公开(公告)号：WO2011159785A1

公开(公告)日：2011-12-22

申请号：PCT/US2011/040501

申请日：2011-06-15

Applicant: ABBOTT LABORATORIES ,  DART, Michael ,  KOLASA, Teodozyj

Inventor： DART, Michael ,  KOLASA, Teodozyj

IPC: A01N43/78 ,  A61K31/425

CPC classification number: A61K31/4985 ,  A61K31/5025 ,  A61K31/519

Abstract: Disclosed herein are cannabinoid receptor ligands of formula (I) wherein A 1 and R x are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.

Abstract translation: 本文公开了式（I）的大麻素受体配体，其中A1和Rx如说明书中所定义。 还提出了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和障碍的方法。

公开(公告)号：WO2010028338A2

公开(公告)日：2010-03-11

申请号：PCT/US2009/056179

申请日：2009-09-08

Applicant: ABBOTT LABORATORIES ,  CARROLL, William, A. ,  DART, Michael, J. ,  FROST, Jennifer, M. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  LIU, Bo ,  PEREZ-MEDRANO, Arturo ,  PATEL, Meena ,  WANG, Xueqing ,  PEDDI, Sridhar

Inventor： CARROLL, William, A. ,  DART, Michael, J. ,  FROST, Jennifer, M. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  LIU, Bo ,  PEREZ-MEDRANO, Arturo ,  PATEL, Meena ,  WANG, Xueqing ,  PEDDI, Sridhar

IPC: C07D277/46 ,  C07D417/06 ,  C07D417/14 ,  A61K31/427 ,  A61P29/00

CPC classification number: C07D417/06 ,  C07D277/46 ,  C07D417/14

Abstract: The present application relates to cannabinoid receptor ligands of formula (I), wherein X 1 , A 1 , R x , R 2 , R 3 , R 4 , and z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions.

Abstract translation: 本申请涉及式（I）的大麻素受体配体，其中X1，A1，Rx，R2，R3，R4和z如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。

公开(公告)号：WO2003099266A3

公开(公告)日：2003-12-04

申请号：PCT/US2003/015868

申请日：2003-05-19

Applicant: ABBOTT LABORATORIES

Inventor： BHATIA, Pramila, A. ,  DAANEN, Jerome, F. ,  HAKEEM, Ahmed, A. ,  KOLASA, Teodozyj ,  MATULENKO, Mark, A. ,  MORTELL, Kathleen, H. ,  PATEL, Meena, V. ,  STEWART, Andrew, O. ,  WANG, Xueqing ,  XIA, Zhiren ,  ZHANG, Henry, Q.

IPC: A61K31/00

Abstract: The present invention relates to the use of compounds of formula (I), for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.

公开(公告)号：WO2003076408A2

公开(公告)日：2003-09-18

申请号：PCT/US2003/006678

申请日：2003-03-04

Applicant: ABBOTT LABORATORIES

Inventor： KOLASA, Teodozyj ,  BRIONI, Jorge, D. ,  GRACIAS, Vijaya ,  NAKANE, Masaki ,  PATEL, Meena, V. ,  ROHDE, Jeffrey

IPC: C07D231/00

CPC classification number: C07D231/56 ,  C07D401/12 ,  C07D405/12 ,  C07D471/04

Abstract: Compounds of formula (I) are novel indazoles useful for increasing cGMP levels in a mammal.

Abstract translation: 式（I）化合物是用于增加哺乳动物中cGMP水平的新型吲唑。

公开(公告)号：WO1997041100A1

公开(公告)日：1997-11-06

申请号：PCT/US1997004981

申请日：1997-03-26

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  BROOKS, C., D., W. ,  CRAIG, Richard, A. ,  GUNN, David, E. ,  KOLASA, Teodozyj ,  MOORE, Jimmie, L. ,  STEWART, Andrew, O.

IPC: C07D209/12

CPC classification number: C07D213/30 ,  C07C317/22 ,  C07C323/19 ,  C07C2602/08 ,  C07D209/12 ,  C07D257/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

Abstract: The present invention provides a class of substituted indole and indene iminoxy derivatives of formulae (I), (II) and (III) which inhibit leukotriene biosynthesis and are useful in the treatment of allergic and inflammatory disease states.

