  GREENWALD, Scott, D.

    IPC: A61B5/0285

    CPC classification number: A61B5/4821 ,  A61B5/02125 ,  A61B5/02416 ,  A61B5/0285 ,  A61B5/0452 ,  A61B5/0456 ,  A61B5/1106

    Abstract: A PTT (Pulse Transit Time) monitoring system for measuring arousal and responses to stress or pain during sedation or anesthesia includes ECG electrodes and a PPG (photo plethysmography) probe connected to a computer via signal conditioning and digitizing hardware. The ECG and PPG waveforms are continuously analyzed to update and display a current estimate of the subject's PPT from heart to hand. For each cardiac cycle, fiducial points are identified to indicate the pulse onset time (via QRS detection in the ECG) and pulse arrival time (via the point of steepest ascent in the PPG). Finally, the current PTT estimate is displayed numerically and the trend of PTT is updated every second. Clinicians may interpret the instantaneous PTT value directly or in context of its recent trend. If there is a rapid decrease in PTT much less than the predetermined baseline value when the patient should be unconscious and free of stress and pain, then supplemental analgesics are administered to bring PTT greater than or equal to such baseline value.

    SYSTEM AND METHOD FOR ENHANCING AND SEPARATING BIOPOTENTIAL SIGNALS
    15.
    发明公开
    SYSTEM AND METHOD FOR ENHANCING AND SEPARATING BIOPOTENTIAL SIGNALS 有权
    系统和方法加强和生物电位信号的分离

    公开(公告)号：EP0971628A1

    公开(公告)日：2000-01-19

    申请号：EP99903375.6

    申请日：1999-01-25

    Applicant: Aspect Medical Systems, Inc.

    Inventor： GREENWALD, Scott, D. ,  DEVLIN, Philip, H. ,  SMITH, Charles, P.

    IPC: A61B5/0496 ,  A61B5/0478

    CPC classification number: A61B5/0496 ,  A61B5/0478 ,  A61B5/7257

    Abstract: Disclosed is an electrode array (i.e., 'sensor') and a method for separating near and far-field signals. In one embodiment a horizontal array is used, and in an alternate embodiment a vertical array is used. The electrode array consists of two well-separated pairs of closely spaced electrodes (and a separate ground element). In a typical application of collecting a channel of EEG, 'sensing' electrodes are placed in standard locations (e.g., R and Ctr) with a ground electrode placed elsewhere on the head. The voltage measured between the well-separated sensing electrodes is the far-field dominant (i.e., EEG-dominant) channel. Additional electrodes are placed near each of the two sensing electrodes. (The additional electrodes are immediately lateral to the existing electrodes in the horizontal array, and are immediately above the existing electrodes in the vertical array.) The voltages measured between the pairs of closely spaced electrodes are near-field dominant (i.e., EMG/EOG-dominant) channels. The EEG, EMG and EOG signals can be enhanced by uncoupling them by combining information from all channels. The sensor is connected to a monitor via a patient interface cable (PIC). The sensor contains additional circuitry at the connection site that is used by the monitor to identify the presence and type of sensor, and to configure the monitor to invoke the appropriate software that will apply the method of the current invention to collect and uncouple the EEG, EMG and EOG.

    SYSTEM AND METHOD OF ASSESSING ANALGESIC ADEQUACY USING BIOPOTENTAL VARIABILITY
    16.
    发明公开
    SYSTEM AND METHOD OF ASSESSING ANALGESIC ADEQUACY USING BIOPOTENTAL VARIABILITY 有权
    用于评估充足性镇痛系统和方法的部件BIOPOTENZIALSCHWANKUNGEN

    公开(公告)号：EP2007279A2

    公开(公告)日：2008-12-31

    申请号：EP07759890.2

    申请日：2007-03-30

    Applicant: ASPECT MEDICAL SYSTEMS, INC.

    Inventor： GREENWALD, Scott, D.

    IPC: A61B5/05

    CPC classification number: A61B5/04012 ,  A61B5/048 ,  A61B5/0488 ,  A61B5/4821

    Abstract: The system and method for predicting and measuring a subject's analgesic state and analgesic adequacy. Biopotential signals are obtained from a subject through electrodes. A processor will compute a measure that is representative of the subject's sedative state and/or muscle activity. A metric representative of such measures is then determined. In the case where a measure is taken of both the subjects’ sedative state and muscle activity the two measures are combined into an index representative of the subject's analgesic state and analgesic adequacy.

    SYSTEM AND METHOD FOR PREDICTION OF ADVERSE EVENTS DURING TREATMENT OF PSYCHOLOGICAL AND NEUROLOGICAL DISORDERS
    17.
    发明公开
    SYSTEM AND METHOD FOR PREDICTION OF ADVERSE EVENTS DURING TREATMENT OF PSYCHOLOGICAL AND NEUROLOGICAL DISORDERS 审中-公开
    系统和方法预测事件不佳的在治疗和精神障碍的神经

    公开(公告)号：EP1856643A1

    公开(公告)日：2007-11-21

    申请号：EP06718167.7

    申请日：2006-01-12

    Applicant: ASPECT MEDICAL SYSTEMS, INC.

    Inventor： GREENWALD, Scott, D. ,  DEVLIN, Philip, H. ,  SIGL, Jeffrey, C.

    IPC: G06F19/00

    CPC classification number: A61B5/048 ,  A61B5/16 ,  G06F19/00 ,  G06F19/3456

    Abstract: The present invention is a system and method of deriving and computing features and indices that predict the likelihood of psychological and neurological adverse events such as suicidal thoughts and/or actions. The method of the present invention further predicts the likelihood of suicidal thoughts and/or actions prior to and or during treatment for psychological disease. To obtain such features and indices, power spectrum and time domain values are derived from biopotential signals acquired from the subject being tested. The system and method identify people who are likely to experience changing, especially worsening, symptoms of psychological and neurological adverse events such as suicidal thoughts or actions and who therefore may be at risk (e.g. suicide).

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