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    SYSTEM AND METHOD OF ASSESSMENT OF AROUSAL, PAIN AND STRESS DURING ANESTHESIA AND SEDATION
    4.
    发明申请
    SYSTEM AND METHOD OF ASSESSMENT OF AROUSAL, PAIN AND STRESS DURING ANESTHESIA AND SEDATION 审中-公开
    麻醉和麻醉期间疼痛，疼痛和压力的评估系统和方法

    公开(公告)号：WO2003084396A1

    公开(公告)日：2003-10-16

    申请号：PCT/US2003/009900

    申请日：2003-04-01

    Applicant: ASPECT MEDICAL SYSTEMS, INC.

    Inventor： DAHAN, Albert ,  GREENWALD, Scott, D.

    IPC: A61B5/0285

    CPC classification number: A61B5/4821 ,  A61B5/02125 ,  A61B5/02416 ,  A61B5/0285 ,  A61B5/0452 ,  A61B5/0456 ,  A61B5/1106

    Abstract: A PTT (Pulse Transit Time) monitoring system for measuring arousal and responses to stress or pain during sedation or anesthesia includes ECG electrodes and a PPG (photo plethysmography) probe connected to a computer via signal conditioning and digitizing hardware. The ECG and PPG waveforms are continuously analyzed to update and display a current estimate of the subject's PPT from heart to hand. For each cardiac cycle, fiducial points are identified to indicate the pulse onset time (via QRS detection in the ECG) and pulse arrival time (via the point of steepest ascent in the PPG). Finally, the current PTT estimate is displayed numerically and the trend of PTT is updated every second. Clinicians may interpret the instantaneous PTT value directly or in context of its recent trend. If there is a rapid decrease in PTT much less than the predetermined baseline value when the patient should be unconscious and free of stress and pain, then supplemental analgesics are administered to bring PTT greater than or equal to such baseline value.

    Abstract translation: PTT（脉搏传输时间）监测系统，用于在镇静或麻醉期间测量觉醒和应激或疼痛的反应，包括ECG电极和通过信号调理和数字化硬件连接到计算机的PPG（照相体积描记术）探针。 持续分析ECG和PPG波形，以更新和显示受试者PPT的当前估计值。 对于每个心动周期，基准点被识别以指示脉搏起始时间（通过ECG中的QRS检测）和脉冲到达时间（通过PPG中最陡峭的上升点）。 最后，当前的PTT估计数字显示，每秒更新PTT的趋势。 临床医生可以直接或在其最近趋势的背景下解释瞬时PTT值。 如果当患者无意识并且没有压力和疼痛时，如果PTT急剧下降远低于预定的基线值，则施用补充镇痛药使PTT大于或等于该基线值。

    SYSTEM AND METHOD OF ASSESSING ANALGESIC ADEQUACY USING BIOPOTENTAL VARIABILITY
    5.
    发明申请
    SYSTEM AND METHOD OF ASSESSING ANALGESIC ADEQUACY USING BIOPOTENTAL VARIABILITY 审中-公开
    使用生物变化评估线性收缩的系统和方法

    公开(公告)号：WO2007115215A2

    公开(公告)日：2007-10-11

    申请号：PCT/US2007/065708

    申请日：2007-03-30

    Applicant: ASPECT MEDICAL SYSTEMS, INC. ,  GREENWALD, Scott, D.

    Inventor： GREENWALD, Scott, D.

    IPC: G06F1/16

    CPC classification number: A61B5/04012 ,  A61B5/048 ,  A61B5/0488 ,  A61B5/4821

    Abstract: The system and method for predicting and measuring a subject's analgesic state and analgesic adequacy. Biopotential signals are obtained from a subject through electrodes. A processor will compute a measure that is representative of the subject's sedative state and/or muscle activity. A metric representative of such measures is then determined. In the case where a measure is taken of both the subjects’ sedative state and muscle activity the two measures are combined into an index representative of the subject's analgesic state and analgesic adequacy.

    Abstract translation: 用于预测和测量受试者镇痛状态和止痛充足性的系统和方法。 通过电极从受试者获得生物电位信号。 处理器将计算代表受试者的镇静状态和/或肌肉活动的度量。 然后确定此类措施的度量标准。 在对受试者的镇静状态和肌肉活动进行测量的情况下，将两种措施组合成代表受试者的止痛状态和止痛充足性的指标。

    SYSTEM AND METHOD OF PREDICTION OF RESPONSE TO NEUROLOGICAL TREATMENT USING THE ELECTROENCEPHALOGRAM
    6.
    发明申请
    SYSTEM AND METHOD OF PREDICTION OF RESPONSE TO NEUROLOGICAL TREATMENT USING THE ELECTROENCEPHALOGRAM 审中-公开
    使用电化学法预测对神经病理治疗的反应系统及方法

    公开(公告)号：WO2006089181A1

    公开(公告)日：2006-08-24

    申请号：PCT/US2006/005767

    申请日：2006-02-17

    Applicant: ASPECT MEDICAL SYSTEMS, INC. ,  DEVLIN, Philip, R. ,  GREENWALD, Scott, D.

    Inventor： DEVLIN, Philip, R. ,  GREENWALD, Scott, D.

    IPC: A61B5/0476 ,  A61N1/36

    CPC classification number: A61B5/0476 ,  A61B5/048 ,  A61N1/0534 ,  A61N1/0551 ,  A61N1/36025 ,  A61N1/36082

    Abstract: Disclosed is a system and method of assessing the efficacy of and predicting response to treatment of neurological or psychological disorders. The preferred embodiment uses at least two surface electrodes to acquire EEG signals from the surface of a patient’s body, a processor for computing from the EEG signals various features and indices that are representative of the patient’s neurological or psychological state. Pretreatment indices represent a patient’s neurological or psychological state and therefore may be used to predict the response to treatment. Changes in these parameters may be used to assess the efficacy of treatment and to modify the treatment to optimize the resultant patient state.

    Abstract translation: 公开了一种评估治疗神经或心理障碍的疗效和预测应答的系统和方法。 优选实施例使用至少两个表面电极从患者身体的表面获取EEG信号，用于从EEG计算的处理器发出代表患者神经或心理状态的各种特征和指数。 预处理指数代表患者的神经或心理状态，因此可用于预测治疗反应。 这些参数的改变可用于评估治疗的功效和修改治疗以优化所得患者状态。

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