Abstract translation: 本发明提供一类抑制白三烯生物合成的式（I），（II）和（III）的吲哚和茚亚氨基衍生物，并且可用于治疗过敏性和炎性疾病状态。

公开(公告)号：WO1996002507A1

公开(公告)日：1996-02-01

申请号：PCT/US1995008367

申请日：1995-06-28

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  BROOKS, Dee, W. ,  BHATIA, Pramila ,  KOLASA, Teodozyj ,  STEWART, Andrew, O.

IPC: C07D215/14

CPC classification number: C07D213/30 ,  C07D215/14 ,  C07D215/227 ,  C07D215/36 ,  C07D235/12 ,  C07D239/26 ,  C07D241/42 ,  C07D263/56 ,  C07D277/24 ,  C07D277/64 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D513/04

Abstract: The present invention relates to a compound of the formula: W-X-Q-Y-CH(R )-O-N=C(R )-A-COM, or a pharmaceutically acceptable salt thereof wherein W is optionally substituted aryl or heteroaryl; X is a valence bond, or methylene, divalent alkylene, alkenylene, alkynylene or alkyloxy; Q is a valence bond, or -O-, -S-, > NR or > NCOR ; Y is optionally substituted phenyl, biphenyl, naphthyl, tetrahydronaphthyl, indolyl, pyridyl, or benzo[b]thienyl, thienyl, thiazolyl, or thiazolylphenyl; R is alkyl, cycloalkyl, alkoxyalkyl, aryl or arylalkyl, heteroaryl or heteroarylalkyl; R is hydrogen, alkyl or hydroxyalkyl; A is a valence bond or is selected from alkylene, alkenylene, alkynylene, cycloalkylene, phenylene, pyridylene, thienylene and furylene; and M is a pharmaceutically acceptable, metabolically cleavable group, -OR , -NR R , -NH-tetrazoyl, -NH-2-, 3-, or 4-pyridyl, and -NH-2-, 4-, or 5-thiazolyl which inhibit leukotriene biosynthesis and are useful in the treatment of inflammatory disease states. Also disclosed are leukotriene biosynthesis inhibiting compositions and a method for inhibiting lipoxygenase activity and leukotriene biosynthesis.

Abstract translation: 本发明涉及下式化合物：W-X-Q-Y-CH（R 1）-O-N = C（R 2）-A-COM或其药学上可接受的盐，其中W为任选取代的芳基或杂芳基; X是价键，或亚甲基，二价亚烷基，亚烯基，亚炔基或烷氧基; Q是价键，或-O - ， - S-，> NR 4或NCOR 5。 Y是任选取代的苯基，联苯基，萘基，四氢萘基，吲哚基，吡啶基或苯并[b]噻吩基，噻吩基，噻唑基或噻唑基苯基; R 1是烷基，环烷基，烷氧基烷基，芳基或芳基烷基，杂芳基或杂芳基烷基; R 2是氢，烷基或羟烷基; A是价键或选自亚烷基，亚烯基，亚炔基，亚环烷基，亚苯基，亚吡啶基，亚噻吩基和亚芳基; 并且M是药学上可接受的代谢可裂解基团-OR 6，-NR 6 R 7，-NH-三唑基，-NH-2-，3-或4-吡啶基和-NH- 抑制白细胞三烯生物合成的2-，4-或5-噻唑基并且可用于治疗炎性疾病状态。 还公开了白三烯生物合成抑制组合物和抑制脂氧合酶活性和白三烯生物合成的方法。

公开(公告)号：WO2010019547A1

公开(公告)日：2010-02-18

申请号：PCT/US2009/053369

申请日：2009-08-11

Applicant: ABBOTT LABORATORIES ,  CARROLL, William, A. ,  DART, Michael, J. ,  FROST, Jennifer, M. ,  KOLASA, Teodozyj ,  LATSHAW, Steven, P. ,  LIU, Bo ,  PATEL, Meena, V. ,  PEREZ-MEDRANO, Arturo ,  WANG, Xueqing

Inventor： CARROLL, William, A. ,  DART, Michael, J. ,  FROST, Jennifer, M. ,  KOLASA, Teodozyj ,  LATSHAW, Steven, P. ,  LIU, Bo ,  PATEL, Meena, V. ,  PEREZ-MEDRANO, Arturo ,  WANG, Xueqing

IPC: C07D261/14 ,  C07D407/06 ,  C07D417/06 ,  C07D285/135 ,  A61K31/433 ,  A61P29/00

CPC classification number: C07D261/14 ,  C07D285/135 ,  C07D407/06 ,  C07D417/06

Abstract: Disclosed herein are cannabinoid receptor ligands of formula (I), wherein Y, X 1 , X 2 , X 3 , R 1 , and R 2 are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

Abstract translation: 本文公开了式（I）的大麻素受体配体，其中Y，X1，X2，X3，R1和R2如说明书中所定义。 还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。

公开(公告)号：WO2009067613A1

公开(公告)日：2009-05-28

申请号：PCT/US2008/084216

申请日：2008-11-20

Applicant: ABBOTT LABORATORIES ,  FLORJANCIC, Alan, S. ,  DART, Michael, J. ,  RYTHER, Keith, B. ,  PEREZ-MEDRANO, Arturo ,  CARROLL, William, A. ,  PATEL, Meena, V. ,  TIETJE, Karin, Rosemarie ,  LI, Tongmei ,  KOLASA, Teodozyj ,  GALLAGHER, Megan, E. ,  PEDDI, Sridhar ,  FROST, Jennifer, M. ,  NELSON, Derek, W.

Inventor： FLORJANCIC, Alan, S. ,  DART, Michael, J. ,  RYTHER, Keith, B. ,  PEREZ-MEDRANO, Arturo ,  CARROLL, William, A. ,  PATEL, Meena, V. ,  TIETJE, Karin, Rosemarie ,  LI, Tongmei ,  KOLASA, Teodozyj ,  GALLAGHER, Megan, E. ,  PEDDI, Sridhar ,  FROST, Jennifer, M. ,  NELSON, Derek, W.

IPC: A01N43/42

CPC classification number: C07D417/12 ,  C07D277/46 ,  C07D417/06 ,  C07D513/04 ,  C07D513/20

Abstract: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, formula (I). wherein R 1 , R 2 , R 3 , R 4 , and L 1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, formula (II). wherein R 1a , R 2a , R x , and n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

Abstract translation: 本发明涉及式（I）的化合物或其药物盐，前药，前药的盐或其组合，式（I）。 其中R1，R2，R3，R4和L1在具体实施方案中被定义，包含这些化合物的组合物以及使用这些化合物和组合物治疗病症和病症的方法。 本发明还涉及式（II）的化合物或其药物盐，前药，前药盐或其组合，式（II）。 其中R1a，R2a，Rx和n如说明书中所定义，包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。

公开(公告)号：WO2003099266A2

公开(公告)日：2003-12-04

申请号：PCT/US2003/015868

申请日：2003-05-19

Applicant: ABBOTT LABORATORIES

Inventor： BHATIA, Pramila, A. ,  DAANEN, Jerome, F. ,  HAKEEM, Ahmed, A. ,  KOLASA, Teodozyj ,  MATULENKO, Mark, A. ,  MORTELL, Kathleen, H. ,  PATEL, Meena, V. ,  STEWART, Andrew, O. ,  WANG, Xueqing ,  XIA, Zhiren ,  ZHANG, Henry, Q.

IPC: A61K31/00

CPC classification number: C07D213/82 ,  A61K31/40 ,  A61K31/41 ,  A61K31/445 ,  A61K31/4453 ,  A61K31/4523 ,  C07D207/06 ,  C07D211/14 ,  C07D211/18 ,  C07D211/22 ,  C07D211/70 ,  C07D213/74 ,  C07D213/85 ,  C07D235/30 ,  C07D239/42 ,  C07D277/38 ,  C07D277/82 ,  C07D295/13 ,  C07D295/15 ,  C07D295/155 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14

Abstract: The present invention relates to the use of compounds of formula (I), for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.

Abstract translation: 本发明涉及式（I）化合物用于治疗性功能障碍和含有式（I）化合物用于治疗性功能障碍的组合物的用途。

公开(公告)号：WO2003076431A1

公开(公告)日：2003-09-18

申请号：PCT/US2003/006406

申请日：2003-03-04

Applicant: ABBOTT LABORATORIES

Inventor： COWART, Marlon, D. ,  BHATIA, Pramila, A. ,  DAANEN, Jerome, F. ,  STEWART, Andrew, O. ,  PATEL, Meena, V. ,  KOLASA, Teodozyj ,  BRIONI, Jorge, D. ,  ROHDE, Jeffrey ,  ENGSTROM, Kenneth, M.

IPC: C07D401/12

CPC classification number: C07D401/12 ,  A61K31/496 ,  C07D403/12

Abstract: The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.

Abstract translation: 本发明涉及式（I）化合物用于治疗性功能障碍的用途，以及含有式（I）化合物用于治疗性功能障碍的组合物的用途。